Asymmetric dimethylarginine (BioDeep_00000002992)

 

Secondary id: BioDeep_00000178363, BioDeep_00000403116, BioDeep_00000405912

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Toxin natural product Volatile Flavor Compounds


代谢物信息卡片


(2S)-2-amino-5-[(E)-[amino(dimethylamino)methylidene]amino]pentanoic acid

化学式: C8H18N4O2 (202.1429688)
中文名称: (2S)-2-氨基-5-[(氨基-二甲基氨基甲基亚基)氨基]戊酸, N5 - [(二甲基氨基)亚氨基甲基] -L-鸟氨酸, 二甲基精氨酸, 不对称二甲基精氨酸
谱图信息: 最多检出来源 Viridiplantae(plant) 0.06%

Reviewed

Last reviewed on 2024-08-26.

Cite this Page

Asymmetric dimethylarginine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/asymmetric_dimethylarginine (retrieved 2024-11-22) (BioDeep RN: BioDeep_00000002992). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CN(C)C(=N)NCCCC(N)C(=O)O
InChI: InChI=1S/C8H18N4O2/c1-12(2)8(10)11-5-3-4-6(9)7(13)14/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14)

描述信息

Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells. It is closely related to L-arginine, a conditionally-essential amino acid. ADMA interferes with L-arginine in the production of nitric oxide, a key chemical to endothelial and hence cardiovascular health. Asymmetric dimethylarginine is created in protein methylation, a common mechanism of post-translational protein modification. This reaction is catalyzed by an enzyme set called S-adenosylmethionine protein N-methyltransferases (protein methylases I and II). The methyl groups transferred to create ADMA are derived from the methyl group donor S-adenosylmethionine, an intermediate in the metabolism of homocysteine. (Homocysteine is an important blood chemical, because it is also a marker of cardiovascular disease). After synthesis, ADMA migrates into the extracellular space and thence into blood plasma. Asymmetric dimethylarginine is measured using high performance liquid chromatography. ADMA has been identified as a uremic toxin according to the European Uremic Toxin Working Group (PMID: 22626821).
Isolated from broad bean seeds (Vicia faba). NG,NG-Dimethyl-L-arginine is found in many foods, some of which are yellow wax bean, spinach, green zucchini, and white cabbage.
D004791 - Enzyme Inhibitors
Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states.

同义名列表

23 个代谢物同义名

(2S)-2-amino-5-[(E)-[amino(dimethylamino)methylidene]amino]pentanoic acid; (2S)-2-amino-5-[[amino(dimethylamino)methylidene]amino]pentanoic acid; 2-Amino-5-(amino-dimethylamino-methylidene)amino-pentanoic acid; 2-Amino-5-(amino-dimethylamino-methylidene)amino-pentanoate; N(5)-((Dimethylamino)iminomethyl)-L-ornithine; N5-[(dimethylamino)iminomethyl]-L-ornithine; N(Omega),N(omega)-dimethyl-L-arginine; Nomega,nomega-dimethyl-L-arginine; L-Arg(Me, Me)-OH (asymmetrical); Guanidino-N,N-dimethylarginine; N(g1),N(g1)-Dimethylarginine; Asymmetric dimethylarginine; N(g),N(g)-Dimethylarginine; NG,NG-Dimethyl-L-arginine; NG,NG-Dimethylarginine; N(g)-Dimethylarginine; N,N-Dimethylarginine; NG-Dimethylarginine; Dimethyl-L-arginine; ADMA; Asymmetric dimethylarginine; NG,NG-Dimethyl-L-arginine; NG,NG-Dimethyl-L-arginine



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

23 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shao-Sung Huang, Wei-Chieh Huang, Chuan-Tsai Tsai, Ying-Ying Chen, Sheng-Hua Lee, Tse-Min Lu. Plasma asymmetric dimethylarginine is associated with vulnerable plaque and long-term outcomes in stable coronary artery disease. Scientific reports. 2023 May; 13(1):7541. doi: 10.1038/s41598-023-32728-9. [PMID: 37160906]
  • Laura Dowsett, Lucie Duluc, Erin Higgins, Fatmah Alghamdi, Walter Fast, Ian P Salt, James Leiper. Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation. Cellular signalling. 2023 Apr; ?(?):110676. doi: 10.1016/j.cellsig.2023.110676. [PMID: 37028778]
  • Asmaa A Mahmoud, Hesham M Aboelghar, Sabry Moawad Abdelmageed, Heba M Abdallah, Mohamed I Garib, Nahla M S Abd El Hady. Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs. Pediatric research. 2022 12; 92(6):1606-1612. doi: 10.1038/s41390-022-02132-6. [PMID: 35688962]
  • Behnaz Pourrajab, Nasim Naderi, Leila Janani, Marjan Hajahmadi, Vahid Mofid, Afsaneh Dehnad, Mohammad Hassan Sohouli, Sharieh Hosseini, Farzad Shidfar. The impact of probiotic yogurt versus ordinary yogurt on serum sTWEAK, sCD163, ADMA, LCAT and BUN in patients with chronic heart failure: a randomized, triple-blind, controlled trial. Journal of the science of food and agriculture. 2022 Oct; 102(13):6024-6035. doi: 10.1002/jsfa.11955. [PMID: 35460085]
  • Roman N Rodionov, Natalia Jarzebska, Dmitrii Burdin, Vladimir Todorov, Jens Martens-Lobenhoffer, Anja Hofmann, Anne Kolouschek, Nada Cordasic, Johannes Jacobi, Elena Rubets, Henning Morawietz, John F O'Sullivan, Alexander G Markov, Stefan R Bornstein, Karl Hilgers, Renke Maas, Christian Pfluecke, YingJie Chen, Stefanie M Bode-Böger, Christian P M Hugo, Bernd Hohenstein, Norbert Weiss. Overexpression of alanine-glyoxylate aminotransferase 2 protects from asymmetric dimethylarginine-induced endothelial dysfunction and aortic remodeling. Scientific reports. 2022 06; 12(1):9381. doi: 10.1038/s41598-022-13169-2. [PMID: 35672381]
  • Zeynep Cetin, Arzu Kosem, Merve Catak, Bulent Can, Ozden Baser, Serdar Guler. The Relationship of Thyroid Functions with ADMA, IMA, and Metabolic Laboratory Parameters in Euthyroid Adults with and without Autoimmune Thyroiditis. Laboratory medicine. 2022 May; 53(3):290-295. doi: 10.1093/labmed/lmab098. [PMID: 34792122]
  • Kensuke Ikenaka, Yasuhiro Maeda, Yuji Hotta, Seiichi Nagano, Shinichiro Yamada, Daisuke Ito, Ryota Torii, Keita Kakuda, Harutsugu Tatebe, Naoki Atsuta, Cesar Aguirre, Yasuyoshi Kimura, Kousuke Baba, Takahiko Tokuda, Masahisa Katsuno, Kazunori Kimura, Gen Sobue, Hideki Mochizuki. Serum asymmetric dimethylarginine level correlates with the progression and prognosis of amyotrophic lateral sclerosis. European journal of neurology. 2022 05; 29(5):1410-1416. doi: 10.1111/ene.15254. [PMID: 35128793]
  • Angelo Zinellu, Arduino A Mangoni. An updated systematic review and meta-analysis of the effect of statins on asymmetric dimethylarginine. Nitric oxide : biology and chemistry. 2022 03; 120(?):26-37. doi: 10.1016/j.niox.2022.01.001. [PMID: 35032642]
  • Beatrice Hanusch, Kathrin Sinningen, Folke Brinkmann, Stefanie Dillenhöfer, Mirjam Frank, Karl-Heinz Jöckel, Cordula Koerner-Rettberg, Martin Holtmann, Tanja Legenbauer, Christian Langrock, Thomas Reinehr, Patricia Maasjosthusmann, Bibiana Beckmann, Eckard Hamelmann, Dimitrios Tsikas, Thomas Lücke. Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases. International journal of molecular sciences. 2022 Feb; 23(4):. doi: 10.3390/ijms23042136. [PMID: 35216250]
  • Suellen Rodrigues Martins, Sílvia Letícia de Oliveira Toledo, Aislander Junio da Silva, Fernanda Santos Mendes, Marina Mendes de Oliveira, Leticia Gonçalves Resende Ferreira, Luci Maria Sant'Ana Dusse, Maria das Graças Carvalho, Danyelle Romana Alves Rios, Patrícia Nessralla Alpoim, Melina de Barros Pinheiro. Endothelial dysfunction biomarkers in sickle cell disease: is there a role for ADMA and PAI-1?. Annals of hematology. 2022 Feb; 101(2):273-280. doi: 10.1007/s00277-021-04695-6. [PMID: 34665295]
  • Guo-Hua Ni, Jin-Fang Cheng, Yuan-Jian Li, Qi-Ying Xie, Tian-Lun Yang, Mei-Fang Chen. Effect of profilin-1 on the asymmetric dimethylarginine-induced vascular lesion-associated hypertension. The Kaohsiung journal of medical sciences. 2022 Feb; 38(2):149-156. doi: 10.1002/kjm2.12468. [PMID: 34741409]
  • Wen-Ting Zhang, Qin Lu, Jie-Jun Ding, Meng Gu. Association of asymmetric dimethylarginine with the pathological process of persistent pulmonary hypertension of the newborn. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. 2022 Jan; 24(1):54-59. doi: 10.7499/j.issn.1008-8830.2108145. [PMID: 35177176]
  • Ziang Xie, Lei Hou, Shuying Shen, Yizheng Wu, Jian Wang, Zhiwei Jie, Xiangde Zhao, Xiang Li, Xuyang Zhang, Junxin Chen, Wenbin Xu, Lei Ning, Qingliang Ma, Shiyu Wang, Haoming Wang, Putao Yuan, Xiangqian Fang, An Qin, Shunwu Fan. Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation. Nature communications. 2022 01; 13(1):50. doi: 10.1038/s41467-021-27629-2. [PMID: 35013196]
  • Arne Gessner, Anna Gemeinhardt, Agnes Bosch, Dennis Kannenkeril, Christian Staerk, Andreas Mayr, Martin F Fromm, Roland E Schmieder, Renke Maas. Effects of treatment with SGLT-2 inhibitors on arginine-related cardiovascular and renal biomarkers. Cardiovascular diabetology. 2022 01; 21(1):4. doi: 10.1186/s12933-021-01436-x. [PMID: 34991562]
  • Ayça Türer Cabbar, M Muzaffer Değertekin, Mustafa A Şimşek, Olcay Özveren, Seda Güleç, Mehmed Yanartaş, Serpil Gezer Taş, Şehnaz Olgun Yıldızeli, Bülent Mutlu, Turgay İşbir, Bedrettin Yıldızeli. Evaluation of Asymmetric Dimethylarginine Levels in Patients With Chronic Thromboembolic Pulmonary Hypertension Undergoing Pulmonary Endarterectomy. Heart, lung & circulation. 2022 Jan; 31(1):110-118. doi: 10.1016/j.hlc.2021.05.090. [PMID: 34130918]
  • Yichen Zhao, Minjie Zhang, Yunxiao Dou, Kangshuai Du, Xueyuan Liu, Yanxin Zhao. DDAH1/ADMA Regulates Adiponectin Resistance in Cerebral Ischemia via the ROS/FOXO1/APR1 Pathway. Oxidative medicine and cellular longevity. 2022; 2022(?):2350857. doi: 10.1155/2022/2350857. [PMID: 35509834]
  • Huseyin Samet Ozcelik, Derya Arslan, Cigdem Damla Deniz, Oguzhan Gunenc, Husamettin Vatansev, Celil Uysal. Evaluation of Plasma Asymmetric Dimethylarginine Levels and Abdominal Aortic Intima-Media Thickness in Infants of Smoker Mothers. American journal of perinatology. 2021 12; 38(14):1494-1499. doi: 10.1055/s-0040-1713816. [PMID: 32683669]
  • Bo Zhou, Gulinigaer Tuerhong Jiang, Hui Liu, Manyun Guo, Junhui Liu, Jianqing She. Dysregulated Arginine Metabolism in Young Patients with Chronic Persistent Asthma and in Human Bronchial Epithelial Cells. Nutrients. 2021 Nov; 13(11):. doi: 10.3390/nu13114116. [PMID: 34836371]
  • Heng Zhang, Shouyan Xiang, Zhe Dai, Yu Fan. Asymmetric dimethylarginine level as biomarkers of cardiovascular or all-cause mortality in patients with chronic kidney disease: a meta-analysis. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2021 Nov; 26(7):579-585. doi: 10.1080/1354750x.2021.1954694. [PMID: 34253095]
  • Hüseyin Korkmaz, Mehmet Asıl, Tuncer Temel, Bahadır Öztürk, Levent Kebapçılar. Evaluation of serum neutrophil gelatinase-associated lipocalin (NGAL), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) levels, and their relations with disease type and activity in inflammatory bowel diseases. Turkish journal of medical sciences. 2021 10; 51(5):2403-2412. doi: 10.3906/sag-2103-220. [PMID: 33984894]
  • Boris K Kurbatov, Ekaterina S Prokudina, Leonid N Maslov, Natalia V Naryzhnaya, Sergey V Logvinov, Alexander S Gorbunov, Alexandr V Mukhomedzyanov, Andrey V Krylatov, Nikita S Voronkov, Andrey S Sementsov, Konstantin V Zavadovsky, Viktor V Saushkin, Rajendra P Nagarajan, Peter R Oeltgen. The role of adrenergic and muscarinic receptors in stress-induced cardiac injury. Pflugers Archiv : European journal of physiology. 2021 10; 473(10):1641-1655. doi: 10.1007/s00424-021-02602-6. [PMID: 34245378]
  • Tzong-Shyuan Lee, Tse-Min Lu, Chia-Hui Chen, Bei-Chia Guo, Chiao-Po Hsu. Hyperuricemia induces endothelial dysfunction and accelerates atherosclerosis by disturbing the asymmetric dimethylarginine/dimethylarginine dimethylaminotransferase 2 pathway. Redox biology. 2021 10; 46(?):102108. doi: 10.1016/j.redox.2021.102108. [PMID: 34438260]
  • Mei-Hsin Hsu, Kow-Aung Chang, Yu-Chieh Chen, I-Chun Lin, Jiunn-Ming Sheen, Li-Tung Huang. Resveratrol prevented spatial deficits and rescued disarrayed hippocampus asymmetric dimethylarginine and brain-derived neurotrophic factor levels in young rats with increased circulating asymmetric dimethylarginine. Neuroreport. 2021 09; 32(13):1091-1099. doi: 10.1097/wnr.0000000000001698. [PMID: 34284453]
  • Mark A McEvoy, John R Attia, Christopher Oldmeadow, Elizabeth Holliday, Wayne T Smith, Arduino A Mangoni, Roseanne Peel, Stephen J Hancock, Marjorie M Walker, Nicholas J Talley. Serum L-arginine and endogenous methylarginine concentrations predict irritable bowel syndrome in adults: A nested case-control study. United European gastroenterology journal. 2021 09; 9(7):809-818. doi: 10.1002/ueg2.12137. [PMID: 34431615]
  • Duygu Eryavuz Onmaz, Kevser Isik, Abdullah Sivrikaya, Sedat Abusoglu, İlknur Albayrak Gezer, Gulsum Abusoglu, Fatma Humeyra Yerlikaya, Ali Unlu. Determination of serum methylarginine levels by tandem mass spectrometric method in patients with ankylosing spondylitis. Amino acids. 2021 Sep; 53(9):1329-1338. doi: 10.1007/s00726-021-03046-z. [PMID: 34273021]
  • Kenta Toyomasu, Hisashi Adachi, Mika Enomoto, Ako Fukami, Sachiko Nakamura, Yume Nohara, Nagisa Morikawa, Akiko Sakaue, Hitoshi Hamamura, Maki Yamamoto, Yoshihiro Fukumoto. Impact of combined elevations of homocysteine and asymmetric dimethylarginine on all-cause death - The Tanushimaru Study. Journal of cardiology. 2021 08; 78(2):129-135. doi: 10.1016/j.jjcc.2021.01.011. [PMID: 33551145]
  • Marius M Mader, Rainer Böger, Daniel Appel, Edzard Schwedhelm, Munif Haddad, Malte Mohme, Katrin Lamszus, Manfred Westphal, Patrick Czorlich, Juliane Hannemann. Intrathecal and systemic alterations of L-arginine metabolism in patients after intracerebral hemorrhage. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021 08; 41(8):1964-1977. doi: 10.1177/0271678x20983216. [PMID: 33461409]
  • Zhen Qin, Lisha Tang, Qianyi Huang, Yan Chen, Wei Zhong, Xiangqi Tang. A systematic review of the correlation between serum asymmetric dimethylarginine, carotid atherosclerosis and ischaemic stroke. European journal of clinical investigation. 2021 Aug; 51(8):e13558. doi: 10.1111/eci.13558. [PMID: 33756002]
  • Tolga Baş, Murat Koç, Onur Işık, Hakan Hançer, Ali Kutsal. Asymmetric dimethylarginine: Is it a risk facgtor in the repair of aortic coarctation?. Journal of cardiac surgery. 2021 Aug; 36(8):2735-2740. doi: 10.1111/jocs.15601. [PMID: 33993556]
  • Damian Gajecki, Jakub Gawryś, Jerzy Wiśniewski, Paulina Fortuna, Ewa Szahidewicz-Krupska, Adrian Doroszko. A Cross-Talk between the Erythrocyte L-Arginine/ADMA/Nitric Oxide Metabolic Pathway and the Endothelial Function in Subjects with Type 2 Diabetes Mellitus. Nutrients. 2021 Jul; 13(7):. doi: 10.3390/nu13072306. [PMID: 34371816]
  • Yichen Zhao, Xiaoye Ma, Yuchen Zhou, Junchao Xie, Xueyuan Liu, Yanxin Zhao. DDAH-1, via regulation of ADMA levels, protects against ischemia-induced blood-brain barrier leakage. Laboratory investigation; a journal of technical methods and pathology. 2021 07; 101(7):808-823. doi: 10.1038/s41374-021-00541-5. [PMID: 33574439]
  • Daniel Braun, Jens Schlossmann, Ekkehard Haen. Asymmetric dimethylarginine in psychiatric disorders. Psychiatry research. 2021 06; 300(?):113901. doi: 10.1016/j.psychres.2021.113901. [PMID: 33819866]
  • Juliane Hannemann, Paul Balfanz, Edzard Schwedhelm, Bojan Hartmann, Johanna Ule, Dirk Müller-Wieland, Edgar Dahl, Michael Dreher, Nikolaus Marx, Rainer Böger. Elevated serum SDMA and ADMA at hospital admission predict in-hospital mortality of COVID-19 patients. Scientific reports. 2021 05; 11(1):9895. doi: 10.1038/s41598-021-89180-w. [PMID: 33972591]
  • Duygu Eryavuz Onmaz, Saziye Melike Turan Isık, Sedat Abusoglu, Ahmet Hakan Ekmekci, Abdullah Sivrikaya, Gulsum Abusoglu, Serefnur Ozturk, Humeyra Yerlikaya Aydemir, Ali Unlu. Serum ADMA levels were positively correlated with EDSS scores in patients with multiple sclerosis. Journal of neuroimmunology. 2021 04; 353(?):577497. doi: 10.1016/j.jneuroim.2021.577497. [PMID: 33549941]
  • Adrian Post, Alexander Bollenbach, Stephan J L Bakker, Dimitrios Tsikas. Whole-body arginine dimethylation is associated with all-cause mortality in adult renal transplant recipients. Amino acids. 2021 Apr; 53(4):541-554. doi: 10.1007/s00726-021-02965-1. [PMID: 33651245]
  • Ozge Tugce Pasaoglu, Filiz Sezen Bircan, Turgut Topal, Nurten Turkozkan. Positive Effects of Melatonin on Renal Nitric Oxide-Asymmetric Dimethylarginine Metabolism in Fructose-Fed Rats. Metabolic syndrome and related disorders. 2021 04; 19(3):120-126. doi: 10.1089/met.2020.0084. [PMID: 33090894]
  • Tadanobu Yoshikawa, Kenji Obayashi, Kimie Miyata, Keigo Saeki, Nahoko Ogata. Association Between the Asymmetric Dimethylarginine Levels and Glaucoma Severity: A Cross-Sectional Analysis of the LIGHT Study. Investigative ophthalmology & visual science. 2021 04; 62(4):7. doi: 10.1167/iovs.62.4.7. [PMID: 33821880]
  • Petr Tůma, Blanka Sommerová, Dušan Koval, François Couderc. Electrophoretic Determination of Symmetric and Asymmetric Dimethylarginine in Human Blood Plasma with Whole Capillary Sample Injection. International journal of molecular sciences. 2021 Mar; 22(6):. doi: 10.3390/ijms22062970. [PMID: 33804011]
  • Parinaz Nikooei, Mohammad J Hosseinzadeh-Attar, Somayyeh Asghari, Abdolreza Norouzy, Mehdi Yaseri, Ali Vasheghani-Farahani. Effects of virgin coconut oil consumption on metabolic syndrome components and asymmetric dimethylarginine: A randomized controlled clinical trial. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2021 03; 31(3):939-949. doi: 10.1016/j.numecd.2020.11.020. [PMID: 33549429]
  • C Bening, V L Sales, K Alhussini, D Radakovic, R Cris Benitez, N Madrahimov, D Keller, R Leyh. Clinically inapparent right heart dysfunction is associated with reduced myofilament force development in coronary artery disease. BMC cardiovascular disorders. 2021 03; 21(1):125. doi: 10.1186/s12872-021-01926-6. [PMID: 33663396]
  • Zanna Fiodorenko-Dumas, Ilias Dumas, Maciej Rabczynski, Rafał Małecki, Rajmund Adamiec, Małgorzata Paprocka-Borowicz. Lack of evidence of the correlation between plasma Asymmetrical Dimethylarginine correlation and IMT in type 2 diabetic patients with chronic vascular complication. Acta biochimica Polonica. 2021 Feb; 68(1):143-149. doi: 10.18388/abp.2020_5424. [PMID: 33543609]
  • Young Lee, Purvi Mehrotra, David Basile, Mahbub Ullah, Arshnoor Singh, Nicholas Skill, Subhi Talal Younes, Jennifer Sasser, Anantha Shekhar, Jaipal Singh. Specific Lowering of Asymmetric Dimethylarginine by Pharmacological Dimethylarginine Dimethylaminohydrolase Improves Endothelial Function, Reduces Blood Pressure and Ischemia-Reperfusion Injury. The Journal of pharmacology and experimental therapeutics. 2021 02; 376(2):181-189. doi: 10.1124/jpet.120.000212. [PMID: 33214214]
  • A Ertelt, F Stumpff, R Merle, S Kuban, L Bollinger, S Liertz, H Gehlen. Asymmetric dimethylarginine-A potential cardiac biomarker in horses. Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology. 2021 Feb; 33(?):43-51. doi: 10.1016/j.jvc.2020.11.002. [PMID: 33360109]
  • Yasin Saygın, Abdullah Sivrikaya, Turan Akdağ, Duygu Dursunoğlu, Mehmet Kaynar, Gülsüm Abuşoğlu, Ali Ünlü. Is there a relation between serum methylarginine levels and infertility?. Hormone molecular biology and clinical investigation. 2021 Jan; 42(3):273-278. doi: 10.1515/hmbci-2020-0083. [PMID: 33544480]
  • Patrycja Molek, Pawel Zmudzki, Aleksandra Wlodarczyk, Jadwiga Nessler, Jaroslaw Zalewski. The shifted balance of arginine metabolites in acute myocardial infarction patients and its clinical relevance. Scientific reports. 2021 01; 11(1):83. doi: 10.1038/s41598-020-80230-3. [PMID: 33420142]
  • Neveen Tawfik Abed, Omima Mohamed Abdel Haie, Amira Ibrahim Mansour, Eman Rateb Abd Almonaem. Relation of asymmetric dimethylarginine with pulmonary morbidities in neonatal respiratory distress syndrome. Journal of neonatal-perinatal medicine. 2021; 14(4):511-517. doi: 10.3233/npm-200604. [PMID: 33646184]
  • Ayako Okada, Takatoshi Murata, Khairul Matin, Meu Ariyoshi, Ryoko Otsuka, Mamiko Yamashita, Masayuki Suzuki, Rumi Wakiyama, Ken Tateno, Megumi Suzuki, Hitomi Aoyagi, Hiromi Uematsu, Akiko Imamura, Miki Kosaka, Tomoko Mizukaki, Tsutomu Sato, Hiroshi Kawahara, Nobuhiro Hanada. Effect of advanced periodontal self-care in patients with early-stage periodontal diseases on endothelial function: An open-label, randomized controlled trial. PloS one. 2021; 16(9):e0257247. doi: 10.1371/journal.pone.0257247. [PMID: 34555048]
  • Hawley E Kunz, Jessica M Dorschner, Taylor E Berent, Thomas Meyer, Xuewei Wang, Aminah Jatoi, Rajiv Kumar, Ian R Lanza. Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting. The Journal of biological chemistry. 2020 12; 295(51):17441-17459. doi: 10.1074/jbc.ra120.014884. [PMID: 33453990]
  • Fatma Tunçez Akyürek, Gulcan Saylam Kurtipek, Huseyin Kurku, Fikret Akyurek, Ali Unlu, Sedat Abusoglu, Arzu Ataseven. Assessment of ADMA, IMA, and Vitamin A and E Levels in Patients with Acne Vulgaris. Journal of cosmetic dermatology. 2020 Dec; 19(12):3408-3413. doi: 10.1111/jocd.13590. [PMID: 32623816]
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