N-NITROSOMETHYLETHYLAMINE (BioDeep_00000002957)

   


代谢物信息卡片


N-Nitrosomethylethylamine (NMEA)

化学式: C3H8N2O (88.0637)
中文名称: N-亚硝基甲基乙基胺, N-亚硝基甲基乙胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCN(C)N=O
InChI: InChI=1S/C3H8N2O/c1-3-5(2)4-6/h3H2,1-2H3

描述信息

CONFIDENCE standard compound; EAWAG_UCHEM_ID 3449

同义名列表

5 个代谢物同义名

N-Methyl-N-nitrosoethanamine; N-NITROSOMETHYLETHYLAMINE; N-Nitrosomethylethylamine (NMEA); N-Nitrosomethylethylamine; N-Nitrosomethylethylamine



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 AOC3, CDC25A, CDK1, CHEK2, CYP2A6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP3A4, GADD45A, HPGDS
Peripheral membrane protein 1 CYP2E1
Endoplasmic reticulum membrane 10 CDK1, CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP3A4, CYP3A5
Nucleus 4 CDC25A, CDK1, CHEK2, GADD45A
cytosol 5 CDC25A, CDK1, GSR, HPGDS, TRDN
centrosome 1 CDK1
nucleoplasm 7 CD2, CDC25A, CDK1, CHEK2, GADD45A, HPGDS, TRDN
Cell membrane 5 AOC3, CD2, NPY1R, SLC38A3, TRDN
Multi-pass membrane protein 2 NPY1R, SLC38A3
cell surface 2 AOC3, CD2
Golgi apparatus 3 AOC3, CD2, CHEK2
mitochondrial inner membrane 1 CYP2E1
plasma membrane 8 AOC3, CD2, CYP2C19, CYP2C8, CYP2C9, NPY1R, SLC38A3, TRDN
Membrane 9 AOC3, CDK1, CYP2A6, CYP2D6, CYP3A4, CYP3A5, NPY1R, SLC38A3, TRDN
apical plasma membrane 1 SLC38A3
basolateral plasma membrane 1 SLC38A3
extracellular exosome 2 CDK1, GSR
endoplasmic reticulum 3 AOC3, CYP2D6, TRDN
mitochondrion 3 CDK1, CYP2D6, GSR
protein-containing complex 1 CD2
intracellular membrane-bounded organelle 10 CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP3A4, CYP3A5, HPGDS
Microsome membrane 6 CYP1A2, CYP2C9, CYP2D6, CYP2E1, CYP3A4, CYP3A5
Single-pass type I membrane protein 1 CD2
extracellular region 1 CD2
cytoplasmic side of plasma membrane 1 CD2
Single-pass membrane protein 1 CYP2D6
mitochondrial matrix 2 CDK1, GSR
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CDK1
external side of plasma membrane 2 CD2, GSR
midbody 1 CDK1
Early endosome 1 AOC3
cell-cell junction 1 CD2
Single-pass type II membrane protein 2 AOC3, TRDN
Mitochondrion inner membrane 1 CYP2E1
sarcoplasmic reticulum 1 TRDN
PML body 1 CHEK2
nuclear speck 1 GADD45A
neuron projection 1 NPY1R
mitotic spindle 1 CDK1
chromosome, telomeric region 1 CDK1
Basolateral cell membrane 1 SLC38A3
microvillus 1 AOC3
Sarcoplasmic reticulum membrane 1 TRDN
Sarcoplasmic reticulum lumen 1 TRDN
junctional sarcoplasmic reticulum membrane 1 TRDN
cytoplasmic microtubule 1 CYP2A6
spindle microtubule 1 CDK1
cyclin-dependent protein kinase holoenzyme complex 1 CDK1
cyclin A1-CDK1 complex 1 CDK1
cyclin A2-CDK1 complex 1 CDK1
cyclin B1-CDK1 complex 1 CDK1
junctional membrane complex 1 TRDN


文献列表

  • James A Hodgson, Tiffany H Seyler, Lanqing Wang. Long-Term Stability of Volatile Nitrosamines in Human Urine. Journal of analytical toxicology. 2016 Jul; 40(6):414-8. doi: 10.1093/jat/bkw038. [PMID: 27274026]
  • Chengkun Wang, Shuming Liu, Jun Wang, Xiaojian Zhang, Chao Chen. Monthly survey of N-nitrosamine yield in a conventional water treatment plant in North China. Journal of environmental sciences (China). 2015 Dec; 38(?):142-9. doi: 10.1016/j.jes.2015.05.025. [PMID: 26702978]
  • E von Hofe, I Schmerold, R W Nims, L K Keefer, E J Reist, P Kleihues. Beta-deuteration of N-nitrosoethylmethylamine causes a shift in DNA methylation from rat liver to esophagus. Carcinogenesis. 1991 Apr; 12(4):545-9. doi: 10.1093/carcin/12.4.545. [PMID: 1901522]
  • A J Streeter, R W Nims, L M Anderson, Y H Heur, E von Hofe, P Kleihues, V C Nelson, B A Mico, L K Keefer. Single-dose toxicokinetics of N-nitrosomethylethylamine and N-nitrosomethyl (2,2,2-trideuterioethyl)amine in the rat. Archives of toxicology. 1990; 64(2):109-15. doi: 10.1007/bf01974395. [PMID: 2350229]
  • W Lijinsky, R M Kovatch, C W Riggs. Carcinogenesis by nitrosodialkylamines and azoxyalkanes given by gavage to rats and hamsters. Cancer research. 1987 Aug; 47(15):3968-72. doi: . [PMID: 3607743]
  • C J Michejda, M B Kroeger-Koepke, R M Kovatch. Carcinogenic effects of sequential administration of two nitrosamines in Fischer 344 rats. Cancer research. 1986 May; 46(5):2252-6. doi: . [PMID: 3697969]
  • E von Hofe, F Grahmann, L K Keefer, W Lijinsky, V Nelson, P Kleihues. Methylation versus ethylation of DNA in target and nontarget tissues of Fischer 344 rats treated with N-nitrosomethylethylamine. Cancer research. 1986 Mar; 46(3):1038-42. doi: . [PMID: 3943083]