N-Acetyl-glucosamine 1-phosphate (BioDeep_00000002972)

 

Secondary id: BioDeep_00001869092

human metabolite Endogenous


代谢物信息卡片


{[(3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phosphonic acid

化学式: C8H16NO9P (301.0563)
中文名称: N-乙酰葡糖胺-1-磷酸
谱图信息: 最多检出来源 Homo sapiens(natural_products) 10.71%

分子结构信息

SMILES: CC(=O)NC1C(C(C(OC1OP(=O)(O)O)CO)O)O
InChI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)

描述信息

N-Acetyl-glucosamine 1-phosphate is an intermediate in aminosugar metabolism. It is a substrate for the enzymes phosphoglucomutase 3 [EC:5.4.2.2 and EC:5.4.2.3] and UDP-N-acteylglucosamine pyrophosphorylase 1 [EC:2.7.7.23] (KEGG). It is involved in UDP-N-acetyl-D-glucosamine biosynthesis and UDP-N-acetylgalactosamine biosynthesis (BioCyc).
N-Acetyl-glucosamine 1-phosphate is an intermeiate in the Aminosugars metabolism, a substrate for the enzymes phosphoglucomutase 3 [EC:5.4.2.2 5.4.2.3] and UDP-N-acteylglucosamine pyrophosphorylase 1 [EC:2.7.7.23] (KEGG), in UDP-N-acetyl-D-glucosamine biosynthesis and UDP-N-acetylgalactosamine biosynthesis (BioCyc) [HMDB]
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

20 个代谢物同义名

{[(3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phosphonic acid; [(3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphosphonic acid; [3-acetylamino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphosphonic acid; 2-(Acetylamino)-2-deoxy-D-glucopyranose 1-(dihydrogen phosphoric acid); 2-(Acetylamino)-2-deoxy-D-glucopyranose 1-(dihydrogen phosphate); 2-Acetamido-2-deoxy-1-O-phosphono-D-glucopyranose; N-Acetyl-alpha-delta-glucosamine 1-phosphate; N-Acetyl-alpha-D-glucosamine 1-phosphate; N-Acetyl-D-glucosamine 1-phosphoric acid; N-Acetyl-glucosamine 1-phosphoric acid; N-Acetyl-delta-glucosamine 1-phosphate; N-Acetylglucosamine-1-phosphoric acid; N-Acetyl-D-glucosamine 1-phosphate; N-acetyl-D-hexosamine 1-phosphate; N-Acetyl-glucosamine 1-phosphate; N-Acetyl-glucosamine-1-phosphate; N-Acetylglucosamine-1-phosphate; delta-Glucosamine 1-phosphate; D-Glucosamine 1-phosphate; GlcNAc-1-phosphate



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

299 个相关的代谢反应过程信息。

Reactome(18)

BioCyc(4)

WikiPathways(1)

Plant Reactome(237)

INOH(3)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(35)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 NR3C1, OGT, PLA2G12A, SP1, STAT5A, TTN, UBAP1
Endosome membrane 1 UBAP1
Endoplasmic reticulum membrane 2 DPAGT1, HSP90B1
Mitochondrion membrane 1 OGT
Nucleus 7 HSP90B1, NR3C1, OGT, SP1, STAT5A, TCF15, TTN
cytosol 11 AMPD1, GALE, GPT, HSP90B1, NR3C1, OGT, PGM3, STAT5A, TTN, UAP1, UBAP1
mitochondrial membrane 1 OGT
centrosome 1 NR3C1
nucleoplasm 5 NR3C1, OGT, SP1, STAT5A, UAP1
RNA polymerase II transcription regulator complex 2 STAT5A, TCF15
Cell membrane 2 OGT, SLC6A8
Multi-pass membrane protein 2 DPAGT1, SLC6A8
Golgi apparatus membrane 1 GBGT1
Synapse 1 NR3C1
cell surface 1 PRLR
glutamatergic synapse 1 OGT
Golgi apparatus 1 GBGT1
Golgi membrane 2 GBGT1, INS
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 2 UAP1, UBAP1
endosome 1 UBAP1
plasma membrane 5 OGT, PRLR, SLC6A8, UAP1, UBAP1
Membrane 8 DPAGT1, GBGT1, HSP90B1, NAGPA, NR3C1, OGT, PRLR, SLC6A8
apical plasma membrane 1 SLC6A8
extracellular exosome 3 GPT, HSP90B1, TTN
endoplasmic reticulum 1 HSP90B1
extracellular space 2 INS, SP1
perinuclear region of cytoplasm 1 HSP90B1
mitochondrion 1 NR3C1
protein-containing complex 3 HSP90B1, NR3C1, OGT
intracellular membrane-bounded organelle 2 DPAGT1, UBAP1
Single-pass type I membrane protein 2 NAGPA, PRLR
Secreted 3 INS, PLA2G12A, SP1
extracellular region 6 HSP90B1, INS, PLA2G12A, PRLR, SP1, TTN
mitochondrial matrix 1 NR3C1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 NR3C1
external side of plasma membrane 1 PRLR
Z disc 1 TTN
midbody 1 HSP90B1
Single-pass type II membrane protein 1 GBGT1
vesicle 1 GBGT1
Apical cell membrane 1 SLC6A8
Cytoplasm, cytoskeleton, spindle 1 NR3C1
focal adhesion 1 HSP90B1
spindle 1 NR3C1
collagen-containing extracellular matrix 1 HSP90B1
nuclear speck 1 NR3C1
receptor complex 1 PRLR
chromatin 4 NR3C1, SP1, STAT5A, TCF15
cell projection 1 OGT
Chromosome 1 NR3C1
[Isoform 2]: Mitochondrion 1 OGT
Golgi apparatus, trans-Golgi network 1 NAGPA
ESCRT I complex 1 UBAP1
Endomembrane system 1 DPAGT1
endosome lumen 2 INS, PRLR
I band 1 TTN
M band 1 TTN
NSL complex 1 OGT
Nucleus, nucleoplasm 1 NR3C1
Melanosome 1 HSP90B1
Golgi cisterna membrane 1 NAGPA
euchromatin 1 SP1
sperm plasma membrane 1 HSP90B1
[Isoform 3]: Cytoplasm 1 OGT
[Isoform 4]: Cytoplasm 1 OGT
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 HSP90B1, INS
transcription repressor complex 1 SP1
transport vesicle 1 INS
Golgi apparatus, Golgi stack membrane 1 NAGPA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
condensed nuclear chromosome 1 TTN
Sarcoplasmic reticulum lumen 1 HSP90B1
histone acetyltransferase complex 1 OGT
protein N-acetylglucosaminyltransferase complex 1 OGT
Sin3-type complex 1 OGT
protein-DNA complex 1 SP1
[Isoform Alpha]: Cytoplasm 1 NR3C1
endocytic vesicle lumen 1 HSP90B1
[Isoform Beta]: Nucleus 1 NR3C1
[Isoform Alpha-B]: Nucleus 1 NR3C1
endoplasmic reticulum chaperone complex 1 HSP90B1
striated muscle thin filament 1 TTN
organelle 1 TTN


文献列表

  • Stefano Benini, Mirco Toccafondi, Martin Rejzek, Francesco Musiani, Ben A Wagstaff, Jochen Wuerges, Michele Cianci, Robert A Field. Glucose-1-phosphate uridylyltransferase from Erwinia amylovora: Activity, structure and substrate specificity. Biochimica et biophysica acta. Proteins and proteomics. 2017 Nov; 1865(11 Pt A):1348-1357. doi: 10.1016/j.bbapap.2017.08.015. [PMID: 28844747]
  • Che-Hsiung Hsu, Mathias Schelwies, Sebastian Enck, Lin-Ya Huang, Shih-Hsien Huang, Yi-Fan Chang, Ting-Jen Rachel Cheng, Wei-Chieh Cheng, Chi-Huey Wong. Iminosugar C-glycoside analogues of α-D-GlcNAc-1-phosphate: synthesis and bacterial transglycosylase inhibition. The Journal of organic chemistry. 2014 Sep; 79(18):8629-37. doi: 10.1021/jo501340s. [PMID: 25137529]
  • Linda J Olson, Francis C Peterson, Alicia Castonguay, Richard N Bohnsack, Mariko Kudo, Russell R Gotschall, William M Canfield, Brian F Volkman, Nancy M Dahms. Structural basis for recognition of phosphodiester-containing lysosomal enzymes by the cation-independent mannose 6-phosphate receptor. Proceedings of the National Academy of Sciences of the United States of America. 2010 Jul; 107(28):12493-8. doi: 10.1073/pnas.1004232107. [PMID: 20615935]
  • Matthew J Stokes, M Lucia S Güther, Daniel C Turnock, Alan R Prescott, Kirstee L Martin, Magnus S Alphey, Michael A J Ferguson. The synthesis of UDP-N-acetylglucosamine is essential for bloodstream form trypanosoma brucei in vitro and in vivo and UDP-N-acetylglucosamine starvation reveals a hierarchy in parasite protein glycosylation. The Journal of biological chemistry. 2008 Jun; 283(23):16147-61. doi: 10.1074/jbc.m709581200. [PMID: 18381290]