10-HCPT (BioDeep_00000000240)

 

Secondary id: BioDeep_00000398762

PANOMIX_OTCML-2023


代谢物信息卡片


(19S)-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione

化学式: C20H16N2O5 (364.1059166)
中文名称: (S)-10-羟基喜树碱, 10-羟基喜树碱, 羟基喜树碱
谱图信息: 最多检出来源 Viridiplantae(plant) 8.17%

分子结构信息

SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
InChI: InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1

描述信息

10-Hydroxycamptothecin is a pyranoindolizinoquinoline.
10-hydroxycamptothecin is under investigation in clinical trial NCT00956787 (Study of AR-67 (DB-67) in Myelodysplastic Syndrome (MDS)).
10-Hydroxycamptothecin is a natural product found in Nothapodytes nimmoniana, Camptotheca acuminata, and Fusarium solani with data available.
D000970 - Antineoplastic Agents
(S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment[1][2][3][4].
(S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment[1][2][3][4].

同义名列表

50 个代谢物同义名

(19S)-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione; (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3 inverted exclamation mark ,4 inverted exclamation mark :6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione; (19S)-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione; (S)-10-Hydroxycamptothecin;-;(+/-)-4-ethyl-4,9-dihydroxy-1h-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione; (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ((S)-10-Hydroxycamptothecin); 4-Ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (10-hydroxycamptothecin); 1H-Pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, hydrate, (S)-; (S)-4-ethyl-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione; 1H-PYRANO(3,4:6,7)INDOLIZINO(1,2-B)QUINOLINE-3,14(4H,12H)-DIONE, 4-ETHYL-4,9-DIHYDROXY-, (4S)-; (20S)-4-Ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; 1H-Pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione-,4-ethyl-4,9-dihydroxy-, (S)-; (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione; (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 1H-Pyrano[3,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione-,4-ethyl-4,9-dihydroxy-, (S)-; 4-Ethyl-4,10-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; 4-Ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; (S)-10-Hydroxycamptothecin hydrate; 10-HYDROXYCAMPTOTHECIN [WHO-DD]; (+)-(S)-10-HYDROXYCAMPTOTHECIN; HAWSQZCWOQZXHI-FQEVSTJZSA-N; (+)-10-HYDROXYCAMPTOTHECIN; Camptothecine, 10-hydroxy-; (S)-10-Hydroxycamptothecin; Camptothecin, 10-hydroxy-; ethyl(dihydroxy)[?]dione; CAMPTOTHECIN, 10-HYDROXY; 10-hydroxycamptothecine; 10-Hydroxy camptothecin; 10-Hydroxy-Camptothecin; Camptothecin, hydroxy-; 10-Hydroxycamptothecin; Hydroxycamptothecine; Hydroxycamptothecin; Spectrum3_001621; Spectrum2_001660; Spectrum5_000549; Spectrum4_001815; UNII-9Z01632KRV; 10-Hydroxy-CPT; DivK1c_006859; KBio2_002119; NCI60_000173; KBio2_007255; KBio1_001803; KBio2_004687; KBio3_002501; 9Z01632KRV; 10-HCPT; 10-HYDROXYCAMTOTHECIN



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yukun Chen, Zhenzhi Wang, Xiaofan Wang, Mingliang Su, Fan Xu, Lian Yang, Lijun Jia, Zhanxia Zhang. Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin. International journal of nanomedicine. 2022; 17(?):4227-4259. doi: 10.2147/ijn.s377149. [PMID: 36134205]
  • Yingjie Qi, Guangxuan Liu. Berberine-10-hydroxy camptothecine-loaded lipid microsphere for the synergistic treatment of liver cancer by inhibiting topoisomerase and HIF-1α. Drug delivery. 2021 Dec; 28(1):171-182. doi: 10.1080/10717544.2020.1870020. [PMID: 33427515]
  • Lingqiang Meng, Jianmin Dai, Shengzhong Rong, Hongmin Gao, Ze Zhang, Yingcong Zhang, Dong Chang, Hongzhi Pan. One-step electrodeposition preparation of polyaniline/f-MWCNTs as electrochemical sensors for detection of 10-hydroxycamptothecine. Biotechnology and applied biochemistry. 2021 Dec; 68(6):1192-1201. doi: 10.1002/bab.2041. [PMID: 32970340]
  • Yanni Sun, Ning Zhang, Cuiling Wang, Xiao Bai, Yahui Wei, Jianli Liu. The biosynthesis of camptothecin derivatives by Camptotheca acuminata seedlings. Natural product research. 2021 Jul; 35(14):2403-2407. doi: 10.1080/14786419.2019.1678616. [PMID: 31631694]
  • Shu Fan, Yong-Xiao Cao, Guang-Yan Li, Hao Lei, Mawusse K I Attiogbe, Jing-Chun Yao, Xue-Yan Yang, Yan-Jie Liu, Yuan-Yuan Hei, Hao Zhang, Lei Cao, Xiao-Yan Zhang, Shuai-Shuai Du, Gui-Min Zhang, San-Qi Zhang. F10, a new camptothecin derivative, was identified as a new orally-bioavailable, potent antitumor agent. European journal of medicinal chemistry. 2020 Sep; 202(?):112528. doi: 10.1016/j.ejmech.2020.112528. [PMID: 32650182]
  • Sixi Huang, Di Ren, Xinrong Wu, Ming Li, Xuesong Yu, Xiaoling Nie, Ying Wang, Yan Wang. Glycyrrhetinic Acid and TAT Peptide Modified Dual-functional Liposomes for Treatment of Hepatocellular Cancer. Current topics in medicinal chemistry. 2020; 20(27):2493-2505. doi: 10.2174/1568026620666200722110244. [PMID: 32703132]
  • Ting Zhou, Xin Tang, Wei Zhang, Jianfang Feng, Wei Wu. Preparation and in vitro and in vivo evaluations of 10-hydroxycamptothecin liposomes modified with stearyl glycyrrhetinate. Drug delivery. 2019 Dec; 26(1):673-679. doi: 10.1080/10717544.2019.1636422. [PMID: 31266376]
  • Wugang Zhang, Mulan Li, Wendi Du, Wuliang Yang, Guofeng Li, Chen Zhang, Xinli Liang, Haifang Chen. Tissue Distribution and Anti-Lung Cancer Effect of 10-Hydroxycamptothecin Combined with Platycodonis Radix and Glycyrrhizae Radix ET Rhizoma. Molecules (Basel, Switzerland). 2019 May; 24(11):. doi: 10.3390/molecules24112068. [PMID: 31151274]
  • Huai-Qiu Li, Wei-Liang Ye, Meng-Lei Huan, Ying Cheng, Dao-Zhou Liu, Han Cui, Miao Liu, Bang-le Zhang, Qi-Bing Mei, Si-Yuan Zhou. Mitochondria and nucleus delivery of active form of 10-hydroxycamptothecin with dual shell to precisely treat colorectal cancer. Nanomedicine (London, England). 2019 04; 14(8):1011-1032. doi: 10.2217/nnm-2018-0227. [PMID: 30925116]
  • Yifei Guo, Ting Wang, Hanhong Qiu, Meihua Han, Zhengqi Dong, Xiangtao Wang, Yanhong Wang. Hydroxycamptothecin nanoparticles based on poly/oligo (ethylene glycol): Architecture effects of nanocarriers on antitumor efficacy. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2019 Jan; 134(?):178-184. doi: 10.1016/j.ejpb.2018.12.003. [PMID: 30529294]
  • Yang Zhou, Tao Hong, Li Tong, Wei Liu, Xueting Yang, Jianghan Luo, Fuling Wang, Jian Li, Lijun Yan. Astragalus polysaccharide combined with 10-hydroxycamptothecin inhibits metastasis in non-small cell lung carcinoma cell lines via the MAP4K3/mTOR signaling pathway. International journal of molecular medicine. 2018 Dec; 42(6):3093-3104. doi: 10.3892/ijmm.2018.3868. [PMID: 30221690]
  • Yifei Guo, Ting Wang, Shuang Zhao, Hanhong Qiu, Meihua Han, Zhengqi Dong, Xiangtao Wang. Effect of alkyl chain on cellular uptake and antitumor activity of hydroxycamptothecin nanoparticles based on amphiphilic linear molecules. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2018 Nov; 124(?):266-272. doi: 10.1016/j.ejps.2018.08.043. [PMID: 30189259]
  • Chun-Gu Wang, Wei-Na Yao, Bin Zhang, Jing Hua, Dong Liang, Heng-Shan Wang. Lung cancer and matrix metalloproteinases inhibitors of polyphenols from Selaginella tamariscina with suppression activity of migration. Bioorganic & medicinal chemistry letters. 2018 08; 28(14):2413-2417. doi: 10.1016/j.bmcl.2018.06.024. [PMID: 29921475]
  • Yifei Guo, Ting Wang, Shuang Zhao, Meihua Han, Zhengqi Dong, Xiangtao Wang, Yanhong Wang. Amphiphilic Hybrid Dendritic-Linear Molecules as Nanocarriers for Shape-Dependent Antitumor Drug Delivery. Molecular pharmaceutics. 2018 07; 15(7):2665-2673. doi: 10.1021/acs.molpharmaceut.8b00190. [PMID: 29782803]
  • Vonny Salim, A Daniel Jones, Dean DellaPenna. Camptotheca acuminata 10-hydroxycamptothecin O-methyltransferase: an alkaloid biosynthetic enzyme co-opted from flavonoid metabolism. The Plant journal : for cell and molecular biology. 2018 07; 95(1):112-125. doi: 10.1111/tpj.13936. [PMID: 29681057]
  • Haiyang Wu, Tongya Yu, Ye Tian, Yinjie Wang, Ruizhi Zhao, Shirui Mao. Enhanced liver-targeting via coadministration of 10-Hydroxycamptothecin polymeric micelles with vinegar baked Radix Bupleuri. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 May; 44(?):1-8. doi: 10.1016/j.phymed.2018.04.022. [PMID: 29895488]
  • Jian Zheng, Yong Ji, Changmin Shao, Lijia Jing, Yang Wang. Pharmacokinetics and tissue distribution study of 10-methoxycamptothecin in rats following intragastric administration. Journal of pharmaceutical and biomedical analysis. 2018 Feb; 149(?):564-571. doi: 10.1016/j.jpba.2017.11.062. [PMID: 29197298]
  • Xiaoshuang Ren, Lan Zhang, Yanning Zhang, Liangang Mao, Hongyun Jiang. Mitochondria response to camptothecin and hydroxycamptothecine-induced apoptosis in Spodoptera exigua cells. Pesticide biochemistry and physiology. 2017 Aug; 140(?):97-104. doi: 10.1016/j.pestbp.2017.07.003. [PMID: 28755702]
  • Minjie Sun, Jing Li, Cuiting Zhang, Ying Xie, Hongzhi Qiao, Zhigui Su, David Oupický, Qineng Ping. Arginine-Modified Nanostructured Lipid Carriers with Charge-Reversal and pH-Sensitive Membranolytic Properties for Anticancer Drug Delivery. Advanced healthcare materials. 2017 Apr; 6(8):. doi: 10.1002/adhm.201600693. [PMID: 28187243]
  • Yifei Guo, Yanna Zhao, Ting Wang, Ran Li, Meihua Han, Zhengqi Dong, Chunyan Zhu, Xiangtao Wang. Hydroxycamptothecin Nanorods Prepared by Fluorescently Labeled Oligoethylene Glycols (OEG) Codendrimer: Antitumor Efficacy in Vitro and in Vivo. Bioconjugate chemistry. 2017 02; 28(2):390-399. doi: 10.1021/acs.bioconjchem.6b00536. [PMID: 27982573]
  • Linjie Yang, Jingyi Hong, Jing Di, Yifei Guo, Meihua Han, Meifeng Liu, Xiangtao Wang. 10-Hydroxycamptothecin (HCPT) nanosuspensions stabilized by mPEG1000-HCPT conjugate: high stabilizing efficiency and improved antitumor efficacy. International journal of nanomedicine. 2017; 12(?):3681-3695. doi: 10.2147/ijn.s134005. [PMID: 28553107]
  • Zhen Liu, Hongfa Li, Yaya Fan, Yuanxue Liu, Shuli Man, Peng Yu, Wenyuan Gao. Combination treatment with Rhizoma Paridis and Rhizoma Curcuma longa extracts and 10-hydroxycamptothecin enhances the antitumor effect in H22 tumor model by increasing the plasma concentration. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2016 Oct; 83(?):627-634. doi: 10.1016/j.biopha.2016.07.026. [PMID: 27459119]
  • Chun Pan, Yan-Fen Hu, Juan Song, Hua-Shan Yi, La Wang, Yi-Ying Yang, Yong-Ping Wang, Man Zhang, Min-Hui Pan, Cheng Lu. Effects of 10-hydroxycamptothecin on intrinsic mitochondrial pathway in silkworm BmN-SWU1 cells. Pesticide biochemistry and physiology. 2016 Feb; 127(?):15-20. doi: 10.1016/j.pestbp.2015.09.001. [PMID: 26821653]
  • Min Liu, Didi Chen, Jean Felix Mukerabigwi, Sha Chen, Yuannian Zhang, Shaojun Lei, Shiying Luo, Zhili Wen, Yu Cao, Xueying Huang, Hongxuan He. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance. Journal of drug targeting. 2016; 24(5):433-40. doi: 10.3109/1061186x.2015.1086358. [PMID: 26422582]
  • Yue Yuan, Jian Wen, Jie Tang, Qiming Kan, Rose Ackermann, Karl Olsen, Anna Schwendeman. Synthetic high-density lipoproteins for delivery of 10-hydroxycamptothecin. International journal of nanomedicine. 2016 ; 11(?):6229-6238. doi: 10.2147/ijn.s112835. [PMID: 27920529]
  • Xiaofeng Yang, Yingying Liu, Yanna Zhao, Meihua Han, Yifei Guo, Haixue Kuang, Xiangtao Wang. A stabilizer-free and organic solvent-free method to prepare 10-hydroxycamptothecin nanocrystals: in vitro and in vivo evaluation. International journal of nanomedicine. 2016; 11(?):2979-94. doi: 10.2147/ijn.s102726. [PMID: 27382284]
  • Yang Li, Jinyan Lin, Yu Huang, Yanxiu Li, Xiangrui Yang, Hongjie Wu, Shichao Wu, Liya Xie, Lizong Dai, Zhenqing Hou. Self-Targeted, Shape-Assisted, and Controlled-Release Self-Delivery Nanodrug for Synergistic Targeting/Anticancer Effect of Cytoplasm and Nucleus of Cancer Cells. ACS applied materials & interfaces. 2015 Nov; 7(46):25553-9. doi: 10.1021/acsami.5b07348. [PMID: 26529185]
  • Peng Li, Qinhua Chen, Fei Yu, Xiaoyu Xie, Sicen Wang. Simultaneous determination of camptothecin and 10-hydroxycamptothecine in the Camptotheca acuminate, its medicinal preparation and in rat plasma by liquid chromatography with fluorescence detection. Biomedical chromatography : BMC. 2015 Oct; 29(10):1522-6. doi: 10.1002/bmc.3452. [PMID: 25728326]
  • Zhenbo Yang, Wei Gong, Zhiyuan Wang, Bingsheng Li, Mingyuan Li, Xiangyang Xie, Hui Zhang, Yang Yang, Zhiping Li, Ying Li, Fanglin Yu, Xingguo Mei. A novel drug-polyethylene glycol liquid compound method to prepare 10-hydroxycamptothecin loaded human serum albumin nanoparticle. International journal of pharmaceutics. 2015 Jul; 490(1-2):412-28. doi: 10.1016/j.ijpharm.2015.05.073. [PMID: 26027489]
  • Sheng-Jie Yang, Ming-Chuan Liu, Qi Zhao, De-Yu Hu, Wei Xue, Song Yang. Synthesis and biological evaluation of betulonic acid derivatives as antitumor agents. European journal of medicinal chemistry. 2015; 96(?):58-65. doi: 10.1016/j.ejmech.2015.04.006. [PMID: 25874331]
  • Min Liu, Didi Chen, Chenxu Wang, Xunhu Chen, Zhili Wen, Yu Cao, Hongxuan He. Intracellular target delivery of 10-hydroxycamptothecin with solid lipid nanoparticles against multidrug resistance. Journal of drug targeting. 2015; 23(9):800-5. doi: 10.3109/1061186x.2015.1020427. [PMID: 25766079]
  • Hui Luo, Shengjie Yang, Yongqiang Cai, Zhijun Peng, Tao Liu. Synthesis and biological evaluation of novel 6-chloro-quinazolin derivatives as potential antitumor agents. European journal of medicinal chemistry. 2014 Sep; 84(?):746-52. doi: 10.1016/j.ejmech.2014.07.053. [PMID: 25064351]
  • Guofei Li, Yan Li, Yilin Tang, Yu Zhang, Yan Zhang, Tian Yin, Hui Xu, Cuifang Cai, Xing Tang. Hydroxyethyl starch conjugates for improving the stability, pharmacokinetic behavior and antitumor activity of 10-hydroxy camptothecin. International journal of pharmaceutics. 2014 Aug; 471(1-2):234-44. doi: 10.1016/j.ijpharm.2014.05.038. [PMID: 24861941]
  • Qinhua Chen, Guangmin Pan, Lin Xiong, Hongsheng He, Hangdong Yang. Characterization and quantification of 10-hydroxycamptothecine in Camptotheca acuminate and its medicinal preparation by liquid chromatography-ion trap mass spectrometry. Biomedical chromatography : BMC. 2013 Dec; 27(12):1615-20. doi: 10.1002/bmc.2969. [PMID: 23813501]
  • Li Gan, Yi-Ping Gao, Chun-Liu Zhu, Xin-Xin Zhang, Yong Gan. Novel pH-sensitive lipid-polymer composite microspheres of 10-hydroxycamptothecin exhibiting colon-specific biodistribution and reduced systemic absorption. Journal of pharmaceutical sciences. 2013 Jun; 102(6):1752-1759. doi: 10.1002/jps.23499. [PMID: 23605625]
  • Zhe Yang, Xingen Luo, Xiaofang Zhang, Jie Liu, Qing Jiang. Targeted delivery of 10-hydroxycamptothecin to human breast cancers by cyclic RGD-modified lipid-polymer hybrid nanoparticles. Biomedical materials (Bristol, England). 2013 Apr; 8(2):025012. doi: 10.1088/1748-6041/8/2/025012. [PMID: 23507576]
  • Jian-Bo Qu, Hui-Hui Shao, Guang-Lun Jing, Fang Huang. PEG-chitosan-coated iron oxide nanoparticles with high saturated magnetization as carriers of 10-hydroxycamptothecin: preparation, characterization and cytotoxicity studies. Colloids and surfaces. B, Biointerfaces. 2013 Feb; 102(?):37-44. doi: 10.1016/j.colsurfb.2012.08.004. [PMID: 23000675]
  • Yuangang Zu, Li Meng, Xiuhua Zhao, Yunlong Ge, Xinyang Yu, Yin Zhang, Yiping Deng. Preparation of 10-hydroxycamptothecin-loaded glycyrrhizic acid-conjugated bovine serum albumin nanoparticles for hepatocellular carcinoma-targeted drug delivery. International journal of nanomedicine. 2013; 8(?):1207-22. doi: 10.2147/ijn.s40493. [PMID: 23569373]
  • Domenico Alloatti, Giuseppe Giannini, Loredana Vesci, Massimo Castorina, Claudio Pisano, Elena Badaloni, Walter Cabri. Camptothecins in tumor homing via an RGD sequence mimetic. Bioorganic & medicinal chemistry letters. 2012 Oct; 22(20):6509-12. doi: 10.1016/j.bmcl.2012.07.061. [PMID: 22959246]
  • Wei Hu, Chao Zhang, Wenjin Hu, Yun Fang, Wenjie Hou. Pharmacokinetics, tissue distribution, and the lactone/carboxylate equilibrium of hydroxycamptothecin delivered via aerosol in mice. Fitoterapia. 2012 Oct; 83(7):1291-8. doi: 10.1016/j.fitote.2011.12.005. [PMID: 22858157]
  • Jian Zheng, Rui Zhang, Changmin Shao, Zhiwei Hu, Di Wang, Tao Yu, Xiufeng Yan, Yang Wang. Development and validation of a RP-HPLC method with fluorescence detection for simultaneous determination of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rat plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Aug; 903(?):81-7. doi: 10.1016/j.jchromb.2012.07.001. [PMID: 22824730]
  • Jian Zheng, Honghong Guo, Na Guo, Wei Ma, Lijia Jing, Rui Zhang, Zhifei Dai, Xiufeng Yan, Yang Wang, Zhenyue Wang. A two-step pH-dependent liquid-liquid extraction combined with HPLC-fluorescence method for the determination of 10-hydroxycamptothecin in mouse liver tissue. Pharmaceutical biology. 2012 Aug; 50(8):954-61. doi: 10.3109/13880209.2011.654228. [PMID: 22486519]
  • Yong-Xing Zhao, Dan-Xing Liu, Wen-Quan Liang, Zhi-Wei Ye. In-vivo pharmacokinetics, tissue distribution and anti-tumour effect of hydroxycamptothecin delivered in oil-in-water submicron emulsions. The Journal of pharmacy and pharmacology. 2012 Jun; 64(6):783-91. doi: 10.1111/j.2042-7158.2012.01484.x. [PMID: 22571256]
  • Hui-Hui Sun, Jing Zhang, Ye-Zhong Zhang, Li-Yun Yang, Li-Li Yuan, Yi Liu. Interaction of human serum albumin with 10-hydroxycamptothecin: spectroscopic and molecular modeling studies. Molecular biology reports. 2012 May; 39(5):5115-23. doi: 10.1007/s11033-011-1307-z. [PMID: 22160573]
  • Yi Xie, Jiajun Ling, Jinhui Gu. [Study on in vitro microdialysis recovery of hydroxycamptothecine]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 May; 37(10):1491-3. doi: 10.4268/cjcmm20121030. [PMID: 22860468]
  • Lan Zhang, Yanning Zhang, Weizhi He, Dejun Ma, Hongyun Jiang. Effects of camptothecin and hydroxycamptothecin on insect cell lines Sf21 and IOZCAS-Spex-II. Pest management science. 2012 Apr; 68(4):652-7. doi: 10.1002/ps.2313. [PMID: 22065515]
  • Qingyong Li, Qiaochu Zhu, Xiaoqiu Deng, Wuna He, Tengfei Zhao, Baoyou Zhang. Binding interactions of water-soluble camptothecin derivatives with bovine serum albumin. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2012 Feb; 86(?):124-30. doi: 10.1016/j.saa.2011.10.017. [PMID: 22051412]
  • Pei Yu, Longfei Xia, Jing Zhao, Gaoxiao Zhang, Zaijun Zhang, Ming Lang, Yuqiang Wang. Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs. Biological & pharmaceutical bulletin. 2012; 35(8):1295-9. doi: 10.1248/bpb.b12-00145. [PMID: 22863928]
  • Patrícia Severino, Tatiana Andreani, Ana Sofia Macedo, Joana F Fangueiro, Maria Helena A Santana, Amélia M Silva, Eliana B Souto. Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery. Journal of drug delivery. 2012; 2012(?):750891. doi: 10.1155/2012/750891. [PMID: 22175030]
  • Lei Yang, Xiaowei Sun, Fengjian Yang, Chunjian Zhao, Lin Zhang, Yuangang Zu. Application of ionic liquids in the microwave-assisted extraction of proanthocyanidins from Larix gmelini bark. International journal of molecular sciences. 2012; 13(4):5163-5178. doi: 10.3390/ijms13045163. [PMID: 22606036]
  • Yong Wang, Chuansheng Zheng, Bin Liang, Hui Zhao, Jun Qian, Huimin Liang, Gansheng Feng. Hepatocellular necrosis, apoptosis, and proliferation after transcatheter arterial embolization or chemoembolization in a standardized rabbit model. Journal of vascular and interventional radiology : JVIR. 2011 Nov; 22(11):1606-12. doi: 10.1016/j.jvir.2011.08.005. [PMID: 21959058]
  • Yongzhen Sun, Hongmei Luo, Ying Li, Chao Sun, Jingyuan Song, Yunyun Niu, Yingjie Zhu, Liang Dong, Aiping Lv, Enzo Tramontano, Shilin Chen. Pyrosequencing of the Camptotheca acuminata transcriptome reveals putative genes involved in camptothecin biosynthesis and transport. BMC genomics. 2011 Oct; 12(?):533. doi: 10.1186/1471-2164-12-533. [PMID: 22035094]
  • Zhigui Su, Jiangxiu Niu, Yanyu Xiao, Qineng Ping, Minjie Sun, Aiwen Huang, Weiliang You, Xiaoye Sang, Dongfen Yuan. Effect of octreotide-polyethylene glycol(100) monostearate modification on the pharmacokinetics and cellular uptake of nanostructured lipid carrier loaded with hydroxycamptothecine. Molecular pharmaceutics. 2011 Oct; 8(5):1641-51. doi: 10.1021/mp100463n. [PMID: 21770405]
  • Hanwen Sun, Peiyun Chen, Shasha Shi, Liqing Li. Development of chemiluminescence method for determination of 10-hydroxycamptothecin based on luminol-[Ag(HIO₆)₂]⁵⁻ reaction in alkaline solution. Luminescence : the journal of biological and chemical luminescence. 2011 Sep; 26(5):356-62. doi: 10.1002/bio.1238. [PMID: 20812199]
  • Wen Tan, Jinjian Lu, Mingqing Huang, Yingbo Li, Meiwan Chen, Guosheng Wu, Jian Gong, Zhangfeng Zhong, Zengtao Xu, Yuanye Dang, Jiajie Guo, Xiuping Chen, Yitao Wang. Anti-cancer natural products isolated from chinese medicinal herbs. Chinese medicine. 2011 Jul; 6(1):27. doi: 10.1186/1749-8546-6-27. [PMID: 21777476]
  • Xiaohui Pu, Jin Sun, Peng Zhang, Yongjun Wang, Yinghua Sun, Zhonggui He. [Study on pharmacokinetics of HCPT nanosuspensions with ability of inhibiting P-gp in rats after oral administration]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Jul; 36(14):1959-63. doi: . [PMID: 22016968]
  • Souvik Kusari, Sebastian Zühlke, Michael Spiteller. Correlations between camptothecin and related metabolites in Camptotheca acuminata reveal similar biosynthetic principles and in planta synergistic effects. Fitoterapia. 2011 Apr; 82(3):497-507. doi: 10.1016/j.fitote.2011.01.005. [PMID: 21238548]
  • Chao Zhang, Wei Hu, Yun Fang. [10-Hydroxycamptothecin aerosol treatment inhibits lung metastases in B16F10 melanoma mice models]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Mar; 36(5):618-23. doi: . [PMID: 21657084]
  • Qingyong Li, Chen Liu, Xiuhua Zhao, Yuangang Zu, Ying Wang, Baoyou Zhang, Dongmei Zhao, Qi Zhao, Lin Su, Yang Gao, Baihe Sun. Preparation, characterization and targeting of micronized 10-hydroxycamptothecin-loaded folate-conjugated human serum albumin nanoparticles to cancer cells. International journal of nanomedicine. 2011; 6(?):397-405. doi: 10.2147/ijn.s16144. [PMID: 21499429]
  • Yiping Gao, Chun-Liu Zhu, Xin-Xin Zhang, Li Gan, Yong Gan. Lipid-polymer composite microspheres for colon-specific drug delivery prepared using an ultrasonic spray freeze-drying technique. Journal of microencapsulation. 2011; 28(6):549-56. doi: 10.3109/02652048.2011.599442. [PMID: 21767115]
  • Su-Wen Yang, Wei Wang, Xin-You Xie, Wan-Ping Zhu, Fang-Qiong Li. In vitro synergistic cytotoxic effect of triptolide combined with hydroxycamptothecin on pancreatic cancer cells. The American journal of Chinese medicine. 2011; 39(1):121-34. doi: 10.1142/s0192415x11008695. [PMID: 21213403]
  • Xiuhua Zhao, Yuangang Zu, Ru Jiang, Ying Wang, Yong Li, Qingyong Li, Dongmei Zhao, Baishi Zu, Baoyou Zhang, Zhiqiang Sun, Xiaonan Zhang. Preparation and physicochemical properties of 10-hydroxycamptothecin (HCPT) nanoparticles by supercritical antisolvent (SAS) process. International journal of molecular sciences. 2011; 12(4):2678-91. doi: 10.3390/ijms12042678. [PMID: 21731466]
  • Kai Shi, Ye Tian, Yanbo Jiang, Lan Wang, Fude Cui. Modified hydrolysis kinetics of the active lactone moiety of 10-hydroxycamptothecin by liposomal encapsulation. Pharmaceutical development and technology. 2010 Dec; 15(6):644-52. doi: 10.3109/10837450903426526. [PMID: 19943738]
  • Yan Pi, Keji Jiang, Rong Hou, Yifu Gong, Juan Lin, Xiaofen Sun, Kexuan Tang. Examination of camptothecin and 10-hydroxycamptothecin in Camptotheca acuminata plant and cell culture, and the affected yields under several cell culture treatments. Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al. 2010 Dec; 34(3):139-43. doi: ". [PMID: 21443144]
  • Jing Li, Ying Zhu, Wenxin Li, Xiaoyong Zhang, Yan Peng, Qing Huang. Nanodiamonds as intracellular transporters of chemotherapeutic drug. Biomaterials. 2010 Nov; 31(32):8410-8. doi: 10.1016/j.biomaterials.2010.07.058. [PMID: 20692696]
  • Wei Wei, San-Jun Shi, Jie Liu, Xun Sun, Ke Ren, Dong Zhao, Xiao-Ning Zhang, Zhi-Rong Zhang, Tao Gong. Lipid nanoparticles loaded with 10-hydroxycamptothecin-phospholipid complex developed for the treatment of hepatoma in clinical application. Journal of drug targeting. 2010 Aug; 18(7):557-66. doi: 10.3109/10611861003599461. [PMID: 20131981]
  • Jun Zhao, Hua-Jie Zhu, Xiao-Jiang Zhou, Tong-Hua Yang, Yuan-Yuan Wang, Jia Su, Yan Li, Yong-Xian Cheng. Diterpenoids from the feces of Trogopterus xanthipes. Journal of natural products. 2010 May; 73(5):865-9. doi: 10.1021/np900814s. [PMID: 20402524]
  • Alessio Valletta, Livio Trainotti, Anna Rita Santamaria, Gabriella Pasqua. Cell-specific expression of tryptophan decarboxylase and 10-hydroxygeraniol oxidoreductase, key genes involved in camptothecin biosynthesis in Camptotheca acuminata Decne (Nyssaceae). BMC plant biology. 2010 Apr; 10(?):69. doi: 10.1186/1471-2229-10-69. [PMID: 20403175]
  • Xiao-Lan Xu, Bao-Cai Xing, Hai-Bo Han, Wei Zhao, Mei-Hao Hu, Zuo-Liang Xu, Ji-You Li, Yong Xie, Jun Gu, Yu Wang, Zhi-Qian Zhang. The properties of tumor-initiating cells from a hepatocellular carcinoma patient's primary and recurrent tumor. Carcinogenesis. 2010 Feb; 31(2):167-74. doi: 10.1093/carcin/bgp232. [PMID: 19897602]
  • S Shweta, S Zuehlke, B T Ramesha, V Priti, P Mohana Kumar, G Ravikanth, M Spiteller, R Vasudeva, R Uma Shaanker. Endophytic fungal strains of Fusarium solani, from Apodytes dimidiata E. Mey. ex Arn (Icacinaceae) produce camptothecin, 10-hydroxycamptothecin and 9-methoxycamptothecin. Phytochemistry. 2010 Jan; 71(1):117-22. doi: 10.1016/j.phytochem.2009.09.030. [PMID: 19863979]
  • A H Adebayo, N H Tan, A A Akindahunsi, G Z Zeng, Y M Zhang. Anticancer and antiradical scavenging activity of Ageratum conyzoides L. (Asteraceae). Pharmacognosy magazine. 2010 Jan; 6(21):62-6. doi: 10.4103/0973-1296.59968. [PMID: 20548938]
  • Hai Liu, Gui-Xin Chou, Tao Wu, Yin-Long Guo, Shun-Chun Wang, Chang-Hong Wang, Zheng-Tao Wang. Steroidal sapogenins and glycosides from the rhizomes of Dioscorea bulbifera. Journal of natural products. 2009 Nov; 72(11):1964-8. doi: 10.1021/np900255h. [PMID: 19842682]
  • Zhe-Feng Yuan, Yong-Min Tang, Hua Song, Shu-Wen Shi, Shi-Long Yang, Bin-Hua Pan, Fen-Ying Zhao. [Efficacy of chemotherapy using 10-hydroxycamptothecin on recurrent or refractory neuroblastoma in children]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. 2009 May; 11(5):361-3. doi: . [PMID: 19470257]
  • Souvik Kusari, Sebastian Zühlke, Michael Spiteller. An endophytic fungus from Camptotheca acuminata that produces camptothecin and analogues. Journal of natural products. 2009 Jan; 72(1):2-7. doi: 10.1021/np800455b. [PMID: 19119919]
  • Yuangang Zu, Yu Zhang, Xiuhua Zhao, Qi Zhang, Yang Liu, Ru Jiang. Optimization of the preparation process of vinblastine sulfate (VBLS)-loaded folate-conjugated bovine serum albumin (BSA) nanoparticles for tumor-targeted drug delivery using response surface methodology (RSM). International journal of nanomedicine. 2009; 4(?):321-33. doi: 10.2147/ijn.s8501. [PMID: 20054435]
  • Guo-dong Huang, Yu You, Yuan-hua Huang, Li-jun Tang, Zhi-fang Yang, Long Xu, Dao-fu Huang, Mei-zhen Xiao. [Effects of Geranium sibirum extracts on liver metastases in nude mice with colonic cancer]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2009 Jan; 32(1):97-9. doi: ". [PMID: 19445132]
  • Xinxin Zhang, Weisan Pan, Li Gan, Chunliu Zhu, Yong Gan, Shufang Nie. Preparation of a dispersible PEGylate nanostructured lipid carriers (NLC) loaded with 10-hydroxycamptothecin by spray-drying. Chemical & pharmaceutical bulletin. 2008 Dec; 56(12):1645-50. doi: 10.1248/cpb.56.1645. [PMID: 19043233]
  • Wei-Guo Shi, Yuan-Gang Zu, Lei Yang, Chun-Jian Zhao, Jia-Hui Li. [Isolation and purification of 10-hydroxycamptothecin and vincoside-lactam from Camptotheca acuminata seed by polyamide]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2008 Nov; 33(21):2486-9. doi: . [PMID: 19149254]
  • Dandan Qin, Haiyan Wu, Huiru Peng, Yingyin Yao, Zhongfu Ni, Zhenxing Li, Chunlei Zhou, Qixin Sun. Heat stress-responsive transcriptome analysis in heat susceptible and tolerant wheat (Triticum aestivum L.) by using Wheat Genome Array. BMC genomics. 2008 Sep; 9(?):432. doi: 10.1186/1471-2164-9-432. [PMID: 18808683]
  • Xinxin Zhang, Yong Gan, Li Gan, Shufang Nie, Weisan Pan. PEGylated nanostructured lipid carriers loaded with 10-hydroxycamptothecin: an efficient carrier with enhanced anti-tumour effects against lung cancer. The Journal of pharmacy and pharmacology. 2008 Aug; 60(8):1077-87. doi: 10.1211/jpp.60.8.0014. [PMID: 18644200]
  • Anxun Wang, Su Li. Hydroxycamptothecin-loaded nanoparticles enhance target drug delivery and anticancer effect. BMC biotechnology. 2008 May; 8(?):46. doi: 10.1186/1472-6750-8-46. [PMID: 18454874]
  • Kai Liu, Jin Sun, Yongjun Wang, Yuan He, Kun Gao, Zhonggui He. Preparation and characterization of 10-hydroxycamptothecin loaded nanostructured lipid carriers. Drug development and industrial pharmacy. 2008 May; 34(5):465-71. doi: 10.1080/03639040701662230. [PMID: 18473227]
  • B T Ramesha, T Amna, G Ravikanth, Rajesh P Gunaga, R Vasudeva, K N Ganeshaiah, R Uma Shaanker, R K Khajuria, S C Puri, G N Qazi. Prospecting for Camptothecines from Nothapodytes nimmoniana in the Western Ghats, South India: identification of high-yielding sources of camptothecin and new families of camptothecines. Journal of chromatographic science. 2008 Apr; 46(4):362-8. doi: 10.1093/chromsci/46.4.362. [PMID: 18402730]
  • Yu-Ling Leu, Chien-Shu Chen, Yih-Jang Wu, Ji-Wang Chern. Benzyl ether-linked glucuronide derivative of 10-hydroxycamptothecin designed for selective camptothecin-based anticancer therapy. Journal of medicinal chemistry. 2008 Mar; 51(6):1740-6. doi: 10.1021/jm701151c. [PMID: 18318465]
  • Zhuo Chen, Yu-Mei Liu, Song Yang, Bao-An Song, Guang-Fang Xu, Pinaki S Bhadury, Lin-Hong Jin, De-Yu Hu, Fang Liu, Wei Xue, Xia Zhou. Studies on the chemical constituents and anticancer activity of Saxifraga stolonifera (L) Meeb. Bioorganic & medicinal chemistry. 2008 Feb; 16(3):1337-44. doi: 10.1016/j.bmc.2007.10.072. [PMID: 17997321]
  • Peng-Cheng Li, Liang-Dong Chen, Fang Zheng, Yan Li. Intraperitoneal chemotherapy with hydroxycamptothecin reduces peritoneal carcinomatosis: results of an experimental study. Journal of cancer research and clinical oncology. 2008 Jan; 134(1):37-44. doi: 10.1007/s00432-007-0242-9. [PMID: 17665213]
  • Xin-Xin Zhang, Yong Gan, Xing-Gang Yang, Chun-Liu Zhu, Li Gan, Shu-Fang Nie, Wei-San Pan. [Preparation of PEG-modified nanostructured lipid carriers loaded with hydroxycamptothecin and tissue distribution in mice]. Yao xue xue bao = Acta pharmaceutica Sinica. 2008 Jan; 43(1):91-6. doi: NULL. [PMID: 18357740]
  • Lei Yang, Fude Cui, Dongmei Cun, Anjin Tao, Kai Shi, Wenhui Lin. Preparation, characterization and biodistribution of the lactone form of 10-hydroxycamptothecin (HCPT)-loaded bovine serum albumin (BSA) nanoparticles. International journal of pharmaceutics. 2007 Aug; 340(1-2):163-72. doi: 10.1016/j.ijpharm.2007.03.028. [PMID: 17482779]
  • Blanka Ziomkowska, Michał Cyrankiewicz, Stefan Kruszewski. Hydroxycamptothecin deactivation rates and binding to model membranes and HSA determined by fluorescence spectra analysis. Combinatorial chemistry & high throughput screening. 2007 Jul; 10(6):459-65. doi: 10.2174/138620707781996394. [PMID: 17896941]
  • Blanka Ziomkowska, Michal Cyrankiewicz, Stefan Kruszewski. Determination of hydroxycamptothecin affinities to albumin and membranes by steady-state fluorescence anisotropy measurements. Combinatorial chemistry & high throughput screening. 2007 Jul; 10(6):486-92. doi: 10.2174/138620707781996420. [PMID: 17896945]
  • Zeljko M Prijovich, Yu-Lin Leu, Steve R Roffler. Effect of pH and human serum albumin on the cytotoxicity of a glucuronide prodrug of 9-aminocamptothecin. Cancer chemotherapy and pharmacology. 2007 Jun; 60(1):7-17. doi: 10.1007/s00280-006-0340-4. [PMID: 16983566]
  • YuanGang Zu, ChongYang Gao, WenJie Wang, FengJian Yang, Ying Liu, Min Wang, YangGuo Zhao. Characteristics of the microbial community in rhizosphere of Camptotheca acuminata cultured with exotic invasive plant Eupatorium adenophorum. Science in China. Series C, Life sciences. 2007 Feb; 50(1):22-30. doi: 10.1007/s11427-007-0012-6. [PMID: 17393079]
  • Jian Zhang, Ying Yu, Dong Liu, Zhijun Liu. Extraction and composition of three naturally occurring anti-cancer alkaloids in Camptotheca acuminata seed and leaf extracts. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2007 Jan; 14(1):50-6. doi: 10.1016/j.phymed.2006.11.004. [PMID: 17137773]
  • Yongxing Zhao, Jianqing Gao, Xiaoyi Sun, Hailiang Chen, Limao Wu, Wenquan Liang. Enhanced nuclear delivery and cytotoxic activity of hydroxycamptothecin using o/w emulsions. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 2007; 10(1):61-70. doi: NULL. [PMID: 17498395]
  • Bin Lu, Zhengquan Zhang. Novel colon-specific microspheres with highly dispersed hydroxycamptothecin cores: their preparation, release behavior, and therapeutic efficiency against colonic cancer. Journal of pharmaceutical sciences. 2006 Dec; 95(12):2619-30. doi: 10.1002/jps.20635. [PMID: 16917869]
  • Yu-Rong Fu, Zheng-Jun Yi, Yu-Rong Yan, Zong-Yin Qiu. Hydroxycamptothecin-induced apoptosis in hepatoma SMMC-7721 cells and the role of mitochondrial pathway. Mitochondrion. 2006 Aug; 6(4):211-7. doi: 10.1016/j.mito.2006.07.005. [PMID: 16926123]
  • Xinlan Zhou, Xiangjiu He, Guanghui Wang, Hao Gao, Guangxiong Zhou, Wencai Ye, Xinsheng Yao. Steroidal saponins from Solanum nigrum. Journal of natural products. 2006 Aug; 69(8):1158-63. doi: 10.1021/np060091z. [PMID: 16933867]
  • Wei Gu, Ya-Ni Zhang, Bai Li, Jie Han, Bin-Bin Cheng, Chang-Quan Ling. [Establishment of a multidrug-resistant cell line BEL-7402/5-FU of human hepatocellular carcinoma and its biological characteristics]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 2006 May; 4(3):265-70. doi: . [PMID: 16696913]
  • Na Xi, Lian-Bing Hou, Xi-Qing Yan, Qing-Feng Jiang, Chun-Xia Wang. [Preparation of 10-hydroxycamptothecin semisolid lipid nanoparticles and investigation of its stability]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2006 Jan; 29(1):63-6. doi: ". [PMID: 16722323]