aniracetam (BioDeep_00000002557)

 

Secondary id: BioDeep_00000398862

human metabolite blood metabolite


代谢物信息卡片


1-(4-methoxybenzoyl)pyrrolidin-2-one

化学式: C12H13NO3 (219.0895388)
中文名称: 阿尼西坦
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC=C(C=C1)C(=O)N1CCCC1=O
InChI: InChI=1S/C12H13NO3/c1-16-10-6-4-9(5-7-10)12(15)13-8-2-3-11(13)14/h4-7H,2-3,8H2,1H3

描述信息

N - Nervous system > N06 - Psychoanaleptics > N06B - Psychostimulants, agents used for adhd and nootropics
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D018697 - Nootropic Agents
C26170 - Protective Agent > C1509 - Neuroprotective Agent
Same as: D01883
Aniracetam (Ro 13-5057) is an orally active neuroprotective agent, possessing nootropics effects. Aniracetam potentiates the ionotropic quisqualate (iQA) responses in the CA1 region of rat hippocampal slices. Aniracetam also potentiates the excitatory post synaptic potentials (EPSPs) in Schaffer collateral-commissural synapses. Aniracetam can prevents the CO2-induced impairment of acquisition in hypercapnia model rats. Aniracetam can be used to research cerebral dysfunctional disorders[1][2][3][4].

同义名列表

6 个代谢物同义名

1-(4-methoxybenzoyl)pyrrolidin-2-one; 1-(4-METHOXYBENZOYL)-2-pyrrolidinone; 1-p-Anisoylpyrrolidin-2-one; 1-Anisoyl-2-pyrrolidinone; aniracetam; Ro 13-5057



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Junjie Bian, Zhixiang Yuan, Xiaoliang Chen, Yuan Gao, Chaoqun Xu, Jianyou Shi. Preparation of surface multiple-coated polylactide acid drug-loaded nanoparticles for intranasal delivery and evaluation on its brain-targeting efficiency. Drug delivery. 2016; 23(1):269-76. doi: 10.3109/10717544.2014.910566. [PMID: 24845477]
  • Guo-Wei Zhang, Wei Zou, Fang Liu. [Effects of the scalp acupuncture at baihui (DU20) through qubin (GB7) on the expressions of GDNF VEGF in the brain tissue of rats with acute intracerebral hemorrhage]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2012 Sep; 32(9):1264-70. doi: . [PMID: 23185772]
  • Shuang Cai, Lei Wang. Determination of aniracetam's main metabolite, N-anisoyl-GABA, in human plasma by LC-MS/MS and its application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 May; 897(?):50-4. doi: 10.1016/j.jchromb.2012.04.007. [PMID: 22552003]
  • Pin Wang, Jing-Yi Tang, Jun Yang. [Effects of moxibustion on the expressions of hippocampal VEGF, flt-1, bFGF, and bFGF-r in vascular dementia rats]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2012 Jan; 32(1):97-101. doi: . [PMID: 22500404]
  • Sui Cheung Man, Kam Wa Chan, Jia-Hong Lu, Siva Sundara Kumar Durairajan, Liang-Feng Liu, Min Li. Systematic review on the efficacy and safety of herbal medicines for vascular dementia. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):426215. doi: 10.1155/2012/426215. [PMID: 22235231]
  • Aswini Gnanasekaran, Mayya Sundukova, Arn M J M van den Maagdenberg, Elsa Fabbretti, Andrea Nistri. Lipid rafts control P2X3 receptor distribution and function in trigeminal sensory neurons of a transgenic migraine mouse model. Molecular pain. 2011 Sep; 7(?):77. doi: 10.1186/1744-8069-7-77. [PMID: 21958474]
  • Xiaodong Shao, Ying Li, Fagen Li, Yangqin Liu, Zhenghua Song. Subnanogram determination of aniracetam in pharmaceutical preparations and biofluids by flow injection analysis with chemiluminescence detection based on its enhancement of the myoglobin-luminol reaction. Journal of AOAC International. 2011 Sep; 94(5):1461-6. doi: 10.5740/jaoacint.10-175. [PMID: 22165010]
  • Adak Nasiripourdori, Valérie Taly, Thomas Grutter, Antoine Taly. From toxins targeting ligand gated ion channels to therapeutic molecules. Toxins. 2011 03; 3(3):260-93. doi: 10.3390/toxins3030260. [PMID: 22069709]
  • Jinzhou Tian, Jing Shi, Xuekai Zhang, Yongyan Wang. Herbal therapy: a new pathway for the treatment of Alzheimer's disease. Alzheimer's research & therapy. 2010 Oct; 2(5):30. doi: 10.1186/alzrt54. [PMID: 21067555]
  • Ren-zhen Guo, Wen-quan Zhou, Zeng-gang Luo. [Effect of modified huanglian wendan decoction in treating senile patients with mild cognitive impairment of turbid-phlegm blocking orifice syndrome]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2010 Jan; 30(1):33-6. doi: . [PMID: 20353029]
  • Hou-Cai Huang, Rong-Ling Zhong, Peng Cao, Chun-Ru Wang, De-Gong Yang. [Effects of Goutengsan on model of Alzheimer dementia in rats by AlCl3]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2008 Mar; 33(5):553-6. doi: . [PMID: 18536382]
  • Hao Li, Ming-Jiang Yao, Wen-Ming Zhao, Jie Guan, Lin-Lin Cai, Ling Cui. [A randomized, controlled, double-blind trial of Huannao Yicong capsule in senile patients with mild cognitive impairment]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 2008 Jan; 6(1):25-31. doi: 10.3736/jcim20080106. [PMID: 18184542]
  • Yuan Tian, Jing-Jing Zhang, Shu-Dan Feng, Zun-Jian Zhang, Yun Chen. Pharmacokinetics and bioequivalence study of aniracetam after single-dose administration in healthy Chinese male volunteers. Arzneimittel-Forschung. 2008; 58(10):497-500. doi: 10.1055/s-0031-1296547. [PMID: 19025058]
  • Jingjing Zhang, Jiabi Liang, Yuan Tian, Zunjian Zhang, Yun Chen. Sensitive and selective liquid chromatography-tandem mass spectrometry method for the quantification of aniracetam in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Oct; 858(1-2):129-34. doi: 10.1016/j.jchromb.2007.08.010. [PMID: 17826366]
  • E Elisabetsky, L Costa-Campos. The alkaloid alstonine: a review of its pharmacological properties. Evidence-based complementary and alternative medicine : eCAM. 2006 Mar; 3(1):39-48. doi: 10.1093/ecam/nek011. [PMID: 16550222]
  • Hanumanthachar Joshi, Milind Parle. Nardostachys jatamansi improves learning and memory in mice. Journal of medicinal food. 2006; 9(1):113-8. doi: 10.1089/jmf.2006.9.113. [PMID: 16579738]
  • Bozena Gabryel, Małgorzata Chalimoniuk, Andrzej Małecki, Joanna B Strosznajder. Effect of aniracetam on phosphatidylinositol transfer protein alpha in cytosolic and plasma membrane fractions of astrocytes subjected to simulated ischemia in vitro. Pharmacological reports : PR. 2005 Sep; 57(5):664-9. doi: . [PMID: 16227651]
  • Mutsumi Ueda, Ryousuke Fujita, Takehiko Koji, Hiroshi Ueda. The cognition-enhancer nefiracetam inhibits both necrosis and apoptosis in retinal ischemic models in vitro and in vivo. The Journal of pharmacology and experimental therapeutics. 2004 Apr; 309(1):200-7. doi: 10.1124/jpet.103.061127. [PMID: 14718588]
  • Jennifer C Quirk, Eric S Nisenbaum. Multiple molecular determinants for allosteric modulation of alternatively spliced AMPA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003 Nov; 23(34):10953-62. doi: 10.1523/jneurosci.23-34-10953.2003. [PMID: 14645491]
  • Ryousuke Fujita, Naoko Takayama, Hiroshi Ueda. The cognition-enhancer nefiracetam is protective in BDNF-independent neuronal cell death under the serum-free condition. Neurochemistry international. 2002 Feb; 40(2):139-43. doi: 10.1016/s0197-0186(01)00080-8. [PMID: 11738480]
  • V Suppiramaniam, B A Bahr, S Sinnarajah, K Owens, G Rogers, S Yilma, V Vodyanoy. Member of the Ampakine class of memory enhancers prolongs the single channel open time of reconstituted AMPA receptors. Synapse (New York, N.Y.). 2001 May; 40(2):154-8. doi: 10.1002/syn.1037. [PMID: 11252027]
  • X Zhao, A Kuryatov, J M Lindstrom, J Z Yeh, T Narahashi. Nootropic drug modulation of neuronal nicotinic acetylcholine receptors in rat cortical neurons. Molecular pharmacology. 2001 Apr; 59(4):674-83. doi: 10.1124/mol.59.4.674. [PMID: 11259610]
  • Y Rao, P Xiao, S Xu. Effects of intrahippocampal aniracetam treatment on Y-maze avoidance learning performance and behavioral long-term potentiation in dentate gyrus in rat. Neuroscience letters. 2001 Feb; 298(3):183-6. doi: 10.1016/s0304-3940(00)01744-4. [PMID: 11165437]
  • T Ogiso, M Iwaki, T Tanino, K Ikeda, T Paku, Y Horibe, H Suzuki. Pharmacokinetics of aniracetam and its metabolites in rats. Journal of pharmaceutical sciences. 1998 May; 87(5):594-8. doi: 10.1021/js970355p. [PMID: 9572910]
  • H Endo, T Tajima, H Yamada, A Igata, Y Yamamoto, H Tsuchida, Y Nakashima, Y Suzuki, H Ikari, A Iguchi. Pharmacokinetic study of aniracetam in elderly patients with cerebrovascular disease. Behavioural brain research. 1997 Feb; 83(1-2):243-4. doi: 10.1016/s0166-4328(97)86079-2. [PMID: 9062694]
  • K M Partin, M W Fleck, M L Mayer. AMPA receptor flip/flop mutants affecting deactivation, desensitization, and modulation by cyclothiazide, aniracetam, and thiocyanate. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1996 Nov; 16(21):6634-47. doi: . [PMID: 8824304]
  • T H Johansen, A Chaudhary, T A Verdoorn. Interactions among GYKI-52466, cyclothiazide, and aniracetam at recombinant AMPA and kainate receptors. Molecular pharmacology. 1995 Nov; 48(5):946-55. doi: . [PMID: 7476926]
  • A Guenzi, M Zanetti. Determination of aniracetam and its main metabolite, N-anisoyl-GABA, in human plasma by high-performance liquid chromatography. Journal of chromatography. 1990 Sep; 530(2):397-406. doi: 10.1016/s0378-4347(00)82342-7. [PMID: 2079514]
  • S Todorov, R Zamfirova, V D Petkov. Study of the effects of nootropic agents on the adrenergic neurotransmission in smooth muscles of young and old animals. Acta physiologica et pharmacologica Bulgarica. 1990; 16(1):38-45. doi: ". [PMID: 2168120]
  • V D Petkov, D Getova, A H Mosharrof. A study of nootropic drugs for anti-anxiety action. Acta physiologica et pharmacologica Bulgarica. 1987; 13(4):25-30. doi: ". [PMID: 2896427]