Ruscogenin (BioDeep_00000000257)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(1S,2S,4S,5R,6R,7S,8R,9S,12S,13R,14R,16R)-5,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2-oxane]-14,16-diol

化学式: C27H42O4 (430.3083)
中文名称: 鲁斯可皂苷元, 螺可吉宁, 芸香精素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 67.09%

分子结构信息

SMILES: C1[C@H](O)CC2[C@@](C)([C@@]3([H])CC[C@]4(C)[C@H]5[C@@H]([C@]6(O[C@H]5C[C@@]4([H])[C@]3([H])CC=2)CC[C@@H](C)CO6)C)[C@@H]1O
InChI: InChI=1S/C27H42O4/c1-15-7-10-27(30-14-15)16(2)24-22(31-27)13-21-19-6-5-17-11-18(28)12-23(29)26(17,4)20(19)8-9-25(21,24)3/h5,15-16,18-24,28-29H,6-14H2,1-4H3/t15-,16+,18-,19-,20+,21+,22+,23-,24+,25+,26+,27-/m1/s1

描述信息

Ruscogenin is a triterpenoid.
Ruscogenin is a natural product found in Cordyline rubra, Cordyline banksii, and other organisms with data available.
Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway. Ruscogenin exerts significant anti-inflammatory and anti-thrombotic activities. Ruscogenin has orally bioactivity[1][2].
Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway. Ruscogenin exerts significant anti-inflammatory and anti-thrombotic activities. Ruscogenin has orally bioactivity[1][2].

同义名列表

23 个代谢物同义名

(1S,2S,4S,5R,6R,7S,8R,9S,12S,13R,14R,16R)-5,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2-oxane]-14,16-diol; Spirost-5-ene-1,3-diol, (1.beta.,3.beta.,25R)-; SPIROST-5-ENE-1.BETA.,3.BETA.-DIOL, (25R)-; (25R)-SPIROST-5-ENE-1.BETA.,3.BETA.-DIOL; (1beta,3beta,25R)-Spirost-5-ene-1,3-diol; ruscogenin, (1beta,3alpha,25S)-isomer; ruscogenin, (1beta,3alpha,25R)-isomer; Spirost-5-ene-1,3-diol, (1b,3b,25R)-; (25R)-Spirost-5-ene-1beta,3beta-diol; (25R)-spirost-5-en-1beta,3beta-diol; Ruscogenin, >=98\\% (HPLC); RUSCOGENIN [WHO-DD]; RUSCOGENIN [MART.]; RUSCOGENIN [INCI]; Ruscorectal (TN); UNII-BXI92R2VUJ; Ruscorectal; Ruscogenins; BXI92R2VUJ; ST 27:3;O4; Ruscogenin; FT-0775876; Ruscogenin



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

28 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 BCL2, CASP1, CDH5, MAPK14, MAPK8, NLRP3, NQO1, PIK3CA, PTGS2, TLR4
Peripheral membrane protein 2 GORASP1, PTGS2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 4 BCL2, HMOX1, PTGS2, SLC7A11
Nucleus 9 BCL2, GABPA, GPX4, HMOX1, MAPK14, MAPK8, MPO, NLRP3, NQO1
cytosol 9 BCL2, CASP1, GPX4, HMOX1, MAPK14, MAPK8, NLRP3, NQO1, PIK3CA
dendrite 1 NQO1
nucleoplasm 6 CDH5, GABPA, HMOX1, MAPK14, MAPK8, MPO
Cell membrane 5 CASP1, CDH5, SLC7A11, TLR4, TNF
Cytoplasmic side 2 GORASP1, HMOX1
lamellipodium 1 PIK3CA
Multi-pass membrane protein 1 SLC7A11
Golgi apparatus membrane 2 GORASP1, NLRP3
Synapse 2 MAPK8, NQO1
cell junction 1 CDH5
cell surface 6 CDH5, F3, ICAM1, SLC7A11, TLR4, TNF
glutamatergic synapse 1 MAPK14
Golgi apparatus 1 GORASP1
Golgi membrane 2 GORASP1, NLRP3
neuronal cell body 2 NQO1, TNF
Cytoplasm, cytosol 2 NLRP3, NQO1
Lysosome 1 MPO
plasma membrane 8 CASP1, CDH5, F3, ICAM1, PIK3CA, SLC7A11, TLR4, TNF
Membrane 9 BCL2, CDH5, F3, HMOX1, ICAM1, NLRP3, NQO1, SLC7A11, TLR4
axon 1 MAPK8
basolateral plasma membrane 1 SLC7A11
caveola 1 PTGS2
extracellular exosome 3 GPX4, ICAM1, MPO
endoplasmic reticulum 4 BCL2, HMOX1, NLRP3, PTGS2
extracellular space 6 F3, HMOX1, ICAM1, IL6, MPO, TNF
perinuclear region of cytoplasm 3 HMOX1, PIK3CA, TLR4
adherens junction 1 CDH5
bicellular tight junction 1 CDH5
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, GPX4, MAPK14, NLRP3
protein-containing complex 4 BCL2, CASP1, GPX4, PTGS2
intracellular membrane-bounded organelle 1 MPO
Microsome membrane 1 PTGS2
Single-pass type I membrane protein 5 CDH5, F3, ICAM1, SLC7A11, TLR4
Secreted 2 IL6, NLRP3
extracellular region 5 IL6, MAPK14, MPO, NLRP3, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
[Isoform 1]: Membrane 1 F3
[Isoform 2]: Secreted 1 F3
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CDH5
external side of plasma membrane 5 CDH5, F3, ICAM1, TLR4, TNF
nucleolus 1 CASP1
Early endosome 1 TLR4
apical part of cell 1 SLC7A11
cell-cell junction 1 CDH5
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 2 ICAM1, TNF
pore complex 1 BCL2
focal adhesion 1 ICAM1
microtubule 1 CASP1
cis-Golgi network 1 GORASP1
Cell junction, adherens junction 1 CDH5
collagen-containing extracellular matrix 2 F3, ICAM1
secretory granule 1 MPO
lateral plasma membrane 1 SLC7A11
nuclear speck 1 MAPK14
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 2 CASP1, NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
neuron projection 1 PTGS2
chromatin 1 GABPA
phagocytic cup 2 TLR4, TNF
brush border membrane 1 SLC7A11
spindle pole 1 MAPK14
Basolateral cell membrane 1 SLC7A11
Cell projection, microvillus membrane 1 SLC7A11
microvillus membrane 1 SLC7A11
nuclear envelope 1 GPX4
Endomembrane system 1 NLRP3
microtubule organizing center 1 NLRP3
myelin sheath 1 BCL2
azurophil granule 1 MPO
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 2 IL6, PTGS2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
immunological synapse 1 ICAM1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
AIM2 inflammasome complex 1 CASP1
phagocytic vesicle lumen 1 MPO
basal dendrite 1 MAPK8
canonical inflammasome complex 1 CASP1
catenin complex 1 CDH5
astrocyte projection 1 SLC7A11
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
[Isoform Mitochondrial]: Mitochondrion 1 GPX4
serine-type peptidase complex 1 F3
BAD-BCL-2 complex 1 BCL2
IPAF inflammasome complex 1 CASP1
NLRP1 inflammasome complex 1 CASP1
protease inhibitor complex 1 CASP1
[Isoform Cytoplasmic]: Cytoplasm 1 GPX4
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Juan Huang, Jianhao Zhou, Yujie Dai, Yuankai Liu, Fang Li, Shuaishuai Gong, Yuanyuan Zhang, Junping Kou. Ruscogenin ameliorates dasatinib-induced intestinal barrier dysfunction via ErbB4/YAP and ROCK/MLC pathways. Journal of natural medicines. 2023 Sep; 77(4):735-747. doi: 10.1007/s11418-023-01715-9. [PMID: 37347409]
  • Jin-Cheng Liu, Qing-Fei Zhao, Ling Zhang, Bo-Yang Yu, Fang Li, Jun-Ping Kou. Ruscogenin Alleviates Myocardial Ischemia via Myosin IIA-Dependent Mitochondrial Fusion and Fission Balance. The American journal of Chinese medicine. 2023 Aug; ?(?):1-26. doi: 10.1142/s0192415x23500830. [PMID: 37650421]
  • Qiong Lai, Xiaozhou Zhu, Lu Zhang, Junping Kou, Fuming Liu, Boyang Yu, Fang Li. Inhibition of OAT1/3 and CMPF uptake attenuates myocardial ischemia-induced chronic heart failure via decreasing fatty acid oxidation and the therapeutic effects of ruscogenin. Translational research : the journal of laboratory and clinical medicine. 2023 Jun; ?(?):. doi: 10.1016/j.trsl.2023.06.001. [PMID: 37315712]
  • Ipek Sahin, Çağatay Ceylan, Oguz Bayraktar. Ruscogenin interacts with DPPC and DPPG model membranes and increases the membrane fluidity: FTIR and DSC studies. Archives of biochemistry and biophysics. 2023 01; 733(?):109481. doi: 10.1016/j.abb.2022.109481. [PMID: 36522815]
  • Linzhou Yin, Pengyu Liu, Yue Jin, Zunxi Ning, Yiren Yang, Huiyuan Gao. Ferroptosis-related small-molecule compounds in cancer therapy: Strategies and applications. European journal of medicinal chemistry. 2022 Dec; 244(?):114861. doi: 10.1016/j.ejmech.2022.114861. [PMID: 36332549]
  • Yu-Wei Wang, Yun-Hao Wu, Jia-Zhi Zhang, Jia-Hui Tang, Rui-Ping Fan, Fang Li, Bo-Yang Yu, Jun-Ping Kou, Yuan-Yuan Zhang. Ruscogenin attenuates particulate matter-induced acute lung injury in mice via protecting pulmonary endothelial barrier and inhibiting TLR4 signaling pathway. Acta pharmacologica Sinica. 2021 May; 42(5):726-734. doi: 10.1038/s41401-020-00502-6. [PMID: 32855531]
  • Gulcin Ercan, Rumeysa Ilbar Tartar, Ali Solmaz, Osman Bilgin Gulcicek, Onur Olgac Karagulle, Serhat Meric, Huseyin Cayoren, Ramazan Kusaslan, Ahu Kemik, Damla Gokceoglu Kayali, Sule Cetinel, Atilla Celik. Potent therapeutic effects of ruscogenin on gastric ulcer established by acetic acid. Asian journal of surgery. 2020 Feb; 43(2):405-416. doi: 10.1016/j.asjsur.2019.07.001. [PMID: 31345657]
  • Abbas Khojasteh, Raul Sanchez-Muñoz, Elisabeth Moyano, Mercedes Bonfill, Rosa M Cusido, Regine Eibl, Javier Palazon. Biotechnological production of ruscogenins in plant cell and organ cultures of Ruscus aculeatus. Plant physiology and biochemistry : PPB. 2019 Aug; 141(?):133-141. doi: 10.1016/j.plaphy.2019.05.029. [PMID: 31163340]
  • Fang Li, Xiao-Xue Fan, Chun Chu, Yu Zhang, Jun-Ping Kou, Bo-Yang Yu. A Strategy for Optimizing the Combination of Active Components Based on Chinese Medicinal Formula Sheng-Mai-San for Myocardial Ischemia. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 45(4):1455-1471. doi: 10.1159/000487572. [PMID: 29466787]
  • Yueying Li, Yuntao Liu, Xia Yan, Qing Liu, Yong-Hua Zhao, Da-Wei Wang. Pharmacological Effects and Mechanisms of Chinese Medicines Modulating NLRP3 Inflammasomes in Ischemic Cardio/Cerebral Vascular Disease. The American journal of Chinese medicine. 2018; 46(8):1727-1741. doi: 10.1142/s0192415x18500878. [PMID: 30525898]
  • Hongwei Zhang, Tao Xu, Lan Gao, Xiufeng Liu, Jihua Liu, Boyang Yu. A Novel Fluoroimmunoassay for Detecting Ruscogenin with Monoclonal Antibodies Conjugated with CdSe/ZnS Quantum Dots. Molecules (Basel, Switzerland). 2017 Jul; 22(8):. doi: 10.3390/molecules22081250. [PMID: 28933731]
  • Fang Li, Xiaoxue Fan, Yu Zhang, Lizhi Pang, Xiaonan Ma, Meijia Song, Junping Kou, Boyang Yu. Cardioprotection by combination of three compounds from ShengMai preparations in mice with myocardial ischemia/reperfusion injury through AMPK activation-mediated mitochondrial fission. Scientific reports. 2016 11; 6(?):37114. doi: 10.1038/srep37114. [PMID: 27869201]
  • Guosheng Cao, Nan Jiang, Yang Hu, Yuanyuan Zhang, Guangyun Wang, Mingzhu Yin, Xiaonan Ma, Kecheng Zhou, Jin Qi, Boyang Yu, Junping Kou. Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway. International journal of molecular sciences. 2016 Aug; 17(9):. doi: 10.3390/ijms17091418. [PMID: 27589720]
  • Hong Liu, Yan-fang Zheng, Chu-yuan Li, Yu-ying Zheng, De-qin Wang, Zhong Wu, Lin Huang, Yong-gang Wang, Pei-bo Li, Wei Peng, Wei-wei Su. Discovery of Anti-inflammatory Ingredients in Chinese Herbal Formula Kouyanqing Granule based on Relevance Analysis between Chemical Characters and Biological Effects. Scientific reports. 2015 Dec; 5(?):18080. doi: 10.1038/srep18080. [PMID: 26657159]
  • Pei-ying Ji, Zhi-wen Li, Qing Yang, Rong Wu. Rapid determination of ruscogenin in rat plasma with application to pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Mar; 985(?):71-4. doi: 10.1016/j.jchromb.2015.01.022. [PMID: 25660717]
  • Yu Xu, Ji-Hua Liu, Jing Wang, Jian Zhang, Bo-Yang Yu. A monoclonal antibody-based competitive ELISA for the determination of ruscogenin in Chinese traditional medicines and biological samples. Chinese journal of natural medicines. 2014 Oct; 12(10):794-9. doi: 10.1016/s1875-5364(14)60121-7. [PMID: 25443374]
  • Hung-Jen Lu, Shorong-Shii Liou, Chia Ju Chang, Sheng Da Lin, Cheng Yang, Ming-Chang Wu, I-Min Liu. Ruscogenin protects against high-fat diet-induced nonalcoholic steatohepatitis in hamsters. Planta medica. 2014 Jul; 80(11):870-9. doi: 10.1055/s-0034-1382841. [PMID: 25116118]
  • Hung-Jen Lu, Thing-Fong Tzeng, Shorong-Shii Liou, Sheng Da Lin, Ming-Chang Wu, I-Min Liu. Ruscogenin ameliorates diabetic nephropathy by its anti-inflammatory and anti-fibrotic effects in streptozotocin-induced diabetic rat. BMC complementary and alternative medicine. 2014 Mar; 14(?):110. doi: 10.1186/1472-6882-14-110. [PMID: 24666993]
  • Hung-Jen Lu, Thing-Fong Tzeng, Shorong-Shii Liou, Chia Ju Chang, Cheng Yang, Ming-Chang Wu, I-Min Liu. Ruscogenin ameliorates experimental nonalcoholic steatohepatitis via suppressing lipogenesis and inflammatory pathway. BioMed research international. 2014; 2014(?):652680. doi: 10.1155/2014/652680. [PMID: 25136608]
  • Qi Sun, Ling Chen, Mengyu Gao, Wenwen Jiang, Fangxian Shao, Jingjing Li, Jun Wang, Junping Kou, Boyang Yu. Ruscogenin inhibits lipopolysaccharide-induced acute lung injury in mice: involvement of tissue factor, inducible NO synthase and nuclear factor (NF)-κB. International immunopharmacology. 2012 Jan; 12(1):88-93. doi: 10.1016/j.intimp.2011.10.018. [PMID: 22079591]
  • Tao Jiang, Xiao-Ying Tang, Jun-Sheng Wu, Li-Qiu Wang, Miao Huang, Ting Han, Lu-Ping Qin. [Study on chemical constituents of the root of Liriope platyphylla]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Oct; 34(10):1537-9. doi: . [PMID: 22372141]
  • Bao-mei Huang, Cheng-wei Yao, Qing-quan Bian, Zhi-guo Wang, Jin-yuan Mo. [Determination of diosgenin and ruscogenin in Radix Ophiopogonis by nonaqueous capillary electrophoresis]. Yao xue xue bao = Acta pharmaceutica Sinica. 2011 Apr; 46(4):443-6. doi: . [PMID: 21751498]
  • Zhengfang Hu, Chang Jiang, Minjian Qin, Jin Qi, Boyang Yu. [Determination of 25(R, S) ruscogenin 1-O-[beta-D-glucopyranosyl (1 --> 2)] [beta-D-xylopyranosyl (1 --> 3)] beta-D-fucopyranoside in Liriope muscari from different habitats and different harvest time by HPLC-ELSD]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Oct; 35(19):2508-10. doi: 10.4268/cjcmm20101902. [PMID: 21174754]
  • Nai-Dong Chen, Lei Yue, Jian Zhang, Jun-Ping Kou, Bo-Yang Yu. One unique steroidal sapogenin obtained through the microbial transformation of ruscogenin by Phytophthora cactorum ATCC 32134 and its potential inhibitory effect on tissue factor (TF) procoagulant activity. Bioorganic & medicinal chemistry letters. 2010 Jul; 20(14):4015-7. doi: 10.1016/j.bmcl.2010.05.103. [PMID: 20561785]
  • Laurian Vlase, Béla Kiss, Georgeta Balica, Mircea Tămas, Gianina Crisan, Sorin E Leucuta. High-throughput LC/MS/MS analysis of ruscogenin and neoruscogenin in Ruscus aculeatus L. Journal of AOAC International. 2009 Jul; 92(4):1055-9. doi: . [PMID: 19714971]
  • Ya-Lin Huang, Jun-Ping Kou, Li Ma, Jia-Xi Song, Bo-Yang Yu. Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB. Journal of pharmacological sciences. 2008 Oct; 108(2):198-205. doi: 10.1254/jphs.08083fp. [PMID: 18946195]
  • Nan Liu, Xingbing Wen, Jihua Liu, Ming Liang, Huajin Zeng, Yining Lin, Boyang Yu. Determination of ruscogenin in crude Chinese medicines and biological samples by immunoassay. Analytical and bioanalytical chemistry. 2006 Nov; 386(6):1727-33. doi: 10.1007/s00216-006-0767-9. [PMID: 16957914]
  • Mercedes Ramírez-Hernández, Javier García-Sellés, Carolina Mérida-Fernández, Jorge A Martínez-Escribano. Allergic contact dermatitis to ruscogenins. Contact dermatitis. 2006 Jan; 54(1):60. doi: 10.1111/j.0105-1873.2006.0729b.x. [PMID: 16426297]
  • F Wu, J Cao, J Jiang, B Yu, Q Xu. Ruscogenin glycoside (Lm-3) isolated from Liriope muscari improves liver injury by dysfunctioning liver-infiltrating lymphocytes. The Journal of pharmacy and pharmacology. 2001 May; 53(5):681-8. doi: 10.1211/0022357011775802. [PMID: 11370707]
  • B Peneva, I Krasteva, S Nikolov, E Minkov. HPTLC densitometric determination of ruscogenins in dry extract of Ruscus aculeatus L. Die Pharmazie. 2000 Jul; 55(7):541-2. doi: ". [PMID: 10944787]