Pyo II (BioDeep_00000261775)
Main id: BioDeep_00000005465
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C16H21NO2 (259.1572)
中文名称: 2-庚基-4-羟基喹啉-N-氧化物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: c1ccc2c(c1)n(=O)c(cc2O)CCCCCCC
InChI: InChI=1S/C16H21NO2/c1-2-3-4-5-6-9-13-12-16(18)14-10-7-8-11-15(14)17(13)19/h7-8,10-12,18H,2-6,9H2,1H3
描述信息
HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III[1]. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species[2].
HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III[1]. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species[2].
同义名列表
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:157768
- ChEBI: CHEBI:28362
- KEGG: C04284
- PubChem: 1561
- DrugBank: DB07918
- ChEMBL: CHEMBL1233401
- ChEMBL: CHEMBL4764074
- KNApSAcK: C00026381
- CAS: 341-88-8
- PMhub: MS000247427
- PubChem: 6946
- PDB-CCD: HQO
- NIKKAJI: J134.034D
- medchemexpress: HY-130055
- KNApSAcK: 28362
分类词条
相关代谢途径
Reactome(0)
BioCyc(14)
- mixed acid fermentation
- NADH to cytochrome bo oxidase electron transfer I
- nitrate reduction III (dissimilatory)
- nitrate reduction VIII (dissimilatory)
- NADH to fumarate electron transfer
- nitrate reduction IX (dissimilatory)
- succinate to cytochrome bo oxidase electron transfer
- NADH to cytochrome bo oxidase electron transfer II
- D-lactate to cytochrome bo oxidase electron transfer
- glycerol-3-phosphate to cytochrome bo oxidase electron transfer
- proline to cytochrome bo oxidase electron transfer
- pyruvate to cytochrome bo oxidase electron transfer
- hydrogen to fumarate electron transfer
- glycerol-3-phosphate to fumarate electron transfer
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 1883 - Streptomyces: 10.3390/MD17020133
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Simon Boulanger, Gabriel Mitchell, Kamal Bouarab, Éric Marsault, André Cantin, Eric H Frost, Eric Déziel, François Malouin. Bactericidal Effect of Tomatidine-Tobramycin Combination against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Is Enhanced by Interspecific Small-Molecule Interactions.
Antimicrobial agents and chemotherapy.
2015 Dec; 59(12):7458-64. doi:
10.1128/aac.01711-15. [PMID: 26392496] - Gabriel Mitchell, Mariza Gattuso, Gilles Grondin, Éric Marsault, Kamal Bouarab, François Malouin. Tomatidine inhibits replication of Staphylococcus aureus small-colony variants in cystic fibrosis airway epithelial cells.
Antimicrobial agents and chemotherapy.
2011 May; 55(5):1937-45. doi:
10.1128/aac.01468-10. [PMID: 21357296] - Sophie A Weiss, Richard J Bushby, Stephen D Evans, Lars J C Jeuken. A study of cytochrome bo3 in a tethered bilayer lipid membrane.
Biochimica et biophysica acta.
2010 Dec; 1797(12):1917-23. doi:
10.1016/j.bbabio.2010.01.012. [PMID: 20096262] - Tanmoy Bera, Nilay Nandi, D Sudhahar, Md Ali Akbar, Abhik Sen, Pradeep Das. Preliminary evidence on existence of transplasma membrane electron transport in Entamoeba histolytica trophozoites: a key mechanism for maintaining optimal redox balance.
Journal of bioenergetics and biomembranes.
2006 Dec; 38(5-6):299-308. doi:
10.1007/s10863-006-9047-9. [PMID: 17039394] - Tsuyoshi Sugio, Tomohiro Hisazumi, Tadayoshi Kanao, Kazuo Kamimura, Fumiaki Takeuchi, Atsunori Negishi. Existence of aa3-type ubiquinol oxidase as a terminal oxidase in sulfite oxidation of Acidithiobacillus thiooxidans.
Bioscience, biotechnology, and biochemistry.
2006 Jul; 70(7):1584-91. doi:
10.1271/bbb.50623. [PMID: 16861791] - Jason W Cooley, Tomoko Ohnishi, Fevzi Daldal. Binding dynamics at the quinone reduction (Qi) site influence the equilibrium interactions of the iron sulfur protein and hydroquinone oxidation (Qo) site of the cytochrome bc1 complex.
Biochemistry.
2005 Aug; 44(31):10520-32. doi:
10.1021/bi050571+. [PMID: 16060661] - Kirsten E Tollefson, James Kroczynski, Michael V Cutaia. Time-dependent interactions of oxidant-sensitive fluoroprobes with inhibitors of cellular metabolism.
Laboratory investigation; a journal of technical methods and pathology.
2003 Mar; 83(3):367-75. doi:
10.1097/01.lab.0000059934.53602.4f. [PMID: 12649337] - S C Chena, J K Liu. The respiratory responses to cyanide of a cyanide-resistant Klebsiella oxytoca bacterial strain.
FEMS microbiology letters.
1999 Jun; 175(1):37-43. doi:
10.1111/j.1574-6968.1999.tb13599.x. [PMID: 10361707] - I Willms, R Malkin, R K Chain. Quinone interactions with the chloroplast cytochrome b6-f complex.
Archives of biochemistry and biophysics.
1988 May; 263(1):36-44. doi:
10.1016/0003-9861(88)90611-x. [PMID: 3285795] - R Barr, A S Sandelius, F L Crane, D J Morré. Oxidation of reduced pyridine nucleotides by plasma membranes of soybean hypocotyl.
Biochemical and biophysical research communications.
1985 Sep; 131(2):943-8. doi:
10.1016/0006-291x(85)91330-0. [PMID: 4052077] - B C Tripathy, J S Rieske. Antimycin-resistant alternate electron pathway to plastocyanin in bovine-heart complex III.
Journal of bioenergetics and biomembranes.
1985 Jun; 17(3):141-50. doi:
10.1007/bf00751058. [PMID: 2989259] - C Hogarth, B J Wilkinson, D J Ellar. Cyanide-resistant electron transport in sporulating Bacillus megaterium KM.
Biochimica et biophysica acta.
1977 Jul; 461(1):109-23. doi:
10.1016/0005-2728(77)90073-1. [PMID: 406913]
