salvinorin A (BioDeep_00000002553)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


Salvinorin A(Divinorin A)

化学式: C23H28O8 (432.1784)
中文名称: 丹酚 A
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 36.02%

分子结构信息

SMILES: CC(=O)OC1CC(C2(CCC3C(=O)OC(CC3(C2C1=O)C)C4=COC=C4)C)C(=O)OC
InChI: InChI=1S/C23H28O8/c1-12(24)30-16-9-15(20(26)28-4)22(2)7-5-14-21(27)31-17(13-6-8-29-11-13)10-23(14,3)19(22)18(16)25/h6,8,11,14-17,19H,5,7,9-10H2,1-4H3/t14-,15-,16-,17-,19-,22-,23-/m0/s1

描述信息

D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D006213 - Hallucinogens
A natural product found in Salvia divinorum.

同义名列表

3 个代谢物同义名

Salvinorin A(Divinorin A); salvinorin A; BDBM86548



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

28 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ABCB1, AKT1, AQP4, CA1, CNR1, CNR2, PIK3CA, PRKAA2, PTGS2, SLC6A3
Peripheral membrane protein 1 PTGS2
Endosome membrane 1 AQP4
Endoplasmic reticulum membrane 1 PTGS2
Nucleus 4 AKT1, FOS, MPO, PRKAA2
cytosol 5 AKT1, CA1, FOS, PIK3CA, PRKAA2
dendrite 5 CNR2, DRD2, OPRM1, PDYN, PRKAA2
nucleoplasm 4 AKT1, FOS, MPO, PRKAA2
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 10 ABCB1, AKT1, AQP4, CNR1, CYSLTR2, DRD2, OPRD1, OPRM1, SLC6A3, TNF
lamellipodium 2 AKT1, PIK3CA
Cell projection, axon 3 CNR1, OPRM1, SLC6A3
Multi-pass membrane protein 8 ABCB1, AQP4, CNR1, CYSLTR2, DRD2, OPRD1, OPRM1, SLC6A3
Golgi apparatus membrane 1 DRD2
Synapse 3 DRD2, OPRM1, PDYN
cell cortex 1 AKT1
cell surface 3 ABCB1, SLC6A3, TNF
glutamatergic synapse 3 AKT1, CNR1, DRD2
Golgi apparatus 2 OPRM1, PRKAA2
Golgi membrane 1 DRD2
growth cone 1 CNR1
neuronal cell body 4 PDYN, PRKAA2, SLC6A3, TNF
postsynapse 1 AKT1
presynaptic membrane 4 CNR1, DRD2, OPRD1, SLC6A3
sarcolemma 1 AQP4
Lysosome 1 MPO
Presynapse 1 CNR1
acrosomal vesicle 1 DRD2
endosome 1 OPRM1
plasma membrane 13 ABCB1, AKT1, AQP4, CNR1, CNR2, CYSLTR2, DRD2, OPRD1, OPRM1, PDYN, PIK3CA, SLC6A3, TNF
synaptic vesicle membrane 2 DRD2, OPRD1
Membrane 7 ABCB1, AKT1, AQP4, OPRD1, OPRM1, PRKAA2, SLC6A3
apical plasma membrane 1 ABCB1
axon 5 CNR1, DRD2, OPRM1, PRKAA2, SLC6A3
basolateral plasma membrane 1 AQP4
caveola 1 PTGS2
extracellular exosome 3 ABCB1, CA1, MPO
endoplasmic reticulum 4 CNR2, FOS, OPRM1, PTGS2
extracellular space 4 IL10, IL4, MPO, TNF
perinuclear region of cytoplasm 1 PIK3CA
intercalated disc 1 PIK3CA
protein-containing complex 2 AKT1, PTGS2
intracellular membrane-bounded organelle 1 MPO
Microsome membrane 1 PTGS2
Secreted 3 IL10, IL4, PDYN
extracellular region 6 AQP4, IL10, IL4, MPO, PDYN, TNF
Mitochondrion outer membrane 1 CNR1
mitochondrial outer membrane 1 CNR1
astrocyte end-foot 1 AQP4
hippocampal mossy fiber to CA3 synapse 1 PDYN
neuronal cell body membrane 1 SLC6A3
ciliary membrane 1 DRD2
external side of plasma membrane 2 AQP4, TNF
actin cytoskeleton 1 CNR1
dendritic spine 1 DRD2
perikaryon 3 CNR2, DRD2, OPRM1
microtubule cytoskeleton 1 AKT1
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
postsynaptic membrane 3 CNR2, DRD2, SLC6A3
Apical cell membrane 1 ABCB1
Cell membrane, sarcolemma 1 AQP4
Membrane raft 3 CNR1, SLC6A3, TNF
spindle 1 AKT1
GABA-ergic synapse 2 CNR1, DRD2
flotillin complex 1 SLC6A3
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 MPO
lateral plasma membrane 1 DRD2
nuclear speck 1 PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, neuron projection 1 SLC6A3
neuron projection 4 OPRD1, OPRM1, PTGS2, SLC6A3
ciliary basal body 1 AKT1
cilium 1 DRD2
chromatin 1 FOS
cell projection 1 AQP4
phagocytic cup 1 TNF
non-motile cilium 1 DRD2
Basolateral cell membrane 1 AQP4
sperm flagellum 1 DRD2
Cell projection, dendrite 2 CNR2, OPRM1
cytoplasmic stress granule 1 PRKAA2
azurophil granule 1 MPO
endoplasmic reticulum lumen 1 PTGS2
nuclear matrix 1 FOS
axon terminus 4 DRD2, OPRD1, PDYN, SLC6A3
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle 1 DRD2
azurophil granule lumen 1 MPO
postsynaptic density membrane 1 OPRD1
neuronal dense core vesicle 2 OPRD1, PDYN
phagocytic vesicle lumen 1 MPO
extrinsic component of cytoplasmic side of plasma membrane 1 CNR2
protein-DNA complex 1 FOS
external side of apical plasma membrane 1 ABCB1
dopaminergic synapse 2 DRD2, SLC6A3
dendrite membrane 1 OPRD1
nucleotide-activated protein kinase complex 1 PRKAA2
transcription factor AP-1 complex 1 FOS
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
G protein-coupled receptor complex 1 DRD2
[Isoform 12]: Cytoplasm 1 OPRM1
spine apparatus 1 OPRD1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Maciej Jakobina, Jacek Łyczko, Antoni Szumny, Renata Galek. The influence of cultivation conditions on the formation of psychoactive salvinorin A, salvinorin B, rosmarinic acid and caffeic acid in Coleus scutellarioides. Scientific reports. 2024 03; 14(1):6693. doi: 10.1038/s41598-024-57399-y. [PMID: 38509159]
  • Yi Zhou, Xihua Lu, Yunfei Zhang, Changsheng Li, Yu Bai, Zhen Zhang. Investigation of the effects of opioids on microglial nitrite and nitric oxide synthase (iNOS) production and phagocytosis during inflammation. Combinatorial chemistry & high throughput screening. 2022 Nov; ?(?):. doi: 10.2174/1386207326666221111093915. [PMID: 36372918]
  • Katarzyna Socała, Urszula Doboszewska, Piotr Wlaź. Salvinorin A Does Not Affect Seizure Threshold in Mice. Molecules (Basel, Switzerland). 2020 Mar; 25(5):. doi: 10.3390/molecules25051204. [PMID: 32155979]
  • Conrad J Mascarenhas, Renyu Liu, Gordon A Barr. Effects of plant-derived analgesic compounds sinomenine and salvinorin A in infant rats. Journal of integrative medicine. 2020 Mar; 18(2):174-180. doi: 10.1016/j.joim.2020.01.002. [PMID: 31992510]
  • Bronwyn M Kivell, Kelly F Paton, Nitin Kumar, Aashish S Morani, Aimee Culverhouse, Amy Shepherd, Susan A Welsh, Andrew Biggerstaff, Rachel S Crowley, Thomas E Prisinzano. Kappa Opioid Receptor Agonist Mesyl Sal B Attenuates Behavioral Sensitization to Cocaine with Fewer Aversive Side-Effects than Salvinorin A in Rodents. Molecules (Basel, Switzerland). 2018 Oct; 23(10):. doi: 10.3390/molecules23102602. [PMID: 30314288]
  • Jeremy J Roach, Ryan A Shenvi. A review of salvinorin analogs and their kappa-opioid receptor activity. Bioorganic & medicinal chemistry letters. 2018 05; 28(9):1436-1445. doi: 10.1016/j.bmcl.2018.03.029. [PMID: 29615341]
  • Joseph El-Khoury, Evelyne Baroud. Case series: Salvia divinorum as a potential addictive hallucinogen. The American journal on addictions. 2018 Apr; 27(3):163-165. doi: 10.1111/ajad.12715. [PMID: 29596726]
  • U Coffeen, A Canseco-Alba, K Simón-Arceo, A Almanza, F Mercado, M León-Olea, F Pellicer. Salvinorin A reduces neuropathic nociception in the insular cortex of the rat. European journal of pain (London, England). 2018 02; 22(2):311-318. doi: 10.1002/ejp.1120. [PMID: 28975684]
  • André Cruz, Sara Domingos, Eugenia Gallardo, Ana Martinho. A unique natural selective kappa-opioid receptor agonist, salvinorin A, and its roles in human therapeutics. Phytochemistry. 2017 May; 137(?):9-14. doi: 10.1016/j.phytochem.2017.02.001. [PMID: 28190678]
  • Kyle A Pelot, Rod Mitchell, Moonhyuk Kwon, Lynne M Hagelthorn, Jacob F Wardman, Angela Chiang, Jörg Bohlmann, Dae-Kyun Ro, Philipp Zerbe. Biosynthesis of the psychotropic plant diterpene salvinorin A: Discovery and characterization of the Salvia divinorum clerodienyl diphosphate synthase. The Plant journal : for cell and molecular biology. 2017 03; 89(5):885-897. doi: 10.1111/tpj.13427. [PMID: 27865008]
  • Xiaoyue Chen, Anna Berim, Franck E Dayan, David R Gang. A (-)-kolavenyl diphosphate synthase catalyzes the first step of salvinorin A biosynthesis in Salvia divinorum. Journal of experimental botany. 2017 02; 68(5):1109-1122. doi: 10.1093/jxb/erw493. [PMID: 28204567]
  • Xiaomeng Xu, Shifan Ma, Zhiwei Feng, Guanxing Hu, Lirong Wang, Xiang-Qun Xie. Chemogenomics knowledgebase and systems pharmacology for hallucinogen target identification-Salvinorin A as a case study. Journal of molecular graphics & modelling. 2016 11; 70(?):284-295. doi: 10.1016/j.jmgm.2016.08.001. [PMID: 27810775]
  • Ana Elda Maqueda, Marta Valle, Peter H Addy, Rosa Maria Antonijoan, Montserrat Puntes, Jimena Coimbra, Maria Rosa Ballester, Maite Garrido, Mireia González, Judit Claramunt, Steven Barker, Izabela Lomnicka, Marian Waguespack, Matthew W Johnson, Roland R Griffiths, Jordi Riba. Naltrexone but Not Ketanserin Antagonizes the Subjective, Cardiovascular, and Neuroendocrine Effects of Salvinorin-A in Humans. The international journal of neuropsychopharmacology. 2016 07; 19(7):. doi: 10.1093/ijnp/pyw016. [PMID: 26874330]
  • Cláudia Margalho, Francisco Corte-Real, Manuel López-Rivadulla, Eugenia Gallardo. Salvia divinorum: toxicological aspects and analysis in human biological specimens. Bioanalysis. 2016 Jul; 8(13):1415-25. doi: 10.4155/bio-2016-0067. [PMID: 27277872]
  • Antonietta Rossi, Simona Pace, Federica Tedesco, Ester Pagano, Germano Guerra, Fabiana Troisi, Markus Werner, Fiorentina Roviezzo, Jordan K Zjawiony, Oliver Werz, Angelo A Izzo, Raffaele Capasso. The hallucinogenic diterpene salvinorin A inhibits leukotriene synthesis in experimental models of inflammation. Pharmacological research. 2016 Apr; 106(?):64-71. doi: 10.1016/j.phrs.2016.01.032. [PMID: 26859523]
  • Matthew W Johnson, Katherine A MacLean, Michael J Caspers, Thomas E Prisinzano, Roland R Griffiths. Time course of pharmacokinetic and hormonal effects of inhaled high-dose salvinorin A in humans. Journal of psychopharmacology (Oxford, England). 2016 Apr; 30(4):323-9. doi: 10.1177/0269881116629125. [PMID: 26880225]
  • Rathi Mahendran, Haikel A Lim, Joyce Y S Tan, Shi Min Chua, Munidasa Winslow. Salvia divinorum: An overview of the usage, misuse, and addiction processes. Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists. 2016 Mar; 8(1):23-31. doi: 10.1111/appy.12225. [PMID: 26617400]
  • George T Taylor, Francesca Manzella. Kappa Opioids, Salvinorin A and Major Depressive Disorder. Current neuropharmacology. 2016; 14(2):165-76. doi: 10.2174/1570159x13666150727220944. [PMID: 26903446]
  • Ana Martinho, Sara M Silva, Eugenia Gallardo. Cytotoxic Effects of Salvinorin A, A Major Constituent of Salvia divinorum. Medicinal chemistry (Shariqah (United Arab Emirates)). 2016; 12(5):432-40. doi: 10.2174/1573406411666151005105617. [PMID: 26434801]
  • Jamie P Smith, Oliver B Sutcliffe, Craig E Banks. An overview of recent developments in the analytical detection of new psychoactive substances (NPSs). The Analyst. 2015 Aug; 140(15):4932-48. doi: 10.1039/c5an00797f. [PMID: 26031385]
  • Ana Elda Maqueda, Marta Valle, Peter H Addy, Rosa Maria Antonijoan, Montserrat Puntes, Jimena Coimbra, Maria Rosa Ballester, Maite Garrido, Mireia González, Judit Claramunt, Steven Barker, Matthew W Johnson, Roland R Griffiths, Jordi Riba. Salvinorin-A Induces Intense Dissociative Effects, Blocking External Sensory Perception and Modulating Interoception and Sense of Body Ownership in Humans. The international journal of neuropsychopharmacology. 2015 Jun; 18(12):. doi: 10.1093/ijnp/pyv065. [PMID: 26047623]
  • Rafael Hernández-Bello, Rosa Virginia García-Rodríguez, Karlina García-Sosa, Luis Manuel Peña-Rodríguez, Maribel Vázquez-Hernández, Fernando Rafael Ramos-Morales, Olivia Corcoran, Alberto Sánchez-Medina. Salvinorin A content in legal high products of Salvia divinorum sold in Mexico. Forensic science international. 2015 Apr; 249(?):197-201. doi: 10.1016/j.forsciint.2015.01.038. [PMID: 25710779]
  • Bronwyn Kivell, Zeljko Uzelac, Santhanalakshmi Sundaramurthy, Jeyaganesh Rajamanickam, Amy Ewald, Vladimir Chefer, Vanaja Jaligam, Elizabeth Bolan, Bridget Simonson, Balasubramaniam Annamalai, Padmanabhan Mannangatti, Thomas E Prisinzano, Ivone Gomes, Lakshmi A Devi, Lankupalle D Jayanthi, Harald H Sitte, Sammanda Ramamoorthy, Toni S Shippenberg. Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism. Neuropharmacology. 2014 Nov; 86(?):228-40. doi: 10.1016/j.neuropharm.2014.07.016. [PMID: 25107591]
  • Prabhakar R Polepally, Krzysztof Huben, Eyal Vardy, Vincent Setola, Philip D Mosier, Bryan L Roth, Jordan K Zjawiony. Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor. European journal of medicinal chemistry. 2014 Oct; 85(?):818-29. doi: 10.1016/j.ejmech.2014.07.077. [PMID: 25193297]
  • Fernando Xavier Moreira, Félix Carvalho, Maria de Lourdes Bastos, Paula Guedes de Pinho. Analytical investigation of legal high products containing Salvia divinorum traded in smartshops and internet. Forensic science international. 2014 Sep; 242(?):255-260. doi: 10.1016/j.forsciint.2014.07.009. [PMID: 25093918]
  • John L Krstenansky, Miguel Muzzio. Analysis of the smoke of cigarettes containing Salvia divinorum. Journal of analytical toxicology. 2014 Sep; 38(7):451-5. doi: 10.1093/jat/bku054. [PMID: 24908261]
  • Georgios Leonis, Aggelos Avramopoulos, Ramin Ekhteiari Salmas, Serdar Durdagi, Mine Yurtsever, Manthos G Papadopoulos. Elucidation of conformational states, dynamics, and mechanism of binding in human κ-opioid receptor complexes. Journal of chemical information and modeling. 2014 Aug; 54(8):2294-308. doi: 10.1021/ci5002873. [PMID: 25060329]
  • Ivan Casselman, Catherine J Nock, Hans Wohlmuth, Robert P Weatherby, Michael Heinrich. From local to global-fifty years of research on Salvia divinorum. Journal of ethnopharmacology. 2014 Feb; 151(2):768-83. doi: 10.1016/j.jep.2013.11.032. [PMID: 24315983]
  • Bronwyn M Kivell, Amy W M Ewald, Thomas E Prisinzano. Salvinorin A analogs and other κ-opioid receptor compounds as treatments for cocaine abuse. Advances in pharmacology (San Diego, Calif.). 2014; 69(?):481-511. doi: 10.1016/b978-0-12-420118-7.00012-3. [PMID: 24484985]
  • R G dos Santos, J A S Crippa, J P Machado-de-Sousa, J E C Hallak. Salvinorin a and related compounds as therapeutic drugs for psychostimulant-related disorders. Current drug abuse reviews. 2014; 7(2):128-32. doi: 10.2174/1874473708666150107122741. [PMID: 25563442]
  • Anna P Kowalczuk, Vijayasankar Raman, Ahmed M Galal, Ikhlas A Khan, Daniel J Siebert, Jordan K Zjawiony. Vegetative anatomy and micromorphology of Salvia divinorum (Lamiaceae) from Mexico, combined with chromatographic analysis of salvinorin A. Journal of natural medicines. 2014 Jan; 68(1):63-73. doi: 10.1007/s11418-013-0769-9. [PMID: 23604975]
  • Madan Kumar Paudel, Osamu Shirota, Kaori Sasaki-Tabata, Hiroyuki Tanaka, Setsuko Sekita, Satoshi Morimoto. Development of an enzyme immunoassay using a monoclonal antibody against the psychoactive diterpenoid salvinorin A. Journal of natural products. 2013 Sep; 76(9):1654-60. doi: 10.1021/np400358n. [PMID: 23987562]
  • Jolanta B Zawilska, Jakub Wojcieszak. Salvia divinorum: from Mazatec medicinal and hallucinogenic plant to emerging recreational drug. Human psychopharmacology. 2013 Sep; 28(5):403-12. doi: 10.1002/hup.2304. [PMID: 23794315]
  • Cláudia Margalho, Eugenia Gallardo, Alice Castanheira, Duarte Nuno Vieira, Manuel López-Rivadulla, Francisco Corte Real. A validated procedure for detection and quantitation of salvinorin a in pericardial fluid, vitreous humor, whole blood and plasma using solid phase extraction and gas chromatography-mass spectrometry. Journal of chromatography. A. 2013 Aug; 1304(?):203-10. doi: 10.1016/j.chroma.2013.07.031. [PMID: 23871557]
  • Prabhakar R Polepally, Kate White, Eyal Vardy, Bryan L Roth, Daneel Ferreira, Jordan K Zjawiony. Kappa-opioid receptor-selective dicarboxylic ester-derived salvinorin A ligands. Bioorganic & medicinal chemistry letters. 2013 May; 23(10):2860-2. doi: 10.1016/j.bmcl.2013.03.111. [PMID: 23587424]
  • Thomas E Prisinzano. Neoclerodanes as atypical opioid receptor ligands. Journal of medicinal chemistry. 2013 May; 56(9):3435-43. doi: 10.1021/jm400388u. [PMID: 23548164]
  • Ivo Moreno, Beatriz da Fonseca, David Oppolzer, Ana Martinho, Mário Barroso, Angelines Cruz, João António Queiroz, Eugenia Gallardo. Analysis of Salvinorin A in urine using microextraction in packed syringe and GC-MS/MS. Bioanalysis. 2013 Mar; 5(6):661-8. doi: 10.4155/bio.13.18. [PMID: 23484784]
  • Jose-Luis Diaz. Salvia divinorum: a psychopharmacological riddle and a mind-body prospect. Current drug abuse reviews. 2013 Mar; 6(1):43-53. doi: 10.2174/18744737112059990004. [PMID: 23627785]
  • Katherine A MacLean, Matthew W Johnson, Chad J Reissig, Thomas E Prisinzano, Roland R Griffiths. Dose-related effects of salvinorin A in humans: dissociative, hallucinogenic, and memory effects. Psychopharmacology. 2013 Mar; 226(2):381-92. doi: 10.1007/s00213-012-2912-9. [PMID: 23135605]
  • Mohini Ranganathan, Ashley Schnakenberg, Patrick D Skosnik, Bruce M Cohen, Brian Pittman, R Andrew Sewell, Deepak Cyril D'Souza. Dose-related behavioral, subjective, endocrine, and psychophysiological effects of the κ opioid agonist Salvinorin A in humans. Biological psychiatry. 2012 Nov; 72(10):871-9. doi: 10.1016/j.biopsych.2012.06.012. [PMID: 22817868]
  • John Stogner, David N Khey, O Hayden Griffin, Bryan Lee Miller, John H Boman. Regulating a novel drug: an evaluation of changes in use of Salvia divinorum in the first year of Florida's ban. The International journal on drug policy. 2012 Nov; 23(6):512-21. doi: 10.1016/j.drugpo.2012.03.001. [PMID: 22502947]
  • Mitchell T Harden, Staci E Smith, Jennifer A Niehoff, Christopher R McCurdy, George T Taylor. Antidepressive effects of the κ-opioid receptor agonist salvinorin A in a rat model of anhedonia. Behavioural pharmacology. 2012 Oct; 23(7):710-5. doi: 10.1097/fbp.0b013e3283586189. [PMID: 22926298]
  • Eduardo R Butelman, Michael Caspers, Kimberly M Lovell, Mary Jeanne Kreek, Thomas E Prisinzano. Behavioral effects and central nervous system levels of the broadly available κ-agonist hallucinogen salvinorin A are affected by P-glycoprotein modulation in vivo. The Journal of pharmacology and experimental therapeutics. 2012 Jun; 341(3):802-8. doi: 10.1124/jpet.112.193227. [PMID: 22434677]
  • Eric G Meyer, Brian W Writer. Salvia divinorum. Psychosomatics. 2012 May; 53(3):277-9. doi: 10.1016/j.psym.2011.07.003. [PMID: 22289631]
  • Brian B Barnes, Nicholas H Snow. Analysis of Salvinorin A in plants, water, and urine using solid-phase microextraction-comprehensive two-dimensional gas chromatography-time of flight mass spectrometry. Journal of chromatography. A. 2012 Feb; 1226(?):110-5. doi: 10.1016/j.chroma.2011.09.056. [PMID: 21999919]
  • Melissa A Bodnar Willard, Victoria L McGuffin, Ruth Waddell Smith. Forensic analysis of Salvia divinorum using multivariate statistical procedures. Part II: association of adulterated samples to S. divinorum. Analytical and bioanalytical chemistry. 2012 Jan; 402(2):843-50. doi: 10.1007/s00216-011-5500-7. [PMID: 22160202]
  • Melissa A Bodnar Willard, Victoria L McGuffin, Ruth Waddell Smith. Forensic analysis of Salvia divinorum using multivariate statistical procedures. Part I: discrimination from related Salvia species. Analytical and bioanalytical chemistry. 2012 Jan; 402(2):833-42. doi: 10.1007/s00216-011-5479-0. [PMID: 22038586]
  • Justyna Piekielna, Jakub Fichna, Anna Janecka. [Salvinorin A and related diterpenes--biological activity and potential therapeutic uses]. Postepy biochemii. 2012; 58(4):485-91. doi: ". [PMID: 23662442]
  • H R Sumnall, F Measham, S D Brandt, J C Cole. Salvia divinorum use and phenomenology: results from an online survey. Journal of psychopharmacology (Oxford, England). 2011 Nov; 25(11):1496-507. doi: 10.1177/0269881110385596. [PMID: 20937616]
  • J Fichna, M Dicay, S A Hirota, D Traboulsi, J A Macdonald, A Janecka, P L Beck, J K Zjawiony, W K Macnaughton, M A Storr. Differential effects of salvinorin A on endotoxin-induced hypermotility and neurogenic ion transport in mouse ileum. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2011 Jun; 23(6):583-e212. doi: 10.1111/j.1365-2982.2011.01699.x. [PMID: 21414104]
  • Matthew W Johnson, Katherine A MacLean, Chad J Reissig, Thomas E Prisinzano, Roland R Griffiths. Human psychopharmacology and dose-effects of salvinorin A, a kappa opioid agonist hallucinogen present in the plant Salvia divinorum. Drug and alcohol dependence. 2011 May; 115(1-2):150-5. doi: 10.1016/j.drugalcdep.2010.11.005. [PMID: 21131142]
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