Quinapril (BioDeep_00000002769)

 

Secondary id: BioDeep_00001868209

human metabolite blood metabolite


代谢物信息卡片


(3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

化学式: C25H30N2O5 (438.2155)
中文名称: 喹那普利
谱图信息: 最多检出来源 Viridiplantae(plant) 23.23%

分子结构信息

SMILES: CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3=CC=CC=C3CC2C(=O)O
InChI: InChI=1S/C25H30N2O5/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30)/t17-,21-,22-/m0/s1

描述信息

Quinapril is a prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to quinaprilat (quinapril diacid) following oral administration. Quinaprilat is a competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Quinapril may be used to treat essential hypertension and congestive heart failure.
C - Cardiovascular system > C09 - Agents acting on the renin-angiotensin system > C09A - Ace inhibitors, plain > C09AA - Ace inhibitors, plain
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents

同义名列表

10 个代谢物同义名

(3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (3S)-2-{N-[(2S)-1-ethoxycarbonyl-4-phenylbutan-2-yl]-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; 2-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; (3S)-2-{N-[(2S)-1-ethoxycarbonyl-4-phenylbutan-2-yl]-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylate; Quinapril hydrochloride; CI-906 (free acid); Quinaprilum; Quinapril; Accupril; Quinapril



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ACE, ALB, APOE, DES, EDN1, NOS3, NR3C2, PTGS2
Peripheral membrane protein 1 PTGS2
Endoplasmic reticulum membrane 2 NR3C2, PTGS2
Nucleus 5 ALB, APOE, DES, NOS3, NR3C2
cytosol 4 ALB, DES, NOS3, NR3C2
dendrite 1 APOE
centrosome 1 ALB
nucleoplasm 2 NOS3, NR3C2
Cell membrane 6 ACE, AGTR1, AGTR2, SELP, SLC15A2, TNF
Multi-pass membrane protein 4 AGTR1, AGTR2, CACNA1I, SLC15A2
cell surface 1 TNF
glutamatergic synapse 1 APOE
Golgi apparatus 3 ALB, APOE, NOS3
Golgi membrane 2 INS, NOS3
neuromuscular junction 1 DES
neuronal cell body 2 APOE, TNF
sarcolemma 1 DES
Lysosome 1 ACE
endosome 1 ACE
plasma membrane 11 ACE, AGTR1, AGTR2, APOE, CACNA1I, KNG1, NOS3, REN, SELP, SLC15A2, TNF
Membrane 6 ACE, AGTR1, APOE, CACNA1I, REN, SLC15A2
apical plasma membrane 1 SLC15A2
caveola 2 NOS3, PTGS2
extracellular exosome 8 ACE, ALB, APOE, DES, KNG1, SELP, SLC15A2, VWF
endoplasmic reticulum 4 ALB, APOE, PTGS2, VWF
extracellular space 12 ACE, ALB, APOE, CRP, EDN1, IL6, INS, KNG1, REN, SELP, TNF, VWF
perinuclear region of cytoplasm 1 NOS3
intercalated disc 1 DES
protein-containing complex 2 ALB, PTGS2
Microsome membrane 1 PTGS2
Single-pass type I membrane protein 2 ACE, SELP
Secreted 10 ACE, ALB, APOE, CRP, EDN1, IL6, INS, REN, SELP, VWF
extracellular region 12 ACE, ALB, APOE, CRP, EDN1, IL6, INS, KNG1, REN, SELP, TNF, VWF
basal part of cell 1 EDN1
anchoring junction 1 ALB
external side of plasma membrane 3 ACE, SELP, TNF
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 2 APOE, VWF
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 1 APOE
Z disc 1 DES
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
Early endosome 1 APOE
apical part of cell 1 REN
cell-cell junction 1 DES
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 SLC15A2
Cell membrane, sarcolemma 1 DES
Membrane raft 1 TNF
extracellular matrix 2 APOE, VWF
collagen-containing extracellular matrix 3 APOE, KNG1, VWF
fascia adherens 1 DES
intermediate filament 1 DES
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 NR3C2
neuron projection 1 PTGS2
ciliary basal body 1 ALB
chromatin 1 NR3C2
Cytoplasmic vesicle, phagosome membrane 1 SLC15A2
phagocytic cup 1 TNF
phagocytic vesicle membrane 1 SLC15A2
cytoskeleton 1 NOS3
centriole 1 ALB
Secreted, extracellular space 2 APOE, KNG1
brush border membrane 1 ACE
spindle pole 1 ALB
blood microparticle 3 ALB, APOE, KNG1
sperm midpiece 1 ACE
nuclear envelope 1 DES
Nucleus envelope 1 DES
endosome lumen 1 INS
Melanosome 1 APOE
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
intermediate filament cytoskeleton 1 DES
Cytoplasm, myofibril, sarcomere, Z line 1 DES
basal plasma membrane 1 ACE
platelet alpha granule 1 VWF
platelet dense granule membrane 1 SELP
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 6 ALB, APOE, IL6, INS, KNG1, PTGS2
platelet alpha granule lumen 3 ALB, KNG1, VWF
voltage-gated calcium channel complex 1 CACNA1I
endocytic vesicle membrane 1 NOS3
transport vesicle 2 EDN1, INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
cell tip 1 DES
clathrin-coated endocytic vesicle membrane 1 APOE
synaptic cleft 1 APOE
platelet alpha granule membrane 1 SELP
discoidal high-density lipoprotein particle 1 APOE
endocytic vesicle lumen 1 APOE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cardiac myofibril 1 DES
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
platelet dense granule lumen 1 SELP
rough endoplasmic reticulum lumen 1 EDN1
Weibel-Palade body 2 EDN1, VWF
interleukin-6 receptor complex 1 IL6
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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