Ethyl icosapentate (BioDeep_00000002664)
Secondary id: BioDeep_00001871069
human metabolite Endogenous
代谢物信息卡片
ethyl (5Z,8Z,11Z,14Z,17E)-icosa-5,8,11,14,17-pentaenoate
化学式: C22H34O2 (330.2558664)
中文名称:
谱图信息:
最多检出来源 Rattus norvegicus(lipidomics) 71.05%
分子结构信息
SMILES: CCC=CCC=CCC=CCC=CCC=CCCCC(=O)OCC
InChI: InChI=1S/C22H34O2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24-4-2/h5-6,8-9,11-12,14-15,17-18H,3-4,7,10,13,16,19-21H2,1-2H3/b6-5+,9-8-,12-11-,15-14-,18-17-
描述信息
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:182156
- KEGG: C13364
- PubChem: 23724822
- PubChem: 3298
- HMDB: HMDB0039530
- CAS: 73310-10-8
- PMhub: MS000004340
- PubChem: 586108
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Michael Szarek, Deepak L Bhatt, Michael Miller, Eliot A Brinton, Terry A Jacobson, Jean-Claude Tardif, Christie M Ballantyne, R Preston Mason, Steven B Ketchum, Armando Lira Pineda, Ralph T Doyle, Ph Gabriel Steg. Lipoprotein(a) Blood Levels and Cardiovascular Risk Reduction With Icosapent Ethyl.
Journal of the American College of Cardiology.
2024 Apr; 83(16):1529-1539. doi:
10.1016/j.jacc.2024.02.016. [PMID: 38530686] - Neila Sayah, Deepak L Bhatt, Michael Miller, Eliot A Brinton, Terry A Jacobson, Steven B Ketchum, Lixia Jiao, Armando Lira Pineda, Ralph T Doyle, Jean Claude Tardif, Christie M Ballantyne, Ph Gabriel Steg. Icosapent ethyl following acute coronary syndrome: the REDUCE-IT trial.
European heart journal.
2024 Apr; 45(13):1173-1176. doi:
10.1093/eurheartj/ehad889. [PMID: 38252107] - William S Weintraub, Deepak L Bhatt, Zugui Zhang, Sarahfaye Dolman, William E Boden, Adam P Bress, Brandon K Bellows, Catherine G Derington, Sephy Philip, Gabriel Steg, Michael Miller, Eliot A Brinton, Terry A Jacobson, Jean-Claude Tardif, Christie M Ballantyne, Paul Kolm. Cost-Effectiveness of Icosapent Ethyl in REDUCE-IT USA: Results From Patients Randomized in the United States.
Journal of the American Heart Association.
2024 Jan; 13(1):e032413. doi:
10.1161/jaha.123.032413. [PMID: 38156550] - Zhen Wang, Xin Zhang, Yanling Qu, Shuyang Zhang, Yundai Chen, Xiaoping Chen, Xin Qi, Peijing Liu, Shuqin Liu, Shan Jiang, Ronghai Man, Liping He, Ling Wu, Zhanquan Li, Yijun Shang, Zhaohui Qiu, Feng Liu, Chenhong Xu, Chunlin Lai, Junbo Ge. Icosapent ethyl therapy for very high triglyceride levels: a 12-week, multi-center, placebo-controlled, randomized, double-blinded, phase III clinical trial in China.
Lipids in health and disease.
2023 Jun; 22(1):71. doi:
10.1186/s12944-023-01838-8. [PMID: 37301827] - Magnus Bäck. Icosapent ethyl in cardiovascular prevention: Resolution of inflammation through the eicosapentaenoic acid - resolvin E1 - ChemR23 axis.
Pharmacology & therapeutics.
2023 May; ?(?):108439. doi:
10.1016/j.pharmthera.2023.108439. [PMID: 37201735] - Brian Olshansky, Deepak L Bhatt, Michael Miller, Ph Gabriel Steg, Eliot A Brinton, Terry A Jacobson, Steven B Ketchum, Ralph T Doyle, Rebecca A Juliano, Lixia Jiao, Peter R Kowey, James A Reiffel, Jean-Claude Tardif, Christie M Ballantyne, Mina K Chung. Cardiovascular Benefits of Icosapent Ethyl in Patients With and Without Atrial Fibrillation in REDUCE-IT.
Journal of the American Heart Association.
2023 03; 12(5):e026756. doi:
10.1161/jaha.121.026756. [PMID: 36802845] - Michael Miller, Deepak L Bhatt, Ph Gabriel Steg, Eliot A Brinton, Terry A Jacobson, Lixia Jiao, Jean-Claude Tardif, Christie M Ballantyne, Matthew Budoff, R Preston Mason. Potential effects of icosapent ethyl on cardiovascular outcomes in cigarette smokers: REDUCE-IT smoking.
European heart journal. Cardiovascular pharmacotherapy.
2023 02; 9(2):129-137. doi:
10.1093/ehjcvp/pvac045. [PMID: 35953437] - Mengyuan Yi, Yue You, Yiren Zhang, Gangcheng Wu, Emad Karrar, Le Zhang, Hui Zhang, Qingzhe Jin, Xingguo Wang. Highly Valuable Fish Oil: Formation Process, Enrichment, Subsequent Utilization, and Storage of Eicosapentaenoic Acid Ethyl Esters.
Molecules (Basel, Switzerland).
2023 Jan; 28(2):. doi:
10.3390/molecules28020672. [PMID: 36677730] - Juan Pedro-Botet, Vivencio Barrios, Víctor Sánchez-Margalet, Juan Tamargo, Francisco Arrieta, José Mª Gámez, José Antonio Gimeno-Orna, Carlos Escobar, Juan José Gómez-Doblas, Antonio Pérez. Treatment of hypertriglyceridaemia with icosapent ethyl in patients with high/very high cardiovascular risk. Consensus document of the Sociedad Española de Cardiología [Spanish Society of Cardiology] and the Sociedad Española de Diabetes [Spanish Diabetes Society].
Endocrinologia, diabetes y nutricion.
2022 Nov; ?(?):. doi:
10.1016/j.endien.2022.11.009. [PMID: 36402735] - M John Chapman, Jose L Zamorano, Klaus G Parhofer. Reducing residual cardiovascular risk in Europe: Therapeutic implications of European medicines agency approval of icosapent ethyl/eicosapentaenoic acid.
Pharmacology & therapeutics.
2022 09; 237(?):108172. doi:
10.1016/j.pharmthera.2022.108172. [PMID: 35304222] - Paul M Ridker, Nader Rifai, Jean MacFadyen, Robert J Glynn, Lixia Jiao, Ph Gabriel Steg, Michael Miller, Eliot A Brinton, Terry A Jacobson, Jean-Claude Tardif, Christie M Ballantyne, R Preston Mason, Deepak L Bhatt. Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1β, Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein-Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy.
Circulation.
2022 08; 146(5):372-379. doi:
10.1161/circulationaha.122.059410. [PMID: 35762321] - Michael Miller, Lale Tokgozoglu, Klaus G Parhofer, Yehuda Handelsman, Lawrence A Leiter, Ulf Landmesser, Eliot A Brinton, Alberico L Catapano. Icosapent ethyl for reduction of persistent cardiovascular risk: a critical review of major medical society guidelines and statements.
Expert review of cardiovascular therapy.
2022 Aug; 20(8):609-625. doi:
10.1080/14779072.2022.2103541. [PMID: 35876118] - Daniel Tobias Michaeli, Julia Caroline Michaeli, Tobias Boch, Thomas Michaeli. Cost-Effectiveness of Icosapent Ethyl, Evolocumab, Alirocumab, Ezetimibe, or Fenofibrate in Combination with Statins Compared to Statin Monotherapy.
Clinical drug investigation.
2022 Aug; 42(8):643-656. doi:
10.1007/s40261-022-01173-3. [PMID: 35819632] - Nick S R Lan, Umar S Ali, Robert Larbalestier, Girish Dwivedi, Damon A Bell. An Opportunity to Improve Secondary Prevention With Icosapent Ethyl in Patients Who Have Undergone Coronary Artery Bypass Graft Surgery.
Cardiovascular revascularization medicine : including molecular interventions.
2022 08; 41(?):170-172. doi:
10.1016/j.carrev.2021.12.025. [PMID: 34974987] - Prakriti Gaba, Deepak L Bhatt, Ph Gabriel Steg, Michael Miller, Eliot A Brinton, Terry A Jacobson, Steven B Ketchum, Rebecca A Juliano, Lixia Jiao, Ralph T Doyle, Craig Granowitz, Jean-Claude Tardif, Robert P Giugliano, Fabrice M A C Martens, C Michael Gibson, Christie M Ballantyne. Prevention of Cardiovascular Events and Mortality With Icosapent Ethyl in Patients With Prior Myocardial Infarction.
Journal of the American College of Cardiology.
2022 05; 79(17):1660-1671. doi:
10.1016/j.jacc.2022.02.035. [PMID: 35483753] - Senthil Selvaraj, Deepak L Bhatt, Ph Gabriel Steg, Michael Miller, Eliot A Brinton, Terry A Jacobson, Rebecca A Juliano, Lixia Jiao, Jean-Claude Tardif, Christie M Ballantyne. Impact of Icosapent Ethyl on Cardiovascular Risk Reduction in Patients With Heart Failure in REDUCE-IT.
Journal of the American Heart Association.
2022 04; 11(7):e024999. doi:
10.1161/jaha.121.024999. [PMID: 35377160] - Kevin C Maki, Harold E Bays, Christie M Ballantyne, James A Underberg, John J P Kastelein, Judith B Johnson, James J Ferguson. A Head-to-Head Comparison of a Free Fatty Acid Formulation of Omega-3 Pentaenoic Acids Versus Icosapent Ethyl in Adults With Hypertriglyceridemia: The ENHANCE-IT Study.
Journal of the American Heart Association.
2022 03; 11(6):e024176. doi:
10.1161/jaha.121.024176. [PMID: 35232215] - Benjamin E Peterson, Deepak L Bhatt, Ph Gabriel Steg, Michael Miller, Eliot A Brinton, Terry A Jacobson, Steven B Ketchum, Rebecca A Juliano, Lixia Jiao, Ralph T Doyle, Craig Granowitz, C Michael Gibson, Duane Pinto, Robert P Giugliano, Matthew J Budoff, Jean-Claude Tardif, Subodh Verma, Christie M Ballantyne. Treatment With Icosapent Ethyl to Reduce Ischemic Events in Patients With Prior Percutaneous Coronary Intervention: Insights From REDUCE-IT PCI.
Journal of the American Heart Association.
2022 03; 11(6):e022937. doi:
10.1161/jaha.121.022937. [PMID: 35261279] - Nickpreet Singh, Deepak L Bhatt, Michael Miller, Ph Gabriel Steg, Eliot A Brinton, Terry A Jacobson, Lixia Jiao, Jean-Claude Tardif, R Preston Mason, Christie M Ballantyne. Consistency of Benefit of Icosapent Ethyl by Background Statin Type in REDUCE-IT.
Journal of the American College of Cardiology.
2022 01; 79(2):220-222. doi:
10.1016/j.jacc.2021.11.005. [PMID: 35027114] - Manan Pareek, R Preston Mason, Deepak L Bhatt. Icosapent ethyl: safely reducing cardiovascular risk in adults with elevated triglycerides.
Expert opinion on drug safety.
2022 Jan; 21(1):31-42. doi:
10.1080/14740338.2021.1954158. [PMID: 34253137] - Subodh Verma, Deepak L Bhatt, Ph Gabriel Steg, Michael Miller, Eliot A Brinton, Terry A Jacobson, Nitish K Dhingra, Steven B Ketchum, Rebecca A Juliano, Lixia Jiao, Ralph T Doyle, Craig Granowitz, C Michael Gibson, Duane Pinto, Robert P Giugliano, Matthew J Budoff, R Preston Mason, Jean-Claude Tardif, Christie M Ballantyne. Icosapent Ethyl Reduces Ischemic Events in Patients With a History of Previous Coronary Artery Bypass Grafting: REDUCE-IT CABG.
Circulation.
2021 12; 144(23):1845-1855. doi:
10.1161/circulationaha.121.056290. [PMID: 34710343] - Arjun Majithia, Deepak L Bhatt, Allon N Friedman, Michael Miller, Ph Gabriel Steg, Eliot A Brinton, Terry A Jacobson, Steven B Ketchum, Rebecca A Juliano, Lixia Jiao, Ralph T Doyle, Craig Granowitz, Matthew Budoff, R Preston Mason, Jean-Claude Tardif, William E Boden, Christie M Ballantyne. Benefits of Icosapent Ethyl Across the Range of Kidney Function in Patients With Established Cardiovascular Disease or Diabetes: REDUCE-IT RENAL.
Circulation.
2021 11; 144(22):1750-1759. doi:
10.1161/circulationaha.121.055560. [PMID: 34706555] - Prakriti Gaba, Deepak L Bhatt, Robert P Giugliano, Ph Gabriel Steg, Michael Miller, Eliot A Brinton, Terry A Jacobson, Steven B Ketchum, Rebecca A Juliano, Lixia Jiao, Ralph T Doyle, Craig Granowitz, Jean-Claude Tardif, Christie M Ballantyne, Duane S Pinto, Matthew J Budoff, C Michael Gibson. Comparative Reductions in Investigator-Reported and Adjudicated Ischemic Events in REDUCE-IT.
Journal of the American College of Cardiology.
2021 10; 78(15):1525-1537. doi:
10.1016/j.jacc.2021.08.009. [PMID: 34620410] - R Preston Mason, Robert H Eckel. Mechanistic Insights from REDUCE-IT STRENGTHen the Case Against Triglyceride Lowering as a Strategy for Cardiovascular Disease Risk Reduction.
The American journal of medicine.
2021 09; 134(9):1085-1090. doi:
10.1016/j.amjmed.2021.03.014. [PMID: 33864765] - Wan-Chi Chang, Jisun So, Stefania Lamon-Fava. Differential and shared effects of eicosapentaenoic acid and docosahexaenoic acid on serum metabolome in subjects with chronic inflammation.
Scientific reports.
2021 08; 11(1):16324. doi:
10.1038/s41598-021-95590-7. [PMID: 34381108] - John R Nelson, Matthew J Budoff, Omar R Wani, Viet Le, Dhiren K Patel, Ashley Nelson, Richard L Nemiroff. EPA's pleiotropic mechanisms of action: a narrative review.
Postgraduate medicine.
2021 Aug; 133(6):651-664. doi:
10.1080/00325481.2021.1921491. [PMID: 33900135] - Glen J Pearson, George Thanassoulis, Todd J Anderson, Arden R Barry, Patrick Couture, Natalie Dayan, Gordon A Francis, Jacques Genest, Jean Grégoire, Steven A Grover, Milan Gupta, Robert A Hegele, David Lau, Lawrence A Leiter, Alexander A Leung, Eva Lonn, G B John Mancini, Priya Manjoo, Ruth McPherson, Daniel Ngui, Marie-Eve Piché, Paul Poirier, John Sievenpiper, James Stone, Rick Ward, Wendy Wray. 2021 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in Adults.
The Canadian journal of cardiology.
2021 08; 37(8):1129-1150. doi:
10.1016/j.cjca.2021.03.016. [PMID: 33781847] - John T Wilkins, Donald M Lloyd-Jones. Novel Lipid-Lowering Therapies to Reduce Cardiovascular Risk.
JAMA.
2021 Jul; 326(3):266-267. doi:
10.1001/jama.2021.2244. [PMID: 34283191] - Andrew P Ambrosy, Umar I Malik, Rachel C Thomas, Rishi V Parikh, Thida C Tan, Choon H Goh, Van N Selby, Matthew D Solomon, Harshith R Avula, Jesse K Fitzpatrick, Jacek Skarbinski, Sephy Philip, Craig Granowitz, Deepak L Bhatt, Alan S Go. Rationale and design of the pragmatic randomized trial of icosapent ethyl for high cardiovascular risk adults (MITIGATE).
American heart journal.
2021 05; 235(?):54-64. doi:
10.1016/j.ahj.2021.01.018. [PMID: 33516752] - Gregory Curfman, Emile Shehada. Icosapent ethyl: scientific and legal controversies.
Open heart.
2021 04; 8(1):. doi:
10.1136/openhrt-2021-001616. [PMID: 33888593] - Mohammed A Abosheasha, Afnan H El-Gowily. Superiority of cilostazol among antiplatelet FDA-approved drugs against COVID 19 Mpro and spike protein: Drug repurposing approach.
Drug development research.
2021 04; 82(2):217-229. doi:
10.1002/ddr.21743. [PMID: 32984987] - Ho Na, Seung-Woo Jo, Jeong-Mi Do, Il-Sup Kim, Ho-Sung Yoon. Production of Algal Biomass and High-Value Compounds Mediated by Interaction of Microalgal Oocystis sp. KNUA044 and Bacterium Sphingomonas KNU100.
Journal of microbiology and biotechnology.
2021 Mar; 31(3):387-397. doi:
10.4014/jmb.2009.09055. [PMID: 33323676] - Matthew J Budoff, Joseph B Muhlestein, Deepak L Bhatt, Viet T Le Pa, Heidi T May, Kashif Shaikh, Chandana Shekar, April Kinninger, Suvasini Lakshmanan, Sion K Roy, John Tayek, John R Nelson. Effect of icosapent ethyl on progression of coronary atherosclerosis in patients with elevated triglycerides on statin therapy: a prospective, placebo-controlled randomized trial (EVAPORATE): interim results.
Cardiovascular research.
2021 03; 117(4):1070-1077. doi:
10.1093/cvr/cvaa184. [PMID: 32609331] - Vanessa Woodard, Melissa Thoene, Matthew Van Ormer, Maranda Thompson, Corrine Hanson, Sathish Kumar Natarajan, Maheswari Mukherjee, Ana Yuil-Valdes, Tara M Nordgren, Arzu Ulu, Kristina Harris Jackson, Ann Anderson-Berry. Intrauterine Transfer of Polyunsaturated Fatty Acids in Mother-Infant Dyads as Analyzed at Time of Delivery.
Nutrients.
2021 Mar; 13(3):. doi:
10.3390/nu13030996. [PMID: 33808763] - Adam H Metherel, Maha Irfan, Shannon L Klingel, David M Mutch, Richard P Bazinet. Higher Increase in Plasma DHA in Females Compared to Males Following EPA Supplementation May Be Influenced by a Polymorphism in ELOVL2: An Exploratory Study.
Lipids.
2021 03; 56(2):211-228. doi:
10.1002/lipd.12291. [PMID: 33174255] - Kei Hamazaki, Yutaka J Matsuoka, Taiki Yamaji, Norie Sawada, Masaru Mimura, Shoko Nozaki, Ryo Shikimoto, Shoichiro Tsugane. Plasma phospholipid n-3 polyunsaturated fatty acids and major depressive disorder in Japanese elderly: the Japan Public Health Center-based Prospective Study.
Scientific reports.
2021 02; 11(1):4003. doi:
10.1038/s41598-021-83478-5. [PMID: 33597590] - Artemis P Simopoulos, Charles N Serhan, Richard P Bazinet. The need for precision nutrition, genetic variation and resolution in Covid-19 patients.
Molecular aspects of medicine.
2021 02; 77(?):100943. doi:
10.1016/j.mam.2021.100943. [PMID: 33551236] - Naoaki Matsuo, Toru Miyoshi, Atsushi Takaishi, Takao Kishinoue, Kentaro Yasuhara, Masafumi Tanimoto, Yukari Nakano, Nobuhiko Onishi, Masayuki Ueeda, Hiroshi Ito. High Plasma Docosahexaenoic Acid Associated to Better Prognoses of Patients with Acute Decompensated Heart Failure with Preserved Ejection Fraction.
Nutrients.
2021 Jan; 13(2):. doi:
10.3390/nu13020371. [PMID: 33530352] - Estefania Aparicio, Carla Martín-Grau, Cristina Bedmar, Núria Serrat Serrat Orus, Josep Basora, Victoria Arija, The Eclipses Study Group. Maternal Factors Associated with Levels of Fatty Acids, Specifically n-3 PUFA during Pregnancy: ECLIPSES Study.
Nutrients.
2021 Jan; 13(2):. doi:
10.3390/nu13020317. [PMID: 33499257] - Leena Myran, Thanh-Nga Nguyen. Icosapent Ethyl (Vascepa) for Hyperlipidemia/Hypercholesterolemia to Reduce Risk of Heart Attack and Stroke.
American family physician.
2021 01; 103(2):117-118. doi:
". [PMID: 33448769] - Benjamin E Peterson, Deepak L Bhatt, Ph Gabriel Steg, Michael Miller, Eliot A Brinton, Terry A Jacobson, Steven B Ketchum, Rebecca A Juliano, Lixia Jiao, Ralph T Doyle, Craig Granowitz, C Michael Gibson, Duane Pinto, Robert P Giugliano, Matthew J Budoff, Jean-Claude Tardif, Subodh Verma, Christie M Ballantyne. Reduction in Revascularization With Icosapent Ethyl: Insights From REDUCE-IT Revascularization Analyses.
Circulation.
2021 01; 143(1):33-44. doi:
10.1161/circulationaha.120.050276. [PMID: 33148016] - Kamini Trivedi, Viet Le, John R Nelson. The case for adding eicosapentaenoic acid (icosapent ethyl) to the ABCs of cardiovascular disease prevention.
Postgraduate medicine.
2021 Jan; 133(1):28-41. doi:
10.1080/00325481.2020.1783937. [PMID: 32762268] - Toshinori Yasuzawa, Tomomi Nakamura, Shigeru Ueshima, Akira Mima. Protective Effects of Eicosapentaenoic Acid on the Glomerular Endothelium via Inhibition of EndMT in Diabetes.
Journal of diabetes research.
2021; 2021(?):2182225. doi:
10.1155/2021/2182225. [PMID: 34977254] - Koen Manusama, Michiel Balvers, Marlies Diepeveen-de Bruin, Laura Headley, Roberta Bosi, Michael Schwarm, Renger Witkamp. In vitro dissolution behaviour and absorption in humans of a novel mixed l-lysine salt formulation of EPA and DHA.
Prostaglandins, leukotrienes, and essential fatty acids.
2021 01; 164(?):102232. doi:
10.1016/j.plefa.2020.102232. [PMID: 33360684] - Winston Suh, Ivan Urits, Omar Viswanath, Alan D Kaye, Haresh Patel, Wade Hall, Jonathan P Eskander. Three Cases of COVID-19 Pneumonia That Responded to Icosapent Ethyl Supportive Treatment.
The American journal of case reports.
2020 Dec; 21(?):e928422. doi:
10.12659/ajcr.928422. [PMID: 33311431] - Subhankar Chatterjee, Adrija Hajra, Dhrubajyoti Bandyopadhyay, Raktim K Ghosh, Prakash C Deedwania. Defining the Role of Icosapent Ethyl in Clinical Practice.
American journal of cardiovascular drugs : drugs, devices, and other interventions.
2020 Dec; 20(6):517-524. doi:
10.1007/s40256-020-00402-4. [PMID: 32157567] - Nathan D Wong, Wenjun Fan, Sephy Philip, Craig Granowitz, Peter P Toth. REDUCE-IT Eligibility and Preventable Cardiovascular Events in the US Population (from the National Health and Nutrition Examination Survey [NHANES]).
The American journal of cardiology.
2020 11; 134(?):62-68. doi:
10.1016/j.amjcard.2020.08.015. [PMID: 32933754] - Xiaoming Jia, Mahmoud Al Rifai, Aliza Hussain, Seth Martin, Anandita Agarwala, Salim S Virani. Highlights from Studies in Cardiovascular Disease Prevention Presented at the Digital 2020 European Society of Cardiology Congress: Prevention Is Alive and Well.
Current atherosclerosis reports.
2020 10; 22(12):72. doi:
10.1007/s11883-020-00895-z. [PMID: 33009957] - Le Li, Ying Xia, Shunbo Zhao, Li Ding, Shunli Ji. LC-APCI-MS/MS assay for quantitation of ethyl esters of eicosapentaenoic acid and docosahexaenoic acid in human plasma and its application in a pharmacokinetic study.
Biomedical chromatography : BMC.
2020 Oct; 34(10):e4905. doi:
10.1002/bmc.4905. [PMID: 32449539] - John Climax, Philip N Newsome, Moayed Hamza, Markus Weissbach, David Coughlan, Naveed Sattar, Darren K McGuire, Deepak L Bhatt. Effects of Epeleuton, a Novel Synthetic Second-Generation n-3 Fatty Acid, on Non-Alcoholic Fatty Liver Disease, Triglycerides, Glycemic Control, and Cardiometabolic and Inflammatory Markers.
Journal of the American Heart Association.
2020 08; 9(16):e016334. doi:
10.1161/jaha.119.016334. [PMID: 32779505] - Najdat Bazarbashi, Michael Miller. Icosapent Ethyl: Niche Drug or for the Masses?.
Current cardiology reports.
2020 08; 22(10):104. doi:
10.1007/s11886-020-01356-4. [PMID: 32770402] - Wei-Ting Chen, Syue-Yi Chen, De-Wei Wu, Cheng-Che Lee, Tsung-Ming Lee. Effect of icosapent ethyl on susceptibility to ventricular arrhythmias in postinfarcted rat hearts: Role of GPR120-mediated connexin43 phosphorylation.
Journal of cellular and molecular medicine.
2020 08; 24(16):9267-9279. doi:
10.1111/jcmm.15575. [PMID: 32639107] - Dave L Dixon. Catch of the Day: Icosapent Ethyl for Reducing Cardiovascular Risk.
The American journal of medicine.
2020 07; 133(7):802-804. doi:
10.1016/j.amjmed.2020.03.006. [PMID: 32243872] - William E Boden, Deepak L Bhatt, Peter P Toth, Kausik K Ray, M John Chapman, Thomas F Lüscher. Profound reductions in first and total cardiovascular events with icosapent ethyl in the REDUCE-IT trial: why these results usher in a new era in dyslipidaemia therapeutics.
European heart journal.
2020 06; 41(24):2304-2312. doi:
10.1093/eurheartj/ehz778. [PMID: 31872245] - Xiaoming Jia, Mahmoud Al Rifai, Jing Liu, Anandita Agarwala, Martha Gulati, Salim S Virani. Highlights of Studies in Cardiovascular Disease Prevention Presented at the 2020 American College of Cardiology Annual Scientific Session.
Current atherosclerosis reports.
2020 06; 22(8):32. doi:
10.1007/s11883-020-00856-6. [PMID: 32556778] - Aliza Hussain, Christie M Ballantyne, Anum Saeed, Salim S Virani. Triglycerides and ASCVD Risk Reduction: Recent Insights and Future Directions.
Current atherosclerosis reports.
2020 06; 22(7):25. doi:
10.1007/s11883-020-00846-8. [PMID: 32494924] - Chen Fan, Lijiao Wen, Xueli Cao. A biphasic system based on guanidinium ionic liquid: Preparative separation of eicosapentaenoic acid ethyl ester and docosahexaenoic acid ethyl ester by countercurrent chromatography.
Journal of chromatography. A.
2020 May; 1618(?):460872. doi:
10.1016/j.chroma.2020.460872. [PMID: 31959458] - Najdat Bazarbashi, Michael Miller. Icosapent ethyl: drug profile and evidence of reduced residual cardiovascular risk in patients with statin-managed LDL-C cholesterol.
Expert review of cardiovascular therapy.
2020 Apr; 18(4):175-180. doi:
10.1080/14779072.2020.1749596. [PMID: 32228246] - Juan Carlos Solomando, Teresa Antequera, Trinidad Perez-Palacios. Evaluating the use of fish oil microcapsules as omega-3 vehicle in cooked and dry-cured sausages as affected by their processing, storage and cooking.
Meat science.
2020 Apr; 162(?):108031. doi:
10.1016/j.meatsci.2019.108031. [PMID: 31864039] - Xi Xue, Jennifer R Hall, Albert Caballero-Solares, Khalil Eslamloo, Richard G Taylor, Christopher C Parrish, Matthew L Rise. Liver Transcriptome Profiling Reveals That Dietary DHA and EPA Levels Influence Suites of Genes Involved in Metabolism, Redox Homeostasis, and Immune Function in Atlantic Salmon (Salmo salar).
Marine biotechnology (New York, N.Y.).
2020 Apr; 22(2):263-284. doi:
10.1007/s10126-020-09950-x. [PMID: 32040779] - Lingyu Zhang, Lin Ding, Haohao Shi, Chengcheng Wang, Changhu Xue, Tiantian Zhang, Yuming Wang. Eicosapentaenoic acid-enriched phospholipids suppressed lipid accumulation by specific inhibition of lipid droplet-associated protein FSP27 in mice.
Journal of the science of food and agriculture.
2020 Mar; 100(5):2244-2251. doi:
10.1002/jsfa.10250. [PMID: 31919850] - Ye Yuan, Xuexi Wang, Min Jin, Lefei Jiao, Peng Sun, Mónica B Betancor, Douglas R Tocher, Qicun Zhou. Modification of nutritional values and flavor qualities of muscle of swimming crab (Portunus trituberculatus): Application of a dietary lipid nutrition strategy.
Food chemistry.
2020 Mar; 308(?):125607. doi:
10.1016/j.foodchem.2019.125607. [PMID: 31677599] - Philippa A Jackson, Cathrine Husberg, Svein-Olaf Hustvedt, Philip C Calder, Julie Khan, Hannah Avery, Joanne Forster, David O Kennedy. Diurnal rhythm of plasma EPA and DHA in healthy adults.
Prostaglandins, leukotrienes, and essential fatty acids.
2020 03; 154(?):102054. doi:
10.1016/j.plefa.2020.102054. [PMID: 32018166] - Deepak L Bhatt, Michael Miller, Eliot A Brinton, Terry A Jacobson, Ph Gabriel Steg, Steven B Ketchum, Ralph T Doyle, Rebecca A Juliano, Lixia Jiao, Craig Granowitz, Jean-Claude Tardif, Brian Olshansky, Mina K Chung, C Michael Gibson, Robert P Giugliano, Matthew J Budoff, Christie M Ballantyne. REDUCE-IT USA: Results From the 3146 Patients Randomized in the United States.
Circulation.
2020 02; 141(5):367-375. doi:
10.1161/circulationaha.119.044440. [PMID: 31707829] - Jodi C McDaniel, Jamie Rausch, Alai Tan. Impact of omega-3 fatty acid oral therapy on healing of chronic venous leg ulcers in older adults: Study protocol for a randomized controlled single-center trial.
Trials.
2020 Jan; 21(1):93. doi:
10.1186/s13063-019-3970-7. [PMID: 31948466] - José Alejandro Roque-Jimenez, Mario Francisco Oviedo-Ojeda, Megan Whalin, Héctor Aaron Lee-Rangel, Alejandro Enrique Relling. Eicosapentaenoic and docosahexaenoic acid supplementation during early gestation modified relative abundance on placenta and fetal liver tissue mRNA and concentration pattern of fatty acids in fetal liver and fetal central nervous system of sheep.
PloS one.
2020; 15(6):e0235217. doi:
10.1371/journal.pone.0235217. [PMID: 32574225] - Luciana Gomes, Leidiane Viana, Jerson L Silva, Claudia Mermelstein, Georgia Atella, Eliane Fialho. Resveratrol Modifies Lipid Composition of Two Cancer Cell Lines.
BioMed research international.
2020; 2020(?):5393041. doi:
10.1155/2020/5393041. [PMID: 32149115] - Pablo Perez-Martinez, Niki Katsiki, Dimitri P Mikhailidis. The Role of n-3 Fatty Acids in Cardiovascular Disease: Back to the Future.
Angiology.
2020 01; 71(1):10-16. doi:
10.1177/0003319719842005. [PMID: 30966756] - Vera A Bittner, Terry A Jacobson, Christie M Ballantyne, John R Guyton. JCL roundtable: Omega-3 fatty acids and cardiovascular outcomes.
Journal of clinical lipidology.
2020 Jan; 14(1):4-15. doi:
10.1016/j.jacl.2020.02.004. [PMID: 32192643] - P A Olsvik, S K Hammer, M Sanden, L Søfteland. Chlorpyrifos-induced dysfunction of lipid metabolism is not restored by supplementation of polyunsaturated fatty acids EPA and ARA in Atlantic salmon liver cells.
Toxicology in vitro : an international journal published in association with BIBRA.
2019 Dec; 61(?):104655. doi:
10.1016/j.tiv.2019.104655. [PMID: 31536758] - Jing Zhang, Ningping Tao, Yueliang Zhao, Xichang Wang, Mingfu Wang. Comparison of the Fatty Acid and Triglyceride Profiles of Big Eye Tuna (Thunnus obesus), Atlantic salmon (Salmo salar) and Bighead Carp (Aristichthysnobilis) Heads.
Molecules (Basel, Switzerland).
2019 Nov; 24(21):. doi:
10.3390/molecules24213983. [PMID: 31689924] - Michael Miller. Icosapent ethyl for hypertriglyceridemia: insights from the REDUCE-IT Trial.
Future cardiology.
2019 11; 15(6):391-394. doi:
10.2217/fca-2019-0054. [PMID: 31524535] - Yi Cui, Skye R Thomas-Hall, Peer M Schenk. Phaeodactylum tricornutum microalgae as a rich source of omega-3 oil: Progress in lipid induction techniques towards industry adoption.
Food chemistry.
2019 Nov; 297(?):124937. doi:
10.1016/j.foodchem.2019.06.004. [PMID: 31253257] - Carl E Orringer, Terry A Jacobson, Kevin C Maki. National Lipid Association Scientific Statement on the use of icosapent ethyl in statin-treated patients with elevated triglycerides and high or very-high ASCVD risk.
Journal of clinical lipidology.
2019 Nov; 13(6):860-872. doi:
10.1016/j.jacl.2019.10.014. [PMID: 31787586] - Parth N Patel, Siddharth M Patel, Deepak L Bhatt. Cardiovascular risk reduction with icosapent ethyl.
Current opinion in cardiology.
2019 11; 34(6):721-727. doi:
10.1097/hco.0000000000000678. [PMID: 31464773] - Jeyakumar Balakrishnan, Sugasini Dhavamani, Selvam Govindan Sadasivam, Muthu Arumugam, Sampathrajan Vellaikumar, Jagadeesan Ramalingam, Kathiresan Shanmugam. Omega-3-rich Isochrysis sp. biomass enhances brain docosahexaenoic acid levels and improves serum lipid profile and antioxidant status in Wistar rats.
Journal of the science of food and agriculture.
2019 Oct; 99(13):6066-6075. doi:
10.1002/jsfa.9884. [PMID: 31228262] - Manesh Gopaldas, Francesca Zanderigo, Serena Zhan, R Todd Ogden, Jeffrey M Miller, Harry Rubin-Falcone, Thomas B Cooper, Maria A Oquendo, Gregory Sullivan, J John Mann, M Elizabeth Sublette. Brain serotonin transporter binding, plasma arachidonic acid and depression severity: A positron emission tomography study of major depression.
Journal of affective disorders.
2019 10; 257(?):495-503. doi:
10.1016/j.jad.2019.07.035. [PMID: 31319341] - Vera Bittner. Implications for REDUCE IT in clinical practice.
Progress in cardiovascular diseases.
2019 Sep; 62(5):395-400. doi:
10.1016/j.pcad.2019.11.003. [PMID: 31715195] - Lan Gao, Marj Moodie, Shu-Chuen Li. The cost-effectiveness of omega-3 polyunsaturated fatty acids - The Australian healthcare perspective.
European journal of internal medicine.
2019 Sep; 67(?):70-76. doi:
10.1016/j.ejim.2019.07.001. [PMID: 31285124] - Hyunsin H Sung, Andrew J Sinclair, Kevin Huynh, Alexander T Smith, Natalie A Mellett, Peter J Meikle, Xiao Q Su. Differential plasma postprandial lipidomic responses to krill oil and fish oil supplementations in women: A randomized crossover study.
Nutrition (Burbank, Los Angeles County, Calif.).
2019 09; 65(?):191-201. doi:
10.1016/j.nut.2019.03.021. [PMID: 31201957] - William S Harris, Kristina H Jackson. Translating plasma eicosapentaenoic acid concentrations into erythrocyte percentages of eicosapentaenoic acid plus docosahexaenoic acid during treatment with icosapent ethyl.
Journal of clinical lipidology.
2019 Sep; 13(5):771-777. doi:
10.1016/j.jacl.2019.07.001. [PMID: 31401072] - Michael Miller, Christie M Ballantyne, Harold E Bays, Craig Granowitz, Ralph T Doyle, Rebecca A Juliano, Sephy Philip. Effects of Icosapent Ethyl (Eicosapentaenoic Acid Ethyl Ester) on Atherogenic Lipid/Lipoprotein, Apolipoprotein, and Inflammatory Parameters in Patients With Elevated High-Sensitivity C-Reactive Protein (from the ANCHOR Study).
The American journal of cardiology.
2019 09; 124(5):696-701. doi:
10.1016/j.amjcard.2019.05.057. [PMID: 31277790] - Xiu-Qing Han, Ling-Yu Zhang, Lin Ding, Hao-Hao Shi, Chang-Hu Xue, Tian-Tian Zhang, Yu-Ming Wang. Synergistic effect of sea cucumber saponins and EPA-enriched phospholipids on insulin resistance in high-fat diet-induced obese mice.
Food & function.
2019 Jul; 10(7):3955-3964. doi:
10.1039/c9fo01147a. [PMID: 31199413] - Nick S R Lan, P Gerry Fegan, Bu B Yeap, James M Rankin, Gerald F Watts. Icosapent ethyl for dyslipidaemia in patients with diabetes and coronary artery disease: Act now to reduce it.
Diabetes, obesity & metabolism.
2019 07; 21(7):1734-1736. doi:
10.1111/dom.13689. [PMID: 30834678] - Meng Lee, Bruce Ovbiagele. Effect of icosapent ethyl on stroke risk: Different strokes for different folks?.
Journal of the neurological sciences.
2019 Jun; 401(?):127. doi:
10.1016/j.jns.2019.04.027. [PMID: 31077950] - Deepak L Bhatt, Ph Gabriel Steg, Michael Miller, Eliot A Brinton, Terry A Jacobson, Steven B Ketchum, Ralph T Doyle, Rebecca A Juliano, Lixia Jiao, Craig Granowitz, Jean-Claude Tardif, John Gregson, Stuart J Pocock, Christie M Ballantyne. Effects of Icosapent Ethyl on Total Ischemic Events: From REDUCE-IT.
Journal of the American College of Cardiology.
2019 06; 73(22):2791-2802. doi:
10.1016/j.jacc.2019.02.032. [PMID: 30898607] - Kirsten R Nickles, Lauren Hamer, Danielle N Coleman, Alejandro E Relling. Supplementation with eicosapentaenoic and docosahexaenoic acids in late gestation in ewes changes adipose tissue gene expression in the ewe and growth and plasma concentration of ghrelin in the offspring1.
Journal of animal science.
2019 May; 97(6):2631-2643. doi:
10.1093/jas/skz141. [PMID: 31073599] - Akira Sezai, Satoshi Unosawa, Makoto Taoka, Shunji Osaka, Kazuaki Obata, Sakie Kanno, Hisakuni Sekino, Masashi Tanaka. Long-Term Comparison of Ethyl Icosapentate vs. Omega-3-Acid Ethyl in Patients With Cardiovascular Disease and Hypertriglyceridemia (DEFAT Trial).
Circulation journal : official journal of the Japanese Circulation Society.
2019 05; 83(6):1368-1376. doi:
10.1253/circj.cj-18-0764. [PMID: 31006728] - Timothy H Ciesielski, Jacquelaine Bartlett, Scott M Williams. Omega-3 polyunsaturated fatty acid intake norms and preterm birth rate: a cross-sectional analysis of 184 countries.
BMJ open.
2019 04; 9(4):e027249. doi:
10.1136/bmjopen-2018-027249. [PMID: 31005937] - Małgorzata Szczuko, Małgorzata Kaczkan, Arleta Drozd, Dominika Maciejewska, Joanna Palma, Anna Owczarzak, Natalia Marczuk, Przemysław Rutkowski, Sylwia Małgorzewicz. Comparison of Fatty Acid Profiles in a Group of Female Patients with Chronic Kidney Diseases (CKD) and Metabolic Syndrome (MetS)⁻Similar Trends of Changes, Different Pathophysiology.
International journal of molecular sciences.
2019 Apr; 20(7):. doi:
10.3390/ijms20071719. [PMID: 30959940] - Shoug M Alashmali, Alex P Kitson, Lin Lin, R J Scott Lacombe, Richard P Bazinet. Maternal dietary n-6 polyunsaturated fatty acid deprivation does not exacerbate post-weaning reductions in arachidonic acid and its mediators in the mouse hippocampus.
Nutritional neuroscience.
2019 Apr; 22(4):223-234. doi:
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Current medical research and opinion.
2019 04; 35(4):587-593. doi:
10.1080/03007995.2018.1512479. [PMID: 30106311] - Xiang Wang, Shan-Wei Luo, Wanghaoyun Luo, Wei-Dong Yang, Jie-Sheng Liu, Hong-Ye Li. Adaptive evolution of microalgal strains empowered by fulvic acid for enhanced polyunsaturated fatty acid production.
Bioresource technology.
2019 Apr; 277(?):204-210. doi:
10.1016/j.biortech.2018.12.116. [PMID: 30630660] - Xiaofan Zhang, Shaochen Pang, Chengjie Liu, Houpeng Wang, Ding Ye, Zuoyan Zhu, Yonghua Sun. A Novel Dietary Source of EPA and DHA: Metabolic Engineering of an Important Freshwater Species-Common Carp by fat1-Transgenesis.
Marine biotechnology (New York, N.Y.).
2019 Apr; 21(2):171-185. doi:
10.1007/s10126-018-9868-7. [PMID: 30588551] - Miguel Ángel Rincón-Cervera, Valeria González-Barriga, Rodrigo Valenzuela, Sandra López-Arana, Jaime Romero, Alfonso Valenzuela. Profile and distribution of fatty acids in edible parts of commonly consumed marine fishes in Chile.
Food chemistry.
2019 Feb; 274(?):123-129. doi:
10.1016/j.foodchem.2018.08.113. [PMID: 30372916] - Maria Grazia Adelfi, Rosa Maria Vitale, Giuliana d'Ippolito, Genoveffa Nuzzo, Carmela Gallo, Pietro Amodeo, Emiliano Manzo, Dario Pagano, Simone Landi, Gianluca Picariello, Maria Immacolata Ferrante, Angelo Fontana. Patatin-like lipolytic acyl hydrolases and galactolipid metabolism in marine diatoms of the genus Pseudo-nitzschia.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2019 02; 1864(2):181-190. doi:
10.1016/j.bbalip.2018.11.008. [PMID: 30521937] - Chenchen Wang, Xiaohe Qing, Mingli Yu, Quanxi Sun, Fengzhen Liu, Baoxiu Qi, Xinzheng Li. Production of eicosapentaenoic acid (EPA, 20:5n-3) in transgenic peanut (Arachis hypogaea L.) through the alternative Δ8-desaturase pathway.
Molecular biology reports.
2019 Feb; 46(1):333-342. doi:
10.1007/s11033-018-4476-1. [PMID: 30511300] - Jie Peng, Yuanfei Zhou, Zhang Hong, Yinghui Wu, Anle Cai, Mao Xia, Zhao Deng, Yang Yang, Tongxing Song, Jia Xiong, Hongkui Wei, Jian Peng. Maternal eicosapentaenoic acid feeding promotes placental angiogenesis through a Sirtuin-1 independent inflammatory pathway.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2019 02; 1864(2):147-157. doi:
10.1016/j.bbalip.2018.11.003. [PMID: 30445165] - Deepak L Bhatt, P Gabriel Steg, Michael Miller, Eliot A Brinton, Terry A Jacobson, Steven B Ketchum, Ralph T Doyle, Rebecca A Juliano, Lixia Jiao, Craig Granowitz, Jean-Claude Tardif, Christie M Ballantyne. Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia.
The New England journal of medicine.
2019 01; 380(1):11-22. doi:
10.1056/nejmoa1812792. [PMID: 30415628]