Ondansetron (BioDeep_00000002819)
Secondary id: BioDeep_00000405968
human metabolite Chemicals and Drugs
代谢物信息卡片
9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-2,3,4,9-tetrahydro-1H-carbazol-4-one
化学式: C18H19N3O (293.1528)
中文名称: 昂丹司琼, 恩丹西酮
谱图信息:
最多检出来源 Homo sapiens(natural_products) 14.42%
分子结构信息
SMILES: CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C
InChI: InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3
描述信息
Ondansetron is a well tolerated drug with few side effects. Headache, constipation, and dizziness are the most commonly reported side effects associated with its use. There have been no significant drug interactions reported with this drugs use. It is broken down by the hepatic cytochrome P450 system and it has little effect on the metabolism of other drugs broken down by this system; Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly to treat nausea and vomiting following chemotherapy. Its effects are thought to be on both peripheral and central nerves. One part is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata, the other is a blockage of serotonin receptors in the chemoreceptor trigger zone. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors; A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties; Ondansetron (INN) is a serotonin 5-HT3 receptor antagonist used mainly to treat nausea and vomiting following chemotherapy. Its effects are thought to be on both peripheral and central nerves. One part is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata, the other is a blockage of serotonin receptors in the chemoreceptor trigger zone. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors. [HMDB]
Ondansetron is a well tolerated drug with few side effects. Headache, constipation, and dizziness are the most commonly reported side effects associated with its use. There have been no significant drug interactions reported with this drugs use. It is broken down by the hepatic cytochrome P450 system and it has little effect on the metabolism of other drugs broken down by this system; Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly to treat nausea and vomiting following chemotherapy. Its effects are thought to be on both peripheral and central nerves. One part is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata, the other is a blockage of serotonin receptors in the chemoreceptor trigger zone. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors; A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties; Ondansetron (INN) is a serotonin 5-HT3 receptor antagonist used mainly to treat nausea and vomiting following chemotherapy. Its effects are thought to be on both peripheral and central nerves. One part is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata, the other is a blockage of serotonin receptors in the chemoreceptor trigger zone. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors.
A - Alimentary tract and metabolism > A04 - Antiemetics and antinauseants > A04A - Antiemetics and antinauseants > A04AA - Serotonin (5ht3) antagonists
C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist > C94726 - 5-HT3 Receptor Antagonist
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D003879 - Dermatologic Agents > D000982 - Antipruritics
CONFIDENCE standard compound; INTERNAL_ID 2746
CONFIDENCE standard compound; INTERNAL_ID 8525
D002491 - Central Nervous System Agents
Ondansetron (GR 38032; SN 307) is a highly selective 5-HT3 receptor antagonist, with IC50 value of 103 pM. Ondansetron exerts antiemetic effects by antagonizing 5-HT receptor located on local neurons in the peripheral and central nervous system. Ondansetron suppresses nausea and vomiting caused by chemotherapy and radiation therapy. Ondansetron has orally bioactivity[1][2][3][4][5][6][7][8].
同义名列表
19 个代谢物同义名
9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-2,3,4,9-tetrahydro-1H-carbazol-4-one; Dihydrate, ondansetron monohydrochloride; Monohydrochloride dihydrate, ondansetron; Ondansetron monohydrochloride dihydrate; Monohydrochloride, ondansetron; Ondansetron monohydrochloride; Hydrochloride, ondansetron; Ondansetron, (+,-)-isomer; Ondansetron hydrochloride; Ondansetron, (R)-isomer; Ondansetron, (S)-isomer; ondansetron; Zofran odt; Zophren; Zofran; Zudan; GR 38032; SN 307; Ondansetron
数据库引用编号
28 个数据库交叉引用编号
- ChEBI: CHEBI:7773
- KEGG: C07325
- KEGGdrug: D00456
- PubChem: 4595
- HMDB: HMDB0005035
- Metlin: METLIN1646
- DrugBank: DB00904
- ChEMBL: CHEMBL46
- Wikipedia: Ondansetron
- MeSH: Ondansetron
- foodb: FDB023602
- chemspider: 4434
- CAS: 116002-70-1
- CAS: 99614-02-5
- MoNA: AU274602
- MoNA: AU274604
- MoNA: AU274605
- MoNA: AU274603
- MoNA: AU274606
- MoNA: SM852501
- MoNA: AU274601
- PMhub: MS000006059
- PubChem: 9533
- PDB-CCD: S87
- NIKKAJI: J245.610I
- RefMet: Ondansetron
- medchemexpress: HY-B0002B
- KNApSAcK: 7773
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kathleen M Job, André Dallmann, Samuel Parry, George Saade, David M Haas, Brenna Hughes, Pamela Berens, Jia-Yu Chen, Christina Fu, Kelsey Humphrey, Christoph Hornik, Stephen Balevic, Kanecia Zimmerman, Kevin Watt. Development of a Generic Physiologically-Based Pharmacokinetic Model for Lactation and Prediction of Maternal and Infant Exposure to Ondansetron via Breast Milk.
Clinical pharmacology and therapeutics.
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10.1002/cpt.2530. [PMID: 35076931] - Masato Aoyama, Minami Shioya, Yume Tsukamoto, Hitomi Hasegawa, Shoei Sugita. The effects of cisplatin, an emetic agent, on behavior and plasma cortisol levels in goats.
Animal science journal = Nihon chikusan Gakkaiho.
2021 Dec; 92(1):e13607. doi:
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Journal of critical care.
2021 12; 66(?):117-122. doi:
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Scientific reports.
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Drug and alcohol dependence.
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Clinical and translational science.
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Biomedical chromatography : BMC.
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Molecular pharmacology.
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Journal of pharmaceutical and biomedical analysis.
2019 Oct; 175(?):112766. doi:
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Biomedical chromatography : BMC.
2019 Oct; 33(10):e4618. doi:
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Alimentary pharmacology & therapeutics.
2019 09; 50(5):538-546. doi:
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Wilderness & environmental medicine.
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American family physician.
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Journal of veterinary pharmacology and therapeutics.
2016 Aug; 39(4):350-5. doi:
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Oncotarget.
2016 Apr; 7(17):24402-14. doi:
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Alcohol and alcoholism (Oxford, Oxfordshire).
2016 Mar; 51(2):164-71. doi:
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Journal of ethnopharmacology.
2016 Feb; 179(?):280-90. doi:
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International journal of pharmaceutics.
2015 Dec; 496(1):33-41. doi:
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Molecular neurobiology.
2015 Oct; 52(2):867-81. doi:
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International journal of urology : official journal of the Japanese Urological Association.
2015 Oct; 22(10):911-4. doi:
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Pharmacology, biochemistry, and behavior.
2015 Sep; 136(?):107-16. doi:
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Alcoholism, clinical and experimental research.
2015 Jul; 39(7):1253-9. doi:
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Drug development and industrial pharmacy.
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Journal of veterinary pharmacology and therapeutics.
2015 Apr; 38(2):199-202. doi:
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American journal of therapeutics.
2015 Mar; 22(2):90-7. doi:
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Clinical pharmacology and therapeutics.
2015 Feb; 97(2):167-76. doi:
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Drug research.
2015 Jan; 65(1):46-51. doi:
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International urology and nephrology.
2015 Jan; 47(1):161-7. doi:
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Cancer letters.
2014 Oct; 353(2):242-7. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2014 Oct; 62(?):180-8. doi:
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Gut.
2014 Oct; 63(10):1617-25. doi:
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Colloids and surfaces. B, Biointerfaces.
2014 Oct; 122(?):143-150. doi:
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Alcohol (Fayetteville, N.Y.).
2014 Sep; 48(6):515-22. doi:
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Pharmacology, biochemistry, and behavior.
2014 Sep; 124(?):129-36. doi:
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Metabolic brain disease.
2014 Sep; 29(3):701-10. doi:
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Journal of veterinary pharmacology and therapeutics.
2014 Aug; 37(4):348-53. doi:
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Alcoholism, clinical and experimental research.
2014 Jun; 38(6):1567-74. doi:
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BMC pediatrics.
2014 May; 14(?):125. doi:
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Journal of medicinal chemistry.
2014 Apr; 57(7):3005-10. doi:
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Journal of chromatography. A.
2014 Feb; 1331(?):117-22. doi:
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Clinical therapeutics.
2014 Feb; 36(2):211-24. doi:
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Phytotherapy research : PTR.
2014 Jan; 28(1):42-8. doi:
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Brazilian journal of anesthesiology (Elsevier).
2014 Jan; 64(1):35-9. doi:
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Toxicology and applied pharmacology.
2013 Nov; 273(1):100-9. doi:
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The American journal of psychiatry.
2013 Sep; 170(9):1020-31. doi:
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Trials.
2013 May; 14(?):153. doi:
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Molecules (Basel, Switzerland).
2013 May; 18(5):5455-71. doi:
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BMC pharmacology & toxicology.
2013 Apr; 14(?):20. doi:
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The New England journal of medicine.
2013 Feb; 368(9):814-23. doi:
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Anticancer research.
2013 Feb; 33(2):521-8. doi:
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PloS one.
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Colloids and surfaces. B, Biointerfaces.
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Colloids and surfaces. B, Biointerfaces.
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Anesthesia and analgesia.
2012 Oct; 115(4):925-8. doi:
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Journal of materials science. Materials in medicine.
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Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.
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Journal of holistic nursing : official journal of the American Holistic Nurses' Association.
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The Journal of pharmacology and experimental therapeutics.
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The pharmacogenomics journal.
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
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