Isoetharine (BioDeep_00000002727)

 

Secondary id: BioDeep_00001868269

human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds


代谢物信息卡片


4-{1-hydroxy-2-[(propan-2-yl)amino]butyl}benzene-1,2-diol

化学式: C13H21NO3 (239.1521356)
中文名称: 异他林, 异黄嘌呤
谱图信息: 最多检出来源 Mus musculus(blood) 1.72%

分子结构信息

SMILES: CCC(C(C1=CC(=C(C=C1)O)O)O)NC(C)C
InChI: InChI=1S/C13H21NO3/c1-4-10(14-8(2)3)13(17)9-5-6-11(15)12(16)7-9/h5-8,10,13-17H,4H2,1-3H3

描述信息

Isoetharine is only found in individuals that have used or taken this drug. It is a selective adrenergic beta-2 agonist used as fast acting bronchodilator for emphysema, bronchitis and asthma. [PubChem]The pharmacologic effects of isoetharine are attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03C - Adrenergics for systemic use > R03CC - Selective beta-2-adrenoreceptor agonists
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03A - Adrenergics, inhalants > R03AC - Selective beta-2-adrenoreceptor agonists
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents

同义名列表

10 个代谢物同义名

4-{1-hydroxy-2-[(propan-2-yl)amino]butyl}benzene-1,2-diol; Mesylate, isoetharine; Isoetharine mesylate; Etyprenalinum; Bronkometer; isoetharine; isoetarine; Isoetarin; Isoetharine; Isoetharine



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • D M Gelmont, J R Balmes, A Yee. Hypokalemia induced by inhaled bronchodilators. Chest. 1988 Oct; 94(4):763-6. doi: 10.1378/chest.94.4.763. [PMID: 3168573]
  • G P Zaloga, U R Hierlwimmer, R J Engler. Anaphylaxis following psyllium ingestion. The Journal of allergy and clinical immunology. 1984 Jul; 74(1):79-80. doi: 10.1016/0091-6749(84)90091-5. [PMID: 6736485]
  • G P Berezuk, S W Schondelmeyer, J J Seidenfeld, W N Jones, J L Bootman. Clinical comparison of albuterol, isoetharine, and metaproterenol given by aerosol inhalation. Clinical pharmacy. 1983 Mar; 2(2):129-34. doi: . [PMID: 6349905]
  • G B Park, R F Koss, J Utter, B A Mayes, J Edelson. Determination of isoetharine in plasma by reversed-phase chromatography with amperometric detection. Journal of pharmaceutical sciences. 1982 Aug; 71(8):932-4. doi: 10.1002/jps.2600710824. [PMID: 7120101]
  • A Arnold, J P McAuliff. Relative lipolytic activities of selected catecholamines in the mouse. Pharmacology. 1976; 14(2):158-65. doi: 10.1159/000136591. [PMID: 959317]