Forskolin (BioDeep_00000000316)

   

PANOMIX_OTCML-2023


代谢物信息卡片


1H-Naphtho(2,1-b)pyran-1-one, dodecahydro-5-(acetyloxy)-3-ethenyl-3,4a,7,7,10a-pentamethyl-6,10,10b-trihydroxy-, (3R-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,10-alpha,10a-beta,10b-alpha))-

化学式: C22H34O7 (410.2304414)
中文名称: 毛喉素, 佛司可林, 佛司可林
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 7.11%

分子结构信息

SMILES: C1C([C@]2([C@]([C@@]3(O)C(=O)C[C@@](C)(O[C@]3(C)[C@H]([C@H]2O)OC(C)=O)C=C)(C)[C@@H](O)C1)[H])(C)C
InChI: InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3

描述信息

Forskolin is a labdane diterpenoid isolated from the Indian Coleus plant. It has a role as a plant metabolite, an anti-HIV agent, a protein kinase A agonist, an adenylate cyclase agonist, an antihypertensive agent and a platelet aggregation inhibitor. It is a labdane diterpenoid, an acetate ester, an organic heterotricyclic compound, a triol, a cyclic ketone and a tertiary alpha-hydroxy ketone.
Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant Coleus forskohlii. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.
Forskolin is a natural product found in Plectranthus, Plectranthus barbatus, and Apis cerana with data available.
Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant Coleus forskohlii. Has antihypertensive, positive ionotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.
Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant Coleus forskohlii. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
A labdane diterpenoid isolated from the Indian Coleus plant.
D020011 - Protective Agents > D002316 - Cardiotonic Agents
C78274 - Agent Affecting Cardiovascular System
D007155 - Immunologic Factors
CONFIDENCE standard compound; INTERNAL_ID 408; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4753; ORIGINAL_PRECURSOR_SCAN_NO 4752
CONFIDENCE standard compound; INTERNAL_ID 408; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4747; ORIGINAL_PRECURSOR_SCAN_NO 4745
CONFIDENCE standard compound; INTERNAL_ID 408; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4785; ORIGINAL_PRECURSOR_SCAN_NO 4783
CONFIDENCE standard compound; INTERNAL_ID 408; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4767; ORIGINAL_PRECURSOR_SCAN_NO 4766
CONFIDENCE standard compound; INTERNAL_ID 408; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4849; ORIGINAL_PRECURSOR_SCAN_NO 4847
CONFIDENCE standard compound; INTERNAL_ID 408; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4753; ORIGINAL_PRECURSOR_SCAN_NO 4748
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.202
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.164
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.188
[Raw Data] CB247_Forskolin_neg_30eV_000046.txt
[Raw Data] CB247_Forskolin_neg_40eV_000046.txt
[Raw Data] CB247_Forskolin_neg_10eV_000046.txt
[Raw Data] CB247_Forskolin_neg_20eV_000046.txt
Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC50 of 41 nM and an EC50 of 0.5 μM for type I adenylyl cyclase[1]. Forskolin is also an inducer of intracellular cAMP formation[2]. Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR[3]. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy[4][5].

同义名列表

74 个代谢物同义名

1H-Naphtho(2,1-b)pyran-1-one, dodecahydro-5-(acetyloxy)-3-ethenyl-3,4a,7,7,10a-pentamethyl-6,10,10b-trihydroxy-, (3R-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,10-alpha,10a-beta,10b-alpha))-; InChI=1/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1; 1H-Naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3R-(3alpha,4abeta,5beta,6beta,6aalpha,10alpha,10abeta,10balpha))-; [3R-(3; [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate; [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl]acetate; [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyl-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate; [3R-(3a,4ab,5b,6b,6aa,10a,10ab,10ba)]-5-(Acetyloxy)-3-e thenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one; [3R-(3?,4a?,5?,6?,6a?,10?,10a?,10b?)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one; N,N-dimethyl-beta-alanine-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-6-yl ester HCl; 1H-Naphtho[2,1-b]pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-; (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-dodecahydro-1H-naphtho[2,1-b]pyran-5-yl acetate; (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-Dodecahydro-5,6,10,10b-tetrahydroxy-3,4a,7,7,10a-pentamethyl-3-vinyl-1H-naphtho[2,1-b]pyran-1-one 5-acetate; (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-Dodecahydro-5,6,10,10b-tetrahydroxy-3,4a,7,7,10a-pentamethyl-3-vinyl-1H-naphtho(2,1-b)pyran-1-one 5-acetate; (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-benzo[f]chromen-5-yl acetate; (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl acetate; 1H-Naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-; 5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho(2,1-b)pyran-1-one; Coleonol;7beta-Acetoxy-8,13-epoxy-1alpha,6beta,9alpha-trihydroxylabd-14-en-11-one; 7-beta-Acetoxy-8,13-epoxy-1-alpha,6-beta,9-alpha-trihydroxylabd-14-en-11-one; 7beta-Acetoxy-8,13-epoxy-1alpha,6beta,9alpha-trihydroxylabd-14-en-11-one; Forskolin, United States Pharmacopeia (USP) Reference Standard; Forskolin, from Coleus forskohlii, >=98\\% (HPLC), powder; Forskolin, For use in molecular biology applications; FORSKOLIN (CONSTITUENT OF FORSKOHLII) [DSC]; Forskolin, analytical standard; OHCQJHSOBUTRHG-KGGHGJDLSA-N; OHCQJHSOBUTRHG-KGGHGJDLSA-; Colforsina [Spanish]; Colforsin [USAN:INN]; Colforsin (USAN/INN); Colforsine [French]; Colforsinum [Latin]; COLFORSIN [WHO-DD]; Coleonol;Colforsin; FORSKOLIN [USP-RS]; FORSKOLIN [VANDF]; COLFORSIN [MART.]; Forskolin- Bio-X; BCBcMAP01_000132; Forskolin - 20\\%; COLFORSIN [USAN]; Forskolin - 40\\%; Forskolin - 10\\%; Forskolin (GMP); COLFORSIN [INN]; UNII-1F7A44V6OU; COLFORSIN [MI]; Tox21_110940_1; (-)-Forskolin; Tox21_302399; Tox21_110940; Timsaponin-C; Bio1_000932; Bio1_000443; colforsinum; Bio1_001421; SMP1_000128; colforsina; L 75 1362B; L-75-1362B; 1F7A44V6OU; colforsine; colforsin; Forskolin; Coleonolk; Boforsin; C22H34O7; Coleonol; ForsLean; Ocufors; FOK; Forskolin Racemate; HL 362



数据库引用编号

39 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Qian Yang, Mohammed Abed Jawad, Abdullah Ali Alzahrani, Zahraa F Hassan, Ahmed Elawady, Ahmed Hjazi, Mehran Naghibi. Synergistic effects of Metformin and Forskolin on oxidative stress induced by diabetes and hepatocellular cancer: An animal study. Toxicon : official journal of the International Society on Toxinology. 2024 May; 243(?):107720. doi: 10.1016/j.toxicon.2024.107720. [PMID: 38614244]
  • Shihao Cheng, Chenhu Dong, Yujie Ma, Xiaoyu Xu, Yu Zhao. Skeletal Transformations of Terpenoid Forskolin Employing an Oxidative Rearrangement Strategy. The Journal of organic chemistry. 2024 Apr; 89(8):5741-5745. doi: 10.1021/acs.joc.4c00312. [PMID: 38568052]
  • Yuqi Yang, Yue Peng, Bin Yu, Huiyan Wang. ABHD5-CPT1B: An Important Way of Regulating Placental Lipid Metabolism in Gestational Diabetes Mellitus. Archives of medical research. 2024 01; 55(1):102925. doi: 10.1016/j.arcmed.2023.102925. [PMID: 38042031]
  • Tongtong Zhang, Xincheng Liao, Yuzhi Chen, Xinru Shu, Deshan Liu, Yusheng Yao. Dexmedetomidine Prolongs Lidocaine Intravenous Regional Anesthesia in Rats by Blocking the Hyperpolarization-Activated Cation Current. Drug design, development and therapy. 2024; 18(?):1103-1114. doi: 10.2147/dddt.s450971. [PMID: 38618283]
  • Caitlyn Henry, Mackenzie Wilcox, Angela L Asirvatham. Forskolin-mediated cAMP activation upregulates TNF-α expression despite NF-κB downregulation in LPS-treated Schwann cells. PloS one. 2024; 19(4):e0302223. doi: 10.1371/journal.pone.0302223. [PMID: 38625986]
  • Tamara Rakhmanova, Valentina Mokrousova, Svetlana Okotrub, Elena Kizilova, Eugeny Brusentsev, Sergei Amstislavsky. Effects of forskolin on cryopreservation and embryo development in the domestic cat. Theriogenology. 2023 Oct; 210(?):192-198. doi: 10.1016/j.theriogenology.2023.07.035. [PMID: 37523940]
  • Zhou Peng, Jingyang Cai, Xirong Guo, Siliang Xu. Brown adipocyte activation mediates lipid metabolism through exosomal tRNA-derived fragments. Biochemical and biophysical research communications. 2023 Jun; 672(?):128-136. doi: 10.1016/j.bbrc.2023.06.038. [PMID: 37352601]
  • Maria Carmen Iglesias-Osma, Maria José García-Barrado, David Hernandez-Gonzalez, Kévin Perrier, Pénélope Viana, Christian Carpéné. The anxiolytic drug opipramol inhibits insulin-induced lipogenesis in fat cells and insulin secretion in pancreatic islets. Journal of physiology and biochemistry. 2023 Feb; ?(?):. doi: 10.1007/s13105-023-00950-8. [PMID: 36821072]
  • Przemysław Sitarek, Tomasz Kowalczyk, Ewelina Synowiec, Anna Merecz-Sadowska, Gabrielle Bangay, Salvatore Princiotto, Tomasz Śliwiński, Patricia Rijo. An Evaluation of the Novel Biological Properties of Diterpenes Isolated from Plectranthus ornatus Codd. In Vitro and In Silico. Cells. 2022 10; 11(20):. doi: 10.3390/cells11203243. [PMID: 36291112]
  • Takehiro Yamamoto, Zhicheng Diao, Masaru Murakami, Fumie Shimokawa, Tohru Matsui, Masayuki Funaba. Factors affecting the induction of uncoupling protein 1 in C2C12 myogenic cells. Cytokine. 2022 09; 157(?):155936. doi: 10.1016/j.cyto.2022.155936. [PMID: 35738051]
  • Ignacio Jiménez Amezcua, Sergio Rivas Blas, Marina Díez Municio, Ana Cristina Soria, Ana Isabel Ruiz Matute, María Luz Sanz. Development of a multianalytical strategy for detection of frauds in Coleus forskohlii supplements. Journal of chromatography. A. 2022 Aug; 1676(?):463198. doi: 10.1016/j.chroma.2022.463198. [PMID: 35704959]
  • Mehran Naghibi, Hamid Tayefi Nasrabadi, Jafar Soleimani Rad, Mohammad Sadegh Gholami Farashah, Daryoush Mohammadnejad. The effects of metformin and forskolin on sperm quality parameters and sexual hormones in type II diabetic male rats. Andrologia. 2022 Aug; 54(7):1605-1617. doi: 10.1111/and.14426. [PMID: 35396719]
  • Reem N El-Naga. Forskolin alleviates cisplatin-induced acute renal toxicity in rats. The Journal of pharmacy and pharmacology. 2022 Jul; 74(7):1051-1060. doi: 10.1093/jpp/rgac016. [PMID: 35512548]
  • Doneti Ravinder, Shailima Rampogu, Gangappa Dharmapuri, Akbar Pasha, Keun Woo Lee, Smita C Pawar. Inhibition of DDX3 and COX-2 by forskolin and evaluation of anti-proliferative, pro-apoptotic effects on cervical cancer cells: molecular modelling and in vitro approaches. Medical oncology (Northwood, London, England). 2022 Apr; 39(5):61. doi: 10.1007/s12032-022-01658-3. [PMID: 35478276]
  • Diana A Quintero-Espinosa, Hector Flavio Ortega-Arellano, Carlos Velez-Pardo, Marlene Jimenez-Del-Rio. Phenolic-rich extract of avocado Persea americana (var. Colinred) peel blunts paraquat/maneb-induced apoptosis through blocking phosphorylation of LRRK2 kinase in human nerve-like cells. Environmental toxicology. 2022 Mar; 37(3):660-676. doi: 10.1002/tox.23433. [PMID: 34897981]
  • Sayed Haidar Abbas Raza, Ayman H Abd El-Aziz, Sameh A Abdelnour, Ahmed A Easa, Mahmoud Alagawany, Mayada R Farag, Mohsen G Al-Mutary, Ahmed Elfadadny, Rajwali Khan, Guobo Quan, Gong Cheng, Linsen Zan. The role of forskolin as a lipolytic stimulator during in vitro oocyte maturation and the in vitro embryo production of livestock. Reproduction in domestic animals = Zuchthygiene. 2021 Dec; 56(12):1486-1496. doi: 10.1111/rda.14021. [PMID: 34592022]
  • Haruka Sasaki, Yi Zhang, Charles W Emala, Kentaro Mizuta. Melatonin MT2 receptor is expressed and potentiates contraction in human airway smooth muscle. American journal of physiology. Lung cellular and molecular physiology. 2021 12; 321(6):L991-L1005. doi: 10.1152/ajplung.00273.2021. [PMID: 34612067]
  • Ping Yang, Pei-Wen Jiang, Chen Li, Ming-Xiang Gao, Yi-Song Sun, Dan-Ying Zhang, Wen-Qian Du, Jing Zhao, Song-Ting Shi, Yan Li, Tai Yang, Li Cheng, Min-Hui Li. Cdc25C/cdc2/cyclin B, raf/MEK/ERK and PERK/eIF2α/CHOP pathways are involved in forskolin-induced growth inhibition of MM.1S cells by G2/M arrest and mitochondrion-dependent apoptosis. Cell cycle (Georgetown, Tex.). 2021 11; 20(22):2402-2412. doi: 10.1080/15384101.2021.1983280. [PMID: 34606419]
  • Chuang Xiao, Sha Cheng, Haochang Lin, Zhiying Weng, Peihua Peng, Deyou Zeng, Xiaohua Du, Xiujuan Zhang, Yaqing Yang, Yaping Liang, Rong Huang, Chen Chen, Lueli Wang, Hongxiang Wu, Runfeng Li, Xinhua Wang, Rongping Zhang, Zifeng Yang, Xian Li, Xue Cao, Weimin Yang. Isoforskolin, an adenylyl cyclase activator, attenuates cigarette smoke-induced COPD in rats. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Oct; 91(?):153701. doi: 10.1016/j.phymed.2021.153701. [PMID: 34438230]
  • Alexander O Pritchard, Dion B Nemez, David E Herbert, Shyamala Dakshinamurti, John L Sorensen. The isolation, purification and complete characterization of the diterpene forskolin from nutritional supplements. Bioorganic & medicinal chemistry letters. 2021 07; 44(?):128119. doi: 10.1016/j.bmcl.2021.128119. [PMID: 34019977]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Christine E Stephens, Jonathan M Whittamore, Marguerite Hatch. The role of NHE3 (Slc9a3) in oxalate and sodium transport by mouse intestine and regulation by cAMP. Physiological reports. 2021 04; 9(7):e14828. doi: 10.14814/phy2.14828. [PMID: 33904662]
  • Anthati Mastan, Digeshwar Rane, Syed G Dastager, C S Vivek Babu. Molecular insights of fungal endophyte co-inoculation with Trichoderma viride for the augmentation of forskolin biosynthesis in Coleus forskohlii. Phytochemistry. 2021 Apr; 184(?):112654. doi: 10.1016/j.phytochem.2021.112654. [PMID: 33461046]
  • Ricardo De La Peña, Elizabeth S Sattely. Rerouting plant terpene biosynthesis enables momilactone pathway elucidation. Nature chemical biology. 2021 02; 17(2):205-212. doi: 10.1038/s41589-020-00669-3. [PMID: 33106662]
  • Adrien Flahault, Pierre-Emmanuel Girault-Sotias, Mathilde Keck, Rodrigo Alvear-Perez, Nadia De Mota, Lucie Estéoulle, Sridévi M Ramanoudjame, Xavier Iturrioz, Dominique Bonnet, Catherine Llorens-Cortes. A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia. Nature communications. 2021 01; 12(1):305. doi: 10.1038/s41467-020-20560-y. [PMID: 33436646]
  • Preeti Manandhar, Shivani Sachdev, Marina Santiago. Evaluating Opioid-Mediated Adenylyl Cyclase Inhibition in Live Cells Using a BRET-Based Assay. Methods in molecular biology (Clifton, N.J.). 2021; 2201(?):117-125. doi: 10.1007/978-1-0716-0884-5_11. [PMID: 32975794]
  • Aaser M Abdelazim, Tamer Ahmed Ismail, Mosleh M Abumaghaid, Islam M Saadaldin. Synergetic Action of Forskolin and Mevastatin Induce Normalization of Lipids Profile in Dyslipidemic Rats through Adenosine Monophosphate Kinase Upregulation. BioMed research international. 2021; 2021(?):6687551. doi: 10.1155/2021/6687551. [PMID: 34104650]
  • Yu G Birulina, V V Ivanov, E E Buyko, E P Efremkina, L V Smagliy, I V Kovalev, A V Nosarev, S V Gusakova. Regulation of Vascular Smooth Muscle Contractions in the Model of Metabolic Syndrome. Bulletin of experimental biology and medicine. 2020 Dec; 170(2):196-199. doi: 10.1007/s10517-020-05031-0. [PMID: 33263844]
  • Annagrazia Adornetto, Laura Rombolà, Luigi Antonio Morrone, Carlo Nucci, Maria Tiziana Corasaniti, Giacinto Bagetta, Rossella Russo. Natural Products: Evidence for Neuroprotection to Be Exploited in Glaucoma. Nutrients. 2020 Oct; 12(10):. doi: 10.3390/nu12103158. [PMID: 33081127]
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