Valerate (BioDeep_00000002865)

 

Secondary id: BioDeep_00000229705, BioDeep_00000405391, BioDeep_00000861813

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


N-Pentanoic acid, 11C-labeled sodium salt

化学式: C5H10O2 (102.068076)
中文名称: 正戊酸, 戊酸, 正戊酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.04%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

Valerate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/valerate (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000002865). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C(=O)O)CCC
InChI: InChI=1S/C5H10O2/c1-2-3-4-5(6)7/h2-4H2,1H3,(H,6,7)

描述信息

Valeric acid, or pentanoic acid, is a straight chain alkyl carboxylic acid with the chemical formula CH3(CH2)3COOH. Like other low molecular weight carboxylic acids, it has a very unpleasant odor. Valeric acid is commonly found in human feces, with an average concentration of 2.4 umol/g feces (range of 0.6-3.8 umol/g) (PMID:6740214). Valeric acid is produced by the gut microbiota, typically Clostridia species and other gut bacterial species such as Megasphaera massiliensis MRx0029 (PMID:30052654) via the condensation of ethanol with propionic acid (PMID:18116989). Valeric acid is largely considered as a gut microbial metabolite. Recently, valeric acid has been found to exert strong gut protective effects. Studies involving mice that received high doses of radiation showed that valeric acid replenishment (via oral gavage) elevated the survival rate of irradiated mice, protected hematogenic organs (such as the thymus and spleen), improved gastrointestinal (GI) tract function and enhanced intestinal epithelial integrity (PMID:31931652 ). Valeric acid was also found to restore the enteric bacteria taxonomic proportions and reprogram the small intestinal protein profile to normal levels. Valeric acid, like butyric acid, also appears to be a potent histone deacetylase (HDAC) inhibitor. High levels of HDAC proteins have been implicated in a variety of disease pathologies, from cancer and colitis to cardiovascular disease and neurodegeneration (PMID:30052654). Valeric acid is also found in certain plants, specifically in the perennial flowering plant valerian (Valeriana officinalis), from which it gets its name. Industrially valeric acid is primarily used is in the synthesis of its esters. Volatile esters of valeric acid tend to have pleasant odors and are used in perfumes and cosmetics. Ethyl valerate and pentyl valerate are used as food additives because of their fruity flavours. Hydrolysis of these valerate-containing food additives in the gut can also lead to the appearance of valerate in blood, urine and stool samples.
Minor constituent of biological systems e.g. yeast fat, some plant oilsand is also present in blue cheeses, wines, apple, banana, morello cherry, cooked shrimp, scallop, roasted peanut, roasted filberts and other foodstuffs. Flavouring agent. Pentanoic acid is found in many foods, some of which are red raspberry, pepper (c. frutescens), tea, and fats and oils.
KEIO_ID V002

同义名列表

37 个代谢物同义名

N-Pentanoic acid, 11C-labeled sodium salt; N-Pentanoic acid, maganese (+2) salt; N-Pentanoic acid, potassium salt; N-Pentanoic acid, ammonium salt; N-Pentanoic acid, sodium salt; N-Pentanoic acid, 11C-labeled; N-Pentanoic acid, zinc salt; 1-Butanecarboxylic acid; Butanecarboxylic acid; Valeric acid, normal; Valeric acid normal; 1-Butanecarboxylate; Lithium pentanoate; Butanecarboxylate; Propylacetic acid; Kyselina valerova; N-Pentanoic acid; Valerate, normal; 1-Pentanoic acid; Valerianic acid; CH3-[CH2]3-COOH; pentanoic acid; N-Valeric acid; Valeriansaeure; Valeriansaure; Propylacetate; Valeric acid; 1-Pentanoate; Pentoic acid; N-Pentanoate; Valerianate; Pentanoate; N-C4H9COOH; N-Valerate; Pentoate; valerate; N-BuCOOH



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

45 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yiming Ni, Liangyin Cai, Xiaojun Gou, Wenjie Li, Mingmei Zhou, Ying Huang. Therapeutic effect of Sanhua decoction on rats with middle cerebral artery occlusion and the associated changes in gut microbiota and short-chain fatty acids. PloS one. 2024; 19(2):e0298148. doi: 10.1371/journal.pone.0298148. [PMID: 38363776]
  • Krzysztof Kowalski, Bogumiła Szponar, Patrycja Bochen, Paulina Żebrowska-Różańska, Łukasz Łaczmański, Jerzy Samochowiec, Błażej Misiak. Altered levels of fecal short-chain fatty acids are associated with subclinical inflammation and worse cognitive performance in patients with schizophrenia. Journal of psychiatric research. 2023 Jul; 165(?):298-304. doi: 10.1016/j.jpsychires.2023.07.042. [PMID: 37552919]
  • Ying He, Bang Cheng, Bing-Jian Guo, Zheng Huang, Jing-Hua Qin, Qian-Yi Wang, Lin-Lin Feng, Yun-Yuan Nong, Dan Zhu, Hong-Wei Guo, Zhi-Heng Su. Metabonomics and 16S rRNA gene sequencing to study the therapeutic mechanism of Danggui Sini decoction on collagen-induced rheumatoid arthritis rats with Cold Bi syndrome. Journal of pharmaceutical and biomedical analysis. 2023 Jan; 222(?):115109. doi: 10.1016/j.jpba.2022.115109. [PMID: 36270097]
  • Rui Han, Hongxing Yang, Ya Li, Changquan Ling, Lingeng Lu. Valeric acid acts as a novel HDAC3 inhibitor against prostate cancer. Medical oncology (Northwood, London, England). 2022 Sep; 39(12):213. doi: 10.1007/s12032-022-01814-9. [PMID: 36175803]
  • Hao Lin, Qingqing Guo, Zhiyong Wen, Songlin Tan, Jie Chen, Lijian Lin, Pengcheng Chen, Jianquan He, Jianbo Wen, Ye Chen. The multiple effects of fecal microbiota transplantation on diarrhea-predominant irritable bowel syndrome (IBS-D) patients with anxiety and depression behaviors. Microbial cell factories. 2021 Dec; 20(1):233. doi: 10.1186/s12934-021-01720-1. [PMID: 34963452]
  • Zhongmeng Lai, Weiran Shan, Jun Li, Jia Min, Xianzhang Zeng, Zhiyi Zuo. Appropriate exercise level attenuates gut dysbiosis and valeric acid increase to improve neuroplasticity and cognitive function after surgery in mice. Molecular psychiatry. 2021 12; 26(12):7167-7187. doi: 10.1038/s41380-021-01291-y. [PMID: 34663905]
  • Yue Du, Jinxue Wei, Xiao Yang, Yikai Dou, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Qiang Wang, Wei Deng, Minli Li, Dongtao Lin, Tao Li, Xiaohong Ma. Plasma metabolites were associated with spatial working memory in major depressive disorder. Medicine. 2021 Feb; 100(8):e24581. doi: 10.1097/md.0000000000024581. [PMID: 33663067]
  • Fengqin Shi, Ya Li, Rui Han, Alan Fu, Ronghua Wang, Olivia Nusbaum, Qin Qin, Xinyi Chen, Li Hou, Yong Zhu. Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Scientific reports. 2021 01; 11(1):2519. doi: 10.1038/s41598-021-81620-x. [PMID: 33510252]
  • Maksymilian Onyszkiewicz, Marta Gawrys-Kopczynska, Maciej Sałagaj, Marta Aleksandrowicz, Aneta Sawicka, Ewa Koźniewska, Emilia Samborowska, Marcin Ufnal. Valeric acid lowers arterial blood pressure in rats. European journal of pharmacology. 2020 Jun; 877(?):173086. doi: 10.1016/j.ejphar.2020.173086. [PMID: 32234527]
  • Giovanna Baron, Alessandra Altomare, Luca Regazzoni, Laura Fumagalli, Angelica Artasensi, Elisa Borghi, Emerenziana Ottaviano, Cristian Del Bo, Patrizia Riso, Pietro Allegrini, Giovanna Petrangolini, Paolo Morazzoni, Antonella Riva, Lolita Arnoldi, Marina Carini, Giancarlo Aldini. Profiling Vaccinium macrocarpon components and metabolites in human urine and the urine ex-vivo effect on Candida albicans adhesion and biofilm-formation. Biochemical pharmacology. 2020 03; 173(?):113726. doi: 10.1016/j.bcp.2019.113726. [PMID: 31778647]
  • Yanling Chang, Yunyan Chen, Qiong Zhou, Chuan Wang, Lei Chen, Wen Di, Yu Zhang. Short-chain fatty acids accompanying changes in the gut microbiome contribute to the development of hypertension in patients with preeclampsia. Clinical science (London, England : 1979). 2020 Jan; 134(2):289-302. doi: 10.1042/cs20191253. [PMID: 31961431]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Thao Duy Nguyen, Olena Prykhodko, Frida Fåk Hållenius, Margareta Nyman. Monovalerin and trivalerin increase brain acetic acid, decrease liver succinic acid, and alter gut microbiota in rats fed high-fat diets. European journal of nutrition. 2019 Jun; 58(4):1545-1560. doi: 10.1007/s00394-018-1688-z. [PMID: 29651541]
  • Jodi E Nettleton, Teja Klancic, Alana Schick, Ashley C Choo, Jane Shearer, Stephanie L Borgland, Faye Chleilat, Shyamchand Mayengbam, Raylene A Reimer. Low-Dose Stevia (Rebaudioside A) Consumption Perturbs Gut Microbiota and the Mesolimbic Dopamine Reward System. Nutrients. 2019 May; 11(6):. doi: 10.3390/nu11061248. [PMID: 31159256]
  • Adrián Cortés-Martín, María Victoria Selma, Juan Carlos Espín, Rocío García-Villalba. The Human Metabolism of Nuts Proanthocyanidins does not Reveal Urinary Metabolites Consistent with Distinctive Gut Microbiota Metabotypes. Molecular nutrition & food research. 2019 01; 63(2):e1800819. doi: 10.1002/mnfr.201800819. [PMID: 30444059]
  • S M Nasrollahi, A Zali, G R Ghorbani, A Kahyani, K A Beauchemin. Short communication: Blood metabolites, body reserves, and feed efficiency of high-producing dairy cows that varied in ruminal pH when fed a high-concentrate diet. Journal of dairy science. 2019 Jan; 102(1):672-677. doi: 10.3168/jds.2018-15022. [PMID: 30343904]
  • Li-Chun Chen, Ke-Xian Chen, Xi-Ying Huang, Jian Lou, Jing-Yuan Li, Shao-Ping Deng. Vesicles from the self-assembly of the ultra-small fatty acids with amino acids under aqueous conditions. Colloids and surfaces. B, Biointerfaces. 2019 Jan; 173(?):69-76. doi: 10.1016/j.colsurfb.2018.07.007. [PMID: 30267956]
  • Jeremy Carlier, Ariane Wohlfarth, Bonita D Salmeron, Karl B Scheidweiler, Marilyn A Huestis, Michael H Baumann. Pharmacodynamic Effects, Pharmacokinetics, and Metabolism of the Synthetic Cannabinoid AM-2201 in Male Rats. The Journal of pharmacology and experimental therapeutics. 2018 12; 367(3):543-550. doi: 10.1124/jpet.118.250530. [PMID: 30266766]
  • Santanu Deb-Choudhury, Emma N Bermingham, Wayne Young, Matthew P G Barnett, Scott O Knowles, Duane Harland, Stefan Clerens, Jolon M Dyer. The effects of a wool hydrolysate on short-chain fatty acid production and fecal microbial composition in the domestic cat (Felis catus). Food & function. 2018 Aug; 9(8):4107-4121. doi: 10.1039/c7fo02004j. [PMID: 30039140]
  • Shota Yoshikawa, Ryosuke Araoka, Yu Kajihara, Toshiyuki Ito, Hirokuni Miyamoto, Hiroaki Kodama. Valerate production by Megasphaera elsdenii isolated from pig feces. Journal of bioscience and bioengineering. 2018 May; 125(5):519-524. doi: 10.1016/j.jbiosc.2017.12.016. [PMID: 29331526]
  • Adil Jadoon, Anna V Mathew, Jaeman Byun, Crystal A Gadegbeku, Debbie S Gipson, Farsad Afshinnia, Subramaniam Pennathur. Gut Microbial Product Predicts Cardiovascular Risk in Chronic Kidney Disease Patients. American journal of nephrology. 2018; 48(4):269-277. doi: 10.1159/000493862. [PMID: 30326477]
  • Lisa R Hoving, Marieke Heijink, Vanessa van Harmelen, Ko Willems van Dijk, Martin Giera. GC-MS Analysis of Short-Chain Fatty Acids in Feces, Cecum Content, and Blood Samples. Methods in molecular biology (Clifton, N.J.). 2018; 1730(?):247-256. doi: 10.1007/978-1-4939-7592-1_17. [PMID: 29363078]
  • Melanie Hutter, Sebastian Broecker, Stefan Kneisel, Florian Franz, Simon D Brandt, Volker Auwarter. Metabolism of Nine Synthetic Cannabinoid Receptor Agonists Encountered in Clinical Casework: Major in vivo Phase I Metabolites of AM-694, AM-2201, JWH-007, JWH-019, JWH-203, JWH-307, MAM-2201, UR-144 and XLR-11 in Human Urine Using LC-MS/MS. Current pharmaceutical biotechnology. 2018; 19(2):144-162. doi: 10.2174/1389201019666180509163114. [PMID: 29745330]
  • John F O'Sullivan, Jordan E Morningstar, Qiong Yang, Baohui Zheng, Yan Gao, Sarah Jeanfavre, Justin Scott, Celine Fernandez, Hui Zheng, Sean O'Connor, Paul Cohen, Ramachandran S Vasan, Michelle T Long, James G Wilson, Olle Melander, Thomas J Wang, Caroline Fox, Randall T Peterson, Clary B Clish, Kathleen E Corey, Robert E Gerszten. Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes. The Journal of clinical investigation. 2017 12; 127(12):4394-4402. doi: 10.1172/jci95995. [PMID: 29083323]
  • Gregorio Peron, Stefania Sut, Anna Pellizzaro, Paola Brun, Dario Voinovich, Ignazio Castagliuolo, Stefano Dall'Acqua. The antiadhesive activity of cranberry phytocomplex studied by metabolomics: Intestinal PAC-A metabolites but not intact PAC-A are identified as markers in active urines against uropathogenic Escherichia coli. Fitoterapia. 2017 Oct; 122(?):67-75. doi: 10.1016/j.fitote.2017.08.014. [PMID: 28844930]
  • James Chun Yip Chan, Dorinda Yan Qin Kioh, Gaik Chin Yap, Bee Wah Lee, Eric Chun Yong Chan. A novel LCMSMS method for quantitative measurement of short-chain fatty acids in human stool derivatized with 12C- and 13C-labelled aniline. Journal of pharmaceutical and biomedical analysis. 2017 May; 138(?):43-53. doi: 10.1016/j.jpba.2017.01.044. [PMID: 28178633]
  • Yu V Holota, O O Holubenko, A M Ostapchuk, T M Serhiychuk, L V Zakordonets, G M Tolstanova. Fecal short-chain fatty acids at different time points after ceftriaxone administration in rats. Ukrainian biochemical journal. 2017 Jan; 89(1):50-8. doi: 10.15407/ubj89.01.050. [PMID: 29236389]
  • Benjamin Kalbe, Marian Schlimm, Sebastian Wojcik, Stathis Philippou, Désirée Maßberg, Fabian Jansen, Paul Scholz, Hermann Luebbert, Burkhard Ubrig, Sabrina Osterloh, Hanns Hatt. Olfactory signaling components and olfactory receptors are expressed in tubule cells of the human kidney. Archives of biochemistry and biophysics. 2016 Nov; 610(?):8-15. doi: 10.1016/j.abb.2016.09.017. [PMID: 27693121]
  • Jeremy Carlier, Karl B Scheidweiler, Ariane Wohlfarth, Bonita D Salmeron, Michael H Baumann, Marilyn A Huestis. Quantification of [1-(5-fluoropentyl)-1H-indol-3-yl](naphthalene-1-yl)methanone (AM-2201) and 13 metabolites in human and rat plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. A. 2016 Jun; 1451(?):97-106. doi: 10.1016/j.chroma.2016.05.020. [PMID: 27208987]
  • Birgitte Moen, Ingunn Berget, Ida Rud, Anastasia S Hole, Nils Petter Kjos, Stefan Sahlstrøm. Extrusion of barley and oat influence the fecal microbiota and SCFA profile of growing pigs. Food & function. 2016 Feb; 7(2):1024-32. doi: 10.1039/c5fo01452b. [PMID: 26758043]
  • Alberto Caminero, Esther Nistal, Alexandra R Herrán, Jénifer Pérez-Andrés, Miguel A Ferrero, Luis Vaquero Ayala, Santiago Vivas, José M G Ruiz de Morales, Silvia M Albillos, Francisco Javier Casqueiro. Differences in gluten metabolism among healthy volunteers, coeliac disease patients and first-degree relatives. The British journal of nutrition. 2015 Oct; 114(8):1157-67. doi: 10.1017/s0007114515002767. [PMID: 26428276]
  • Sang-Oh Park, Byung-Sung Park. Bifidogenic effect of grain larvae extract on serum lipid, glucose and intestinal microflora in rats. Journal of biosciences. 2015 Sep; 40(3):513-20. doi: 10.1007/s12038-015-9540-6. [PMID: 26333397]
  • Yeter Erol Öztürk, Oya Yeter, Buket Alpertunga. Validation of JWH-018 and its metabolites in blood and urine by UPLC-MS/MS: Monitoring in forensic cases. Forensic science international. 2015 Mar; 248(?):88-93. doi: 10.1016/j.forsciint.2014.12.029. [PMID: 25616218]
  • E Verhoeven, A Capron, P Hantson. Pink urine. Clinical toxicology (Philadelphia, Pa.). 2014 Nov; 52(9):980-1. doi: 10.3109/15563650.2014.961068. [PMID: 25233954]
  • Akiko Takagaki, Yuko Kato, Fumio Nanjo. Isolation and characterization of rat intestinal bacteria involved in biotransformation of (-)-epigallocatechin. Archives of microbiology. 2014 Oct; 196(10):681-95. doi: 10.1007/s00203-014-1006-y. [PMID: 24947740]
  • Karolina Varga, Katalin Pászty, Rita Padányi, Luca Hegedűs, Jean-Philippe Brouland, Béla Papp, Agnes Enyedi. Histone deacetylase inhibitor- and PMA-induced upregulation of PMCA4b enhances Ca2+ clearance from MCF-7 breast cancer cells. Cell calcium. 2014 Feb; 55(2):78-92. doi: 10.1016/j.ceca.2013.12.003. [PMID: 24439526]
  • Cyren M Rico, Maria Isabel Morales, Ana Cecilia Barrios, Ricardo McCreary, Jie Hong, Wen-Yee Lee, Jose Nunez, Jose R Peralta-Videa, Jorge L Gardea-Torresdey. Effect of cerium oxide nanoparticles on the quality of rice ( Oryza sativa L.) grains. Journal of agricultural and food chemistry. 2013 Nov; 61(47):11278-85. doi: 10.1021/jf404046v. [PMID: 24188281]
  • Elisa Brasili, Elena Mengheri, Alberta Tomassini, Giorgio Capuani, Marianna Roselli, Alberto Finamore, Fabio Sciubba, Federico Marini, Alfredo Miccheli. Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 induce different age-related metabolic profiles revealed by 1H-NMR spectroscopy in urine and feces of mice. The Journal of nutrition. 2013 Oct; 143(10):1549-57. doi: 10.3945/jn.113.177105. [PMID: 23946343]
  • Moonhee Jang, Wonkyung Yang, Hyeyoung Choi, Hyejin Chang, Sooyeun Lee, Eunmi Kim, Heesun Chung. Monitoring of urinary metabolites of JWH-018 and JWH-073 in legal cases. Forensic science international. 2013 Sep; 231(1-3):13-9. doi: 10.1016/j.forsciint.2013.03.053. [PMID: 23890611]
  • Beth Emerson, Bill Durham, Jennifer Gidden, Jackson O Lay. Gas chromatography-mass spectrometry of JWH-018 metabolites in urine samples with direct comparison to analytical standards. Forensic science international. 2013 Jun; 229(1-3):1-6. doi: 10.1016/j.forsciint.2013.03.006. [PMID: 23683902]
  • Greta Jakobsdottir, Jens Holst Bjerregaard, Hanne Skovbjerg, Margareta Nyman. Fasting serum concentration of short-chain fatty acids in subjects with microscopic colitis and celiac disease: no difference compared with controls, but between genders. Scandinavian journal of gastroenterology. 2013 Jun; 48(6):696-701. doi: 10.3109/00365521.2013.786128. [PMID: 23600961]
  • Akiko Takagaki, Fumio Nanjo. Catabolism of (+)-catechin and (-)-epicatechin by rat intestinal microbiota. Journal of agricultural and food chemistry. 2013 May; 61(20):4927-35. doi: 10.1021/jf304431v. [PMID: 23621128]
  • Daniela Fischer, Christian Imholt, Hans-Joachim Pelz, Michael Wink, Andreas Prokop, Jens Jacob. The repelling effect of plant secondary metabolites on water voles, Arvicola amphibius. Pest management science. 2013 Mar; 69(3):437-43. doi: 10.1002/ps.3438. [PMID: 23225271]
  • Bo Tjellström, Lotta Högberg, Lars Stenhammar, Karl-Eric Magnusson, Tore Midtvedt, Elisabeth Norin, Tommy Sundqvist. Effect of exclusive enteral nutrition on gut microflora function in children with Crohn's disease. Scandinavian journal of gastroenterology. 2012 Dec; 47(12):1454-9. doi: 10.3109/00365521.2012.703234. [PMID: 23016828]
  • J Nery, R Goudez, V Biourge, C Tournier, V Leray, L Martin, C Thorin, P Nguyen, H Dumon. Influence of dietary protein content and source on colonic fermentative activity in dogs differing in body size and digestive tolerance. Journal of animal science. 2012 Aug; 90(8):2570-80. doi: 10.2527/jas.2011-4112. [PMID: 22328724]
  • R A Reimer, X Pelletier, I G Carabin, M R Lyon, R J Gahler, S Wood. Faecal short chain fatty acids in healthy subjects participating in a randomised controlled trial examining a soluble highly viscous polysaccharide versus control. Journal of human nutrition and dietetics : the official journal of the British Dietetic Association. 2012 Aug; 25(4):373-7. doi: 10.1111/j.1365-277x.2012.01230.x. [PMID: 22320902]
  • J Álvarez-Rodríguez, E Monleón, A Sanz, J J Badiola, M Joy. Rumen fermentation and histology in light lambs as affected by forage supply and lactation length. Research in veterinary science. 2012 Apr; 92(2):247-53. doi: 10.1016/j.rvsc.2011.03.010. [PMID: 21458834]
  • Ruud A Timmers, Michael Rothballer, David P B T B Strik, Marion Engel, Stephan Schulz, Michael Schloter, Anton Hartmann, Bert Hamelers, Cees Buisman. Microbial community structure elucidates performance of Glyceria maxima plant microbial fuel cell. Applied microbiology and biotechnology. 2012 Apr; 94(2):537-48. doi: 10.1007/s00253-012-3894-6. [PMID: 22361855]
  • J M Jensen, A Scherer, C Wanke, M Bräutigam, S Bongiovanni, M Letzkus, F Staedtler, J Kehren, M Zuehlsdorf, T Schwarz, M Weichenthal, R Fölster-Holst, E Proksch. Gene expression is differently affected by pimecrolimus and betamethasone in lesional skin of atopic dermatitis. Allergy. 2012 Mar; 67(3):413-23. doi: 10.1111/j.1398-9995.2011.02747.x. [PMID: 22142306]
  • K R Kerr, B M Vester Boler, C L Morris, K J Liu, K S Swanson. Apparent total tract energy and macronutrient digestibility and fecal fermentative end-product concentrations of domestic cats fed extruded, raw beef-based, and cooked beef-based diets. Journal of animal science. 2012 Feb; 90(2):515-22. doi: 10.2527/jas.2010-3266. [PMID: 22003235]
  • Victoria Tyndall, Marie Broyde, Richard Sharpe, Michelle Welsh, Amanda J Drake, Alan S McNeilly. Effect of androgen treatment during foetal and/or neonatal life on ovarian function in prepubertal and adult rats. Reproduction (Cambridge, England). 2012 Jan; 143(1):21-33. doi: 10.1530/rep-11-0239. [PMID: 22016380]
  • J-Y Chee, N-S Lau, M-R Samian, T Tsuge, K Sudesh. Expression of Aeromonas caviae polyhydroxyalkanoate synthase gene in Burkholderia sp. USM (JCM15050) enables the biosynthesis of SCL-MCL PHA from palm oil products. Journal of applied microbiology. 2012 Jan; 112(1):45-54. doi: 10.1111/j.1365-2672.2011.05189.x. [PMID: 22054430]
  • Bingkun Zhang, Xin Yang, Yuming Guo, Fangyu Long. Effects of dietary lipids and Clostridium butyricum on the performance and the digestive tract of broiler chickens. Archives of animal nutrition. 2011 Aug; 65(4):329-39. doi: 10.1080/1745039x.2011.568274. [PMID: 21888038]
  • Arnaldo Glogauer, Viviane P Martini, Helisson Faoro, Gustavo H Couto, Marcelo Müller-Santos, Rose A Monteiro, David A Mitchell, Emanuel M de Souza, Fabio O Pedrosa, Nadia Krieger. Identification and characterization of a new true lipase isolated through metagenomic approach. Microbial cell factories. 2011 Jul; 10(?):54. doi: 10.1186/1475-2859-10-54. [PMID: 21762508]
  • Xin Chen, Shi-Ling Chen. A woman with premature ovarian failure induced by Tripterygium wilfordii Hook.f. gives birth to a healthy child. Fertility and sterility. 2011 Jul; 96(1):e19-21. doi: 10.1016/j.fertnstert.2011.05.005. [PMID: 21640345]
  • R Huang, G Q Li, J Zhang, L Yang, H J Che, D H Jiang, H C Huang. Control of postharvest Botrytis fruit rot of strawberry by volatile organic compounds of Candida intermedia. Phytopathology. 2011 Jul; 101(7):859-69. doi: 10.1094/phyto-09-10-0255. [PMID: 21323467]
  • R Song, D N Foster, G C Shurson. Effects of feeding diets containing bacitracin methylene disalicylate to heat-stressed finishing pigs. Journal of animal science. 2011 Jun; 89(6):1830-43. doi: 10.2527/jas.2010-3218. [PMID: 21297060]
  • Koichi Tomoda, Kaoru Kubo, Takashi Asahara, Akira Andoh, Koji Nomoto, Yasue Nishii, Yoshifumi Yamamoto, Masanori Yoshikawa, Hiroshi Kimura. Cigarette smoke decreases organic acids levels and population of bifidobacterium in the caecum of rats. The Journal of toxicological sciences. 2011 Jun; 36(3):261-6. doi: 10.2131/jts.36.261. [PMID: 21628954]
  • K Kanakupt, B M Vester Boler, B R Dunsford, G C Fahey. Effects of short-chain fructooligosaccharides and galactooligosaccharides, individually and in combination, on nutrient digestibility, fecal fermentative metabolite concentrations, and large bowel microbial ecology of healthy adults cats. Journal of animal science. 2011 May; 89(5):1376-84. doi: 10.2527/jas.2010-3201. [PMID: 21216981]
  • S Kakishima, Y Terajima, J Murata, H Tsukaya. Infrared thermography and odour composition of the Amorphophallus gigas (Araceae) inflorescence: the cooling effect of the odorous liquid. Plant biology (Stuttgart, Germany). 2011 May; 13(3):502-7. doi: 10.1111/j.1438-8677.2010.00399.x. [PMID: 21489101]
  • Nina Neidig, Rüdiger J Paul, Stefan Scheu, Alexandre Jousset. Secondary metabolites of Pseudomonas fluorescens CHA0 drive complex non-trophic interactions with bacterivorous nematodes. Microbial ecology. 2011 May; 61(4):853-9. doi: 10.1007/s00248-011-9821-z. [PMID: 21360140]
  • Emma Dixon, Cynthia Clubb, Sara Pittman, Larry Ammann, Zeehasham Rasheed, Nazia Kazmi, Ali Keshavarzian, Pat Gillevet, Huzefa Rangwala, Robin D Couch. Solid-phase microextraction and the human fecal VOC metabolome. PloS one. 2011 Apr; 6(4):e18471. doi: 10.1371/journal.pone.0018471. [PMID: 21494609]
  • Ramesh B Potu, Amer A AbuGhazaleh, Darcie Hastings, Karen Jones, Salam A Ibrahim. The effect of lipid supplements on ruminal bacteria in continuous culture fermenters varies with the fatty acid composition. Journal of microbiology (Seoul, Korea). 2011 Apr; 49(2):216-23. doi: 10.1007/s12275-011-0365-1. [PMID: 21538241]
  • Jan Idkowiak, Stephen O'Riordan, Nicole Reisch, Ewa M Malunowicz, Felicity Collins, Michiel N Kerstens, Birgit Köhler, Luitgard Margarete Graul-Neumann, Maria Szarras-Czapnik, Mehul Dattani, Martin Silink, Cedric H L Shackleton, Dominique Maiter, Nils Krone, Wiebke Arlt. Pubertal presentation in seven patients with congenital adrenal hyperplasia due to P450 oxidoreductase deficiency. The Journal of clinical endocrinology and metabolism. 2011 Mar; 96(3):E453-62. doi: 10.1210/jc.2010-1607. [PMID: 21190981]
  • Jaeduk Goh, Junhyun Jeon, Kyoung Su Kim, Jongsun Park, Sook-Young Park, Yong-Hwan Lee. The PEX7-mediated peroxisomal import system is required for fungal development and pathogenicity in Magnaporthe oryzae. PloS one. 2011; 6(12):e28220. doi: 10.1371/journal.pone.0028220. [PMID: 22194815]
  • T W Binsl, A A De Graaf, K Venema, J Heringa, A Maathuis, P De Waard, J H G M Van Beek. Measuring non-steady-state metabolic fluxes in starch-converting faecal microbiota in vitro. Beneficial microbes. 2010 Nov; 1(4):391-405. doi: 10.3920/bm2010.0038. [PMID: 21831778]
  • Mohammed El Amine Dib, Nassim Djabou, Jean-Marie Desjobert, Houcine Allali, Boufeldja Tabti, Alain Muselli, Jean Costa. Characterization of volatile compounds of Daucus crinitus Desf. Headspace Solid Phase Microextraction as alternative technique to Hydrodistillation. Chemistry Central journal. 2010 Sep; 4(?):16. doi: 10.1186/1752-153x-4-16. [PMID: 20858266]
  • K A Barry, B J Wojcicki, I S Middelbos, B M Vester, K S Swanson, G C Fahey. Dietary cellulose, fructooligosaccharides, and pectin modify fecal protein catabolites and microbial populations in adult cats. Journal of animal science. 2010 Sep; 88(9):2978-87. doi: 10.2527/jas.2009-2464. [PMID: 20495116]
  • Francesca Valerio, Francesco Russo, Silvia de Candia, Giuseppe Riezzo, Antonella Orlando, Stella Lisa Lonigro, Paola Lavermicocca. Effects of probiotic Lactobacillus paracasei-enriched artichokes on constipated patients: a pilot study. Journal of clinical gastroenterology. 2010 Sep; 44 Suppl 1(?):S49-53. doi: 10.1097/mcg.0b013e3181d2dca4. [PMID: 20495470]
  • Ludmila V Roze, Anindya Chanda, Maris Laivenieks, Randolph M Beaudry, Katherine A Artymovich, Anna V Koptina, Deena W Awad, Dina Valeeva, Arthur D Jones, John E Linz. Volatile profiling reveals intracellular metabolic changes in Aspergillus parasiticus: veA regulates branched chain amino acid and ethanol metabolism. BMC biochemistry. 2010 Aug; 11(?):33. doi: 10.1186/1471-2091-11-33. [PMID: 20735852]
  • Leticia Morales-Ledesma, Rosa Linares, Gabriela Rosas, Carolina Morán, Roberto Chavira, Mario Cárdenas, Roberto Domínguez. Unilateral sectioning of the superior ovarian nerve of rats with polycystic ovarian syndrome restores ovulation in the innervated ovary. Reproductive biology and endocrinology : RB&E. 2010 Aug; 8(?):99. doi: 10.1186/1477-7827-8-99. [PMID: 20723258]
  • Mark Eggink, Maikel Wijtmans, Ansgar Kretschmer, Jeroen Kool, Henk Lingeman, Iwan J P de Esch, Wilfried M A Niessen, Hubertus Irth. Targeted LC-MS derivatization for aldehydes and carboxylic acids with a new derivatization agent 4-APEBA. Analytical and bioanalytical chemistry. 2010 May; 397(2):665-75. doi: 10.1007/s00216-010-3575-1. [PMID: 20238107]
  • Eman A Elgindy, Dahlia O El-Haieg, Magdy I Mostafa, Mostafa Shafiek. Does luteal estradiol supplementation have a role in long agonist cycles?. Fertility and sterility. 2010 May; 93(7):2182-8. doi: 10.1016/j.fertnstert.2009.01.066. [PMID: 19243745]
  • Susan C Connor, Michael K Hansen, Adam Corner, Randall F Smith, Terence E Ryan. Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes. Molecular bioSystems. 2010 May; 6(5):909-21. doi: 10.1039/b914182k. [PMID: 20567778]
  • Angika Basant, Mayuri Rege, Shobhona Sharma, Haripalsingh M Sonawat. Alterations in urine, serum and brain metabolomic profiles exhibit sexual dimorphism during malaria disease progression. Malaria journal. 2010 Apr; 9(?):110. doi: 10.1186/1475-2875-9-110. [PMID: 20412601]
  • Hiroshi Sato, Yumiko Shiogama. Acetone and isopropanol in ruminal fluid and feces of lactating dairy cows. The Journal of veterinary medical science. 2010 Mar; 72(3):297-300. doi: 10.1292/jvms.09-0227. [PMID: 19959888]
  • J Cameron Thrash, Jarrod Pollock, Tamas Torok, John D Coates. Description of the novel perchlorate-reducing bacteria Dechlorobacter hydrogenophilus gen. nov., sp. nov.and Propionivibrio militaris, sp. nov. Applied microbiology and biotechnology. 2010 Mar; 86(1):335-43. doi: 10.1007/s00253-009-2336-6. [PMID: 19921177]
  • K Dafopoulos, N Chalvatzas, G Kosmas, A Kallitsaris, S Pournaras, I E Messinis. The effect of estrogens on plasma ghrelin concentrations in women. Journal of endocrinological investigation. 2010 Feb; 33(2):109-12. doi: 10.1007/bf03346563. [PMID: 20348837]
  • I Goiri, L M Oregui, A Garcia-Rodriguez. Use of chitosans to modulate ruminal fermentation of a 50:50 forage-to-concentrate diet in sheep. Journal of animal science. 2010 Feb; 88(2):749-55. doi: 10.2527/jas.2009-2377. [PMID: 19854994]
  • M B Hall, C C Larson, C J Wilcox. Carbohydrate source and protein degradability alter lactation, ruminal, and blood measures. Journal of dairy science. 2010 Jan; 93(1):311-22. doi: 10.3168/jds.2009-2552. [PMID: 20059929]
  • Sung Ho Kim, Hae June Lee, Joong Sun Kim, Changjong Moon, Jong Choon Kim, Chun Sik Bae, Hae Ran Park, Uhee Jung, Sung Kee Jo. HemoHIM improves ovarian morphology and decreases expression of nerve growth factor in rats with steroid-induced polycystic ovaries. Journal of medicinal food. 2009 Dec; 12(6):1348-52. doi: 10.1089/jmf.2008.1323. [PMID: 20041792]
  • P Ganesan Adaikan, B Srilatha, Amanda J Wheat. Efficacy of red clover isoflavones in the menopausal rabbit model. Fertility and sterility. 2009 Dec; 92(6):2008-13. doi: 10.1016/j.fertnstert.2008.09.020. [PMID: 18973881]
  • M L May, M J Quinn, C D Reinhardt, L Murray, M L Gibson, K K Karges, J S Drouillard. Effects of dry-rolled or steam-flaked corn finishing diets with or without twenty-five percent dried distillers grains on ruminal fermentation and apparent total tract digestion. Journal of animal science. 2009 Nov; 87(11):3630-8. doi: 10.2527/jas.2008-0857. [PMID: 19648506]
  • Hai-Feng Zhang, Long Ma, Zhi-Hui Wang, Guo-Qiang Chen. Biosynthesis and characterization of 3-hydroxyalkanoate terpolyesters with adjustable properties by Aeromonas hydrophila. Biotechnology and bioengineering. 2009 Oct; 104(3):582-9. doi: 10.1002/bit.22409. [PMID: 19517520]
  • G N Gozho, J J McKinnon, D A Christensen, V Racz, T Mutsvangwa. Effects of type of canola protein supplement on ruminal fermentation and nutrient flow to the duodenum in beef heifers. Journal of animal science. 2009 Oct; 87(10):3363-71. doi: 10.2527/jas.2009-1841. [PMID: 19542502]
  • K A Barry, D C Hernot, I S Middelbos, C Francis, B Dunsford, K S Swanson, G C Fahey. Low-level fructan supplementation of dogs enhances nutrient digestion and modifies stool metabolite concentrations, but does not alter fecal microbiota populations. Journal of animal science. 2009 Oct; 87(10):3244-52. doi: 10.2527/jas.2008-1659. [PMID: 19574565]
  • Kenji Ishihara, Naruo Katsutani, Naoki Asai, Akira Inomata, Yuji Uemura, Akiyoshi Suganuma, Kohei Sawada, Tsuyoshi Yokoi, Toyohiko Aoki. Identification of urinary biomarkers useful for distinguishing a difference in mechanism of toxicity in rat model of cholestasis. Basic & clinical pharmacology & toxicology. 2009 Sep; 105(3):156-66. doi: 10.1111/j.1742-7843.2009.00410.x. [PMID: 19486331]
  • Y-H Chung, C M Martinez, N E Brown, T W Cassidy, G A Varga. Ruminal and blood responses to propylene glycol during frequent feeding. Journal of dairy science. 2009 Sep; 92(9):4555-64. doi: 10.3168/jds.2009-2131. [PMID: 19700718]
  • Mohamad E Ghanem, Ehab E Sadek, Laila A Elboghdady, Adel S Helal, Anas Gamal, Amany Eldiasty, Nagwa I Bakre, Maha Houssen. The effect of luteal phase support protocol on cycle outcome and luteal phase hormone profile in long agonist protocol intracytoplasmic sperm injection cycles: a randomized clinical trial. Fertility and sterility. 2009 Aug; 92(2):486-93. doi: 10.1016/j.fertnstert.2008.07.1717. [PMID: 19464001]
  • Donovan P German. Do herbivorous minnows have 'plug-flow reactor' guts? Evidence from digestive enzyme activities, gastrointestinal fermentation, and luminal nutrient concentrations. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 2009 Aug; 179(6):759-71. doi: 10.1007/s00360-009-0359-z. [PMID: 19363616]
  • Martina McGuinness, David Dowling. Plant-associated bacterial degradation of toxic organic compounds in soil. International journal of environmental research and public health. 2009 08; 6(8):2226-47. doi: 10.3390/ijerph6082226. [PMID: 19742157]
  • I Ntaikou, C Kourmentza, E C Koutrouli, K Stamatelatou, A Zampraka, M Kornaros, G Lyberatos. Exploitation of olive oil mill wastewater for combined biohydrogen and biopolymers production. Bioresource technology. 2009 Aug; 100(15):3724-30. doi: 10.1016/j.biortech.2008.12.001. [PMID: 19138844]
  • Satoshi Yoshida, Qin-Zeng Zhang, Shu Sakuyama, Satoshi Matsushima. Metabolism of fatty acids and lipid hydroperoxides in human body monitoring with Fourier transform Infrared Spectroscopy. Lipids in health and disease. 2009 Jul; 8(?):28. doi: 10.1186/1476-511x-8-28. [PMID: 19627618]
  • Hiroshi Sato. Increased fecal lactate and decreased volatile fatty acid (VFA), particularly n-butyrate concentrations in diarrheic young calves. The Journal of veterinary medical science. 2009 Jan; 71(1):117-9. doi: 10.1292/jvms.71.117. [PMID: 19194088]
  • Reagan L Ross, Michelle R Serock, Raouf A Khalil. Experimental benefits of sex hormones on vascular function and the outcome of hormone therapy in cardiovascular disease. Current cardiology reviews. 2008 Nov; 4(4):309-22. doi: 10.2174/157340308786349462. [PMID: 20066139]
  • A F Brito, G F Tremblay, A Bertrand, Y Castonguay, G Bélanger, R Michaud, H Lapierre, C Benchaar, H V Petit, D R Ouellet, R Berthiaume. Alfalfa cut at sundown and harvested as baleage improves milk yield of late-lactation dairy cows. Journal of dairy science. 2008 Oct; 91(10):3968-82. doi: 10.3168/jds.2008-1282. [PMID: 18832221]
  • Wing-Hin Lee, Ching-Yee Loo, Christopher T Nomura, Kumar Sudesh. Biosynthesis of polyhydroxyalkanoate copolymers from mixtures of plant oils and 3-hydroxyvalerate precursors. Bioresource technology. 2008 Oct; 99(15):6844-51. doi: 10.1016/j.biortech.2008.01.051. [PMID: 18325764]
  • Jian-Xu Zhang, Lixing Sun, Jin-Hua Zhang, Zhi-Yong Feng. Sex- and gonad-affecting scent compounds and 3 male pheromones in the rat. Chemical senses. 2008 Sep; 33(7):611-21. doi: 10.1093/chemse/bjn028. [PMID: 18515819]
  • Akila Ganesan, Sébastien Chaussonnerie, Anne Tarrade, Catherine Dauga, Théodore Bouchez, Eric Pelletier, Denis Le Paslier, Abdelghani Sghir. Cloacibacillus evryensis gen. nov., sp. nov., a novel asaccharolytic, mesophilic, amino-acid-degrading bacterium within the phylum 'Synergistetes', isolated from an anaerobic sludge digester. International journal of systematic and evolutionary microbiology. 2008 Sep; 58(Pt 9):2003-12. doi: 10.1099/ijs.0.65645-0. [PMID: 18768595]