Pyridine (BioDeep_00000003037)

 

Secondary id: BioDeep_00000405403, BioDeep_00000869536

human metabolite


代谢物信息卡片


Pyridine perbromate, 82BR-labeled

化学式: C5H5N (79.042197)
中文名称: 吡啶
谱图信息: 最多检出来源 Viridiplantae(plant) 64.06%

分子结构信息

SMILES: C(C1)CCNC1
InChI: InChI=1S/C5H5N/c1-2-4-6-5-3-1/h1-5H

描述信息

Pyridine is a clear liquid with an odor that is sour, putrid, and fish-like. It is a relatively simple heterocyclic aromatic organic compound that is structurally related to benzene, with one CH group in the six-membered ring replaced by a nitrogen atom. Pyridine is obtained from crude coal tar or is synthesized from acetaldehyde, formaldehyde and ammonia. Pyridine is often used as a denaturant for antifreeze mixtures, for ethyl alcohol, for fungicides, and as a dyeing aid for textiles. It is a harmful substance if inhaled, ingested or absorbed through the skin. In particular, it is known to reduce male fertility and is considered carcinogenic. Common symptoms of acute exposure to pyridine include: headache, coughing, asthmatic breathing, laryngitis, nausea and vomiting. -- Wikipedia.
Flavouring ingredient. Pyridine is found in many foods, some of which are kohlrabi, red bell pepper, green bell pepper, and papaya.
CONFIDENCE standard compound; INTERNAL_ID 8135
KEIO_ID P041

同义名列表

35 个代谢物同义名

Pyridine perbromate, 82BR-labeled; Pyridine ion (1-), potassium salt; Pyridine perchlorate, 2H-labeled; Pyridine ion (1-), lithium salt; Pyridine ion (1-), sodium salt; Pyridine, hydrogen fluoride; Pyridine ion (1-), hydrogen; Pyridine, hydrogen bromide; Pyridine, hydrogen iodide; Pyridine phosphate (2:1); Pyridine monophosphate; Pyridine hydride (2:1); Monopyridine phosphate; Pyridine hydrochloride; Pyridine sulfate (2:1); Pyridine monosulfate; Pyridine perchlorate; Pyridine diphosphate; Pyridine monohydrate; Pyridine disulfate; Pyridine dinitrate; Pyridine phosphate; Pyridine ion (2+); Pyridine nitrate; Pyridine hydride; Pyridine cyanate; Pyridine sulfate; Azabenzene; PYRIDINE; Tritisan; Pirydyna; Piridina; Pyridin; Azine; py



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(1)

PlantCyc(0)

代谢反应

36 个相关的代谢反应过程信息。

Reactome(36)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

37 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Etify A Bakhite, Suzan Abuelhassan, Mohamed A Gad, Abdu E Abdel-Rahman, Omaima F Ibrahim, Islam S Marae, Shaaban K Mohamed, Joel T Mague, Ayman Nafady. Pyridine Derivatives as Insecticides─Part 4: Synthesis, Crystal Structure, and Insecticidal Activity of Some New Thienylpyridines, Thienylthieno[2,3-b]pyridines, and Related Heterocyclic Derivatives. Journal of agricultural and food chemistry. 2023 Nov; ?(?):. doi: 10.1021/acs.jafc.3c01202. [PMID: 37941360]
  • Stone Woo, Ryan A Shenvi. Synthesis and target annotation of the alkaloid GB18. Nature. 2022 06; 606(7916):917-921. doi: 10.1038/s41586-022-04840-9. [PMID: 35551513]
  • Xiandeng Li, Tao Yang, Mengshi Hu, Yingxue Yang, Minghai Tang, Dexin Deng, Kongjun Liu, Suhong Fu, Yan Tan, Huan Wang, Yong Chen, Chufeng Zhang, Yong Guo, Bin Peng, Wenting Si, Zhuang Yang, Lijuan Chen. Synthesis and biological evaluation of 6-(pyrimidin-4-yl)-1H-pyrazolo[4,3-b]pyridine derivatives as novel dual FLT3/CDK4 inhibitors. Bioorganic chemistry. 2022 04; 121(?):105669. doi: 10.1016/j.bioorg.2022.105669. [PMID: 35180490]
  • Takuji Oyama, Kazuki Takiguchi, Hiroyuki Miyachi. Crystal structures of the ligand-binding domain of human peroxisome proliferator-activated receptor δ in complexes with phenylpropanoic acid derivatives and a pyridine carboxylic acid derivative. Acta crystallographica. Section F, Structural biology communications. 2022 Feb; 78(Pt 2):81-87. doi: 10.1107/s2053230x22000449. [PMID: 35102897]
  • Shamil N Galimov, Julia Y Gromenko, Kirill V Bulygin, Kamil Sh Galimov, Elmira F Galimova, Mikhail Y Sinelnikov. The level of secondary messengers and the redox state of NAD+/NADH are associated with sperm quality in infertility. Journal of reproductive immunology. 2021 11; 148(?):103383. doi: 10.1016/j.jri.2021.103383. [PMID: 34534880]
  • Arun K Ghosh, Jakka Raghavaiah, Dana Shahabi, Monika Yadav, Brandon J Anson, Emma K Lendy, Shin-Ichiro Hattori, Nobuyo Higashi-Kuwata, Hiroaki Mitsuya, Andrew D Mesecar. Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies. Journal of medicinal chemistry. 2021 10; 64(19):14702-14714. doi: 10.1021/acs.jmedchem.1c01214. [PMID: 34528437]
  • Ranran Zhang, Junhong Liu, Hui Yan, Xingrong Peng, Ling Zhang, Minghua Qiu. Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.). Molecules (Basel, Switzerland). 2021 Aug; 26(16):. doi: 10.3390/molecules26164934. [PMID: 34443522]
  • Snežana Jovanović-Stević, Snežana Radisavljević, Andreas Scheurer, Dušan Ćoćić, Biljana Šmit, Marijana Petković, Marko N Živanović, Katarina Virijević, Biljana Petrović. Bis(triazinyl)pyridine complexes of Pt(II) and Pd(II): studies of the nucleophilic substitution reactions, DNA/HSA interactions, molecular docking and biological activity. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 2021 08; 26(5):625-637. doi: 10.1007/s00775-021-01879-3. [PMID: 34268603]
  • Xuan Zhang, Kyle G Nottingham, Chirag Patel, Juan V Alegre-Requena, Jeffrey N Levy, Robert S Paton, Andrew McNally. Phosphorus-mediated sp2-sp3 couplings for C-H fluoroalkylation of azines. Nature. 2021 06; 594(7862):217-222. doi: 10.1038/s41586-021-03567-3. [PMID: 33910228]
  • Lipiar K M O Goni, Mohammad A Jafar Mazumder, M A Quraishi, Mohammad Mizanur Rahman. Bioinspired Heterocyclic Compounds as Corrosion Inhibitors: A Comprehensive Review. Chemistry, an Asian journal. 2021 Jun; 16(11):1324-1364. doi: 10.1002/asia.202100201. [PMID: 33844882]
  • Jason M Meyer, Debra Crumrine, Holm Schneider, Angela Dick, Matthias Schmuth, Robert Gruber, Franz P W Radner, Susanne Grond, Joan S Wakefield, Theodora M Mauro, Peter M Elias. Unbound Corneocyte Lipid Envelopes in 12R-Lipoxygenase Deficiency Support a Specific Role in Lipid-Protein Cross-Linking. The American journal of pathology. 2021 05; 191(5):921-929. doi: 10.1016/j.ajpath.2021.02.005. [PMID: 33607042]
  • Iurii Galadzhun, Rafal Kulmaczewski, Namrah Shahid, Oscar Cespedes, Mark J Howard, Malcolm A Halcrow. The flexibility of long chain substituents influences spin-crossover in isomorphous lipid bilayer crystals. Chemical communications (Cambridge, England). 2021 Apr; 57(33):4039-4042. doi: 10.1039/d1cc01073e. [PMID: 33885699]
  • Diana Cosovanu, Montserrat Llovera, Gemma Villorbina, Ramon Canela-Garayoa, Jordi Eras. A simple and fast method for metabolomic analysis by gas liquid chromatography-mass spectrometry. Metabolomics : Official journal of the Metabolomic Society. 2021 02; 17(2):22. doi: 10.1007/s11306-021-01771-w. [PMID: 33547979]
  • Xicheng Liu, Mingxiao Shao, Congcong Liang, Jinghang Guo, Guangxuan Wang, Xiang-Ai Yuan, Zhihong Jing, Laijin Tian, Zhe Liu. Preparation and Bioactivity of Iridium(III) Phenanthroline Complexes with Halide Ions and Pyridine Leaving Groups. Chembiochem : a European journal of chemical biology. 2021 02; 22(3):557-564. doi: 10.1002/cbic.202000511. [PMID: 32964620]
  • Diana Berman, Yuchen Sha, Elena V Shevchenko. Effect of Polymer Removal on the Morphology and Phase of the Nanoparticles in All-Inorganic Heterostructures Synthesized via Two-Step Polymer Infiltration. Molecules (Basel, Switzerland). 2021 Jan; 26(3):. doi: 10.3390/molecules26030679. [PMID: 33525515]
  • Fang Yang, Xie-Er Jian, Peng-Cheng Diao, Xian-Sen Huo, Wen-Wei You, Pei-Liang Zhao. Synthesis, and biological evaluation of 3,6-diaryl-[1,2,4]triazolo[4,3-a]pyridine analogues as new potent tubulin polymerization inhibitors. European journal of medicinal chemistry. 2020 Oct; 204(?):112625. doi: 10.1016/j.ejmech.2020.112625. [PMID: 32717486]
  • Maja Savic, Aleksandar Arsenijevic, Jelena Milovanovic, Bojana Stojanovic, Vesna Stankovic, Ana Rilak Simovic, Dejan Lazic, Nebojsa Arsenijevic, Marija Milovanovic. Antitumor Activity of Ruthenium(II) Terpyridine Complexes towards Colon Cancer Cells In Vitro and In Vivo. Molecules (Basel, Switzerland). 2020 Oct; 25(20):. doi: 10.3390/molecules25204699. [PMID: 33066568]
  • Gongquan Liu, Weiwei Wang, Fangyuan He, Peng Zhang, Ping Xu, Hongzhi Tang. Structural Insights into 6-Hydroxypseudooxynicotine Amine Oxidase from Pseudomonas geniculata N1, the Key Enzyme Involved in Nicotine Degradation. Applied and environmental microbiology. 2020 09; 86(19):. doi: 10.1128/aem.01559-20. [PMID: 32737127]
  • Yan Zheng, Fei He, Mingxu Chen, Jin Zhang, Guangzhi Hu, Delong Ma, Jinghua Guo, Huailin Fan, Wei Li, Xun Hu. Mimicking Hydrazine Dehydrogenase for Efficient Electrocatalytic Oxidation of N2H4 by Fe-NC. ACS applied materials & interfaces. 2020 Aug; 12(34):38183-38191. doi: 10.1021/acsami.0c10637. [PMID: 32799446]
  • Yongfu Liu, Jun Wu, Mingwei Zhou, Wenming Chen, Dongbo Li, Zhanguo Wang, Benoit Hornsperger, Johannes D Aebi, Hans-Peter Märki, Bernd Kuhn, Lisha Wang, Andreas Kuglstatter, Jörg Benz, Stephan Müller, Remo Hochstrasser, Giorgio Ottaviani, Jian Xin, Stephan Kirchner, Susanne Mohr, Philippe Verry, William Riboulet, Hong C Shen, Alexander V Mayweg, Kurt Amrein, Xuefei Tan. Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors. Journal of medicinal chemistry. 2020 07; 63(13):6876-6897. doi: 10.1021/acs.jmedchem.0c00233. [PMID: 32530624]
  • Elias Feitosa-Araujo, Izabel de Souza Chaves, Alexandra Florian, Paula da Fonseca-Pereira, Jorge Alberto Condori Apfata, Elmien Heyneke, David Barbosa Medeiros, Marcel Viana Pires, Tabea Mettler-Altmann, H Ekkehard Neuhaus, Ferdinando Palmieri, Wagner L Araï Jo, Toshihiro Obata, Andreas P M Weber, Nicole Linka, Alisdair R Fernie, Adriano Nunes-Nesi. Downregulation of a Mitochondrial NAD+ Transporter (NDT2) Alters Seed Production and Germination in Arabidopsis. Plant & cell physiology. 2020 May; 61(5):897-908. doi: 10.1093/pcp/pcaa017. [PMID: 32065636]
  • Xiuqiang Yu, Xinyue Zhu, Yang Zhou, Qinglin Li, Zhan Hu, Ting Li, Jun Tao, Menglan Dou, Meng Zhang, Yu Shao, Ranfeng Sun. Discovery of N-Aryl-pyridine-4-ones as Novel Potential Agrochemical Fungicides and Bactericides. Journal of agricultural and food chemistry. 2019 Dec; 67(50):13904-13913. doi: 10.1021/acs.jafc.9b06296. [PMID: 31765135]
  • Yeheng Zhou, Wei Sun, Jiale Peng, Hui Yan, Li Zhang, Xingyong Liu, Zhili Zuo. Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine and N-benzylpiperidine fragments. Bioorganic chemistry. 2019 12; 93(?):103322. doi: 10.1016/j.bioorg.2019.103322. [PMID: 31585263]
  • Zhijiang Fan, Jun Shi, Na Luo, Muhan Ding, Xiaoping Bao. Synthesis, Crystal Structure, and Agricultural Antimicrobial Evaluation of Novel Quinazoline Thioether Derivatives Incorporating the 1,2,4-Triazolo[4,3-a]pyridine Moiety. Journal of agricultural and food chemistry. 2019 Oct; 67(42):11598-11606. doi: 10.1021/acs.jafc.9b04733. [PMID: 31560195]
  • Yaojie Shi, Qianqian Wang, Juan Rong, Jing Ren, Xuejiao Song, Xiaoli Fan, Mengyi Shen, Yong Xia, Ningyu Wang, Zhihao Liu, Quanfang Hu, Tinghong Ye, Luoting Yu. Synthesis and biological evaluation of (1,2,4)triazole[4,3-a]pyridine derivatives as potential therapeutic agents for concanavalin A-induced hepatitis. European journal of medicinal chemistry. 2019 Oct; 179(?):182-195. doi: 10.1016/j.ejmech.2019.06.025. [PMID: 31254920]
  • Marzieh Anjomshoa, Masoud Torkzadeh-Mahani, Mehdi Sahihi, Corrado Rizzoli, Mehdi Ansari, Jan Janczak, Sheila Sherafat Esfahani, Farangis Ataei, Monireh Dehkhodaei, Bagher Amirheidari. Tris-chelated complexes of nickel(II) with bipyridine derivatives: DNA binding and cleavage, BSA binding, molecular docking, and cytotoxicity. Journal of biomolecular structure & dynamics. 2019 09; 37(15):3887-3904. doi: 10.1080/07391102.2018.1534700. [PMID: 30309295]
  • Jing-Hui Zhu, Ben Zhong Tang, Kenneth Kam-Wing Lo. Luminescent Molecular Octopuses with a Polyhedral Oligomeric Silsesquioxane (POSS) Core and Iridium(III) Polypyridine Arms: Synthesis, Aggregation Induced Emission, Cellular Uptake, and Bioimaging Studies. Chemistry (Weinheim an der Bergstrasse, Germany). 2019 Aug; 25(45):10633-10641. doi: 10.1002/chem.201901029. [PMID: 31025784]
  • Zhequan Fu, Qingyu Lin, Bingxin Hu, Yingying Zhang, Weijia Chen, Jing Zhu, Yanzhao Zhao, Hak Soo Choi, Hongcheng Shi, Dengfeng Cheng. P2X7 PET Radioligand 18F-PTTP for Differentiation of Lung Tumor from Inflammation. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2019 07; 60(7):930-936. doi: 10.2967/jnumed.118.222547. [PMID: 30655332]
  • Daniel Petinatti Pavarini, Denise Medeiros Selegato, Ian Castro-Gamboa, Luiz Vitor Silva do Sacramento, Maysa Furlan. Ecological Insights to Track Cytotoxic Compounds among Maytenus ilicifolia Living Individuals and Clones of an Ex Situ Collection. Molecules (Basel, Switzerland). 2019 Mar; 24(6):. doi: 10.3390/molecules24061160. [PMID: 30909567]
  • Qinyuan Lu, Chenyuan Zhang, Wenyi Wang, Biyue Yuan, Yongming Zhang, Bruce E Rittmann. Bioavailable electron donors leached from leaves accelerate biodegradation of pyridine and quinoline. The Science of the total environment. 2019 Mar; 654(?):473-479. doi: 10.1016/j.scitotenv.2018.11.129. [PMID: 30447586]
  • Dongsheng Fan, Ting Li, Zhiyuan Zheng, Guo-Yuan Zhu, Xiaojun Yao, Zhi-Hong Jiang, Li-Ping Bai. Macrolide sesquiterpene pyridine alkaloids from the stems of Tripterygium regelii. Journal of natural medicines. 2019 Jan; 73(1):23-33. doi: 10.1007/s11418-018-1232-8. [PMID: 30105475]
  • María-José Dávila-Rodríguez, João Paulo Barolli, Katia Mara de Oliveira, Legna Colina-Vegas, Fábio da Silva Miranda, Eduardo Ernesto Castellano, Gustavo Von Poelhsitz, Alzir Azevedo Batista. Carbonyl-heterobimetallic Ru(II)/Fe(II)-complexes containing polypyridyl ligands: Synthesis, characterization, cellular viability assays and interactions with biomolecules. Archives of biochemistry and biophysics. 2018 12; 660(?):156-167. doi: 10.1016/j.abb.2018.10.020. [PMID: 30389443]
  • Fabio Henrique Silva, Kleber Yotsumoto Fertrin, Eduardo Costa Alexandre, Fabiano Beraldi Calmasini, Carla Fernanda Franco-Penteado, Fernando Ferreira Costa. Impairment of Nitric Oxide Pathway by Intravascular Hemolysis Plays a Major Role in Mice Esophageal Hypercontractility: Reversion by Soluble Guanylyl Cyclase Stimulator. The Journal of pharmacology and experimental therapeutics. 2018 11; 367(2):194-202. doi: 10.1124/jpet.118.249581. [PMID: 30108160]
  • Lijie Wei, Yuan Chen, Wenqiang Tan, Qing Li, Guodong Gu, Fang Dong, Zhanyong Guo. Synthesis, Characterization, and Antifungal Activity of Pyridine-Based Triple Quaternized Chitosan Derivatives. Molecules (Basel, Switzerland). 2018 Oct; 23(10):. doi: 10.3390/molecules23102604. [PMID: 30314307]
  • Fang Cheng, Mingyang Li, Wei He, Bingbing Sun, Jinyan Qin, Jingping Qu. Activation of resin with controllable ligand density via catalytic oxa-Michael addition and application in antibody purification. Journal of chromatography. A. 2018 Oct; 1570(?):1-9. doi: 10.1016/j.chroma.2018.07.032. [PMID: 30153981]
  • Anna Podgórska, Monika Ostaszewska-Bugajska, Klaudia Borysiuk, Agata Tarnowska, Monika Jakubiak, Maria Burian, Allan G Rasmusson, Bożena Szal. Suppression of External NADPH Dehydrogenase-NDB1 in Arabidopsis thaliana Confers Improved Tolerance to Ammonium Toxicity via Efficient Glutathione/Redox Metabolism. International journal of molecular sciences. 2018 May; 19(5):. doi: 10.3390/ijms19051412. [PMID: 29747392]
  • B V Egorova, E V Matazova, A A Mitrofanov, G Yu Aleshin, A L Trigub, A D Zubenko, O A Fedorova, Yu V Fedorov, S N Kalmykov. Novel pyridine-containing azacrownethers for the chelation of therapeutic bismuth radioisotopes: Complexation study, radiolabeling, serum stability and biodistribution. Nuclear medicine and biology. 2018 05; 60(?):1-10. doi: 10.1016/j.nucmedbio.2018.01.005. [PMID: 29499420]
  • Sara Nourizadeh, Adeleh Divsalar, Mina Fekri, Behafarid Ghalandari, Mahbubeh Eslami-Moghadam, Ali Akbar Saboury, Saba Abbasi. Multiple Spectroscopic, Docking and Cytotoxic Study of a Synthesized 2,2' Bipyridin Phenyl Isopentylglycin Pt(II) Nitrate Complex: Human Serum Albumin and Breast Cancer Cell Line of MDA-MB231 as Targets. Journal of fluorescence. 2018 Mar; 28(2):551-559. doi: 10.1007/s10895-018-2216-5. [PMID: 29476398]
  • Juliette Emmerich, Chris J van Koppen, Jens L Burkhart, Roger T Engeli, Qingzhong Hu, Alex Odermatt, Rolf W Hartmann. Accelerated skin wound healing by selective 11β-Hydroxylase (CYP11B1) inhibitors. European journal of medicinal chemistry. 2018 Jan; 143(?):591-597. doi: 10.1016/j.ejmech.2017.11.018. [PMID: 29207342]
  • Raluca-Ioana Stefan-van Staden, Liliana-Roxana Balahura, Livia Alexandra Gugoasa, Jacobus F van Staden, Hassan Y Aboul-Enein, Marcela-Corina Rosu, Stela Maria Pruneanu. Pattern recognition of 8-hydroxy-2'-deoxyguanosine in biological fluids. Analytical and bioanalytical chemistry. 2018 Jan; 410(1):115-121. doi: 10.1007/s00216-017-0698-7. [PMID: 29067480]
  • Xin Shi, Zhen-Tao Deng, Yu Zhu, Ying Bao, Li-Dong Shao, Qin-Shi Zhao. Total Synthesis of (±)-Cermizine B. The Journal of organic chemistry. 2017 10; 82(20):11110-11116. doi: 10.1021/acs.joc.7b02073. [PMID: 28971679]
  • Feng Shao, Ding-Qing Wang, Wei Xiong, Pu-Zhao Zhang, Guang-Qiang Ma, Rong-Hua Liu, Xue-Lian Yao. A new pyridine alkaloid from Zingiberis rhizoma. Natural product research. 2017 Jul; 31(13):1486-1489. doi: 10.1080/14786419.2016.1277347. [PMID: 28056544]
  • Debin Wan, Jun Yang, Bogdan Barnych, Sung Hee Hwang, Kin Sing Stephen Lee, Yongliang Cui, Jun Niu, Mitchell A Watsky, Bruce D Hammock. A new sensitive LC/MS/MS analysis of vitamin D metabolites using a click derivatization reagent, 2-nitrosopyridine. Journal of lipid research. 2017 04; 58(4):798-808. doi: 10.1194/jlr.d073536. [PMID: 28148721]
  • Adenike Okunlola, Amusa Sarafadeen Adebayo, Moji Christianah Adeyeye. Development of repaglinide microspheres using novel acetylated starches of bitter and Chinese yams as polymers. International journal of biological macromolecules. 2017 Jan; 94(Pt A):544-553. doi: 10.1016/j.ijbiomac.2016.10.032. [PMID: 27769931]
  • Janice E Chambers, Howard W Chambers, Kristen E Funck, Edward C Meek, Ronald B Pringle, Matthew K Ross. Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX. Chemico-biological interactions. 2016 Nov; 259(Pt B):154-159. doi: 10.1016/j.cbi.2016.07.004. [PMID: 27387540]
  • Pierre Pétriacq, Jurriaan Ton, Oriane Patrit, Guillaume Tcherkez, Bertrand Gakière. NAD Acts as an Integral Regulator of Multiple Defense Layers. Plant physiology. 2016 11; 172(3):1465-1479. doi: 10.1104/pp.16.00780. [PMID: 27621425]
  • Chungang Gu, Michelle L Lamb, Jeffrey W Johannes, Mark A Sylvester, Mark S Eisman, Rane A Harrison, Haiqing Hu, Steven Kazmirski, Keith Mikule, Bo Peng, Nancy Su, Wenxian Wang, Qing Ye, Xiaolan Zheng, Paul D Lyne, David A Scott. Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering. Bioorganic & medicinal chemistry letters. 2016 10; 26(19):4775-4780. doi: 10.1016/j.bmcl.2016.08.030. [PMID: 27578247]
  • Haoming Zhang, D Adam Lauver, Hui Wang, Duxin Sun, Paul F Hollenberg, Y Eugene Chen, Yoichi Osawa, Daniel T Eitzman. Significant Improvement of Antithrombotic Responses to Clopidogrel by Use of a Novel Conjugate as Revealed in an Arterial Model of Thrombosis. The Journal of pharmacology and experimental therapeutics. 2016 10; 359(1):11-7. doi: 10.1124/jpet.116.236034. [PMID: 27511819]
  • Dustin Wayne Demoin, Masahiro Shindo, Hanwen Zhang, Kimberly J Edwards, Inna Serganova, Naga Vara Kishore Pillarsetty, Jason S Lewis, Ronald G Blasberg. Synthesis and evaluation of an (18)F-labeled pyrimidine-pyridine amine for targeting CXCR4 receptors in gliomas. Nuclear medicine and biology. 2016 10; 43(10):606-11. doi: 10.1016/j.nucmedbio.2016.05.005. [PMID: 27485481]
  • Wei Cui, Wei Lv, Ying Qu, Rui Ma, Yi-Wei Wang, Yong-Jun Xu, Di Wu, Xuanhuang Chen. Discovery of 2-((3-cyanopyridin-2-yl)thio)acetamides as human lactate dehydrogenase A inhibitors to reduce the growth of MG-63 osteosarcoma cells: Virtual screening and biological validation. Bioorganic & medicinal chemistry letters. 2016 08; 26(16):3984-7. doi: 10.1016/j.bmcl.2016.06.083. [PMID: 27406795]
  • Chundi Yu, Zeping Shao, Bing Liu, Yan Zhang, Shuo Wang. Inhibition of 2-Amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) Formation by Alkoxy Radical Scavenging of Flavonoids and Their Quantitative Structure-Activity Relationship in a Model System. Journal of food science. 2016 Aug; 81(8):C1908-13. doi: 10.1111/1750-3841.13381. [PMID: 27384350]
  • M E Senn, G E Gergoff Grozeff, M L Alegre, F Barrile, M C De Tullio, C G Bartoli. Effect of mitochondrial ascorbic acid synthesis on photosynthesis. Plant physiology and biochemistry : PPB. 2016 Jul; 104(?):29-35. doi: 10.1016/j.plaphy.2016.03.012. [PMID: 27010742]
  • Guangyi Wang, Jinqiao Wan, Yujian Hu, Xiangyang Wu, Marija Prhavc, Natalia Dyatkina, Vivek K Rajwanshi, David B Smith, Andreas Jekle, April Kinkade, Julian A Symons, Zhinan Jin, Jerome Deval, Qingling Zhang, Yuen Tam, Sushmita Chanda, Lawrence Blatt, Leonid Beigelman. Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C-Nucleosides as Favipiravir (T-705) Analogues. Journal of medicinal chemistry. 2016 05; 59(10):4611-24. doi: 10.1021/acs.jmedchem.5b01933. [PMID: 27120583]
  • Xiao-Ming Yuan, Dong-Qiang Lin, Qi-Lei Zhang, Dong Gao, Shan-Jing Yao. A microcalorimetric study of molecular interactions between immunoglobulin G and hydrophobic charge-induction ligand. Journal of chromatography. A. 2016 Apr; 1443(?):145-51. doi: 10.1016/j.chroma.2016.03.041. [PMID: 27017449]
  • Pei-Yi Wang, Lei Zhou, Jian Zhou, Zhi-Bing Wu, Wei Xue, Bao-An Song, Song Yang. Synthesis and antibacterial activity of pyridinium-tailored 2,5-substituted-1,3,4-oxadiazole thioether/sulfoxide/sulfone derivatives. Bioorganic & medicinal chemistry letters. 2016 Feb; 26(4):1214-7. doi: 10.1016/j.bmcl.2016.01.029. [PMID: 26810264]
  • Changhua Mu, Stephanie W Chang, Kathleen E Prosser, Ada W Y Leung, Stephanie Santacruz, Thalia Jang, John R Thompson, Donald T T Yapp, Jeffrey J Warren, Marcel B Bally, Timothy V Beischlag, Charles J Walsby. Induction of Cytotoxicity in Pyridine Analogues of the Anti-metastatic Ru(III) Complex NAMI-A by Ferrocene Functionalization. Inorganic chemistry. 2016 Jan; 55(1):177-90. doi: 10.1021/acs.inorgchem.5b02109. [PMID: 26652771]
  • Shin-Ichi Nakakita, Jun Hirabayashi. Preparation of Glycan Arrays Using Pyridylaminated Glycans. Methods in molecular biology (Clifton, N.J.). 2016; 1368(?):225-35. doi: 10.1007/978-1-4939-3136-1_16. [PMID: 26614079]
  • Hao Yu, Hongzhi Tang, Yangyang Li, Ping Xu. Molybdenum-containing nicotine hydroxylase genes in a nicotine degradation pathway that is a variant of the pyridine and pyrrolidine pathways. Applied and environmental microbiology. 2015 Dec; 81(24):8330-8. doi: 10.1128/aem.02253-15. [PMID: 26407884]
  • Weiwei Wang, Ping Xu, Hongzhi Tang. Sustainable production of valuable compound 3-succinoyl-pyridine by genetically engineering Pseudomonas putida using the tobacco waste. Scientific reports. 2015 Nov; 5(?):16411. doi: 10.1038/srep16411. [PMID: 26574178]
  • Chih-Wei Fu, Yun-Jung Hsieh, Tzu Ting Chang, Chia-Ling Chen, Cheng-Yu Yang, Anne Liao, Pei-Wen Hsiao, Wen-Shan Li. Anticancer efficacy of unique pyridine-based tetraindoles. European journal of medicinal chemistry. 2015 Nov; 104(?):165-76. doi: 10.1016/j.ejmech.2015.09.032. [PMID: 26457743]
  • Eda Rami Reddy, Rajiv Trivedi, Akella Venkata Subrahmanya Sarma, Balasubramanian Sridhar, Hasitha Shilpa Anantaraju, Dharmarajan Sriram, Perumal Yogeeswari, Narayana Nagesh. Sugar-boronate ester scaffold tethered pyridyl-imine palladium(II) complexes: synthesis and their in vitro anticancer evaluation. Dalton transactions (Cambridge, England : 2003). 2015 Oct; 44(40):17600-16. doi: 10.1039/c5dt03266k. [PMID: 26394366]
  • Stefan Timm, Maria Wittmiß, Sabine Gamlien, Ralph Ewald, Alexandra Florian, Marcus Frank, Markus Wirtz, Rüdiger Hell, Alisdair R Fernie, Hermann Bauwe. Mitochondrial Dihydrolipoyl Dehydrogenase Activity Shapes Photosynthesis and Photorespiration of Arabidopsis thaliana. The Plant cell. 2015 Jul; 27(7):1968-84. doi: 10.1105/tpc.15.00105. [PMID: 26116608]
  • Yana Aizenberg-Gershtein, Ido Izhaki, Rakesh Santhanam, Pavan Kumar, Ian T Baldwin, Malka Halpern. Pyridine-type alkaloid composition affects bacterial community composition of floral nectar. Scientific reports. 2015 Jun; 5(?):11536. doi: 10.1038/srep11536. [PMID: 26122961]
  • Keita Kato, Nobukazu Shitan, Tsubasa Shoji, Takashi Hashimoto. Tobacco NUP1 transports both tobacco alkaloids and vitamin B6. Phytochemistry. 2015 May; 113(?):33-40. doi: 10.1016/j.phytochem.2014.05.011. [PMID: 24947336]
  • Li-Jie Zhang, Jing-An Zhang, Xun-Zhong Zou, Ya-Jie Liu, Ning Li, Zi-Jie Zhang, Yu Li. Studies on antimicrobial effects of four ligands and their transition metal complexes with 8-mercaptoquinoline and pyridine terminal groups. Bioorganic & medicinal chemistry letters. 2015 Apr; 25(8):1778-1781. doi: 10.1016/j.bmcl.2015.02.056. [PMID: 25791454]
  • Cui Liu, Jin Chen, Entao Li, Qiang Fan, Deyun Wang, Peng Li, Xiuping Li, Xingying Chen, Shulei Qiu, Zhenzhen Gao, Hongquan Li, Yuanliang Hu. The comparison of antioxidative and hepatoprotective activities of Codonopsis pilosula polysaccharide (CP) and sulfated CP. International immunopharmacology. 2015 Feb; 24(2):299-305. doi: 10.1016/j.intimp.2014.12.023. [PMID: 25543057]
  • Pooja Singh, Swati Aggarwal, Anjani K Tiwari, Vikas Kumar, Ramendra Pratap, Krishna Chuttani, Anil K Mishra. Bis(methylpyridine)-EDTA derivative as a potential ligand for PET imaging: synthesis, complexation, and biological evaluation. Chemical biology & drug design. 2014 Dec; 84(6):704-11. doi: 10.1111/cbdd.12366. [PMID: 24894071]
  • Etify A Bakhite, Aly A Abd-Ella, Mohamed E A El-Sayed, Shaban A A Abdel-Raheem. Pyridine derivatives as insecticides. Part 1: synthesis and toxicity of some pyridine derivatives against cowpea aphid, Aphis craccivora Koch (Homoptera: Aphididae). Journal of agricultural and food chemistry. 2014 Oct; 62(41):9982-6. doi: 10.1021/jf503992y. [PMID: 25226271]
  • Takuro Hasegawa, Jun-ichi Eiki, Masato Chiba. Interindividual variations in metabolism and pharmacokinetics of 3-(6-methylpyridine-3-yl-sulfanyl)-6-(4H-[1,2,4]triazole-3-yl-sulfanyl)-N-(1,3-thiazole-2-yl)-2-pyridine carboxamide, a glucokinase activator, in rats caused by the genetic polymorphism of CYP2D1. Drug metabolism and disposition: the biological fate of chemicals. 2014 Sep; 42(9):1548-55. doi: 10.1124/dmd.114.058081. [PMID: 24924387]
  • Natasha Arksey, Tayebeh Hadizad, Basma Ismail, Maryam Hachem, Ana C Valdivia, Rob S Beanlands, Robert A deKemp, Jean N DaSilva. Synthesis and evaluation of the novel 2-[¹⁸F]fluoro-3-propoxy-triazole-pyridine-substituted losartan for imaging AT₁ receptors. Bioorganic & medicinal chemistry. 2014 Aug; 22(15):3931-7. doi: 10.1016/j.bmc.2014.06.011. [PMID: 25023539]
  • Rosa Adam, Pablo Bilbao-Ramos, Sonia López-Molina, Belén Abarca, Rafael Ballesteros, M Eugenia González-Rosende, M Auxiliadora Dea-Ayuela, Gloria Alzuet-Piña. Triazolopyridyl ketones as a novel class of antileishmanial agents. DNA binding and BSA interaction. Bioorganic & medicinal chemistry. 2014 Aug; 22(15):4018-27. doi: 10.1016/j.bmc.2014.05.069. [PMID: 24953952]
  • Leila Arjomandi-Behzad, Yadollah Yamini, Maryam Rezazadeh. Extraction of pyridine derivatives from human urine using electromembrane extraction coupled to dispersive liquid-liquid microextraction followed by gas chromatography determination. Talanta. 2014 Aug; 126(?):73-81. doi: 10.1016/j.talanta.2014.02.066. [PMID: 24881536]
  • Chao Wang, Chuang-Jun Li, Jie Ma, Jing-Zhi Yang, Xiao-Guang Chen, Qi Hou, Dong-Ming Zhang. Bioactive sesquiterpene polyol esters from the leaves of Tripterygium wilfordii. Fitoterapia. 2014 Jul; 96(?):103-8. doi: 10.1016/j.fitote.2014.04.014. [PMID: 24752142]
  • Xiao-Long Li, Jing-Jing Xiao, Xue-Qiang Zha, Li-Hua Pan, Muhammad-Naeem Asghar, Jian-Ping Luo. Structural identification and sulfated modification of an antiglycation Dendrobium huoshanense polysaccharide. Carbohydrate polymers. 2014 Jun; 106(?):247-54. doi: 10.1016/j.carbpol.2014.02.029. [PMID: 24721075]
  • Jian Xu, Qian Li, Ying Yue, Yong Guo, Shijun Shao. A water-soluble BODIPY derivative as a highly selective 'Turn-On' fluorescent sensor for H2O2 sensing in vivo. Biosensors & bioelectronics. 2014 Jun; 56(?):58-63. doi: 10.1016/j.bios.2013.12.065. [PMID: 24463197]
  • Yun Chen, Wen Xiong, Ling Zeng, Yu Wang, Shuaibing Zhang, Meiyun Xu, Meiyun Song, Yixuan Wang, Hongxu Du, Jiaguo Liu, Deyun Wang, Yi Wu, Yuanliang Hu. Bush Sophora Root polysaccharide and its sulfate can scavenge free radicals resulted from duck virus hepatitis. International journal of biological macromolecules. 2014 May; 66(?):186-93. doi: 10.1016/j.ijbiomac.2014.02.038. [PMID: 24582875]
  • Sungeun Cho, Edwin Nuijten, Robert L Shewfelt, Stanley J Kays. Aroma chemistry of African Oryza glaberrima and Oryza sativa rice and their interspecific hybrids. Journal of the science of food and agriculture. 2014 Mar; 94(4):727-35. doi: 10.1002/jsfa.6329. [PMID: 23907855]
  • Jean-François Renard, Frédéric Lecomte, Philippe Hubert, Xavier de Leval, Bernard Pirotte. N-(3-Arylaminopyridin-4-yl)alkanesulfonamides as pyridine analogs of nimesulide: cyclooxygenases inhibition, anti-inflammatory studies and insight on metabolism. European journal of medicinal chemistry. 2014 Mar; 74(?):12-22. doi: 10.1016/j.ejmech.2013.12.033. [PMID: 24440378]
  • P Wang, X Yang, W W Huang, M Zhang, W H Lu, H T Zhao, J Wang, H L Liu, A J Dong, H Zhang, R B Xu, P Zou, C L Cheng, Y C Zhang, J Jing. Effect of pesticide 1-[6-chloro-3-methyl-pyridyl-8-nitro-7-methyl-1 2 3 5 6 7-hexahydro imidazo (1,2a)]-pyridine when responding to a wheat plant's antioxidant defense system. Food chemistry. 2014 Mar; 146(?):569-76. doi: 10.1016/j.foodchem.2013.09.085. [PMID: 24176382]
  • Aldenir Feitosa dos Santos, Saskya Araújo Fonseca, Fernanda Andrade César, Mônica Camelo Pessoa de Azevedo Albuquerque, José Valfrido Santana, Antônio Euzébio Goulart Santana. A penta-substituted pyridine alkaloid from the rhizome of Jatropha elliptica (Pohl) Muell. Arg. is active against Schistosoma mansoni and Biomphalaria glabrata. Parasitology research. 2014 Mar; 113(3):1077-84. doi: 10.1007/s00436-013-3743-2. [PMID: 24500523]
  • Benedict T Green, Stephen T Lee, Kevin D Welch, Kip E Panter. Plant alkaloids that cause developmental defects through the disruption of cholinergic neurotransmission. Birth defects research. Part C, Embryo today : reviews. 2013 Dec; 99(4):235-46. doi: 10.1002/bdrc.21049. [PMID: 24339035]
  • M R Bindhu, V Sathe, M Umadevi. Synthesis, characterization and SERS activity of biosynthesized silver nanoparticles. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2013 Nov; 115(?):409-15. doi: 10.1016/j.saa.2013.06.047. [PMID: 23867642]
  • Dengyou Zhang, Xiaowei Zhang, Jing Ai, Yun Zhai, Zhongjie Liang, Ying Wang, Yi Chen, Chunpu Li, Fei Zhao, Hualiang Jiang, Meiyu Geng, Cheng Luo, Hong Liu. Synthesis and biological evaluation of 2-amino-5-aryl-3-benzylthiopyridine scaffold based potent c-Met inhibitors. Bioorganic & medicinal chemistry. 2013 Nov; 21(21):6804-20. doi: 10.1016/j.bmc.2013.07.032. [PMID: 23993328]
  • Chinar D Sanghvi, Pauline M Olsen, Catherine Elix, Shifang Bruce Peng, Dongsheng Wang, Zhuo Georgia Chen, Dong M Shin, Kenneth I Hardcastle, Cora E MacBeth, Jack F Eichler. Antitumor properties of five-coordinate gold(III) complexes bearing substituted polypyridyl ligands. Journal of inorganic biochemistry. 2013 Nov; 128(?):68-76. doi: 10.1016/j.jinorgbio.2013.07.014. [PMID: 23948576]
  • Vivian C Silveira, Mariana P Abbott, Maurício Cavicchioli, Marcos B Gonçalves, Helena M Petrilli, Leandro de Rezende, Antonia T Amaral, David E P Fonseca, Giovanni F Caramori, Ana M da Costa Ferreira. Peculiar reactivity of a di-imine copper(II) complex regarding its binding to albumin protein. Dalton transactions (Cambridge, England : 2003). 2013 May; 42(18):6386-96. doi: 10.1039/c3dt00108c. [PMID: 23462863]
  • Nihar Dash, Anasuya Mishra, G Krishnamoorthy. Alkyl chain dependent interactions of ligands with bovine serum albumin. Journal of pharmaceutical and biomedical analysis. 2013 Apr; 77(?):55-62. doi: 10.1016/j.jpba.2013.01.002. [PMID: 23376725]
  • Vandana Bhalla, Harshveer Arora, Manoj Kumar. Aggregates of a triphenylene based chemosensing ensemble for sensitive detection of cyanide ions in an aqueous medium. Dalton transactions (Cambridge, England : 2003). 2013 Apr; 42(13):4450-5. doi: 10.1039/c2dt32427j. [PMID: 23348716]
  • Feng Li, Ken Tanaka, Shiro Watanabe, Yasuhiro Tezuka, Ikuo Saiki. Dipasperoside A, a novel pyridine alkaloid-coupled iridoid glucoside from the roots of Dipsacus asper. Chemical & pharmaceutical bulletin. 2013; 61(12):1318-22. doi: 10.1248/cpb.c13-00546. [PMID: 24436964]
  • Tatsuya Higashi, Katsumi Kawasaki, Nagisa Matsumoto, Shoujiro Ogawa, Kuniko Mitamura, Shigeo Ikegawa. LC/MS/MS of steroids having vicinal diol as electrospray-active boronates. Chemical & pharmaceutical bulletin. 2013; 61(3):326-32. doi: 10.1248/cpb.c12-00979. [PMID: 23449202]
  • Omid Sayar, Hamid Reza Lotfi Zadeh Zhad, Omid Sadeghi, Vahid Amani, Ezzatolla Najafi, Najmeh Tavassoli. Pyridine-functionalized Fe₃O₄ nanoparticles as a novel sorbent for the preconcentration of lead and cadmium ions in tree leaf as a bioindicator of urban traffic pollution. Biological trace element research. 2012 Dec; 150(1-3):403-10. doi: 10.1007/s12011-012-9467-9. [PMID: 22707248]
  • Daniele Sanna, Péter Buglyó, Ana Isabel Tomaz, João Costa Pessoa, Slađana Borović, Giovanni Micera, Eugenio Garribba. V(IV)O and Cu(II) complexation by ligands based on pyridine nitrogen donors. Dalton transactions (Cambridge, England : 2003). 2012 Nov; 41(41):12824-38. doi: 10.1039/c2dt31109g. [PMID: 22975792]
  • Mohana Krishna Reddy Mudiam, Abhishek Chauhan, Rajeev Jain, Ratnasekhar Ch, Ghizal Fatima, Ekta Malhotra, R C Murthy. Development, validation and comparison of two microextraction techniques for the rapid and sensitive determination of pregabalin in urine and pharmaceutical formulations after ethyl chloroformate derivatization followed by gas chromatography-mass spectrometric analysis. Journal of pharmaceutical and biomedical analysis. 2012 Nov; 70(?):310-9. doi: 10.1016/j.jpba.2012.05.001. [PMID: 22677651]
  • Jing Zhang, Yuanliang Hu, Deyun Wang, Tao Qin, Cui Liu, Xu Liu, Xin Sheng, Shanshan Chang, Yunpeng Fan, Liwei Guo, The Luong Nguyen. The optimization of sulfation modification conditions for ophiopogonpolysaccharide based on antiviral activity. International journal of biological macromolecules. 2012 Nov; 51(4):657-62. doi: 10.1016/j.ijbiomac.2012.06.023. [PMID: 22732131]
  • Marianela Rodríguez, Nacira Muñoz, Sergio Lenardon, Ramiro Lascano. The chlorotic symptom induced by Sunflower chlorotic mottle virus is associated with changes in redox-related gene expression and metabolites. Plant science : an international journal of experimental plant biology. 2012 Nov; 196(?):107-16. doi: 10.1016/j.plantsci.2012.08.008. [PMID: 23017905]
  • Xin Jin, Lei Yu, Yang Wu, Shuang Zhang, Zhenda Shi, Xianfeng Chen, Yang Yang, Xiaoli Zhang, Chun Jiang. S-Glutathionylation underscores the modulation of the heteromeric Kir4.1-Kir5.1 channel in oxidative stress. The Journal of physiology. 2012 Nov; 590(21):5335-48. doi: 10.1113/jphysiol.2012.236885. [PMID: 22907060]
  • Zhipeng Deng, Dafang Zhong, Xiaoyan Chen. Identification of modification sites on human serum albumin and human hemoglobin adducts with houttuynin using liquid chromatography coupled with mass spectrometry. Biomedical chromatography : BMC. 2012 Nov; 26(11):1377-85. doi: 10.1002/bmc.2708. [PMID: 22334394]
  • Hiroshi Ashihara, Wei-Wei Deng. Pyridine metabolism in tea plants: salvage, conjugate formation and catabolism. Journal of plant research. 2012 Nov; 125(6):781-91. doi: 10.1007/s10265-012-0490-x. [PMID: 22527843]
  • Kai Bernitzki, Michael Maue, Thomas Schrader. Artificial signal transduction with primary and secondary messengers. Chemistry (Weinheim an der Bergstrasse, Germany). 2012 Oct; 18(42):13412-7. doi: 10.1002/chem.201200623. [PMID: 22961842]
  • Melvin A Ambele, Timothy J Egan. Neutral lipids associated with haemozoin mediate efficient and rapid β-haematin formation at physiological pH, temperature and ionic composition. Malaria journal. 2012 Oct; 11(?):337. doi: 10.1186/1475-2875-11-337. [PMID: 23043460]