Hydrocodone (BioDeep_00000002446)
Secondary id: BioDeep_00000397858
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(1S,5R,13R,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10-trien-14-one
化学式: C18H21NO3 (299.1521356)
中文名称: 氢可酮
谱图信息:
最多检出来源 Homo sapiens(blood) 29.21%
分子结构信息
SMILES: CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(=O)CC4
InChI: InChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-12,17H,4-5,7-9H2,1-2H3
描述信息
Hydrocodone is only found in individuals that have used or taken this drug. It is a narcotic analgesic related to codeine, but more potent and more addicting by weight. It is used also as cough suppressant. [PubChem]Hydrocodone acts as a weak agonist at OP1, OP2, and OP3 opiate receptors within the central nervous system (CNS). Hydrocodone primarily affects OP3 receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as hydrocodone also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
R - Respiratory system > R05 - Cough and cold preparations > R05D - Cough suppressants, excl. combinations with expectorants > R05DA - Opium alkaloids and derivatives
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
C78273 - Agent Affecting Respiratory System > C66917 - Antitussive Agent
D019141 - Respiratory System Agents > D000996 - Antitussive Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
28 个代谢物同义名
(1S,5R,13R,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10-trien-14-one; 4,5-alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one; 4,5-a-Epoxy-3-methoxy-17-methylmorphinan-6-one; 4,5-Α-epoxy-3-methoxy-17-methylmorphinan-6-one; Nourypharma brand OF hydrocodone tartrate; Hydrocodone tartrate (1:1), hydrate (2:5); Du pont brand OF hydrocodone tartrate; Robins brand OF hydrocodone tartrate; Wyeth brand OF hydrocodone tartrate; Knoll brand OF hydrocodone tartrate; Hydrocodeinonebitartrate; hydrocodone bitartrate; (-)-Dihydrocodeinone; Dihydrocodeinone; Hydrocodonum; Hydrocodone; Hidrocodona; Idrocodone; Hydrocodon; Multacodin; Hydroconum; Hydrocone; Hydrocon; Robidone; Codinovo; Dicodid; Hycodan; Hycon
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:181668
- ChEBI: CHEBI:5779
- KEGG: C08024
- KEGGdrug: D08045
- PubChem: 5284569
- PubChem: 411697
- HMDB: HMDB0015091
- DrugBank: DB00956
- ChEMBL: CHEMBL1457
- Wikipedia: Hydrocodone
- MeSH: Hydrocodone
- chemspider: 4447623
- CAS: 1082738-67-7
- CAS: 50678-79-0
- CAS: 125-29-1
- PMhub: MS000002635
- PubChem: 10224
- NIKKAJI: J5.369D
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 3469 Papaver somniferum: 10.1016/J.JPBA.2008.06.022
- 3469 Papaver somniferum: 10.1016/J.JPBA.2008.06.022
- 9606 Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Loralie J Langman, Jeremy Gaskins, Erik Korte, Cynthia Maluf, Whitney L Wooderchak-Donahue, Gwendolyn A McMillin, Paul J Jannetto, Brandi Hartley, Arthur Malkani, Madhusudhan Yakkanti, Saeed A Jortani. Endogenous and iatrogenic sources of variability in response to opioid therapy in Post-Surgical and injured orthopedic patients.
Clinica chimica acta; international journal of clinical chemistry.
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Angewandte Chemie (International ed. in English).
2020 04; 59(15):5958-5964. doi:
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Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2020 01; 16(1):49-60. doi:
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Analytical chemistry.
2019 08; 91(16):10582-10588. doi:
10.1021/acs.analchem.9b01638. [PMID: 31314489] - Keivan Hosseinnejad, Tyler Yin, Jeremy T Gaskins, M Elaine Stauble, Yanhong Wu, Paul Jannetto, Loralie L Langman, Saeed A Jortani. Lack of Influence by CYP3A4 and CYP3A5 Genotypes on Pain Relief by Hydrocodone in Postoperative Cesarean Section Pain Management.
The journal of applied laboratory medicine.
2019 05; 3(6):954-964. doi:
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Nature chemical biology.
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Clinical chemistry.
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2019 Jan; 43(1):e7-e9. doi:
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Journal of analytical toxicology.
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Pain physician.
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Journal of analytical toxicology.
2012 Sep; 36(7):507-14. doi:
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Journal of analytical toxicology.
2012 May; 36(4):257-64. doi:
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Journal of analytical toxicology.
2012 Mar; 36(2):106-11. doi:
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BMC infectious diseases.
2012 Feb; 12(?):32. doi:
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Lung.
2012 Feb; 190(1):41-4. doi:
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European journal of clinical pharmacology.
2012 Jan; 68(1):55-64. doi:
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American journal of therapeutics.
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2011 Apr; 36(2):200-7. doi:
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International journal of hypertension.
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Journal of opioid management.
2011 Mar; 7(2):117-22. doi:
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Pharmacogenomics.
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Clinica chimica acta; international journal of clinical chemistry.
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Pain research and treatment.
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PloS one.
2011; 6(6):e20977. doi:
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Journal of biomedicine & biotechnology.
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Analytical and bioanalytical chemistry.
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The Journal of family practice.
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Journal of analytical toxicology.
2010 Oct; 34(8):470-5. doi:
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Journal of medical case reports.
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BMC musculoskeletal disorders.
2010 Jul; 11(?):156. doi:
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Journal of opioid management.
2010 Jul; 6(4):253-7. doi:
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Forensic science international.
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American family physician.
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Journal of analytical toxicology.
2010 Jan; 34(1):32-8. doi:
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Methods in molecular biology (Clifton, N.J.).
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Pharmacology, biochemistry, and behavior.
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