Propionylcarnitine (BioDeep_00000003013)

Main id: BioDeep_00000630422

 


代谢物信息卡片


O-propanoyl-carnitine

化学式: C10H19NO4 (217.1314014)
中文名称:
谱图信息: 最多检出来源 Ailuropoda melanoleuca(viridiplantae) 97.37%

分子结构信息

SMILES: CCC(=O)OC(CC(=O)[O-])C[N+](C)(C)C
InChI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3

描述信息

D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
An O-acylcarnitine compound having propanoyl as the acyl substituent.
D002491 - Central Nervous System Agents > D000700 - Analgesics
D020011 - Protective Agents > D002316 - Cardiotonic Agents
D000893 - Anti-Inflammatory Agents
D002317 - Cardiovascular Agents
D018501 - Antirheumatic Agents

同义名列表

4 个代谢物同义名

O-Propanoylcarnitine; Propionylcarnitine; O-propanoyl-carnitine; Propionyl-L-carnitine



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(0)

PlantCyc(0)

代谢反应

66 个相关的代谢反应过程信息。

Reactome(60)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(6)

PharmGKB(0)

12 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ru-Yue Chen, Xiao-Zhong Li, Qiang Lin, Yun Zhu, Yun-Yan Shen, Qin-Ying Xu, Xue-Ming Zhu, Lin-Qi Chen, Hai-Ying Wu, Xu-Qin Chen. Proteinuria as a presenting sign of combined methylmalonic acidemia and homocysteinemia: case report. BMC medical genetics. 2020 09; 21(1):183. doi: 10.1186/s12881-020-01122-x. [PMID: 32957924]
  • Josefin Söder, Sara Wernersson, Johan Dicksved, Ragnvi Hagman, Johnny R Östman, Ali A Moazzami, Katja Höglund. Indication of metabolic inflexibility to food intake in spontaneously overweight Labrador Retriever dogs. BMC veterinary research. 2019 Mar; 15(1):96. doi: 10.1186/s12917-019-1845-5. [PMID: 30894172]
  • Giovanni Brotzu, Anna Maria Fadda, Maria Letizia Manca, Thomas Manca, Francesca Marongiu, Monica Campisi, Francesca Consolaro. A liposome-based formulation containing equol, dihomo-γ-linolenic acid and propionyl-l-carnitine to prevent and treat hair loss: A prospective investigation. Dermatologic therapy. 2019 01; 32(1):e12778. doi: 10.1111/dth.12778. [PMID: 30371981]
  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • Patrick Forny, Anke Schumann, Merima Mustedanagic, Déborah Mathis, Marie-Angela Wulf, Nadine Nägele, Claus-Dieter Langhans, Assem Zhakupova, Joerg Heeren, Ludger Scheja, Ralph Fingerhut, Heidi L Peters, Thorsten Hornemann, Beat Thony, Stefan Kölker, Patricie Burda, D Sean Froese, Olivier Devuyst, Matthias R Baumgartner. Novel Mouse Models of Methylmalonic Aciduria Recapitulate Phenotypic Traits with a Genetic Dosage Effect. The Journal of biological chemistry. 2016 09; 291(39):20563-73. doi: 10.1074/jbc.m116.747717. [PMID: 27519416]
  • Cynthia Roy, Pierre-Yves Tremblay, Jean-François Bienvenu, Pierre Ayotte. Quantitative analysis of amino acids and acylcarnitines combined with untargeted metabolomics using ultra-high performance liquid chromatography and quadrupole time-of-flight mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Aug; 1027(?):40-9. doi: 10.1016/j.jchromb.2016.05.006. [PMID: 27240302]
  • Y P Liu, X Y Li, Y Ding, Q Wang, J Q Song, Y Zhang, D X Li, Y P Qin, Y L Yang. [Clinical and laboratory studies on four Chinese patients with succinate-CoA ligase deficiency noticed by mild methylmalonic aciduria]. Zhonghua er ke za zhi = Chinese journal of pediatrics. 2016 May; 54(5):365-9. doi: 10.3760/cma.j.issn.0578-1310.2016.05.011. [PMID: 27143079]
  • Bjørn Waagsbø, Asbjørn Svardal, Thor Ueland, Linn Landrø, Olav Øktedalen, Rolf K Berge, Trude H Flo, Pål Aukrust, Jan K Damås. Low levels of short- and medium-chain acylcarnitines in HIV-infected patients. European journal of clinical investigation. 2016 May; 46(5):408-17. doi: 10.1111/eci.12609. [PMID: 26913383]
  • Lianshu Han, Shengnan Wu, Jun Ye, Wenjuan Qiu, Huiwen Zhang, Xiaolan Gao, Yu Wang, Zhuwen Gong, Jing Jin, Xuefan Gu. Biochemical, molecular and outcome analysis of eight chinese asymptomatic individuals with methyl malonic acidemia detected through newborn screening. American journal of medical genetics. Part A. 2015 Oct; 167A(10):2300-5. doi: 10.1002/ajmg.a.37147. [PMID: 25982642]
  • Ying-Mei Tang, Jia-Ping Wang, Wei-Min Bao, Jin-Hui Yang, Lin-Kun Ma, Jing Yang, Hui Chen, Ying Xu, Li-Hong Yang, Wen Li, Yan-Ping Zhu, Ji-Bin Cheng. Urine and serum metabolomic profiling reveals that bile acids and carnitine may be potential biomarkers of primary biliary cirrhosis. International journal of molecular medicine. 2015 Aug; 36(2):377-85. doi: 10.3892/ijmm.2015.2233. [PMID: 26046127]
  • Yupeng Liu, Tongfei Wu, Haijun Wang, Yuan Ding, Jinqing Song, Xiyuan Li, Yao Zhang, Qiao Wang, Yanling Yang. [Acute encephalopathy induced by vaccination in an infant with methylmalonic aciduria cblA]. Zhonghua er ke za zhi = Chinese journal of pediatrics. 2015 Jan; 53(1):62-5. doi: . [PMID: 25748407]
  • Anna Bogusiewicz, Gunnar Boysen, Donald M Mock. In HepG2 cells, coexisting carnitine deficiency masks important indicators of marginal biotin deficiency. The Journal of nutrition. 2015 Jan; 145(1):32-40. doi: 10.3945/jn.114.201343. [PMID: 25527659]
  • Maria Giovanna Scioli, Pietro Lo Giudice, Alessandra Bielli, Valeria Tarallo, Alfonso De Rosa, Sandro De Falco, Augusto Orlandi. Propionyl-L-Carnitine Enhances Wound Healing and Counteracts Microvascular Endothelial Cell Dysfunction. PloS one. 2015; 10(10):e0140697. doi: 10.1371/journal.pone.0140697. [PMID: 26473356]
  • Emanuela Scolamiero, Guglielmo Rosario Domenico Villani, Laura Ingenito, Rita Pecce, Lucia Albano, Marianna Caterino, Maria Grazia di Girolamo, Cristina Di Stefano, Ignazio Franzese, Giovanna Gallo, Margherita Ruoppolo. Maternal vitamin B12 deficiency detected in expanded newborn screening. Clinical biochemistry. 2014 Dec; 47(18):312-7. doi: 10.1016/j.clinbiochem.2014.08.020. [PMID: 25204964]
  • Réjane Morand, Jamal Bouitbir, Andrea Felser, Jürgen Hench, Christoph Handschin, Stephan Frank, Stephan Krähenbühl. Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice. European journal of nutrition. 2014 Sep; 53(6):1313-25. doi: 10.1007/s00394-013-0631-6. [PMID: 24337254]
  • D Hailemariam, R Mandal, F Saleem, S M Dunn, D S Wishart, B N Ametaj. Identification of predictive biomarkers of disease state in transition dairy cows. Journal of dairy science. 2014 May; 97(5):2680-93. doi: 10.3168/jds.2013-6803. [PMID: 24630653]
  • Maria Giovanna Scioli, Alessandra Bielli, Sara Agostinelli, Chiara Tarquini, Gaetano Arcuri, Amedeo Ferlosio, Gaetana Costanza, Elena Doldo, Augusto Orlandi. Antioxidant treatment prevents serum deprivation- and TNF-α-induced endothelial dysfunction through the inhibition of NADPH oxidase 4 and the restoration of β-oxidation. Journal of vascular research. 2014; 51(5):327-37. doi: 10.1159/000365926. [PMID: 25401479]
  • Anita Dayaldasani, Juan Ruiz-Escalera, Manuel Rodríguez-Espinosa, Inmaculada Rueda, Vidal Pérez-Valero, Raquel Yahyaoui. Serum vitamin B12 levels during the first trimester of pregnancy correlate with newborn screening markers of vitamin B12 deficiency. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. 2014; 84(1-2):92-7. doi: 10.1024/0300-9831/a000196. [PMID: 25835239]
  • Jenna Pekkinen, Kaisa Olli, Anne Huotari, Kirsti Tiihonen, Pekka Keski-Rahkonen, Marko Lehtonen, Seppo Auriola, Marjukka Kolehmainen, Hannu Mykkänen, Kaisa Poutanen, Kati Hanhineva. Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC-MS metabolomics approach. Molecular nutrition & food research. 2013 Nov; 57(11):1959-68. doi: 10.1002/mnfr.201300142. [PMID: 23868375]
  • Attilio Naccarato, Sacha Moretti, Giovanni Sindona, Antonio Tagarelli. Identification and assay of underivatized urinary acylcarnitines by paper spray tandem mass spectrometry. Analytical and bioanalytical chemistry. 2013 Oct; 405(25):8267-76. doi: 10.1007/s00216-013-7232-3. [PMID: 23907684]
  • Qiang Huang, Yexiong Tan, Peiyuan Yin, Guozhu Ye, Peng Gao, Xin Lu, Hongyang Wang, Guowang Xu. Metabolic characterization of hepatocellular carcinoma using nontargeted tissue metabolomics. Cancer research. 2013 Aug; 73(16):4992-5002. doi: 10.1158/0008-5472.can-13-0308. [PMID: 23824744]
  • Zhuo Huang, Lian-shu Han, Jun Ye, Wen-juan Qiu, Hui-wen Zhang, Xiao-lan Gao, Yu Wang, Wen-jun Ji, Xiao-yan Li, Xue-fan Gu. [Outcomes of patients with combined methylmalonic acidemia and homocystinuria after treatment]. Zhonghua er ke za zhi = Chinese journal of pediatrics. 2013 Mar; 51(3):194-8. doi: NULL. [PMID: 23751581]
  • Sheng-nan Wu, Lian-shu Han, Jun Ye, Wen-juan Qiu, Hui-wen Zhang, Xiao-lan Gao, Yu Wang, Xiao-yan Li, Hao Xu, Xue-fan Gu. [Analysis of propionylcarnitine in blood and methylmalonic acid in urine of 162 patients with methylmalonic acidemia]. Zhonghua yi xue za zhi. 2013 Feb; 93(8):561-5. doi: . [PMID: 23663331]
  • Réjane Morand, Liliane Todesco, Massimiliano Donzelli, David Fischer-Barnicol, Peter J Mullen, Stephan Krähenbühl. Effect of short- and long-term treatment with valproate on carnitine homeostasis in humans. Therapeutic drug monitoring. 2012 Aug; 34(4):406-14. doi: 10.1097/ftd.0b013e3182608e2f. [PMID: 22743351]
  • Mureo Kasahara, Seisuke Sakamoto, Hiroyuki Kanazawa, Chiaki Karaki, Toshihiko Kakiuchi, Takanobu Shigeta, Akinari Fukuda, Rika Kosaki, Atsuko Nakazawa, Mika Ishige, Masayoshi Nagao, Yosuke Shigematsu, Tohru Yorifuji, Yasuhiro Naiki, Reiko Horikawa. Living-donor liver transplantation for propionic acidemia. Pediatric transplantation. 2012 May; 16(3):230-4. doi: 10.1111/j.1399-3046.2011.01607.x. [PMID: 22151065]
  • Mariano Malaguarnera. Carnitine derivatives: clinical usefulness. Current opinion in gastroenterology. 2012 Mar; 28(2):166-76. doi: 10.1097/mog.0b013e3283505a3b. [PMID: 22333562]
  • Sandro La Vignera, Rosita Condorelli, Enzo Vicari, Rosario D'Agata, Aldo E Calogero. Endothelial antioxidant compound prolonged the endothelial antiapoptotic effects registered after tadalafil treatment in patients with arterial erectile dysfunction. Journal of andrology. 2012 Mar; 33(2):170-5. doi: 10.2164/jandrol.111.013342. [PMID: 21546612]
  • Carmen Mingorance, Lucie Duluc, Matthieu Chalopin, Gilles Simard, Pierre-Henri Ducluzeau, Maria Dolores Herrera, Maria Alvarez de Sotomayor, Ramaroson Andriantsitohaina. Propionyl-L-carnitine corrects metabolic and cardiovascular alterations in diet-induced obese mice and improves liver respiratory chain activity. PloS one. 2012; 7(3):e34268. doi: 10.1371/journal.pone.0034268. [PMID: 22457831]
  • Claudia C Wagner, Antonio Rusca, Kurt Kletter, Manfred Tschurlovits, Silvia Pace, Antonio Longo, Massimo Pedrani, Roberto Villa, Enrico Frimonti, Markus Müller, Martin Brunner. Plasma pharmacokinetics and gastrointestinal transit of a new propionyl-L-carnitine controlled release formulation. Xenobiotica; the fate of foreign compounds in biological systems. 2011 Nov; 41(11):988-95. doi: 10.3109/00498254.2011.597454. [PMID: 21810044]
  • Carmen Mingorance, Rosalia Rodriguez-Rodriguez, Maria Luisa Justo, Maria Dolores Herrera, Maria Alvarez de Sotomayor. Pharmacological effects and clinical applications of propionyl-L-carnitine. Nutrition reviews. 2011 May; 69(5):279-90. doi: 10.1111/j.1753-4887.2011.00387.x. [PMID: 21521230]
  • Fei Wang, Lianshu Han, Yanling Yang, Xuefan Gu, Jun Ye, Wenjuan Qiu, Huiwen Zhang, Yafen Zhang, Xiaolan Gao, Yu Wang. Clinical, biochemical, and molecular analysis of combined methylmalonic acidemia and hyperhomocysteinemia (cblC type) in China. Journal of inherited metabolic disease. 2010 Dec; 33 Suppl 3(?):S435-42. doi: 10.1007/s10545-010-9217-0. [PMID: 20924684]
  • Yosuke Shigematsu, Ikue Hata, Go Tajima. Useful second-tier tests in expanded newborn screening of isovaleric acidemia and methylmalonic aciduria. Journal of inherited metabolic disease. 2010 Oct; 33(Suppl 2):S283-8. doi: 10.1007/s10545-010-9111-9. [PMID: 20440648]
  • Kang-Hsiang Cheng, Mei-Ying Liu, Chuan-Hong Kao, Yann-Jang Chen, Kwang-Jen Hsiao, Tze-Tze Liu, Hsiang-Yu Lin, Cheng-Hung Huang, Chuan-Chi Chiang, Huey-Jane Ho, Shuan-Pei Lin, Ni-Chung Lee, Wuh-Liang Hwu, Ju-Li Lin, Ping-Yao Hung, Dau-Ming Niu. Newborn screening for methylmalonic aciduria by tandem mass spectrometry: 7 years' experience from two centers in Taiwan. Journal of the Chinese Medical Association : JCMA. 2010 Jun; 73(6):314-8. doi: 10.1016/s1726-4901(10)70067-8. [PMID: 20603089]
  • Amal G Fatani, Amal Q Darweesh, Lubna Rizwan, Abdulaziz M Aleisa, Othman A Al-Shabanah, Mohamed M Sayed-Ahmed. Carnitine deficiency aggravates cyclophosphamide-induced cardiotoxicity in rats. Chemotherapy. 2010; 56(1):71-81. doi: 10.1159/000298822. [PMID: 20299794]
  • Carmen Mingorance, Maria Gonzalez del Pozo, Maria Dolores Herrera, Maria Alvarez de Sotomayor. Oral supplementation of propionyl-l-carnitine reduces body weight and hyperinsulinaemia in obese Zucker rats. The British journal of nutrition. 2009 Oct; 102(8):1145-53. doi: 10.1017/s0007114509389230. [PMID: 19545458]
  • Richard J Bloomer, Lesley C Tschume, Webb A Smith. Glycine propionyl-L-carnitine modulates lipid peroxidation and nitric oxide in human subjects. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. 2009 May; 79(3):131-41. doi: 10.1024/0300-9831.79.3.131. [PMID: 20209464]
  • Yu Cao, Yun-xiao Wang, Cheng-juan Liu, Le-xin Wang, Zhi-wu Han, Chun-bo Wang. Comparison of pharmacokinetics of L-carnitine, acetyl-L-carnitine and propionyl-L-carnitine after single oral administration of L-carnitine in healthy volunteers. Clinical and investigative medicine. Medecine clinique et experimentale. 2009 Feb; 32(1):E13-9. doi: 10.25011/cim.v32i1.5082. [PMID: 19178874]
  • Nadia Azzollini, Daniela Cugini, Paola Cassis, Anna Pezzotta, Elena Gagliardini, Mauro Abbate, Arduino Arduini, Alessandro Peschechera, Giuseppe Remuzzi, Marina Noris. Propionyl-L-carnitine prevents early graft dysfunction in allogeneic rat kidney transplantation. Kidney international. 2008 Dec; 74(11):1420-8. doi: 10.1038/ki.2008.399. [PMID: 19008910]
  • Yao Zhang, Yan-ling Yang, Yuki Hasegawa, Seiji Yamaguchi, Chun-yan Shi, Jin-qing Song, Sujan Sayami, Ping Liu, Rong Yan, Jin-hua Dong, Jiong Qin. Prenatal diagnosis of methylmalonic aciduria by analysis of organic acids and total homocysteine in amniotic fluid. Chinese medical journal. 2008 Feb; 121(3):216-9. doi: . [PMID: 18298912]
  • William R Wikoff, Jon A Gangoiti, Bruce A Barshop, Gary Siuzdak. Metabolomics identifies perturbations in human disorders of propionate metabolism. Clinical chemistry. 2007 Dec; 53(12):2169-76. doi: 10.1373/clinchem.2007.089011. [PMID: 17951291]
  • Abdulaziz M Aleisa, Abdulhakeem A Al-Majed, Abdulaziz A Al-Yahya, Salim S Al-Rejaie, Saleh A Bakheet, Othman A Al-Shabanah, Mohamed M Sayed-Ahmed. Reversal of cisplatin-induced carnitine deficiency and energy starvation by propionyl-L-carnitine in rat kidney tissues. Clinical and experimental pharmacology & physiology. 2007 Dec; 34(12):1252-9. doi: 10.1111/j.1440-1681.2007.04714.x. [PMID: 17973863]
  • Carmen Delgado, Carlos Macías, Maria de la Sierra García-Valdecasas, Manuel Pérez, Luis Ruiz del Portal, Luis Manuel Jiménez. Subacute presentation of propionic acidemia. Journal of child neurology. 2007 Dec; 22(12):1405-7. doi: 10.1177/0883073807307080. [PMID: 18174561]
  • Abdulhakeem A Al-Majed. Carnitine deficiency provokes cisplatin-induced hepatotoxicity in rats. Basic & clinical pharmacology & toxicology. 2007 Mar; 100(3):145-50. doi: 10.1111/j.1742-7843.2006.00024.x. [PMID: 17309516]
  • Augusto Orlandi, Arianna Francesconi, Marcella Marcellini, Antonio Di Lascio, Luigi Giusto Spagnoli. Propionyl-L-carnitine reduces proliferation and potentiates Bax-related apoptosis of aortic intimal smooth muscle cells by modulating nuclear factor-kappaB activity. The Journal of biological chemistry. 2007 Feb; 282(7):4932-4942. doi: 10.1074/jbc.m606148200. [PMID: 17178728]
  • Alessandra F Perna, Filomena Acanfora, Ersilia Satta, Cinzia Lombardi, Rosanna Capasso, Diego Ingrosso, Natale G De Santo. L-Propionyl carnitine, homocysteine and S-adenosylhomocysteine in hemodialysis. Journal of nephrology. 2007 Jan; 20(1):63-5. doi: . [PMID: 17347975]
  • Lorenzo Loffredo, Pasquale Pignatelli, Roberto Cangemi, Paola Andreozzi, Maria Antonietta Panico, Valerio Meloni, Francesco Violi. Imbalance between nitric oxide generation and oxidative stress in patients with peripheral arterial disease: effect of an antioxidant treatment. Journal of vascular surgery. 2006 Sep; 44(3):525-30. doi: 10.1016/j.jvs.2006.05.023. [PMID: 16950429]
  • Lucía Gómez-Amores, Alfonso Mate, Elisa Revilla, Consuelo Santa-María, Carmen M Vázquez. Antioxidant activity of propionyl-L-carnitine in liver and heart of spontaneously hypertensive rats. Life sciences. 2006 Mar; 78(17):1945-52. doi: 10.1016/j.lfs.2005.08.023. [PMID: 16263137]
  • Abdulhakeem A Al-Majed, Mohamed M Sayed-Ahmed, Abdulaziz A Al-Yahya, Abdulaziz M Aleisa, Salim S Al-Rejaie, Othman A Al-Shabanah. Propionyl-L-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model. Pharmacological research. 2006 Mar; 53(3):278-86. doi: 10.1016/j.phrs.2005.12.005. [PMID: 16436331]
  • Antonio Silvestro, Vittorio Schiano, Roxana Bucur, Gregorio Brevetti, Francesco Scopacasa, Massimo Chiariello. Effect of propionylcarnitine on changes in endothelial function and plasma levels of adhesion molecules induced by acute exercise in patients with intermittent claudication. Angiology. 2006 Mar; 57(2):145-54. doi: 10.1177/000331970605700203. [PMID: 16518521]
  • Nicola Origlia, Massimiliano Migliori, Vincenzo Panichi, Cristina Filippi, Aldo Bertelli, Angelo Carpi, Luca Giovannini. Protective effect of L-propionylcarnitine in chronic cyclosporine-a induced nephrotoxicity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2006 Feb; 60(2):77-81. doi: 10.1016/j.biopha.2005.06.014. [PMID: 16472963]
  • Judit Bene, Katalin Komlósi, Viktória Havasi, Gábor Talián, Beáta Gasztonyi, Krisztina Horváth, Gyula Mózsik, Béla Hunyady, Béla Melegh, Mária Figler. Changes of plasma fasting carnitine ester profile in patients with ulcerative colitis. World journal of gastroenterology. 2006 Jan; 12(1):110-3. doi: 10.3748/wjg.v12.i1.110. [PMID: 16440427]
  • Salvatore Santo Signorelli, Pasquale Fatuzzo, Francesco Rapisarda, Sergio Neri, Margherita Ferrante, Gea Oliveri Conti, Roberto Fallico, Luigi Di Pino, Giuseppe Pennisi, Gabriella Celotta, Anzaldi Massimiliano. A randomised, controlled clinical trial evaluating changes in therapeutic efficacy and oxidative parameters after treatment with propionyl L-carnitine in patients with peripheral arterial disease requiring haemodialysis. Drugs & aging. 2006; 23(3):263-70. doi: 10.2165/00002512-200623030-00008. [PMID: 16608381]
  • Salvatore Santo Signorelli, Pasquale Fatuzzo, Francesco Rapisarda, Sergio Neri, Margherita Ferrante, Gea Oliveri Conti, Roberto Fallico, Luigi Di Pino, Giuseppe Pennisi, Gabriella Celotta, Massimiliano Anzaldi. Propionyl-L-carnitine therapy: effects on endothelin-1 and homocysteine levels in patients with peripheral arterial disease and end-stage renal disease. Kidney & blood pressure research. 2006; 29(2):100-7. doi: 10.1159/000094363. [PMID: 16809937]
  • C D Campbell, J Ganesh, C Ficicioglu. Two newborns with nutritional vitamin B12 deficiency: challenges in newborn screening for vitamin B12 deficiency. Haematologica. 2005 Dec; 90(12 Suppl):ECR45. doi: . [PMID: 16464760]
  • Rosario Bueno, Maria Alvarez de Sotomayor, Concepción Perez-Guerrero, Lucia Gomez-Amores, Carmen M Vazquez, M Dolores Herrera. L-carnitine and propionyl-L-carnitine improve endothelial dysfunction in spontaneously hypertensive rats: different participation of NO and COX-products. Life sciences. 2005 Sep; 77(17):2082-97. doi: 10.1016/j.lfs.2005.01.035. [PMID: 15958269]
  • Roberto Ferrari, E Merli, G Cicchitelli, D Mele, A Fucili, C Ceconi. Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: a review. Annals of the New York Academy of Sciences. 2004 Nov; 1033(?):79-91. doi: 10.1196/annals.1320.007. [PMID: 15591005]
  • Ruud C W Vermeulen, Hans R Scholte. Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome. Psychosomatic medicine. 2004 Mar; 66(2):276-82. doi: 10.1097/01.psy.0000116249.60477.e9. [PMID: 15039515]
  • G Gasbarrini, G Mingrone, A Giancaterini, A De Gaetano, A Scarfone, E Capristo, M Calvani, V Caso, A V Greco. Effects of propionyl-L-carnitine topical irrigation in distal ulcerative colitis: a preliminary report. Hepato-gastroenterology. 2003 Sep; 50(53):1385-9. doi: NULL. [PMID: 14571743]
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