Isocitric acid (BioDeep_00000002693)

 

Secondary id: BioDeep_00000400037, BioDeep_00002053048

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


3-carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid

化学式: C6H8O7 (192.0270018)
中文名称: 异柠檬酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.1%

Reviewed

Last reviewed on 2024-07-01.

Cite this Page

Isocitric acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/isocitric_acid (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000002693). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C(C(C(=O)O)O)C(=O)O)C(=O)O
InChI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)

描述信息

Isocitric acid, also known as isocitrate belongs to the class of organic compounds known as tricarboxylic acids and derivatives. These are carboxylic acids containing exactly three carboxyl groups. Isocitric acid is a TCA (tricarboxylic acid) cycle intermediate. It is a structural isomer of citric acid and is formed from citrate with the help of the enzyme aconitase. More specifically, Isocitric acid is synthesized from citric acid via the intermediate cis-aconitic acid by the enzyme aconitase (aconitate hydratase). Isocitrate is acted upon by isocitrate dehydrogenase (IDH) to form alpha-ketoglutarate. This is a two-step process, which involves oxidation of isocitrate to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. In humans, IDH exists in three isoforms: IDH3 catalyzes the third step of the citric acid cycle while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP+ as a cofactor instead of NAD+. They localize to the cytosol as well as the mitochondrion and peroxisome. Isocitric acid exists in all living species, ranging from bacteria to plants to humans. Isocitric acid is a minor organic acid found in most fruit juices, especially in blackberries, youngberries, and boyberries, and in vegetables, especially in carrots. The determination of D-isocitric acid has become of importance in the analysis of fruit juices for the detection of illegal additives (adulteration). Since the quantities of citric and isocitric acids are correlated in fruit juices, a high ratio of citric to isocitric acid can indicate the addition of citric acid as an alduterant. In authentic orange juice, for example, the ratio of citric acid to D-isocitric acid is usually less than 130. Isocitric acid is mostly used in the food industry (food additive) as a food acidulant.
The citrate oxidation to isocitrate is catalyzed by the enzyme aconitase. Human prostatic secretion is remarkably rich in citric acid and low aconitase activity will therefore play a significant role in enabling accumulation of high citrate levels (PubMed ID 8115279) [HMDB]. Isocitric acid is found in many foods, some of which are wild carrot, redcurrant, carrot, and soursop.
[Spectral] Isocitrate (exact mass = 192.027) and CDP (exact mass = 403.01818) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions.

Isocitric acid. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=320-77-4 (retrieved 2024-07-01) (CAS RN: 320-77-4). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Isocitric acid is an endogenous metabolite present in Saliva and Cellular_Cytoplasm that can be used for the research of Alzheimer's Disease, Lewy Body Dementia and Anoxia[1][2][3].
Isocitric acid is an endogenous metabolite present in Saliva and Cellular_Cytoplasm that can be used for the research of Alzheimer's Disease, Lewy Body Dementia and Anoxia[1][2][3].

同义名列表

25 个代谢物同义名

3-carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid; 3-Carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylate; 1-Hydroxy-1,2,3-propanetricarboxylic acid; 1-Hydroxypropane-1,2,3-tricarboxylic acid; 1-Hydroxypropane-1,2,3-tricarboxylate; 1-Hydroxy-1,2,3-propanetricarboxylate; 3-Carboxy-2,3-dideoxy-pentaric acid; DL-Isocitric acid trisodium salt; 3-Carboxy-2,3-dideoxy-pentarate; Isocitric acid, potassium salt; Isocitric acid, trisodium salt; Isocitric acid, disodium salt; Isocitric acid, (11)C-labeled; Isocitric acid, calcium salt; 1-Hydroxytricarballylic acid; Isocitric acid, sodium salt; 1-Hydroxytricarballylate; Threo-D(S)-iso-citrate; Threo-DS-isocitrate; isocitric acid; D-Isocitrate; Iso-citrate; Isocitrate; I-cit; Isocitric acid



数据库引用编号

33 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

61 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(5)

Plant Reactome(0)

INOH(5)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(49)

PharmGKB(0)

36 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zhaojun Nie, Linglu Wang, Peng Zhao, Zhenbo Wang, Qiuzhe Shi, Hongen Liu. Metabolomics reveals the impact of nitrogen combined with the zinc supply on zinc availability in calcareous soil via root exudates of winter wheat (Triticum aestivum). Plant physiology and biochemistry : PPB. 2023 Nov; 204(?):108069. doi: 10.1016/j.plaphy.2023.108069. [PMID: 37852066]
  • Alberto Jaramillo-Jimenez, Lasse M Giil, Miguel Germán Borda, Diego A Tovar-Rios, Kåre Andre Kristiansen, Per Bruheim, Dag Aarsland, George E Barreto, Rolf Kristian Berge. Serum TCA cycle metabolites in Lewy bodies dementia and Alzheimer's disease: Network analysis and cognitive prognosis. Mitochondrion. 2023 May; 71(?):17-25. doi: 10.1016/j.mito.2023.05.002. [PMID: 37172667]
  • Mònica Bulló, Christopher Papandreou, Jesus García-Gavilán, Miguel Ruiz-Canela, Jun Li, Marta Guasch-Ferré, Estefanía Toledo, Clary Clish, Dolores Corella, Ramon Estruch, Emilio Ros, Montserrat Fitó, Chih-Hao Lee, Kerry Pierce, Cristina Razquin, Fernando Arós, Lluís Serra-Majem, Liming Liang, Miguel A Martínez-González, Frank B Hu, Jordi Salas-Salvadó. Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure. Metabolism: clinical and experimental. 2021 12; 125(?):154915. doi: 10.1016/j.metabol.2021.154915. [PMID: 34678258]
  • Kerri M Smith, Ian D Wilson, Paul D Rainville. Sensitive and Reproducible Mass Spectrometry-Compatible RP-UHPLC Analysis of Tricarboxylic Acid Cycle and Related Metabolites in Biological Fluids: Application to Human Urine. Analytical chemistry. 2021 01; 93(2):1009-1015. doi: 10.1021/acs.analchem.0c03863. [PMID: 33290053]
  • Lucas A Luna, Zachary Lesecq, Katharine A White, An Hoang, David A Scott, Olga Zagnitko, Andrey A Bobkov, Diane L Barber, Jamie M Schiffer, Daniel G Isom, Christal D Sohl. An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity. The Biochemical journal. 2020 08; 477(16):2999-3018. doi: 10.1042/bcj20200311. [PMID: 32729927]
  • Li Su, Xinglong Zhang, Lei Zheng, Miaomiao Wang, Zhifa Zhu, Ping Li. Mutation of Isocitrate Dehydrogenase 1 in Cholangiocarcinoma Impairs Tumor Progression by Inhibiting Isocitrate Metabolism. Frontiers in endocrinology. 2020; 11(?):189. doi: 10.3389/fendo.2020.00189. [PMID: 32373065]
  • Svetlana V Kamzolova, Igor G Morgunov. Microbial production of (2R,3S)-isocitric acid: state of the arts and prospects. Applied microbiology and biotechnology. 2019 Dec; 103(23-24):9321-9333. doi: 10.1007/s00253-019-10207-4. [PMID: 31748825]
  • Stein Hallan, Maryam Afkarian, Leila R Zelnick, Bryan Kestenbaum, Shoba Sharma, Rintaro Saito, Manjula Darshi, Gregory Barding, Daniel Raftery, Wenjun Ju, Matthias Kretzler, Kumar Sharma, Ian H de Boer. Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients. EBioMedicine. 2017 Dec; 26(?):68-77. doi: 10.1016/j.ebiom.2017.10.027. [PMID: 29128444]
  • Maren Vollmer, David Schröter, Selma Esders, Susanne Neugart, Freda M Farquharson, Sylvia H Duncan, Monika Schreiner, Petra Louis, Ronald Maul, Sascha Rohn. Chlorogenic acid versus amaranth's caffeoylisocitric acid - Gut microbial degradation of caffeic acid derivatives. Food research international (Ottawa, Ont.). 2017 10; 100(Pt 3):375-384. doi: 10.1016/j.foodres.2017.06.013. [PMID: 28964360]
  • Jun-Chi Wang, Guang-Zhi Li, Na Lv, Lian-Gang Shen, Lei-Ling Shi, Jian-Yong Si. Cryptoporic acid S, a new drimane-type sesquiterpene ether of isocitric acid from the fruiting bodies of Cryptoporus volvatus. Journal of Asian natural products research. 2017 Jul; 19(7):719-724. doi: 10.1080/10286020.2016.1240170. [PMID: 27756154]
  • Lucia Abela, Ronen Spiegel, Lisa M Crowther, Andrea Klein, Katharina Steindl, Sorina Mihaela Papuc, Pascal Joset, Yoav Zehavi, Anita Rauch, Barbara Plecko, Thomas Luke Simmons. Plasma metabolomics reveals a diagnostic metabolic fingerprint for mitochondrial aconitase (ACO2) deficiency. PloS one. 2017; 12(5):e0176363. doi: 10.1371/journal.pone.0176363. [PMID: 28463998]
  • Chen Yuan, Clary B Clish, Chen Wu, Jared R Mayers, Peter Kraft, Mary K Townsend, Mingfeng Zhang, Shelley S Tworoger, Ying Bao, Zhi Rong Qian, Douglas A Rubinson, Kimmie Ng, Edward L Giovannucci, Shuji Ogino, Meir J Stampfer, John Michael Gaziano, Jing Ma, Howard D Sesso, Garnet L Anderson, Barbara B Cochrane, JoAnn E Manson, Margaret E Torrence, Alec C Kimmelman, Laufey T Amundadottir, Matthew G Vander Heiden, Charles S Fuchs, Brian M Wolpin. Circulating Metabolites and Survival Among Patients With Pancreatic Cancer. Journal of the National Cancer Institute. 2016 Jun; 108(6):djv409. doi: 10.1093/jnci/djv409. [PMID: 26755275]
  • Svetlana V Kamzolova, Ramil K Allayarov, Julia N Lunina, Igor G Morgunov. The effect of oxalic and itaconic acids on threo-Ds-isocitric acid production from rapeseed oil by Yarrowia lipolytica. Bioresource technology. 2016 Apr; 206(?):128-133. doi: 10.1016/j.biortech.2016.01.092. [PMID: 26851896]
  • Airie Kim, Eileen Fung, Sona G Parikh, Victoria Gabayan, Elizabeta Nemeth, Tomas Ganz. Isocitrate treatment of acute anemia of inflammation in a mouse model. Blood cells, molecules & diseases. 2016 Jan; 56(1):31-6. doi: 10.1016/j.bcmd.2015.09.007. [PMID: 26603720]
  • Susan Cheng, Martin G Larson, Elizabeth L McCabe, Joanne M Murabito, Eugene P Rhee, Jennifer E Ho, Paul F Jacques, Anahita Ghorbani, Martin Magnusson, Amanda L Souza, Amy A Deik, Kerry A Pierce, Kevin Bullock, Christopher J O'Donnell, Olle Melander, Clary B Clish, Ramachandran S Vasan, Robert E Gerszten, Thomas J Wang. Distinct metabolomic signatures are associated with longevity in humans. Nature communications. 2015 Apr; 6(?):6791. doi: 10.1038/ncomms7791. [PMID: 25864806]
  • S V Kamzolova, Y N Lunin, R K Allayarov, I F Puntus, I A Laptev, V A Samojlenko, I G Morgunov. [Biosynthesis of isocitric acid by the yeast yarrowia lipolytica and its regulation]. Prikladnaia biokhimiia i mikrobiologiia. 2015 Mar; 51(2):251-7. doi: 10.7868/s0555109915020075. [PMID: 26027362]
  • Helena Gibbons, Breige A McNulty, Anne P Nugent, Janette Walton, Albert Flynn, Michael J Gibney, Lorraine Brennan. A metabolomics approach to the identification of biomarkers of sugar-sweetened beverage intake. The American journal of clinical nutrition. 2015 Mar; 101(3):471-7. doi: 10.3945/ajcn.114.095604. [PMID: 25733631]
  • Haldis H Lillefosse, Morten R Clausen, Christian C Yde, Ditte B Ditlev, Xumin Zhang, Zhen-Yu Du, Hanne C Bertram, Lise Madsen, Karsten Kristiansen, Bjørn Liaset. Urinary loss of tricarboxylic acid cycle intermediates as revealed by metabolomics studies: an underlying mechanism to reduce lipid accretion by whey protein ingestion?. Journal of proteome research. 2014 May; 13(5):2560-70. doi: 10.1021/pr500039t. [PMID: 24702026]
  • Xian-You Wang, Ping Wang, Yi-Ping Qi, Chen-Ping Zhou, Lin-Tong Yang, Xin-Yan Liao, Liu-Qing Wang, Dong-Huang Zhu, Li-Song Chen. Effects of granulation on organic acid metabolism and its relation to mineral elements in Citrus grandis juice sacs. Food chemistry. 2014 Feb; 145(?):984-90. doi: 10.1016/j.foodchem.2013.09.021. [PMID: 24128573]
  • Svetlana V Kamzolova, Emiliya G Dedyukhina, Vladimir A Samoilenko, Julia N Lunina, Irina F Puntus, Ramil L Allayarov, Maria N Chiglintseva, Alexey A Mironov, Igor G Morgunov. Isocitric acid production from rapeseed oil by Yarrowia lipolytica yeast. Applied microbiology and biotechnology. 2013 Oct; 97(20):9133-44. doi: 10.1007/s00253-013-5182-5. [PMID: 23989918]
  • P Stanely Mainzen Prince. (-) Epicatechin attenuates mitochondrial damage by enhancing mitochondrial multi-marker enzymes, adenosine triphosphate and lowering calcium in isoproterenol induced myocardial infarcted rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013 Mar; 53(?):409-16. doi: 10.1016/j.fct.2012.12.010. [PMID: 23261676]
  • Papiya Saha, Pranamita Kunda, Asok K Biswas. Influence of sodium chloride on the regulation of Krebs cycle intermediates and enzymes of respiratory chain in mungbean (Vigna radiata L. Wilczek) seedlings. Plant physiology and biochemistry : PPB. 2012 Nov; 60(?):214-22. doi: 10.1016/j.plaphy.2012.08.008. [PMID: 23000814]
  • Sonia Dorion, Audrey Clendenning, Julie Jeukens, Joaquín J Salas, Nanhi Parveen, Andrea A Haner, R David Law, Enrique Martínez Force, Jean Rivoal. A large decrease of cytosolic triosephosphate isomerase in transgenic potato roots affects the distribution of carbon in primary metabolism. Planta. 2012 Oct; 236(4):1177-90. doi: 10.1007/s00425-012-1675-1. [PMID: 22678033]
  • Jorge Barrios-Payán, Milena Saqui-Salces, Mangalakumari Jeyanathan, Avissai Alcántara-Vazquez, Mauricio Castañon-Arreola, Graham Rook, Rogelio Hernandez-Pando. Extrapulmonary locations of mycobacterium tuberculosis DNA during latent infection. The Journal of infectious diseases. 2012 Oct; 206(8):1194-205. doi: 10.1093/infdis/jis381. [PMID: 22732919]
  • Keiko Murakami, Miyako Haneda, Shouko Iwata, Masataka Yoshino. Differential effects of polyamine on the cytosolic and mitochondrial NADP-isocitrate dehydrogenases. BioFactors (Oxford, England). 2012 Sep; 38(5):365-71. doi: 10.1002/biof.1026. [PMID: 22674798]
  • Abu Hena Mostafa Kamal, Kun Cho, Da-Eun Kim, Nobuyuki Uozumi, Keun-Yook Chung, Sang Young Lee, Jong-Soon Choi, Seong-Woo Cho, Chang-Seob Shin, Sun Hee Woo. Changes in physiology and protein abundance in salt-stressed wheat chloroplasts. Molecular biology reports. 2012 Sep; 39(9):9059-74. doi: 10.1007/s11033-012-1777-7. [PMID: 22736107]
  • M H Deng, J F Wen, J L Huo, H S Zhu, X Z Dai, Z Q Zhang, H Zhou, X X Zou. Molecular cloning, sequence characterization of a novel pepper gene NADP-ICDH and its effect on cytoplasmic male sterility. Genetics and molecular research : GMR. 2012 Aug; 11(3):3020-31. doi: 10.4238/2012.may.18.15. [PMID: 22653649]
  • David Capper, Matthias Simon, Claus-Dieter Langhans, Jürgen G Okun, Jörg C Tonn, Michael Weller, Andreas von Deimling, Christian Hartmann. 2-Hydroxyglutarate concentration in serum from patients with gliomas does not correlate with IDH1/2 mutation status or tumor size. International journal of cancer. 2012 Aug; 131(3):766-8. doi: 10.1002/ijc.26425. [PMID: 21913188]
  • Hironori Matsunaga, Akiko Futakuchi-Tsuchida, Makoto Takahashi, Tomio Ishikawa, Makoto Tsuji, Osamu Ando. IDH1 and IDH2 have critical roles in 2-hydroxyglutarate production in D-2-hydroxyglutarate dehydrogenase depleted cells. Biochemical and biophysical research communications. 2012 Jul; 423(3):553-6. doi: 10.1016/j.bbrc.2012.06.002. [PMID: 22683334]
  • Carolina Gimiliani Lembke, Milton Yutaka Nishiyama, Paloma Mieko Sato, Rodrigo Fandiño de Andrade, Glaucia Mendes Souza. Identification of sense and antisense transcripts regulated by drought in sugarcane. Plant molecular biology. 2012 Jul; 79(4-5):461-77. doi: 10.1007/s11103-012-9922-1. [PMID: 22610347]
  • L Ma, B A Corl. Transcriptional regulation of lipid synthesis in bovine mammary epithelial cells by sterol regulatory element binding protein-1. Journal of dairy science. 2012 Jul; 95(7):3743-55. doi: 10.3168/jds.2011-5083. [PMID: 22720931]
  • Fan Yang, Sufang Zhang, Yongjin J Zhou, Zhiwei Zhu, Xinping Lin, Zongbao K Zhao. Characterization of the mitochondrial NAD+ -dependent isocitrate dehydrogenase of the oleaginous yeast Rhodosporidium toruloides. Applied microbiology and biotechnology. 2012 May; 94(4):1095-105. doi: 10.1007/s00253-011-3820-3. [PMID: 22223103]
  • Candida Vannini, Milena Marsoni, Carlo Cantara, Maria Concetta De Pinto, Vittoria Locato, Laura De Gara, Marcella Bracale. The soluble proteome of tobacco Bright Yellow-2 cells undergoing H₂O₂-induced programmed cell death. Journal of experimental botany. 2012 May; 63(8):3137-55. doi: 10.1093/jxb/ers031. [PMID: 22355080]
  • Joshua P Fessel, Rizwan Hamid, Bryan M Wittmann, Linda J Robinson, Tom Blackwell, Yuji Tada, Nobuhiro Tanabe, Koichiro Tatsumi, Anna R Hemnes, James D West. Metabolomic analysis of bone morphogenetic protein receptor type 2 mutations in human pulmonary endothelium reveals widespread metabolic reprogramming. Pulmonary circulation. 2012 Apr; 2(2):201-13. doi: 10.4103/2045-8932.97606. [PMID: 22837861]
  • Ioannis S Minas, Georgia Tanou, Maya Belghazi, Dominique Job, George A Manganaris, Athanassios Molassiotis, Miltiadis Vasilakakis. Physiological and proteomic approaches to address the active role of ozone in kiwifruit post-harvest ripening. Journal of experimental botany. 2012 Apr; 63(7):2449-64. doi: 10.1093/jxb/err418. [PMID: 22268155]
  • Kristofer S Fritz, James J Galligan, Matthew D Hirschey, Eric Verdin, Dennis R Petersen. Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice. Journal of proteome research. 2012 Mar; 11(3):1633-43. doi: 10.1021/pr2008384. [PMID: 22309199]
  • Alberto González, M de Los Ángeles Cabrera, M Josefa Henríquez, Rodrigo A Contreras, Bernardo Morales, Alejandra Moenne. Cross talk among calcium, hydrogen peroxide, and nitric oxide and activation of gene expression involving calmodulins and calcium-dependent protein kinases in Ulva compressa exposed to copper excess. Plant physiology. 2012 Mar; 158(3):1451-62. doi: 10.1104/pp.111.191759. [PMID: 22234999]
  • Benjamin Faix, Volodymyr Radchuk, Annika Nerlich, Christine Hümmer, Ruslana Radchuk, R J Neil Emery, Harald Keller, Klaus-Peter Götz, Winfriede Weschke, Peter Geigenberger, Hans Weber. Barley grains, deficient in cytosolic small subunit of ADP-glucose pyrophosphorylase, reveal coordinate adjustment of C:N metabolism mediated by an overlapping metabolic-hormonal control. The Plant journal : for cell and molecular biology. 2012 Mar; 69(6):1077-93. doi: 10.1111/j.1365-313x.2011.04857.x. [PMID: 22098161]
  • Axel Tiessen, Annika Nerlich, Benjamin Faix, Christine Hümmer, Simon Fox, Kay Trafford, Hans Weber, Winfriede Weschke, Peter Geigenberger. Subcellular analysis of starch metabolism in developing barley seeds using a non-aqueous fractionation method. Journal of experimental botany. 2012 Mar; 63(5):2071-87. doi: 10.1093/jxb/err408. [PMID: 22200665]
  • Neelja Singhal, Prashant Sharma, Manish Kumar, Beenu Joshi, Deepa Bisht. Analysis of intracellular expressed proteins of Mycobacterium tuberculosis clinical isolates. Proteome science. 2012 Mar; 10(1):14. doi: 10.1186/1477-5956-10-14. [PMID: 22375954]
  • Raija K Ahmed, Zoyia Rohava, Kithiganahalli N Balaji, Sven E Hoffner, Hans Gaines, Isabelle Magalhaes, Alimuddin Zumla, Alena Skrahina, Markus J Maeurer. Pattern recognition and cellular immune responses to novel Mycobacterium tuberculosis-antigens in individuals from Belarus. BMC infectious diseases. 2012 Feb; 12(?):41. doi: 10.1186/1471-2334-12-41. [PMID: 22336002]
  • Fengwei Tan, Ying Jiang, Nan Sun, Zhaoli Chen, Yongzhuang Lv, Kang Shao, Ning Li, Bin Qiu, Yibo Gao, Baozhong Li, Xiaogang Tan, Fang Zhou, Zhen Wang, Dapeng Ding, Jiwen Wang, Jian Sun, Jie Hang, Susheng Shi, Xiaoli Feng, Fuchu He, Jie He. Identification of isocitrate dehydrogenase 1 as a potential diagnostic and prognostic biomarker for non-small cell lung cancer by proteomic analysis. Molecular & cellular proteomics : MCP. 2012 Feb; 11(2):M111.008821. doi: 10.1074/mcp.m111.008821. [PMID: 22064513]
  • Darren M Soanes, Apratim Chakrabarti, Konrad H Paszkiewicz, Angus L Dawe, Nicholas J Talbot. Genome-wide transcriptional profiling of appressorium development by the rice blast fungus Magnaporthe oryzae. PLoS pathogens. 2012 Feb; 8(2):e1002514. doi: 10.1371/journal.ppat.1002514. [PMID: 22346750]
  • H Artee Luchman, Owen D Stechishin, N Ha Dang, Michael D Blough, Charles Chesnelong, John J Kelly, Stephanie A Nguyen, Jennifer A Chan, Aalim M Weljie, J Gregory Cairncross, Samuel Weiss. An in vivo patient-derived model of endogenous IDH1-mutant glioma. Neuro-oncology. 2012 Feb; 14(2):184-91. doi: 10.1093/neuonc/nor207. [PMID: 22166263]
  • Trevor Tyson, Georgina O'Mahony Zamora, Simon Wong, Máirin Skelton, Brian Daly, John T Jones, Eoin D Mulvihill, Benjamin Elsworth, Mark Phillips, Mark Blaxter, Ann M Burnell. A molecular analysis of desiccation tolerance mechanisms in the anhydrobiotic nematode Panagrolaimus superbus using expressed sequenced tags. BMC research notes. 2012 Jan; 5(?):68. doi: 10.1186/1756-0500-5-68. [PMID: 22281184]
  • Mi-Sun Koo, Selvakumar Subbian, Gilla Kaplan. Strain specific transcriptional response in Mycobacterium tuberculosis infected macrophages. Cell communication and signaling : CCS. 2012 Jan; 10(1):2. doi: 10.1186/1478-811x-10-2. [PMID: 22280836]
  • Ilka Haferkamp, Stephan Schmitz-Esser. The plant mitochondrial carrier family: functional and evolutionary aspects. Frontiers in plant science. 2012; 3(?):2. doi: 10.3389/fpls.2012.00002. [PMID: 22639632]
  • Elisa Mitiko Kawamoto, Carmen Vivar, Simonetta Camandola. Physiology and pathology of calcium signaling in the brain. Frontiers in pharmacology. 2012; 3(?):61. doi: 10.3389/fphar.2012.00061. [PMID: 22518105]
  • Young-Man Kim, Sung-Eun Lee, Byeoung-Soo Park, Mi-Kyung Son, Young-Mi Jung, Seung-Ok Yang, Hyung-Kyoon Choi, Sung-Ho Hur, Jong Hwa Yum. Proteomic analysis on acetate metabolism in Citrobacter sp. BL-4. International journal of biological sciences. 2012; 8(1):66-78. doi: 10.7150/ijbs.8.66. [PMID: 22211106]
  • Marc Galland, Dominique Job, Loïc Rajjou. The seed proteome web portal. Frontiers in plant science. 2012; 3(?):98. doi: 10.3389/fpls.2012.00098. [PMID: 22701460]
  • Dibyendu Talukdar. Flavonoid-deficient mutants in grass pea (Lathyrus sativus L.): genetic control, linkage relationships, and mapping with aconitase and S-nitrosoglutathione reductase isozyme loci. TheScientificWorldJournal. 2012; 2012(?):345983. doi: 10.1100/2012/345983. [PMID: 22593675]
  • Haider Raza, Annie John. Implications of altered glutathione metabolism in aspirin-induced oxidative stress and mitochondrial dysfunction in HepG2 cells. PloS one. 2012; 7(4):e36325. doi: 10.1371/journal.pone.0036325. [PMID: 22558435]
  • Andreas Aurich, Robert Specht, Roland A Müller, Ulrich Stottmeister, Venelina Yovkova, Christina Otto, Martina Holz, Gerold Barth, Philipp Heretsch, Franziska A Thomas, Dieter Sicker, Athanassios Giannis. Microbiologically produced carboxylic acids used as building blocks in organic synthesis. Sub-cellular biochemistry. 2012; 64(?):391-423. doi: 10.1007/978-94-007-5055-5_19. [PMID: 23080261]
  • Vijai Bhadauria, Sabine Banniza, Albert Vandenberg, Gopalan Selvaraj, Yangdou Wei. Peroxisomal alanine: glyoxylate aminotransferase AGT1 is indispensable for appressorium function of the rice blast pathogen, Magnaporthe oryzae. PloS one. 2012; 7(4):e36266. doi: 10.1371/journal.pone.0036266. [PMID: 22558413]
  • Timothy E Richardson, Amanda E Yu, Yi Wen, Shao-Hua Yang, James W Simpkins. Estrogen prevents oxidative damage to the mitochondria in Friedreich's ataxia skin fibroblasts. PloS one. 2012; 7(4):e34600. doi: 10.1371/journal.pone.0034600. [PMID: 22509330]
  • Stephanus J Ferreira, Uwe Sonnewald. The mode of sucrose degradation in potato tubers determines the fate of assimilate utilization. Frontiers in plant science. 2012; 3(?):23. doi: 10.3389/fpls.2012.00023. [PMID: 22639642]
  • Khalid S Al Numair, Govindasamy Chandramohan, Mohammed A Alsaif, Arul Albert Baskar. Protective effect of morin on cardiac mitochondrial function during isoproterenol-induced myocardial infarction in male Wistar rats. Redox report : communications in free radical research. 2012; 17(1):14-21. doi: 10.1179/1351000211y.0000000019. [PMID: 22340511]
  • Yasuhiro Ishimaru, Ryuichi Takahashi, Khurram Bashir, Hugo Shimo, Takeshi Senoura, Kazuhiko Sugimoto, Kazuko Ono, Masahiro Yano, Satoru Ishikawa, Tomohito Arao, Hiromi Nakanishi, Naoko K Nishizawa. Characterizing the role of rice NRAMP5 in Manganese, Iron and Cadmium Transport. Scientific reports. 2012; 2(?):286. doi: 10.1038/srep00286. [PMID: 22368778]
  • Hendrik Führs, André Specht, Alexander Erban, Joachim Kopka, Walter J Horst. Functional associations between the metabolome and manganese tolerance in Vigna unguiculata. Journal of experimental botany. 2012 Jan; 63(1):329-40. doi: 10.1093/jxb/err276. [PMID: 21934118]
  • Janine Kirchberg, Daniela Büttner, Barbara Thiemer, R Gary Sawers. Aconitase B is required for optimal growth of Xanthomonas campestris pv. vesicatoria in pepper plants. PloS one. 2012; 7(4):e34941. doi: 10.1371/journal.pone.0034941. [PMID: 22493725]
  • Ana Carolina Ariza, Peter Meinardus T Deen, Joris Hubertus Robben. The succinate receptor as a novel therapeutic target for oxidative and metabolic stress-related conditions. Frontiers in endocrinology. 2012; 3(?):22. doi: 10.3389/fendo.2012.00022. [PMID: 22649411]
  • Mario Chojkier, Hisham Elkhayat, Dina Sabry, Michael Donohue, Martina Buck. Pioglitazone decreases hepatitis C viral load in overweight, treatment naïve, genotype 4 infected-patients: a pilot study. PloS one. 2012; 7(3):e31516. doi: 10.1371/journal.pone.0031516. [PMID: 22412837]
  • Euan J Rodger, Rachel J Suetani, Gregory T Jones, Torsten Kleffmann, Alan Carne, Michael Legge, Sally P A McCormick. Proteomic analysis of aortae from human lipoprotein(a) transgenic mice shows an early metabolic response independent of atherosclerosis. PloS one. 2012; 7(1):e30383. doi: 10.1371/journal.pone.0030383. [PMID: 22276189]
  • Dorit Samocha-Bonet, Lesley V Campbell, Trevor A Mori, Kevin D Croft, Jerry R Greenfield, Nigel Turner, Leonie K Heilbronn. Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humans. PloS one. 2012; 7(5):e36320. doi: 10.1371/journal.pone.0036320. [PMID: 22586466]
  • Prabhat Singh, Shrawan Kumar Mishra, Sanjeev Noel, Sharad Sharma, Srikanta Kumar Rath. Acute exposure of apigenin induces hepatotoxicity in Swiss mice. PloS one. 2012; 7(2):e31964. doi: 10.1371/journal.pone.0031964. [PMID: 22359648]
  • Marina Leterrier, Juan B Barroso, Raquel Valderrama, José M Palma, Francisco J Corpas. NADP-dependent isocitrate dehydrogenase from Arabidopsis roots contributes in the mechanism of defence against the nitro-oxidative stress induced by salinity. TheScientificWorldJournal. 2012; 2012(?):694740. doi: 10.1100/2012/694740. [PMID: 22649311]
  • Gopinath S Palanisamy, Natalie M Kirk, David F Ackart, Andrés Obregón-Henao, Crystal A Shanley, Ian M Orme, Randall J Basaraba. Uptake and accumulation of oxidized low-density lipoprotein during Mycobacterium tuberculosis infection in guinea pigs. PloS one. 2012; 7(3):e34148. doi: 10.1371/journal.pone.0034148. [PMID: 22493658]
  • Adrian P Brown, Johan T M Kroon, David Swarbreck, Melanie Febrer, Tony R Larson, Ian A Graham, Mario Caccamo, Antoni R Slabas. Tissue-specific whole transcriptome sequencing in castor, directed at understanding triacylglycerol lipid biosynthetic pathways. PloS one. 2012; 7(2):e30100. doi: 10.1371/journal.pone.0030100. [PMID: 22319559]
  • Jessie Fernandez, Janet D Wright, David Hartline, Cristian F Quispe, Nandakumar Madayiputhiya, Richard A Wilson. Principles of carbon catabolite repression in the rice blast fungus: Tps1, Nmr1-3, and a MATE-family pump regulate glucose metabolism during infection. PLoS genetics. 2012; 8(5):e1002673. doi: 10.1371/journal.pgen.1002673. [PMID: 22570632]
  • Rudolf J Schilder, Anthony J Zera, Christine Black, Mallary Hoidal, Cody Wehrkamp. The biochemical basis of life history adaptation: molecular and enzymological causes of NADP(+)-isocitrate dehydrogenase activity differences between morphs of Gryllus firmus that differ in lipid biosynthesis and life history. Molecular biology and evolution. 2011 Dec; 28(12):3381-93. doi: 10.1093/molbev/msr171. [PMID: 21705380]
  • Jeong-Min Jeon, Hae-In Lee, Andrew J Donati, Jae-Seong So, David W Emerich, Woo-Suk Chang. Whole-genome expression profiling of Bradyrhizobium japonicum in response to hydrogen peroxide. Molecular plant-microbe interactions : MPMI. 2011 Dec; 24(12):1472-81. doi: 10.1094/mpmi-03-11-0072. [PMID: 21864047]
  • Abbas A Alibhoy, Hui-Ling Chiang. Vacuole import and degradation pathway: Insights into a specialized autophagy pathway. World journal of biological chemistry. 2011 Nov; 2(11):239-45. doi: 10.4331/wjbc.v2.i11.239. [PMID: 22125667]
  • Jörg Toepel, Stefan P Albaum, Samuel Arvidsson, Alexander Goesmann, Marco la Russa, Kristin Rogge, Olaf Kruse. Construction and evaluation of a whole genome microarray of Chlamydomonas reinhardtii. BMC genomics. 2011 Nov; 12(?):579. doi: 10.1186/1471-2164-12-579. [PMID: 22118351]
  • Celine Diaz, Miyako Kusano, Ronan Sulpice, Mitsutaka Araki, Henning Redestig, Kazuki Saito, Mark Stitt, Ryoung Shin. Determining novel functions of Arabidopsis 14-3-3 proteins in central metabolic processes. BMC systems biology. 2011 Nov; 5(?):192. doi: 10.1186/1752-0509-5-192. [PMID: 22104211]
  • Christian M Metallo, Paulo A Gameiro, Eric L Bell, Katherine R Mattaini, Juanjuan Yang, Karsten Hiller, Christopher M Jewell, Zachary R Johnson, Darrell J Irvine, Leonard Guarente, Joanne K Kelleher, Matthew G Vander Heiden, Othon Iliopoulos, Gregory Stephanopoulos. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature. 2011 Nov; 481(7381):380-4. doi: 10.1038/nature10602. [PMID: 22101433]
  • Andrew R Mullen, William W Wheaton, Eunsook S Jin, Pei-Hsuan Chen, Lucas B Sullivan, Tzuling Cheng, Youfeng Yang, W Marston Linehan, Navdeep S Chandel, Ralph J DeBerardinis. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature. 2011 Nov; 481(7381):385-8. doi: 10.1038/nature10642. [PMID: 22101431]
  • Chao Tan, Hui Wang, Yue Zhang, Bin Qi, Guoxin Xu, Huiqiong Zheng. A proteomic approach to analyzing responses of Arabidopsis thaliana root cells to different gravitational conditions using an agravitropic mutant, pin2 and its wild type. Proteome science. 2011 Nov; 9(?):72. doi: 10.1186/1477-5956-9-72. [PMID: 22085406]
  • Ana M Fortes, Patricia Agudelo-Romero, Marta S Silva, Kashif Ali, Lisete Sousa, Federica Maltese, Young H Choi, Jerome Grimplet, José M Martinez-Zapater, Robert Verpoorte, Maria S Pais. Transcript and metabolite analysis in Trincadeira cultivar reveals novel information regarding the dynamics of grape ripening. BMC plant biology. 2011 Nov; 11(?):149. doi: 10.1186/1471-2229-11-149. [PMID: 22047180]
  • Wei-Luen Yu, William Ansari, Nathan G Schoepp, Michael J Hannon, Stephen P Mayfield, Michael D Burkart. Modifications of the metabolic pathways of lipid and triacylglycerol production in microalgae. Microbial cell factories. 2011 Nov; 10(?):91. doi: 10.1186/1475-2859-10-91. [PMID: 22047615]
  • Gautham Vivek Sridharan, Soha Hassoun, Kyongbum Lee. Identification of biochemical network modules based on shortest retroactive distances. PLoS computational biology. 2011 Nov; 7(11):e1002262. doi: 10.1371/journal.pcbi.1002262. [PMID: 22102800]
  • Stefanie Cornelius, Sandra Witz, Hardy Rolletschek, Torsten Möhlmann. Pyrimidine degradation influences germination seedling growth and production of Arabidopsis seeds. Journal of experimental botany. 2011 Nov; 62(15):5623-32. doi: 10.1093/jxb/err251. [PMID: 21865177]
  • Ehud Katz, Kyung Hwan Boo, Ho Youn Kim, Richard A Eigenheer, Brett S Phinney, Vladimir Shulaev, Florence Negre-Zakharov, Avi Sadka, Eduardo Blumwald. Label-free shotgun proteomics and metabolite analysis reveal a significant metabolic shift during citrus fruit development. Journal of experimental botany. 2011 Nov; 62(15):5367-84. doi: 10.1093/jxb/err197. [PMID: 21841177]
  • Lisenka E L M Vissers, Virginia Fano, Diego Martinelli, Belinda Campos-Xavier, Domenico Barbuti, Tae-Joon Cho, Ahmet Dursun, Ok Hwa Kim, Sun Hee Lee, Giuseppina Timpani, Gen Nishimura, Sheila Unger, Jörn Oliver Sass, Joris A Veltman, Han G Brunner, Luisa Bonafé, Carlo Dionisi-Vici, Andrea Superti-Furga. Whole-exome sequencing detects somatic mutations of IDH1 in metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria (MC-HGA). American journal of medical genetics. Part A. 2011 Nov; 155A(11):2609-16. doi: 10.1002/ajmg.a.34325. [PMID: 22025298]
  • Sameya Anjum, Shakilur Rahman, Manpreet Kaur, Firoz Ahmad, Hina Rashid, Rizwan Ahmad Ansari, Sheikh Raisuddin. Melatonin ameliorates bisphenol A-induced biochemical toxicity in testicular mitochondria of mouse. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011 Nov; 49(11):2849-54. doi: 10.1016/j.fct.2011.07.062. [PMID: 21840368]
  • Wen-Zheng Chen, Bo Pang, Bo Yang, Jian-Guang Zhou, Ying-Hao Sun. Differential proteome analysis of conditioned medium of BPH-1 and LNCaP cells. Chinese medical journal. 2011 Nov; 124(22):3806-9. doi: . [PMID: 22340245]
  • Emily B Merewitz, Thomas Gianfagna, Bingru Huang. Protein accumulation in leaves and roots associated with improved drought tolerance in creeping bentgrass expressing an ipt gene for cytokinin synthesis. Journal of experimental botany. 2011 Nov; 62(15):5311-33. doi: 10.1093/jxb/err166. [PMID: 21831843]
  • Vinoy K Ramachandran, Alison K East, Ramakrishnan Karunakaran, J Allan Downie, Philip S Poole. Adaptation of Rhizobium leguminosarum to pea, alfalfa and sugar beet rhizospheres investigated by comparative transcriptomics. Genome biology. 2011 Oct; 12(10):R106. doi: 10.1186/gb-2011-12-10-r106. [PMID: 22018401]
  • Julie Adam, Emine Hatipoglu, Linda O'Flaherty, Nicola Ternette, Natasha Sahgal, Helen Lockstone, Dilair Baban, Emma Nye, Gordon W Stamp, Kathryn Wolhuter, Marcus Stevens, Roman Fischer, Peter Carmeliet, Patrick H Maxwell, Chris W Pugh, Norma Frizzell, Tomoyoshi Soga, Benedikt M Kessler, Mona El-Bahrawy, Peter J Ratcliffe, Patrick J Pollard. Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling. Cancer cell. 2011 Oct; 20(4):524-37. doi: 10.1016/j.ccr.2011.09.006. [PMID: 22014577]
  • Sławomir Borek, Katarzyna Nuc. Sucrose controls storage lipid breakdown on gene expression level in germinating yellow lupine (Lupinus luteus L.) seeds. Journal of plant physiology. 2011 Oct; 168(15):1795-803. doi: 10.1016/j.jplph.2011.05.016. [PMID: 21752490]
  • Joanna Teul, Antonia Garcia, José Tuñón, Jose Luis Martin-Ventura, Nieves Tarín, Lorenzo López Bescós, Jesús Egido, Coral Barbas, Francisco J Rupérez. Targeted and non-targeted metabolic time trajectory in plasma of patients after acute coronary syndrome. Journal of pharmaceutical and biomedical analysis. 2011 Sep; 56(2):343-51. doi: 10.1016/j.jpba.2011.05.020. [PMID: 21696905]
  • Xin Fang, Anders Wallqvist, Jaques Reifman. Modeling synergistic drug inhibition of Mycobacterium tuberculosis growth in murine macrophages. Molecular bioSystems. 2011 Sep; 7(9):2622-36. doi: 10.1039/c1mb05106g. [PMID: 21713281]
  • Timo Mühlhaus, Julia Weiss, Dorothea Hemme, Frederik Sommer, Michael Schroda. Quantitative shotgun proteomics using a uniform ¹⁵N-labeled standard to monitor proteome dynamics in time course experiments reveals new insights into the heat stress response of Chlamydomonas reinhardtii. Molecular & cellular proteomics : MCP. 2011 Sep; 10(9):M110.004739. doi: 10.1074/mcp.m110.004739. [PMID: 21610104]
  • Asfaw Degu, Bayissa Hatew, Adriano Nunes-Nesi, Ludmila Shlizerman, Naftali Zur, Ehud Katz, Alisdair R Fernie, Eduardo Blumwald, Avi Sadka. Inhibition of aconitase in citrus fruit callus results in a metabolic shift towards amino acid biosynthesis. Planta. 2011 Sep; 234(3):501-13. doi: 10.1007/s00425-011-1411-2. [PMID: 21528417]
  • O A Safonova, T N Popova, L F Panchenko. Effects of 2,4-dimethoxyphenyl biguanide on glutathione system activity in rat tissues in brain ischemia-reperfusion. Bulletin of experimental biology and medicine. 2011 Sep; 151(5):556-9. doi: 10.1007/s10517-011-1381-1. [PMID: 22462044]
  • Morten R Clausen, Kirstine L Christensen, Mette S Hedemann, Ying Liu, Stig Purup, Mette Schmidt, Henrik Callesen, Jan Stagsted, Hanne C Bertram. Metabolomic phenotyping of a cloned pig model. BMC physiology. 2011 Aug; 11(?):14. doi: 10.1186/1472-6793-11-14. [PMID: 21859467]
  • Juergen Scharner, Peter S Zammit. The muscle satellite cell at 50: the formative years. Skeletal muscle. 2011 Aug; 1(1):28. doi: 10.1186/2044-5040-1-28. [PMID: 21849021]
  • Lee D Roberts, Andrew J Murray, David Menassa, Tom Ashmore, Andrew W Nicholls, Julian L Griffin. The contrasting roles of PPARδ and PPARγ in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue. Genome biology. 2011 Aug; 12(8):R75. doi: 10.1186/gb-2011-12-8-r75. [PMID: 21843327]
  • Adam N Famoso, Keyan Zhao, Randy T Clark, Chih-Wei Tung, Mark H Wright, Carlos Bustamante, Leon V Kochian, Susan R McCouch. Genetic architecture of aluminum tolerance in rice (Oryza sativa) determined through genome-wide association analysis and QTL mapping. PLoS genetics. 2011 Aug; 7(8):e1002221. doi: 10.1371/journal.pgen.1002221. [PMID: 21829395]
  • Jordan Hay, Jörg Schwender. Computational analysis of storage synthesis in developing Brassica napus L. (oilseed rape) embryos: flux variability analysis in relation to ¹³C metabolic flux analysis. The Plant journal : for cell and molecular biology. 2011 Aug; 67(3):513-25. doi: 10.1111/j.1365-313x.2011.04611.x. [PMID: 21501261]