Skullcapflavone II (BioDeep_00000002777)

Main id: BioDeep_00000017598

 

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxy-4H-chromen-4-one

化学式: C19H18O8 (374.1002)
中文名称: 黄芩新素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(c(c(c2c(c1OC)oc(cc2=O)c1c(cccc1O)OC)O)OC)OC
InChI: InChI=1S/C19H18O8/c1-23-11-7-5-6-9(20)13(11)12-8-10(21)14-15(22)17(24-2)19(26-4)18(25-3)16(14)27-12/h5-8,20,22H,1-4H3

描述信息

Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2].
Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2].

同义名列表

8 个代谢物同义名

5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxy-4H-chromen-4-one; 5-hydroxy-2-(2-hydroxy-6-methoxy-phenyl)-6,7,8-trimethoxy-chromen-4-one; 5,2-dihydroxy-6,7,8,6-tetramethoxy-flavone; 5,2-Dihydroxy-6,7,8,6-tetramethoxyflavone; Skullcapflavone II; Scullcapflavone II; Neobaicalein; Scullcapflavone II



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

49 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AIF1, BCL2, CASP3, EGFR, HSP90AA1, MAPK14, MAPK8, STAT1, STAT3, STAT5A, STAT6, VEGFA
Peripheral membrane protein 1 AIF1
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 2 BCL2, EGFR
Nucleus 14 AIF1, BCL2, CASP3, CREB1, EGFR, HSP90AA1, MAPK14, MAPK8, PARP1, STAT1, STAT3, STAT5A, STAT6, VEGFA
cytosol 11 AIF1, BCL2, CASP3, HSP90AA1, MAPK14, MAPK8, PARP1, STAT1, STAT3, STAT5A, STAT6
dendrite 1 STAT1
nuclear body 1 PARP1
nucleoplasm 10 CASP3, CREB1, HSP90AA1, MAPK14, MAPK8, PARP1, STAT1, STAT3, STAT5A, STAT6
RNA polymerase II transcription regulator complex 5 CREB1, STAT1, STAT3, STAT5A, STAT6
Cell membrane 3 EGFR, HSP90AA1, TNF
Cytoplasmic side 1 AIF1
lamellipodium 1 AIF1
ruffle membrane 2 AIF1, EGFR
Early endosome membrane 1 EGFR
Synapse 1 MAPK8
cell junction 1 EGFR
cell surface 4 EGFR, HSP90AA1, TNF, VEGFA
glutamatergic synapse 3 CASP3, EGFR, MAPK14
Golgi apparatus 1 VEGFA
Golgi membrane 1 EGFR
lysosomal membrane 1 GAA
neuronal cell body 3 CASP3, HSP90AA1, TNF
Cytoplasm, cytosol 1 PARP1
Lysosome 1 GAA
endosome 1 EGFR
plasma membrane 6 EGFR, GAA, HSP90AA1, IGHE, STAT3, TNF
Membrane 6 BCL2, EGFR, GAA, HSP90AA1, PARP1, VEGFA
apical plasma membrane 2 EGFR, HSP90AA1
axon 2 MAPK8, STAT1
basolateral plasma membrane 2 EGFR, HSP90AA1
extracellular exosome 2 GAA, HSP90AA1
Lysosome membrane 1 GAA
endoplasmic reticulum 2 BCL2, VEGFA
extracellular space 7 EGFR, IGHE, IL17A, IL4, IL6, TNF, VEGFA
lysosomal lumen 2 GAA, HSP90AA1
perinuclear region of cytoplasm 4 AIF1, EGFR, HSP90AA1, STAT1
adherens junction 1 VEGFA
mitochondrion 4 BCL2, HSP90AA1, MAPK14, PARP1
protein-containing complex 5 BCL2, EGFR, HSP90AA1, PARP1, STAT1
intracellular membrane-bounded organelle 1 GAA
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 EGFR, IGHE
Secreted 5 GAA, IL17A, IL4, IL6, VEGFA
extracellular region 9 GAA, HSP90AA1, IGHE, IL17A, IL4, IL6, MAPK14, TNF, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
transcription regulator complex 2 PARP1, STAT3
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, EGFR
external side of plasma membrane 2 IL17A, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
nucleolus 2 PARP1, STAT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cell projection, ruffle membrane 1 AIF1
Membrane raft 2 EGFR, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 AIF1
focal adhesion 1 EGFR
extracellular matrix 1 VEGFA
intracellular vesicle 1 EGFR
collagen-containing extracellular matrix 1 HSP90AA1
secretory granule 1 VEGFA
nuclear speck 1 MAPK14
ruffle 1 AIF1
receptor complex 1 EGFR
chromatin 6 CREB1, PARP1, STAT1, STAT3, STAT5A, STAT6
IgE immunoglobulin complex 1 IGHE
axonal growth cone 1 HSP90AA1
Cell projection, phagocytic cup 1 AIF1
phagocytic cup 2 AIF1, TNF
Chromosome 1 PARP1
brush border membrane 1 HSP90AA1
Nucleus, nucleolus 1 PARP1
spindle pole 1 MAPK14
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
actin filament 1 AIF1
[Isoform 2]: Cell membrane 1 IGHE
site of double-strand break 1 PARP1
nuclear envelope 1 PARP1
tertiary granule membrane 1 GAA
Melanosome 1 HSP90AA1
euchromatin 1 CREB1
dendritic growth cone 1 HSP90AA1
myelin sheath 2 BCL2, HSP90AA1
sperm mitochondrial sheath 1 HSP90AA1
sperm plasma membrane 1 HSP90AA1
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 2 HSP90AA1, MAPK14
secretory granule lumen 2 HSP90AA1, MAPK14
endoplasmic reticulum lumen 1 IL6
platelet alpha granule lumen 1 VEGFA
azurophil granule membrane 1 GAA
clathrin-coated endocytic vesicle membrane 1 EGFR
protein-DNA complex 1 PARP1
ficolin-1-rich granule membrane 1 GAA
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
site of DNA damage 1 PARP1
[Isoform 3]: Cell membrane 1 IGHE
glial cell projection 1 AIF1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
endocytic vesicle lumen 1 HSP90AA1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
interleukin-6 receptor complex 1 IL6
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
ATF4-CREB1 transcription factor complex 1 CREB1
ISGF3 complex 1 STAT1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Soha Parsafar, Farhang Aliakbari, Sepideh Sadat Seyedfatemi, Zahra Najarzadeh, Hamdam Hourfar, Hassan Bardania, Mohsen Farhadpour, Mehdi Mohammadi, Dina Morshedi. Insights into the inhibitory mechanism of skullcapflavone II against α-synuclein aggregation and its mediated cytotoxicity. International journal of biological macromolecules. 2022 Jun; 209(Pt A):426-440. doi: 10.1016/j.ijbiomac.2022.03.092. [PMID: 35398391]
  • Julia Solnier, Liam Martin, Sanjib Bhakta, Franz Bucar. Flavonoids as Novel Efflux Pump Inhibitors and Antimicrobials Against Both Environmental and Pathogenic Intracellular Mycobacterial Species. Molecules (Basel, Switzerland). 2020 Feb; 25(3):. doi: 10.3390/molecules25030734. [PMID: 32046221]
  • Young Hun Lee, Eun Kyoung Seo, Seung-Taek Lee. Skullcapflavone II Inhibits Degradation of Type I Collagen by Suppressing MMP-1 Transcription in Human Skin Fibroblasts. International journal of molecular sciences. 2019 Jun; 20(11):. doi: 10.3390/ijms20112734. [PMID: 31167359]
  • Thi Tho Bui, Chun Hua Piao, Chang Ho Song, Ok Hee Chai. Skullcapflavone II attenuates ovalbumin-induced allergic rhinitis through the blocking of Th2 cytokine production and mast cell histamine release. International immunopharmacology. 2017 Nov; 52(?):77-84. doi: 10.1016/j.intimp.2017.08.029. [PMID: 28886581]
  • Qing-wei Yan, Rui-jian Zhong, Guo-ping Zhou, Hui-zheng Fu, Tian-xiao Zhang. [Chemical Constituents from Camellia oleifera Stem]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Oct; 38(10):2102-4. doi: . [PMID: 27254924]
  • Motahareh Boozari, Ameneh Mohammadi, Javad Asili, Seyed Ahmad Emami, Zahra Tayarani-Najaran. Growth inhibition and apoptosis induction by Scutellaria pinnatifida A. Ham. on HL-60 and K562 leukemic cell lines. Environmental toxicology and pharmacology. 2015 Jan; 39(1):307-12. doi: 10.1016/j.etap.2014.12.002. [PMID: 25546119]
  • Ha-Young Jang, Kyung-Seop Ahn, Mi-Jeong Park, Ok-Kyoung Kwon, Hyeong-Kyu Lee, Sei-Ryang Oh. Skullcapflavone II inhibits ovalbumin-induced airway inflammation in a mouse model of asthma. International immunopharmacology. 2012 Apr; 12(4):666-74. doi: 10.1016/j.intimp.2012.01.010. [PMID: 22314230]
  • Harendra S Parekh, Gang Liu, Ming Q Wei. A new dawn for the use of traditional Chinese medicine in cancer therapy. Molecular cancer. 2009 Mar; 8(?):21. doi: 10.1186/1476-4598-8-21. [PMID: 19298677]
  • Zhao-Tang Ma, Xiu-Wei Yang. [Studies on ethyl acetate soluble constituents of Huanglian Jiedutang]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2008 Sep; 33(18):2080-6. doi: . [PMID: 19160789]
  • Michael Bonham, Jeff Posakony, Ilsa Coleman, Bruce Montgomery, Julian Simon, Peter S Nelson. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005 May; 11(10):3905-14. doi: 10.1158/1078-0432.ccr-04-1974. [PMID: 15897592]
  • Li-xin Yang, Dai Liu, Xue-feng Feng, Shu-lian Cui, Jing-yu Yang, Xiao-jun Tang, Xi-rong He, Ju-fu Liu, Shi-lin Hu. [Determination of flavone for Scutellaria baicalensis from different areas by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2002 Mar; 27(3):166-70. doi: . [PMID: 12774393]