Spectinomycin (BioDeep_00000002645)

 

Secondary id: BioDeep_00000398457

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(1R,3S,5R,8R,10R,11S,12S,13R,14S)-8,12,14-trihydroxy-5-methyl-11,13-bis(methylamino)-2,4,9-trioxatricyclo[8.4.0.0³,⁸]tetradecan-7-one

化学式: C14H24N2O7 (332.1583434)
中文名称: 大观霉素
谱图信息: 最多检出来源 Homo sapiens(blood) 3.91%

分子结构信息

SMILES: CC1CC(=O)C2(C(O1)OC3C(C(C(C(C3O2)NC)O)NC)O)O
InChI: InChI=1S/C14H24N2O7/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14/h5,7-13,15-16,18-20H,4H2,1-3H3

描述信息

Spectinomycin is only found in individuals that have used or taken this drug. It is an antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea. Spectinomycin is an inhibitor of protein synthesis in the bacterial cell; the site of action is the 30S ribosomal subunit. It is bactericidal in its action.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use
C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
KEIO_ID S044; [MS2] KO009242
KEIO_ID S044

同义名列表

42 个代谢物同义名

(1R,3S,5R,8R,10R,11S,12S,13R,14S)-8,12,14-trihydroxy-5-methyl-11,13-bis(methylamino)-2,4,9-trioxatricyclo[8.4.0.0³,⁸]tetradecan-7-one; Pharmacia spain brand OF spectinomycin dihydrochloride; Interpharm brand OF spectinomycin dihydrochloride; Pharmacia brand OF spectinomycin dihydrochloride; Chevita brand OF spectinomycin dihydrochloride; Sanofi brand OF spectinomycin dihydrochloride; Osborn brand OF spectinomycin dihydrochloride; Aspen brand OF spectinomycin dihydrochloride; CEVA brand OF spectinomycin dihydrochloride; Spectinomycin dihydrochloride, pentahydrate; Spectinomycin dihydrochloride, pharmacia; Spectinomycin dihydrochloride, anhydrous; Dihydrochloride, pharmacia spectinomycin; Pharmacia spectinomycin dihydrochloride; Anhydrous spectinomycin dihydrochloride; Pharmacia brand OF spectinomycin; Spectinomycin pharmacia brand; Valdar brand OF spectinomycin; Spectinomycin hcl/ sulphate; Spectinomycin hydrochloride; Spectinomycin valdar brand; Antibiotic 2233WP; Spectinomycinum; Spectam, ferkel; Actinospectacin; Espectinomicina; Specitinomycin; Spectinomycine; Spectinomicina; Ferkel spectam; Spectinomycin; Salmosan-T; Salmosan T; SalmosanT; Trobicin; Stanilo; Spectam; Prospec; Adspec; Kempi; SPCM; SCM



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Harry O Jackson, Henry N Taunt, Paweł M Mordaka, Sujata Kumari, Alison G Smith, Saul Purton. CpPosNeg: A positive-negative selection strategy allowing multiple cycles of marker-free engineering of the Chlamydomonas plastome. Biotechnology journal. 2022 Oct; 17(10):e2200088. doi: 10.1002/biot.202200088. [PMID: 35509114]
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  • Ji Luo, Xiaobo Li, Siyuan Dong, Peiyao Zhu, Wenke Liu, Shuguang Zhang, Jiang Du. Layer-by-layer coated hybrid nanoparticles with pH-sensitivity for drug delivery to treat acute lung infection. Drug delivery. 2021 Dec; 28(1):2460-2468. doi: 10.1080/10717544.2021.2000676. [PMID: 34766544]
  • Mercedes Gonzalez-Juarrero, Pradeep B Lukka, Santosh Wagh, Amanda Walz, Jennifer Arab, Camron Pearce, Zohaib Ali, Josiah T Ryman, Keyur Parmar, Zaid Temrikar, Juan Munoz-Gutierrez, Gregory T Robertson, Jiuyu Liu, Anne J Lenaerts, Charles Daley, Richard E Lee, Miriam Braunstein, Anthony J Hickey, Bernd Meibohm. Preclinical Evaluation of Inhalational Spectinamide-1599 Therapy against Tuberculosis. ACS infectious diseases. 2021 10; 7(10):2850-2863. doi: 10.1021/acsinfecdis.1c00213. [PMID: 34546724]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Serena Bettoni, Karolina Maziarz, M Rhia L Stone, Mark A T Blaskovich, Jan Potempa, Maria Luiza Bazzo, Magnus Unemo, Sanjay Ram, Anna M Blom. Serum Complement Activation by C4BP-IgM Fusion Protein Can Restore Susceptibility to Antibiotics in Neisseria gonorrhoeae. Frontiers in immunology. 2021; 12(?):726801. doi: 10.3389/fimmu.2021.726801. [PMID: 34539665]
  • Mohamed A Seleem, Nathalia Rodrigues de Almeida, Yashpal Singh Chhonker, Daryl J Murry, Zaira da Rosa Guterres, Amanda M Blocker, Shiomi Kuwabara, Derek J Fisher, Emilse S Leal, Manuela R Martinefski, Mariela Bollini, María Eugenia Monge, Scot P Ouellette, Martin Conda-Sheridan. Synthesis and Antichlamydial Activity of Molecules Based on Dysregulators of Cylindrical Proteases. Journal of medicinal chemistry. 2020 04; 63(8):4370-4387. doi: 10.1021/acs.jmedchem.0c00371. [PMID: 32227948]
  • Samiha A Hussein, Baher I Salman, Marwa F B Ali, Mostafa A Marzouq. Development of sensitive benzofurazan-based spectrometric methods for analysis of spectinomycin in vials and human biological samples. Luminescence : the journal of biological and chemical luminescence. 2019 Dec; 34(8):895-902. doi: 10.1002/bio.3688. [PMID: 31379072]
  • Q Ren, C Y Zhang, X F Ma, R Z Cheng, X Y Bian, X L Xiao, X Z Liu, H F Zhou. [Spectomycin B1 induces VEGFR2 de-SUMO modification to inhibit angiogenesis in nasopharyngeal carcinoma]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. 2019 Dec; 33(12):1181-1184. doi: 10.13201/j.issn.1001-1781.2019.12.016. [PMID: 31914270]
  • Chetan Rathi, Pradeep B Lukka, Santosh Wagh, Richard E Lee, Anne J Lenaerts, Miriam Braunstein, Anthony Hickey, Mercedes Gonzalez-Juarrero, Bernd Meibohm. Comparative pharmacokinetics of spectinamide 1599 after subcutaneous and intrapulmonary aerosol administration in mice. Tuberculosis (Edinburgh, Scotland). 2019 01; 114(?):119-122. doi: 10.1016/j.tube.2018.12.006. [PMID: 30711150]
  • Wattana Jeamton, Sudarat Dulsawat, Morakot Tanticharoen, Avigad Vonshak, Supapon Cheevadhanarak. Overcoming Intrinsic Restriction Enzyme Barriers Enhances Transformation Efficiency in Arthrospira platensis C1. Plant & cell physiology. 2017 04; 58(4):822-830. doi: 10.1093/pcp/pcx016. [PMID: 28158667]
  • Lars Falk, Jørgen Skov Jensen. Successful outcome of macrolide-resistant Mycoplasma genitalium urethritis after spectinomycin treatment: a case report. The Journal of antimicrobial chemotherapy. 2017 02; 72(2):624-625. doi: 10.1093/jac/dkw405. [PMID: 27707988]
  • Daniel Köhler, Stefan Helm, Birgit Agne, Sacha Baginsky. Importance of Translocon Subunit Tic56 for rRNA Processing and Chloroplast Ribosome Assembly. Plant physiology. 2016 12; 172(4):2429-2444. doi: 10.1104/pp.16.01393. [PMID: 27733515]
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  • Dora Babu Madhura, Ashit Trivedi, Jiuyu Liu, Vincent A Boyd, Cynthia Jeffries, Vivian Loveless, Richard E Lee, Bernd Meibohm. Tissue Penetration of a Novel Spectinamide Antibiotic for the Treatment of Tuberculosis. The AAPS journal. 2016 05; 18(3):788-91. doi: 10.1208/s12248-016-9900-7. [PMID: 26984832]
  • Aisling Dunne, Jodi Maple-Grødem, Daniela Gargano, Richard P Haslam, Johnathan A Napier, Nam-Hai Chua, Rosalind Russell, Simon Geir Møller. Modifying fatty acid profiles through a new cytokinin-based plastid transformation system. The Plant journal : for cell and molecular biology. 2014 Dec; 80(6):1131-8. doi: 10.1111/tpj.12684. [PMID: 25280363]
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  • Kailash C Bansal, Ajay K Singh. Plastid transformation in eggplant. Methods in molecular biology (Clifton, N.J.). 2014; 1132(?):305-16. doi: 10.1007/978-1-62703-995-6_19. [PMID: 24599862]
  • Tarinee Tungsuchat-Huang, Pal Maliga. Plastid marker gene excision in greenhouse-grown tobacco by agrobacterium-delivered Cre recombinase. Methods in molecular biology (Clifton, N.J.). 2014; 1132(?):205-20. doi: 10.1007/978-1-62703-995-6_12. [PMID: 24599855]
  • Vladimir T Valkov, Daniela Gargano, Nunzia Scotti, Teodoro Cardi. Plastid transformation in potato: Solanum tuberosum. Methods in molecular biology (Clifton, N.J.). 2014; 1132(?):295-303. doi: 10.1007/978-1-62703-995-6_18. [PMID: 24599861]
  • Stephanie Ruf, Ralph Bock. Plastid transformation in tomato. Methods in molecular biology (Clifton, N.J.). 2014; 1132(?):265-76. doi: 10.1007/978-1-62703-995-6_16. [PMID: 24599859]
  • Tracey A Ruhlman. Plastid transformation in lettuce (Lactuca sativa L.) by biolistic DNA delivery. Methods in molecular biology (Clifton, N.J.). 2014; 1132(?):331-43. doi: 10.1007/978-1-62703-995-6_21. [PMID: 24599864]
  • Manuel Dubald, Ghislaine Tissot, Bernard Pelissier. Plastid transformation in soybean. Methods in molecular biology (Clifton, N.J.). 2014; 1132(?):345-54. doi: 10.1007/978-1-62703-995-6_22. [PMID: 24599865]
  • Francesca De Marchis, Michele Bellucci. Plastid transformation in sugar beet: Beta vulgaris. Methods in molecular biology (Clifton, N.J.). 2014; 1132(?):367-73. doi: 10.1007/978-1-62703-995-6_24. [PMID: 24599867]
  • Shaochen Xing, Zhengyi Wei, Yunpeng Wang, Yanzhi Liu, Chunjing Lin. Integration and Expression of gfp in the plastid of Medicago sativa L. Methods in molecular biology (Clifton, N.J.). 2014; 1132(?):375-87. doi: 10.1007/978-1-62703-995-6_25. [PMID: 24599868]
  • Pal Maliga, Tarinee Tungsuchat-Huang. Plastid transformation in Nicotiana tabacum and Nicotiana sylvestris by biolistic DNA delivery to leaves. Methods in molecular biology (Clifton, N.J.). 2014; 1132(?):147-63. doi: 10.1007/978-1-62703-995-6_8. [PMID: 24599851]
  • Areli Herrera Díaz, Hans-Ulrich Koop. Nicotiana tabacum: PEG-mediated plastid transformation. Methods in molecular biology (Clifton, N.J.). 2014; 1132(?):165-75. doi: 10.1007/978-1-62703-995-6_9. [PMID: 24599852]
  • Elena Martin Avila, Anil Day. Stable plastid transformation of petunia. Methods in molecular biology (Clifton, N.J.). 2014; 1132(?):277-93. doi: 10.1007/978-1-62703-995-6_17. [PMID: 24599860]
  • Shota Chiyoda, Katsuyuki T Yamato, Takayuki Kohchi. Plastid transformation of sporelings and suspension-cultured cells from the liverwort Marchantia polymorpha L. Methods in molecular biology (Clifton, N.J.). 2014; 1132(?):439-47. doi: 10.1007/978-1-62703-995-6_30. [PMID: 24599873]
  • Yajun Chang, Nobuyuki Takatani, Makiko Aichi, Shin-Ichi Maeda, Tatsuo Omata. Evaluation of the effects of P(II) deficiency and the toxicity of PipX on growth characteristics of the P(II)-Less mutant of the cyanobacterium Synechococcus elongatus. Plant & cell physiology. 2013 Sep; 54(9):1504-14. doi: 10.1093/pcp/pct092. [PMID: 23811238]
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  • Jiefeng Zhang, Victor W C Chang, Apostolos Giannis, Jing-Yuan Wang. Removal of cytostatic drugs from aquatic environment: a review. The Science of the total environment. 2013 Feb; 445-446(?):281-98. doi: 10.1016/j.scitotenv.2012.12.061. [PMID: 23337605]
  • Xuguang Jiang, Yuheng Feng, Guojun Lv, Yuying Du, Dianshan Qin, Xiaodong Li, Yong Chi, Jianhua Yan, Xudong Liu. Bioferment residue: TG-FTIR study and cocombustion in a MSW incineration plant. Environmental science & technology. 2012 Dec; 46(24):13539-44. doi: 10.1021/es3032133. [PMID: 23163404]
  • Brigitta Dudas, Barnabas Jenes, Gyorgy Botond Kiss, Pal Maliga. Spectinomycin resistance mutations in the rrn16 gene are new plastid markers in Medicago sativa. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik. 2012 Nov; 125(7):1517-23. doi: 10.1007/s00122-012-1930-7. [PMID: 22791077]
  • Sandrine Demanèche, Jean-Michel Monier, Eric Dugat-Bony, Pascal Simonet. Exploration of horizontal gene transfer between transplastomic tobacco and plant-associated bacteria. FEMS microbiology ecology. 2011 Oct; 78(1):129-36. doi: 10.1111/j.1574-6941.2011.01126.x. [PMID: 21564143]
  • Tarinee Tungsuchat-Huang, Kristina Marie Slivinski, Sugey Ramona Sinagawa-Garcia, Pal Maliga. Visual spectinomycin resistance (aadA(au)) gene for facile identification of transplastomic sectors in tobacco leaves. Plant molecular biology. 2011 Jul; 76(3-5):453-61. doi: 10.1007/s11103-010-9724-2. [PMID: 21193947]
  • Y Tao, D Chen, G Yu, H Yu, Y Pan, Y Wang, L Huang, Z Yuan. Simultaneous determination of lincomycin and spectinomycin residues in animal tissues by gas chromatography-nitrogen phosphorus detection and gas chromatography-mass spectrometry with accelerated solvent extraction. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2011 Feb; 28(2):145-54. doi: 10.1080/19440049.2010.538440. [PMID: 21240824]
  • Kerry Ann Lutz, Arun Azhagiri, Pal Maliga. Transplastomics in Arabidopsis: progress toward developing an efficient method. Methods in molecular biology (Clifton, N.J.). 2011; 774(?):133-47. doi: 10.1007/978-1-61779-234-2_9. [PMID: 21822837]
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  • Jingjing Yao, Qingye Zhang, Jun Min, Jin He, Ziniu Yu. Novel enoyl-ACP reductase (FabI) potential inhibitors of Escherichia coli from Chinese medicine monomers. Bioorganic & medicinal chemistry letters. 2010 Jan; 20(1):56-9. doi: 10.1016/j.bmcl.2009.11.042. [PMID: 19959361]
  • Agnes Oszlánczi, Attila Bóta, Erwin Klumpp. Influence of aminoglycoside antibiotics on the thermal behaviour and structural features of DPPE-DPPG model membranes. Colloids and surfaces. B, Biointerfaces. 2010 Jan; 75(1):141-8. doi: 10.1016/j.colsurfb.2009.08.027. [PMID: 19748239]
  • Sandra L Kuchta, Allan J Cessna. Lincomycin and spectinomycin concentrations in liquid swine manure and their persistence during simulated manure storage. Archives of environmental contamination and toxicology. 2009 Jul; 57(1):1-10. doi: 10.1007/s00244-008-9229-z. [PMID: 18800201]
  • Sugey Ramona Sinagawa-García, Tarinee Tungsuchat-Huang, Octavio Paredes-López, Pal Maliga. Next generation synthetic vectors for transformation of the plastid genome of higher plants. Plant molecular biology. 2009 Jul; 70(5):487-98. doi: 10.1007/s11103-009-9486-x. [PMID: 19387846]
  • Sandra Stegemann, Ralph Bock. Exchange of genetic material between cells in plant tissue grafts. Science (New York, N.Y.). 2009 May; 324(5927):649-51. doi: 10.1126/science.1170397. [PMID: 19407205]
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  • Shota Chiyoda, Kimitsune Ishizaki, Hideo Kataoka, Katsuyuki T Yamato, Takayuki Kohchi. Direct transformation of the liverwort Marchantia polymorpha L. by particle bombardment using immature thalli developing from spores. Plant cell reports. 2008 Sep; 27(9):1467-73. doi: 10.1007/s00299-008-0570-5. [PMID: 18553085]
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  • Cilia L C Lelivelt, Matthew S McCabe, Christine A Newell, C Bastiaan deSnoo, Kees M P van Dun, Ian Birch-Machin, John C Gray, Kingston H G Mills, Jacqueline M Nugent. Stable plastid transformation in lettuce (Lactuca sativa L.). Plant molecular biology. 2005 Aug; 58(6):763-774. doi: 10.1007/s11103-005-7704-8. [PMID: 16240172]
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