Citrulline (BioDeep_00000002963)

 

Secondary id: BioDeep_00000177884, BioDeep_00000229677, BioDeep_00000398052, BioDeep_00000400373, BioDeep_00001875128

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


(S)-2-Amino-5-(aminocarbonyl)aminopentanoic acid

化学式: C6H13N3O3 (175.0957)
中文名称: L-瓜氨酸, 瓜氨酸, DL-瓜氨酸
谱图信息: 最多检出来源 Homo sapiens(feces) 12.65%

分子结构信息

SMILES: C(CC(C(=O)O)N)CNC(=O)N
InChI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)

描述信息

Citrulline, also known as Cit or δ-ureidonorvaline, belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom. Citrulline has the formula H2NC(O)NH(CH2)3CH(NH2)CO2H. Citrulline exists in all living species, ranging from bacteria to humans. Within humans, citrulline participates in a number of enzymatic reactions. In particular, citrulline can be biosynthesized from carbamoyl phosphate and ornithine which is catalyzed by the enzyme ornithine carbamoyltransferase. In addition, citrulline and L-aspartic acid can be converted into argininosuccinic acid through the action of the enzyme argininosuccinate synthase. In humans, citrulline is involved in the metabolic disorder called argininemia. Citrulline has also been found to be associated with several diseases such as ulcerative colitis, rheumatoid arthritis, and citrullinemia type II. Citrulline has also been linked to several inborn metabolic disorders including argininosuccinic aciduria and fumarase deficiency. Outside of the human body, citrulline is found, on average, in the highest concentration in a few different foods such as wheats, oats, and cucumbers and in a lower concentration in swiss chards, yellow wax beans, and potato. Citrulline has also been detected, but not quantified in several different foods, such as epazotes, lotus, common buckwheats, strawberry guava, and italian sweet red peppers. Citrulline is a potentially toxic compound. Proteins that normally contain citrulline residues include myelin basic protein (MBP), filaggrin, and several histone proteins, whereas other proteins, such as fibrin and vimentin are susceptible to citrullination during cell death and tissue inflammation. Citrulline is also produced as a byproduct of the enzymatic production of nitric oxide from the amino acid arginine, catalyzed by nitric oxide synthase. It is also produced from arginine as a byproduct of the reaction catalyzed by NOS family (NOS; EC1.14.13.39).
[Spectral] L-Citrulline (exact mass = 175.09569) and L-Glutamate (exact mass = 147.05316) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions.
Acquisition and generation of the data is financially supported in part by CREST/JST.
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
Occurs in the juice of watermelon (Citrullus vulgaris)
IPB_RECORD: 257; CONFIDENCE confident structure
KEIO_ID C013
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
2-Amino-5-ureidopentanoic acid is an endogenous metabolite.
2-Amino-5-ureidopentanoic acid is an endogenous metabolite.
L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.
L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.

同义名列表

69 个代谢物同义名

(S)-2-Amino-5-(aminocarbonyl)aminopentanoic acid; (2S)-2-Amino-5-(carbamoylamino)pentanoic acid; (S)-2-Amino-5-(aminocarbonyl)aminopentanoate; (2S)-2-Amino-5-(carbamoylamino)pentanoate; alpha-Amino-gamma-ureidovaleric acid; alpha-Amino-delta-ureidovaleric acid; (S)-2-Amino-5-ureidopentanoic acid; N(5)-(Aminocarbonyl)-DL-ornithine; L(+)-2-Amino-5-ureidovaleric acid; alpha-Amino-gamma-ureidovalerate; N(5)-(Aminocarbonyl)-L-ornithine; a-Amino-delta-ureidovaleric acid; alpha-Amino-delta-ureidovalerate; L-2-Amino-5-ureido-valeric acid; L-2-Amino-5-ureidovaleric acid; N5-(Aminocarbonyl)-L-ornithine; (S)-2-Amino-5-ureidopentanoate; L(+)-2-Amino-5-ureidovalerate; a-Amino-δ-ureidovaleric acid; 2-Amino-5-ureidovaleric acid; a-Amino-delta-ureidovalerate; a-Amino-D-ureidovaleric acid; N5-(Aminocarbonyl)-ornithine; Α-amino-δ-ureidovaleric acid; N5-(Aminocarbonyl)ornithine; 2-Amino-5-uredovaleric acid; L-2-Amino-5-ureido-valerate; L-2-Amino-5-ureidovalerate; N(delta)-Carbamylornithine; 2-Amino-5-ureidovalerate; Ngamma-carbamylornithine; Ndelta-carbamylornithine; Ndelta-carbamy-ornithine; N5-Carbamoyl-L-ornithine; Α-amino-δ-ureidovalerate; Amino-ureidovaleric acid; a-Amino-δ-ureidovalerate; L-N5-Carbamoyl-ornithine; a-Amino-D-ureidovalerate; 2-Amino-5-uredovalerate; N(Δ)-carbamylornithine; N5-Carbamoylornithine; N()-Carbamylornithine; delta-Ureidonorvaline; Gammaureidonorvaline; N5-Carbamylornithine; Amino-ureidovalerate; ND-Carbamylornithine; N-Carbamylornithine; Ureidovaleric acid; Δ-ureidonorvaline; D-Ureidonorvaline; Ureidonorvaline; L(+)-Citrulline; Ureidovalerate; DL-Citrulline; L-Citrulline; L-Cytrulline; Cytrulline; Sitrulline; Citrulline; H-Cit-OH; CIR; Cit; Citrulline; DL-Citrulline; 2-Amino-5-ureidopentanoic acid; L-Citrulline; Citrulline



数据库引用编号

68 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(1)

BioCyc(2)

PlantCyc(0)

代谢反应

648 个相关的代谢反应过程信息。

Reactome(33)

BioCyc(4)

WikiPathways(2)

Plant Reactome(607)

INOH(2)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

41 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ALB, ARG1, ASL, CPS1, GLUL, MTOR, NOS1, OAT, ODC1
Peripheral membrane protein 5 CPS1, CYP1B1, MBP, MTOR, NOS1
Endoplasmic reticulum membrane 3 CD4, CYP1B1, MTOR
Nucleus 8 ALB, ARG1, FABP2, GLUL, MBP, MPO, MTOR, NOS1
cytosol 9 ALB, ARG1, ASL, FABP2, GLUL, MBP, MTOR, NOS1, ODC1
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 1 ALB
nucleoplasm 4 MPO, MTOR, NOS1, OAT
Cell membrane 4 CD4, CPS1, GLUL, TNF
Lipid-anchor 1 GLUL
Cytoplasmic side 2 MBP, MTOR
Cytoplasmic granule 1 ARG1
Golgi apparatus membrane 1 MTOR
Synapse 2 MBP, NOS1
cell surface 2 MBP, TNF
Golgi apparatus 1 ALB
Golgi membrane 2 INS, MTOR
lysosomal membrane 1 MTOR
mitochondrial inner membrane 1 CPS1
neuronal cell body 2 MBP, TNF
sarcolemma 1 NOS1
Cytoplasm, cytosol 1 GLUL
Lysosome 2 MPO, MTOR
plasma membrane 8 CD4, CPS1, GCG, GLUL, IFNLR1, MBP, NOS1, TNF
Membrane 3 CYP1B1, IFNLR1, MTOR
extracellular exosome 5 ALB, ASL, GLUL, MBP, MPO
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 ALB, GLUL
extracellular space 8 ALB, ARG1, CXCL8, GCG, IL10, INS, MPO, TNF
perinuclear region of cytoplasm 1 NOS1
mitochondrion 5 CPS1, CYP1B1, GLUL, NOS1, OAT
protein-containing complex 4 ALB, CPS1, MBP, NOS1
intracellular membrane-bounded organelle 2 CYP1B1, MPO
Microsome membrane 2 CYP1B1, MTOR
postsynaptic density 1 NOS1
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 CD4, IFNLR1
Secreted 5 ALB, CXCL8, GCG, IL10, INS
extracellular region 9 ALB, ARG1, CXCL8, GCG, IL10, INS, MBP, MPO, TNF
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
Mitochondrion matrix 1 OAT
mitochondrial matrix 2 CPS1, OAT
Extracellular side 1 CPS1
anchoring junction 1 ALB
photoreceptor inner segment 1 NOS1
external side of plasma membrane 2 CD4, TNF
dendritic spine 1 NOS1
nucleolus 1 CPS1
Early endosome 1 CD4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cell membrane, sarcolemma 1 NOS1
Cytoplasm, perinuclear region 1 NOS1
Membrane raft 3 CD4, NOS1, TNF
mitochondrial nucleoid 1 CPS1
sarcoplasmic reticulum 1 NOS1
Cell projection, dendritic spine 1 NOS1
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 1 MBP
secretory granule 1 MPO
ciliary basal body 1 ALB
phagocytic cup 1 TNF
cell periphery 2 MBP, NOS1
cytoskeleton 1 NOS1
[Isoform 3]: Nucleus 1 MBP
centriole 1 ALB
Nucleus, nucleolus 1 CPS1
spindle pole 1 ALB
blood microparticle 1 ALB
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
endosome lumen 1 INS
microvillus 1 FABP2
cell body 1 GLUL
myelin sheath 1 MBP
azurophil granule 1 MPO
Microsome 1 GLUL
ficolin-1-rich granule lumen 1 MBP
secretory granule lumen 2 GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, CD4, GCG, INS
platelet alpha granule lumen 1 ALB
specific granule lumen 1 ARG1
transport vesicle 2 INS, MBP
azurophil granule lumen 2 ARG1, MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 1 CD4
phagocytic vesicle lumen 1 MPO
Cytoplasmic vesicle, phagosome 1 MTOR
glial cell projection 1 GLUL
[Glucagon-like peptide 1]: Secreted 1 GCG
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD4
compact myelin 1 MBP
internode region of axon 1 MBP
apical cortex 1 FABP2
[Bone marrow proteoglycan]: Secreted 1 MBP
ciliary transition fiber 1 ALB
Myelin membrane 1 MBP
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Fatemeh Bagheripour, Sajad Jeddi, Khosrow Kashfi, Asghar Ghasemi. Anti-obesity and anti-diabetic effects of L-citrulline are sex-dependent. Life sciences. 2024 Feb; 339(?):122432. doi: 10.1016/j.lfs.2024.122432. [PMID: 38237764]
  • Juanjuan Zhao, Yanfeng Li, Chunli Gao, Zeyuan Zhao, Shengxiang Zhang, Jianhui Dong, Haiyue Zuo, Xufei Chen, Binxi Xie, Zhengwei Guo, Yanming Wang, Hui Li, Yangyang Bian. Screening of natural inhibitors against peptidyl arginine deiminase 4 from herbal extracts by a high-performance liquid chromatography ultraviolet-visible based method. Journal of chromatography. A. 2024 Feb; 1716(?):464643. doi: 10.1016/j.chroma.2024.464643. [PMID: 38232639]
  • Liping Qu, Xiao Ma, Feifei Wang. The roles of gut microbiome and metabolites associated with skin photoaging in mice by intestinal flora sequencing and metabolomics. Life sciences. 2024 Feb; ?(?):122487. doi: 10.1016/j.lfs.2024.122487. [PMID: 38316265]
  • Petar Pujic, Lorena Carro, Pascale Fournier, Jean Armengaud, Guylaine Miotello, Nathalie Dumont, Caroline Bourgeois, Xavier Saupin, Patrick Jame, Gabriela Vuletin Selak, Nicole Alloisio, Philippe Normand. Frankia alni Carbonic Anhydrase Regulates Cytoplasmic pH of Nitrogen-Fixing Vesicles. International journal of molecular sciences. 2023 May; 24(11):. doi: 10.3390/ijms24119162. [PMID: 37298114]
  • Li Yin, Xiaomin Wei, Yanjun Zhang, Chengshu Lu, Huakun Wang. Citrulline inhibits LPS-induced pyroptosis of RAW264.7 macrophages through NF-κB signaling pathway. Immunity, inflammation and disease. 2023 04; 11(4):e832. doi: 10.1002/iid3.832. [PMID: 37102651]
  • Jolanta Bugajska, Joanna Berska, Małgorzata Wójcik, Krystyna Sztefko. Amino acid profile in overweight and obese prepubertal children - can simple biochemical tests help in the early prevention of associated comorbidities?. Frontiers in endocrinology. 2023; 14(?):1274011. doi: 10.3389/fendo.2023.1274011. [PMID: 37964971]
  • Xiangjuan Yan, Fei Zhao, Guosheng Wang, Zhen Wang, Mingxi Zhou, Limin Zhang, Guoxiang Wang, Yanshan Chen. Metabolomic Analysis of Microcystis aeruginosa After Exposure to the Algicide L-Lysine. Bulletin of environmental contamination and toxicology. 2022 Dec; 110(1):12. doi: 10.1007/s00128-022-03658-5. [PMID: 36512146]
  • Yan-Kun Zhang, Bing-Kun Yang, Chun-Nuan Zhang, Shi-Xiao Xu, Ping Sun. Effects of polystyrene microplastics acute exposure in the liver of swordtail fish (Xiphophorus helleri) revealed by LC-MS metabolomics. The Science of the total environment. 2022 Dec; 850(?):157772. doi: 10.1016/j.scitotenv.2022.157772. [PMID: 35934030]
  • Tongtong Ba, Dai Zhao, Yiqin Chen, Cuiping Zeng, Cheng Zhang, Sai Niu, Hanchuan Dai. L-Citrulline Supplementation Restrains Ferritinophagy-Mediated Ferroptosis to Alleviate Iron Overload-Induced Thymus Oxidative Damage and Immune Dysfunction. Nutrients. 2022 Oct; 14(21):. doi: 10.3390/nu14214549. [PMID: 36364817]
  • Shangqing Li, Guorong Lyu, Shaohui Li, Hainan Yang, Yiru Yang. Metabolic characterization of amniotic fluid of fetuses with isolated choroid plexus cyst. Journal of perinatal medicine. 2022 Oct; 50(8):1100-1106. doi: 10.1515/jpm-2022-0028. [PMID: 35607760]
  • Tao Wen, Penghao Xie, C Ryan Penton, Lauren Hale, Linda S Thomashow, Shengdie Yang, Zhexu Ding, Yaqi Su, Jun Yuan, Qirong Shen. Specific metabolites drive the deterministic assembly of diseased rhizosphere microbiome through weakening microbial degradation of autotoxin. Microbiome. 2022 10; 10(1):177. doi: 10.1186/s40168-022-01375-z. [PMID: 36271396]
  • Lei Zhang, Lin Han, Ziyan Liu, Jiaru Jing, Jingyu Wang, Wei Zhang, Ai Gao. Early hematopoietic injury triggered by benzene characterized with inhibition of erythrocyte differentiation involving the mollicutes_RF39-derived citrulline. Chemosphere. 2022 Sep; 303(Pt 1):135009. doi: 10.1016/j.chemosphere.2022.135009. [PMID: 35597459]
  • Guodong Zhao, Xi Zhao, Yukun Song, Aerman Haire, Airixiati Dilixiati, Zhiqiang Liu, Shangshang Zhao, Aikebaier Aihemaiti, Xiangwei Fu, Abulizi Wusiman. Effect of L-citrulline supplementation on sperm characteristics and hormonal and antioxidant levels in blood and seminal plasma of rams. Reproduction in domestic animals = Zuchthygiene. 2022 Jul; 57(7):722-733. doi: 10.1111/rda.14111. [PMID: 35262979]
  • Svetlana Baskal, Alexander Bollenbach, Bettina Henzi, Patricia Hafner, Dirk Fischer, Dimitrios Tsikas. Stable-Isotope Dilution GC-MS Measurement of Metformin in Human Serum and Urine after Derivatization with Pentafluoropropionic Anhydride and Its Application in Becker Muscular Dystrophy Patients Administered with Metformin, l-Citrulline, or Their Combination. Molecules (Basel, Switzerland). 2022 Jun; 27(12):. doi: 10.3390/molecules27123850. [PMID: 35744973]
  • Vincent Marcangeli, Layale Youssef, Maude Dulac, Livia P Carvalho, Guy Hajj-Boutros, Olivier Reynaud, Bénédicte Guegan, Fanny Buckinx, Pierrette Gaudreau, José A Morais, Pascale Mauriège, Philippe Noirez, Mylène Aubertin-Leheudre, Gilles Gouspillou. Impact of high-intensity interval training with or without l-citrulline on physical performance, skeletal muscle, and adipose tissue in obese older adults. Journal of cachexia, sarcopenia and muscle. 2022 06; 13(3):1526-1540. doi: 10.1002/jcsm.12955. [PMID: 35257499]
  • Chervin Hassel, Morgane Couchet, Nathalie Jacquemot, Christelle Blavignac, Cécile Loï, Christophe Moinard, David Cia. Citrulline protects human retinal pigment epithelium from hydrogen peroxide and iron/ascorbate induced damages. Journal of cellular and molecular medicine. 2022 05; 26(10):2808-2818. doi: 10.1111/jcmm.17294. [PMID: 35460170]
  • Ozcan Esen, Mustafa Can Eser, Mekki Abdioglu, Daniela Benesova, Tomasz Gabrys, Raci Karayigit. Eight Days of L-Citrulline or L-Arginine Supplementation Did Not Improve 200-m and 100-m Swimming Time Trials. International journal of environmental research and public health. 2022 04; 19(8):. doi: 10.3390/ijerph19084462. [PMID: 35457330]
  • Claudia Sikorski, Sandi Azab, Russell J de Souza, Meera Shanmuganathan, Dipika Desai, Koon Teo, Stephanie A Atkinson, Katherine Morrison, Milan Gupta, Philip Britz-McKibbin, Sonia S Anand. Serum metabolomic signatures of gestational diabetes in South Asian and white European women. BMJ open diabetes research & care. 2022 04; 10(2):. doi: 10.1136/bmjdrc-2021-002733. [PMID: 35450870]
  • Victoria Anthony Uyanga, Jingpeng Zhao, Xiaojuan Wang, Hongchao Jiao, Okanlawon M Onagbesan, Hai Lin. Effects of dietary L-citrulline supplementation on nitric oxide synthesis, immune responses and mitochondrial energetics of broilers during heat stress. Journal of thermal biology. 2022 Apr; 105(?):103227. doi: 10.1016/j.jtherbio.2022.103227. [PMID: 35393039]
  • Druszczynska Magdalena, Seweryn Michal, Sieczkowska Marta, Kowalewska-Pietrzak Magdalena, Pankowska Anna, Godkowicz Magdalena, Szewczyk Rafał. Targeted metabolomics analysis of serum and Mycobacterium tuberculosis antigen-stimulated blood cultures of pediatric patients with active and latent tuberculosis. Scientific reports. 2022 03; 12(1):4131. doi: 10.1038/s41598-022-08201-4. [PMID: 35260782]
  • Victoria Anthony Uyanga, Lei Liu, Jingpeng Zhao, Xiaojuan Wang, Hongchao Jiao, Hai Lin. Central and peripheral effects of L-citrulline on thermal physiology and nitric oxide regeneration in broilers. Poultry science. 2022 Mar; 101(3):101669. doi: 10.1016/j.psj.2021.101669. [PMID: 35101686]
  • Katherine S Peters, Emilio Rivera, Cassandra Warden, Paula A Harlow, Sabrina L Mitchell, M Wade Calcutt, David C Samuels, Milam A Brantley. Plasma Arginine and Citrulline are Elevated in Diabetic Retinopathy. American journal of ophthalmology. 2022 03; 235(?):154-162. doi: 10.1016/j.ajo.2021.09.021. [PMID: 34587493]
  • Florian Reizine, Murielle Grégoire, Mathieu Lesouhaitier, Valentin Coirier, Juliette Gauthier, Céline Delaloy, Elise Dessauge, Florent Creusat, Fabrice Uhel, Arnaud Gacouin, Frédéric Dessauge, Cécile Le Naoures, Caroline Moreau, Claude Bendavid, Yoann Daniel, Kilian Petitjean, Valérie Bordeau, Claire Lamaison, Caroline Piau, Vincent Cattoir, Mikael Roussel, Bernard Fromenty, Christian Michelet, Yves Le Tulzo, Jaroslaw Zmijewski, Ronan Thibault, Michel Cogné, Karin Tarte, Jean-Marc Tadié. Beneficial effects of citrulline enteral administration on sepsis-induced T cell mitochondrial dysfunction. Proceedings of the National Academy of Sciences of the United States of America. 2022 02; 119(8):. doi: 10.1073/pnas.2115139119. [PMID: 35173051]
  • Oskar Ciesielski, Marta Biesiekierska, Baptiste Panthu, Mirosław Soszyński, Luciano Pirola, Aneta Balcerczyk. Citrullination in the pathology of inflammatory and autoimmune disorders: recent advances and future perspectives. Cellular and molecular life sciences : CMLS. 2022 Jan; 79(2):94. doi: 10.1007/s00018-022-04126-3. [PMID: 35079870]
  • Victoria Anthony Uyanga, Jingpeng Zhao, Xiaojuan Wang, Hongchao Jiao, Okanlawon M Onagbesan, Hai Lin. Dietary L-citrulline influences body temperature and inflammatory responses during nitric oxide synthase inhibition and endotoxin challenge in chickens. Stress (Amsterdam, Netherlands). 2022 01; 25(1):74-86. doi: 10.1080/10253890.2021.2023495. [PMID: 34962227]
  • Neymar de Oliveira, Joelma Gandolfi, Lígia Contrim, Roseli Pereira, Loraine Fernandes, João Silva, Brenno Gomes, Francisco Garcia Soriano, Suzana Lobo. The effects of vasopressors with and without dobutamine on haemodynamics, metabolism and gut injury during endotoxic shock in rabbits. A controlled study. Anaesthesiology intensive therapy. 2022; 54(2):141-149. doi: 10.5114/ait.2022.117264. [PMID: 35792110]
  • José Burgos, Aitor Viribay, Diego Fernández-Lázaro, Julio Calleja-González, Josefa González-Santos, Juan Mielgo-Ayuso. Combined Effects of Citrulline Plus Nitrate-Rich Beetroot Extract Co-Supplementation on Maximal and Endurance-Strength and Aerobic Power in Trained Male Triathletes: A Randomized Double-Blind, Placebo-Controlled Trial. Nutrients. 2021 Dec; 14(1):. doi: 10.3390/nu14010040. [PMID: 35010917]
  • Eduardo Sommella, Giulio Verna, Marina Liso, Emanuela Salviati, Tiziana Esposito, Daniela Carbone, Camilla Pecoraro, Marcello Chieppa, Pietro Campiglia. Hop-derived fraction rich in beta acids and prenylflavonoids regulates the inflammatory response in dendritic cells differently from quercetin: unveiling metabolic changes by mass spectrometry-based metabolomics. Food & function. 2021 Dec; 12(24):12800-12811. doi: 10.1039/d1fo02361f. [PMID: 34859812]
  • Vishwajit S Chowdhury, Yoshimitsu Ouchi, Guofeng Han, Hatem M Eltahan, Shogo Haraguchi, Takuro Miyazaki, Jun-Ichi Shiraishi, Toshihisa Sugino, Takashi Bungo. Oral administration of L-citrulline changes the concentrations of plasma hormones and biochemical profile in heat-exposed broilers. Animal science journal = Nihon chikusan Gakkaiho. 2021 Dec; 92(1):e13578. doi: 10.1111/asj.13578. [PMID: 34235825]
  • E Lichar Dillon, Guoyao Wu. Cortisol enhances citrulline synthesis from proline in enterocytes of suckling piglets. Amino acids. 2021 Dec; 53(12):1957-1966. doi: 10.1007/s00726-021-03039-y. [PMID: 34244859]
  • Bo Zhou, Gulinigaer Tuerhong Jiang, Hui Liu, Manyun Guo, Junhui Liu, Jianqing She. Dysregulated Arginine Metabolism in Young Patients with Chronic Persistent Asthma and in Human Bronchial Epithelial Cells. Nutrients. 2021 Nov; 13(11):. doi: 10.3390/nu13114116. [PMID: 34836371]
  • Karolina A P Wijnands, Dennis M Meesters, Benjamin Vandendriessche, Jacob J Briedé, Hans M H van Eijk, Peter Brouckaert, Anje Cauwels, Wouter H Lamers, Martijn Poeze. Microcirculatory Function during Endotoxemia-A Functional Citrulline-Arginine-NO Pathway and NOS3 Complex Is Essential to Maintain the Microcirculation. International journal of molecular sciences. 2021 Nov; 22(21):. doi: 10.3390/ijms222111940. [PMID: 34769369]
  • Nilima Jawale, Mallory Prideaux, Malavika Prasad, Malki Miller, Shantanu Rastogi. Plasma Citrulline as a Biomarker for Early Diagnosis of Necrotizing Enterocolitis in Preterm Infants. American journal of perinatology. 2021 11; 38(13):1435-1441. doi: 10.1055/s-0040-1713406. [PMID: 32604444]
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