C-Quens (BioDeep_00000002528)
代谢物信息卡片
Chlormadinone Acetate
化学式: C23H29ClO4 (404.1754)
中文名称: 氯地孕酮醋酸盐
谱图信息:
最多检出来源 Homo sapiens(not specific) 7.14%
分子结构信息
SMILES: CC(=O)C1(CCC2C1(CCC3C2C=C(C4=CC(=O)CCC34C)Cl)C)OC(=O)C
InChI: InChI=1S/C23H29ClO4/c1-13(25)23(28-14(2)26)10-7-18-16-12-20(24)19-11-15(27)5-8-21(19,3)17(16)6-9-22(18,23)4/h11-12,16-18H,5-10H2,1-4H3
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
同义名列表
3 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- KEGG: C12729
- PubChem: 2714
- Metlin: METLIN69476
- CAS: 302-22-7
- PMhub: MS000003403
- ChEBI: CHEBI:31394
- PubChem: 583118
- KNApSAcK: 31394
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Valéria A Gomes, Carolina S Vieira, Anna L Jacob-Ferreira, Vanessa A Belo, Gustavo M Soares, Janaína B França, Rui A Ferriani, Jose E Tanus-Santos. Oral contraceptive containing chlormadinone acetate and ethinylestradiol reduces plasma concentrations of matrix metalloproteinase-2 in women with polycystic ovary syndrome.
Basic & clinical pharmacology & toxicology.
2012 Sep; 111(3):211-6. doi:
10.1111/j.1742-7843.2012.00895.x. [PMID: 22510229] - Christine Klipping, Ingrid Duijkers, Michel P Fortier, Joachim Marr, Dietmar Trummer, Jörg Elliesen. Long-term tolerability of ethinylestradiol 20 μg/drospirenone 3 mg in a flexible extended regimen: results from a randomised, controlled, multicentre study.
The journal of family planning and reproductive health care.
2012 Apr; 38(2):84-93. doi:
10.1136/jfprhc-2011-100214. [PMID: 22454004] - Masayoshi Zaitsu, Mariko Yamanoi, Koji Mikami, Yuta Takeshima, Naohiko Okamoto, Sadao Imao, Akiko Tonooka, Takumi Takeuchi. Surgical castration in hormone-refractory metastatic prostate cancer patients can be an alternative for medical castration.
Advances in urology.
2012; 2012(?):979154. doi:
10.1155/2012/979154. [PMID: 21754927] - Kiyohide Fujimoto, Yoshihiko Hirao, Yasuo Ohashi, Yasuhiro Shibata, Kohzo Fuji, Hidenori Tsuji, Nobutaka Shimizu, Katsuhito Miyazawa, Masao Nagata, Nikinobu Ohtani, Ryoji Furuya, Eitetsu Boku. [Changes in serum prostate specific antigen and testosterone levels after chlormadinone acetate treatment in patients with benign prostatic hyperplasia : a prospective multicenter clinical study].
Hinyokika kiyo. Acta urologica Japonica.
2011 Apr; 57(4):177-83. doi:
NULL. [PMID: 21646847] - Vincenzo De Leo, Alessandra Di Sabatino, Maria C Musacchio, Giuseppe Morgante, Valeria Scolaro, Antonio Cianci, Felice Petraglia. Effect of oral contraceptives on markers of hyperandrogenism and SHBG in women with polycystic ovary syndrome.
Contraception.
2010 Sep; 82(3):276-80. doi:
10.1016/j.contraception.2010.04.002. [PMID: 20705157] - Maurizio Guido, Daniela Romualdi, Giuseppe Campagna, Luigi Ricciardi, Alessandro Bompiani, Antonio Lanzone. Ethinylestradiol-chlormadinone acetate combination for the treatment of hirsutism and hormonal alterations of normal-weight women with polycystic ovary syndrome: evaluation of the metabolic impact.
Reproductive sciences (Thousand Oaks, Calif.).
2010 Aug; 17(8):767-75. doi:
10.1177/1933719110371515. [PMID: 20595709] - Ulrich H Winkler, Petra Röhm, Kornelia Höschen. An open-label, comparative study of the effects of a dose-reduced oral contraceptive containing 0.02 mg ethinylestradiol/2 mg chlormadinone acetate on hemostatic parameters and lipid and carbohydrate metabolism variables.
Contraception.
2010 May; 81(5):391-400. doi:
10.1016/j.contraception.2009.12.005. [PMID: 20399945] - Salvatore Caruso, Salvatore Rugolo, Carmela Agnello, Mattea Romano, Antonio Cianci. Quality of sexual life in hyperandrogenic women treated with an oral contraceptive containing chlormadinone acetate.
The journal of sexual medicine.
2009 Dec; 6(12):3376-84. doi:
10.1111/j.1743-6109.2009.01529.x. [PMID: 19832931] - Edward Malone, Geraldine Dowling, Chris Elliott, Glenn Kennedy, Liam Regan. Confirmatory method for the determination of various acetylgestagens in animal kidney fat using liquid chromatography-tandem mass spectrometry.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2009 May; 26(5):672-82. doi:
10.1080/02652030802642110. [PMID: 19680939] - Roberto Uras, Marisa Orrù, Rossella Etzi, Giangavino Peppi, Maria Francesca Marotto, Monica Pilloni, Pierina Zedda, Stefano Lello, Gian Benedetto Melis, Anna Maria Paoletti. Evidence that in healthy young women, a six-cycle treatment with oral contraceptive containing 30 mcg of ethinylestradiol plus 2 mg of chlormadinone acetate reduces fat mass.
Contraception.
2009 Feb; 79(2):117-21. doi:
10.1016/j.contraception.2008.08.007. [PMID: 19135568] - Angelo Cagnacci, Serena Ferrari, Alessandra Tirelli, Renata Zanin, Annibale Volpe. Insulin sensitivity and lipid metabolism with oral contraceptives containing chlormadinone acetate or desogestrel: a randomized trial.
Contraception.
2009 Feb; 79(2):111-6. doi:
10.1016/j.contraception.2008.09.002. [PMID: 19135567] - Ulrich H Winkler, Roland Sudik. The effects of two monophasic oral contraceptives containing 30 mcg of ethinyl estradiol and either 2 mg of chlormadinone acetate or 0.15 mg of desogestrel on lipid, hormone and metabolic parameters.
Contraception.
2009 Jan; 79(1):15-23. doi:
10.1016/j.contraception.2008.08.011. [PMID: 19041436] - Michael Bonn, Urte Eydeler, Martin Barkworth, Lucio C Rovati. Bioequivalence study of generic tablet formulations containing ethinylestradiol and chlormadinone acetate in healthy female volunteers.
Arzneimittel-Forschung.
2009; 59(12):651-8. doi:
10.1055/s-0031-1296455. [PMID: 20108652] - Yasir Hasan Siddique, Gulshan Ara, Tanveer Beg, Mohammad Afzal. Possible modulating action of plant infusion of Ocimum sanctum L. on chromosomal aberrations and sister chromatid exchanges induced by chlormadinone acetate in human lymphocytes in vitro.
Journal of environmental biology.
2008 Nov; 29(6):845-8. doi:
". [PMID: 19297977] - Akira Iwase, Hisao Ando, Shigeru Toda, Shino Ishimatsu, Toko Harata, Shozo Kurotsuchi, Yuji Shimomura, Maki Goto, Fumitaka Kikkawa. Oral progestogen versus intramuscular progesterone for luteal support after assisted reproductive technology treatment: a prospective randomized study.
Archives of gynecology and obstetrics.
2008 Apr; 277(4):319-24. doi:
10.1007/s00404-007-0484-4. [PMID: 17938943] - Martina Kerscher, Tilmann Reuther, Julia Bayrhammer, Georg Schramm. Effects of an oral contraceptive containing chlormadinone and ethinylestradiol on acne-prone skin of women of different age groups: an open-label, single-centre, phase IV study.
Clinical drug investigation.
2008; 28(11):703-11. doi:
10.2165/00044011-200828110-00004. [PMID: 18840013] - Sarah Kelly Mortensen, Mikael Pedersen. Confirmatory analysis of acetylgestagens in plasma using liquid chromatography-tandem mass spectrometry.
Analytica chimica acta.
2007 Mar; 586(1-2):217-22. doi:
10.1016/j.aca.2006.10.016. [PMID: 17386714] - Madis Lõhmus, Tiia Kender. Determination of gestagens in kidney fat by liquid chromatography tandem mass spectrometry.
Analytica chimica acta.
2007 Mar; 586(1-2):233-8. doi:
10.1016/j.aca.2006.10.052. [PMID: 17386717] - Nobuyuki Goya, Kotaro Gotanda, Takako Sasaki, Mami Okada, Yasuko Tomizawa, Hiroshi Toma. Local injection of a sustained-release antiandrogen formulation into a target prostatic site: an experimental study.
BJU international.
2007 Jan; 99(1):202-6. doi:
10.1111/j.1464-410x.2006.06440.x. [PMID: 17092292] - Rolf Terlinden, Heinz Uragg, Karin Göhler, Christa Kneip. Pharmacokinetics of chlormadinone acetate following single and multiple oral dosing of chlormadinone acetate (2 mg) and ethinylestradiol (0.03 mg) and elimination and clearance of a single dose of radiolabeled chlormadinone acetate.
Contraception.
2006 Sep; 74(3):239-44. doi:
10.1016/j.contraception.2006.03.011. [PMID: 16904418] - Kouichi Minato, Seijirou Honma, Yoshihiko Shinohara, Takao Hashimoto. Metabolism of osaterone acetate in dogs and humans.
Steroids.
2005 Aug; 70(9):563-72. doi:
10.1016/j.steroids.2005.03.012. [PMID: 15923016] - Nao Iwatani, Yuichiro Inatomi, Toshiro Yonehara, Shodo Fujioka, Yoichiro Hashimoto, Teruyuki Hirano, Makoto Uchino. [Portal vein thrombosis associated with hepatic encephalopathy].
Rinsho shinkeigaku = Clinical neurology.
2005 Mar; 45(3):235-8. doi:
NULL. [PMID: 15835295] - Tatsuya Hori, Kazuyo Mukai, Kaoru Komoriya, Noriko Shimizu, Masanori Murakoshi, Eiichi Kawakami, Toshihiko Tsutsui. Fertility of bitches in which estrus was prevented with implantations of chlormadinone acetate for four years.
The Journal of veterinary medical science.
2005 Feb; 67(2):151-6. doi:
10.1292/jvms.67.151. [PMID: 15750310] - P Bouchard. Chlormadinone acetate (CMA) in oral contraception--a new opportunity.
The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception.
2005; 10 Suppl 1(?):7-11. doi:
10.1080/13625180500434889. [PMID: 16356876] - M Alhenc-Gelas, G Plu-Bureau, S Guillonneau, J-M Kirzin, M Aiach, N Ochat, P-Y Scarabin. Impact of progestagens on activated protein C (APC) resistance among users of oral contraceptives.
Journal of thrombosis and haemostasis : JTH.
2004 Sep; 2(9):1594-600. doi:
10.1111/j.1538-7836.2004.00894.x. [PMID: 15333036] - Yukio Homma, Hideyuki Akaza, Kiyoki Okada, Masao Yokoyama, Nobuo Moriyama, Michiyuki Usami, Yoshihiko Hirao, Tomoyasu Tsushima, Atsuhiko Sakamoto, Yasuo Ohashi, Yoshio Aso. Radical prostatectomy and adjuvant endocrine therapy for prostate cancer with or without preoperative androgen deprivation: Five-year results.
International journal of urology : official journal of the Japanese Urological Association.
2004 May; 11(5):295-303. doi:
10.1111/j.1442-2042.2004.00795.x. [PMID: 15147545] - A Teichmann. Pharmacology of estradiol valerate/dienogest.
Climacteric : the journal of the International Menopause Society.
2003 Aug; 6 Suppl 2(?):17-23. doi:
NULL. [PMID: 14669840] - D Meisl, M Hubler, S Arnold. [Treatment of fibroepithelial hyperplasia (FEH) of the mammary gland in the cat with the progesterone antagonist Aglépristone (Alizine)].
Schweizer Archiv fur Tierheilkunde.
2003 Mar; 145(3):130-6. doi:
10.1024/0036-7281.145.3.130. [PMID: 12677773] - Didier Chassard, Pascale Legallicier, Michel Dib. [The relative pharmacokinetics of two oral formulations of chlormadinone acetate: Lutéran 5mg. and Lutéran tablet 10 mg].
Therapie.
2003 Mar; 58(2):127-31. doi:
10.2515/therapie:2003018. [PMID: 12942852] - H Seeger, D Wallwiener, A O Mueck. The effect of progesterone and synthetic progestins on serum- and estradiol-stimulated proliferation of human breast cancer cells.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2003 Feb; 35(2):76-80. doi:
10.1055/s-2003-39061. [PMID: 12734785] - K Gotanda, A Shinbo, M Okada, Y Nakano, H Kobayashi, T Sasaki, M Hagiwara, H Akaza. Effects of combination therapy with a luteinizing hormone-releasing hormone agonist and chlormadinone acetate on rat prostate weight and plasma testosterone levels.
Prostate cancer and prostatic diseases.
2003; 6(1):66-72. doi:
10.1038/sj.pcan.4500617. [PMID: 12664069] - Yuzo Furuya, Osamu Nagakawa, Hideki Fuse. Prognostic significance of changes in short-term prostate volume and serum prostate-specific antigen after androgen withdrawal in men with metastatic prostate cancer.
Urologia internationalis.
2003; 70(3):195-9. doi:
10.1159/000068769. [PMID: 12660456] - H Akaza, Y Homma, K Okada, M Yokoyama, M Usami, Y Hirao, T Tsushima, Y Ohashi, Y Aso. A prospective and randomized study of primary hormonal therapy for patients with localized or locally advanced prostate cancer unsuitable for radical prostatectomy: results of the 5-year follow-up.
BJU international.
2003 Jan; 91(1):33-6. doi:
10.1046/j.1464-410x.2003.04014.x. [PMID: 12614246] - Jean Fiet, Frank Giton, Jack Auzerie, Hervé Galons. Development of a new sensitive and specific time-resolved fluoroimmunoassay (TR-FIA) of chlormadinone acetate in the serum of treated menopausal women.
Steroids.
2002 Dec; 67(13-14):1045-55. doi:
10.1016/s0039-128x(02)00050-8. [PMID: 12441190] - Isao Kiriyama, Kenji Ogaki, Shuji Ohba, Taiji Nishimura. Neoadjuvant hormonal therapy prior to radical prostatectomy: evaluation of pathological downstaging and biochemical relapse.
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi.
2002 Oct; 69(5):422-7. doi:
10.1272/jnms.69.422. [PMID: 12382001] - Alida A M Stolker, Paulus W Zoontjes, Paulus L W J Schwillens, Peter R Kootstra, Leendert A van Ginkel, Rainer W Stephany, Udo A Th Brinkman. Determination of acetyl gestagenic steroids in kidney fat by automated supercritical fluid extraction and liquid chromatography ion-trap mass spectrometry.
The Analyst.
2002 Jun; 127(6):748-54. doi:
10.1039/b201268p. [PMID: 12146906] - Sebastián Carranza-Lira, Norma Regina Magaña-Padilla. [Ultrasonographic and lipid changes in polycystic ovary syndrome according to the type of treatment ].
Ginecologia y obstetricia de Mexico.
2002 Jun; 70(?):285-8. doi:
". [PMID: 12148471] - Arturo Zárate, Eugenia Fonseca, Raquel Ochoa, Lourdes Basurto, Marcelino Hernández. Low-dose conjugated equine estrogens elevate circulating neurotransmitters and improve the psychological well-being of menopausal women.
Fertility and sterility.
2002 May; 77(5):952-5. doi:
10.1016/s0015-0282(02)03077-7. [PMID: 12009349] - Yuzo Furuya, Tetsuo Nozaki, Osamu Nagakawa, Hideki Fuse. Low serum testosterone level predicts worse response to endocrine therapy in Japanese patients with metastatic prostate cancer.
Endocrine journal.
2002 Feb; 49(1):85-90. doi:
10.1507/endocrj.49.85. [PMID: 12008754] - Kouichi Minato, Naoyuki Koizumi, Seijirou Honma, Kunio Tsukamoto, Satoshi Iwamura. Pharmacokinetics and biliary excretion of osaterone acetate, a new steroidal antiandrogen, in dogs.
Drug metabolism and disposition: the biological fate of chemicals.
2002 Feb; 30(2):167-72. doi:
10.1124/dmd.30.2.167. [PMID: 11792686] - C Pélissier, M Maroni, H Yaneva, S Brin, F Peltier-Pujol, M Jondet. Chlormadinone acetate versus micronized progesterone in the sequential combined hormone replacement therapy of the menopause.
Maturitas.
2001 Oct; 40(1):85-94. doi:
10.1016/s0378-5122(01)00170-0. [PMID: 11684377] - K Lange, E K Cordes, H O Hoppen, A R Günzel-Apel. Determination of concentrations of sex steroids in blood plasma and semen of male dogs treated with delmadinone acetate or finasteride.
Journal of reproduction and fertility. Supplement.
2001; 57(?):83-91. doi:
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Zentralblatt fur Gynakologie.
1990; 112(8):489-96. doi:
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Polski tygodnik lekarski (Warsaw, Poland : 1960).
1988 Feb; 43(8):256-8. doi:
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Zentralblatt fur Gynakologie.
1988; 110(4):241-5. doi:
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Folia haematologica (Leipzig, Germany : 1928).
1984; 111(4):519-27. doi:
NULL. [PMID: 6083922] - W Carol, A Börner, G Klinger, C Greinke. Transcortin as an indicator of estrogenic potency in oral contraceptives.
Endokrinologie.
1980 Mar; 75(2):167-72. doi:
NULL. [PMID: 6156820] - W Carol, G Klinger. [Effects of hormonal contraceptives on parameters of lipid metabolism (author's transl)].
Zentralblatt fur Gynakologie.
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