Trihexyphenidyl (BioDeep_00000002363)

 

Secondary id: BioDeep_00001867882

human metabolite blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


Pharmaceutical associates brand OF trihexyphenidyl hydrochloride

化学式: C20H31NO (301.2406)
中文名称: 苯海索
谱图信息: 最多检出来源 Viridiplantae(plant) 4.53%

分子结构信息

SMILES: C1CCC(CC1)C(CCN2CCCCC2)(C3=CC=CC=C3)O
InChI: InChI=1S/C20H31NO/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2

描述信息

Trihexyphenidyl is only found in individuals that have used or taken this drug. It is one of the centrally acting muscarinic antagonists used for treatment of parkinsonian disorders and drug-induced extrapyramidal movement disorders and as an antispasmodic. [PubChem]Trihexyphenidyl is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). Trihexyphenidyl partially blocks cholinergic activity in the CNS, which is responsible for the symptoms of Parkinsons disease. It is also thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth control of voluntary muscle movement.
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
N - Nervous system > N04 - Anti-parkinson drugs > N04A - Anticholinergic agents > N04AA - Tertiary amines
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
C78272 - Agent Affecting Nervous System > C38149 - Antiparkinsonian Agent

同义名列表

38 个代谢物同义名

Pharmaceutical associates brand OF trihexyphenidyl hydrochloride; 1-cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol; Liquipharm brand OF trihexyphenidyl hydrochloride; Psicofarma brand OF trihexyphenidyl hydrochloride; Lederle brand OF trihexyphenidyl hydrochloride; Cypress brand OF trihexyphenidyl hydrochloride; Schrein brand OF trihexyphenidyl hydrochloride; Aventis brand OF trihexyphenidyl hydrochloride; Apotex brand OF trihexyphenidyl hydrochloride; Hexal brand OF trihexyphenidyl hydrochloride; Wyeth brand OF trihexyphenidyl hydrochloride; Rugby brand OF trihexyphenidyl hydrochloride; Eisai brand OF trihexyphenidyl hydrochloride; AHP brand OF trihexyphenidyl hydrochloride; Trihexyphenidyl hydrochloride elixir; Wyeth brand OF trihexyphenidyl; Trihexyphenidyl hydrochloride; Trihexyphenidyl wyeth brand; Trihexidyl hydrochloride; Trihexylphenidyle; Trihexyphenidyle; Trihexylphenidyl; Trihexylphenizyl; Trihexylphenedyl; trihexyphenidyl; Triphenidyl; Apo-trihex; apo Trihex; ApoTrihex; Benzhexol; Parkinane; Hipokinon; Trihexane; Cyclodol; Parkopan; Artane; Trihexyphenidyl; Trihexyphenidyl



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

64 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 APOE, CHAT, DDC, GCH1, MME, POMC, SLC6A3, SNCA
Peripheral membrane protein 1 ACHE
Endoplasmic reticulum membrane 1 DRD1
Nucleus 8 ACHE, APOE, CHAT, DNMT3B, DRD1, GCH1, KMT2B, SNCA
cytosol 6 AVP, CHAT, DCAF17, DDC, GCH1, SNCA
dendrite 6 APOE, AVP, DRD2, MAOB, MME, PENK
trans-Golgi network 1 MME
nucleoplasm 4 DCAF17, DNMT3B, GCH1, KMT2B
Cell membrane 5 ACHE, DRD1, DRD2, MME, SLC6A3
Cytoplasmic side 1 MAOB
Cell projection, axon 2 SLC6A3, SNCA
Multi-pass membrane protein 4 DCAF17, DRD1, DRD2, SLC6A3
Golgi apparatus membrane 1 DRD2
Synapse 6 ACHE, CHAT, DRD2, MME, SNCA, TAC1
cell cortex 1 SNCA
cell surface 3 ACHE, MME, SLC6A3
glutamatergic synapse 3 APOE, DRD1, DRD2
Golgi apparatus 2 ACHE, APOE
Golgi membrane 1 DRD2
growth cone 1 SNCA
neuromuscular junction 1 ACHE
neuronal cell body 7 APOE, MAOB, MME, PENK, SLC6A3, SNCA, TAC1
postsynapse 1 SNCA
presynaptic membrane 3 DRD1, DRD2, SLC6A3
synaptic vesicle 1 MME
Lysosome 1 SNCA
Presynapse 1 MME
acrosomal vesicle 1 DRD2
plasma membrane 9 ACHE, APOE, BCHE, DRD1, DRD2, MME, PENK, SLC6A3, SNCA
synaptic vesicle membrane 2 DRD2, SNCA
Membrane 6 ACHE, APOE, DCAF17, MME, SLC6A3, SNCA
axon 5 DRD2, MME, SLC6A3, SNCA, TAC1
brush border 1 MME
extracellular exosome 3 APOE, DDC, MME
endoplasmic reticulum 1 APOE
extracellular space 8 ACHE, APOE, AVP, BCHE, POMC, SNCA, TAC1, TG
perinuclear region of cytoplasm 2 ACHE, SNCA
mitochondrion 3 GCH1, MAOB, SNCA
protein-containing complex 2 GCH1, SNCA
Secreted 8 ACHE, APOE, AVP, BCHE, PENK, POMC, SNCA, TG
extracellular region 9 ACHE, APOE, AVP, BCHE, PENK, POMC, SNCA, TAC1, TG
Mitochondrion outer membrane 1 MAOB
mitochondrial outer membrane 1 MAOB
neuronal cell body membrane 1 SLC6A3
Extracellular side 1 ACHE
ciliary membrane 2 DRD1, DRD2
nuclear membrane 1 GCH1
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 1 APOE
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 1 APOE
actin cytoskeleton 1 SNCA
dendritic spine 2 DRD1, DRD2
neuronal dense core vesicle lumen 1 PENK
perikaryon 2 DRD2, PENK
cytoplasmic vesicle 2 GCH1, MME
nucleolus 1 DCAF17
Early endosome 2 APOE, MME
Single-pass type II membrane protein 1 MME
postsynaptic membrane 3 DRD1, DRD2, SLC6A3
Membrane raft 2 MME, SLC6A3
focal adhesion 1 MME
GABA-ergic synapse 2 DRD1, DRD2
flotillin complex 1 SLC6A3
extracellular matrix 1 APOE
basement membrane 1 ACHE
Cell projection, dendritic spine 1 DRD1
collagen-containing extracellular matrix 1 APOE
secretory granule 2 AVP, POMC
lateral plasma membrane 1 DRD2
Cell projection, neuron projection 1 SLC6A3
neuron projection 2 CHAT, SLC6A3
cilium 2 DRD1, DRD2
supramolecular fiber 1 SNCA
Secreted, extracellular space 1 APOE
Nucleus, nucleolus 1 DCAF17
blood microparticle 2 APOE, BCHE
non-motile cilium 2 DRD1, DRD2
Lipid-anchor, GPI-anchor 1 ACHE
sperm flagellum 1 DRD2
cell body fiber 1 PENK
Cell projection, dendrite 1 DRD1
Melanosome 1 APOE
side of membrane 1 ACHE
secretory granule lumen 1 POMC
secretory granule membrane 1 MME
endoplasmic reticulum lumen 3 APOE, BCHE, PENK
histone methyltransferase complex 1 KMT2B
MLL1/2 complex 1 KMT2B
axon terminus 4 DRD2, PENK, SLC6A3, SNCA
endocytic vesicle 1 DRD2
mitochondrial envelope 1 MAOB
neuronal dense core vesicle 1 AVP
Single-pass type IV membrane protein 1 MAOB
nuclear envelope lumen 1 BCHE
clathrin-coated endocytic vesicle membrane 2 APOE, AVP
synaptic cleft 2 ACHE, APOE
dopaminergic synapse 2 DRD2, SLC6A3
Cell projection, cilium membrane 1 DRD1
discoidal high-density lipoprotein particle 1 APOE
endocytic vesicle lumen 1 APOE
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen 1 PENK
chromaffin granule lumen 1 PENK
symmetric synapse 1 PENK
synaptic vesicle lumen 1 PENK
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
inclusion body 1 SNCA
catalytic complex 1 DNMT3B
neuron projection terminus 2 GCH1, MME
G protein-coupled receptor complex 2 DRD1, DRD2
[Isoform H]: Cell membrane 1 ACHE
Cul4-RING E3 ubiquitin ligase complex 1 DCAF17


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Yang Lv, Hongyu Liang, Jun Li, Xiuxiu Li, Xiaohui Tang, Songyu Gao, Hao Zou, Jing Zhang, Mei Wang, Liang Xiao. Central inhibition prevents the in vivo acute toxicity of harmine in mice. The Journal of toxicological sciences. 2021; 46(6):289-301. doi: 10.2131/jts.46.289. [PMID: 34078836]
  • Alka A Subramanyam, Hrishikesh B Nachane, Niraj N Mahajan, Snehal Shinde, Smita D Mahale, Rahul K Gajbhiye. Postpartum psychosis in mothers with SARS-CoV-2 infection: A case series from India. Asian journal of psychiatry. 2020 Dec; 54(?):102406. doi: 10.1016/j.ajp.2020.102406. [PMID: 33271702]
  • Harpreet Kaur, Ravjot Kaur, Amteshwar Singh Jaggi, Anjana Bali. Beneficial role of central anticholinergic agent in preventing the development of symptoms in mouse model of post-traumatic stress disorder. Journal of basic and clinical physiology and pharmacology. 2020 Jul; 31(6):. doi: 10.1515/jbcpp-2019-0196. [PMID: 32712590]
  • Xiaoxia Chen, Junmei Zhang, Yue Li, Suqin Han. Chemiluminescence of copper nanoclusters and its application for trihexyphenidyl hydrochloride detection. Luminescence : the journal of biological and chemical luminescence. 2018 Aug; 33(5):962-967. doi: 10.1002/bio.3496. [PMID: 29785806]
  • Rajesh Verma, Rakesh Lalla, Tushar B Patil. Is blinking of the eyes affected in extrapyramidal disorders? An interesting observation in a patient with Wilson disease. BMJ case reports. 2012 Nov; 2012(?):. doi: 10.1136/bcr-2012-007367. [PMID: 23188863]
  • Stojan Petković, Maja Durendić-Brenesel, Matilda Dolai, Isidora Samojlik. Fatal intoxication because of trihexyphenidyl. Journal of forensic sciences. 2011 Sep; 56(5):1383-6. doi: 10.1111/j.1556-4029.2011.01816.x. [PMID: 21644988]
  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
  • Babiker El-Haj, Abdulkader Al-Amri, Heyam Saad Ali. Target urinary analytes for the gas chromatographic- mass spectrometric detection of procyclidine and benzhexol in drug abuse cases. Journal of analytical toxicology. 2011 Mar; 35(2):92-8. doi: 10.1093/anatox/35.2.92. [PMID: 21396228]
  • Zhen-Zhen Liu, Bian-Sheng Ji. The protective effect of trihexyphenidyl on the beta-amyloid peptide (25-35)-induced cytotoxicity in PC12 cells. Clinical and experimental medicine. 2010 Dec; 10(4):237-43. doi: 10.1007/s10238-010-0090-9. [PMID: 20101432]
  • Poonam Verma, K Pathak. Therapeutic and cosmeceutical potential of ethosomes: An overview. Journal of advanced pharmaceutical technology & research. 2010 Jul; 1(3):274-82. doi: 10.4103/0110-5558.72415. [PMID: 22247858]
  • Min Wu, Guang-hua Xiao, Min Yao, Jian-ming Zhang, Xin Zhang, Ya-bing Zhou, Jing-yan Zhang, Shu-xia Wang, Bo Ma, Yan-ping Chen. Multicenter clinical study on the treatment of children's tic disorder with Qufeng Zhidong Recipe. Chinese journal of integrative medicine. 2009 Aug; 15(4):254-60. doi: 10.1007/s11655-009-0254-1. [PMID: 19688312]
  • D E Dar, M Thiruvazhi, P Abraham, S Kitayama, T A Kopajtic, A Gamliel, B S Slusher, F I Carroll, G R Uhl. Structure-activity relationship of trihexyphenidyl analogs with respect to the dopamine transporter in the on going search for a cocaine inhibitor. European journal of medicinal chemistry. 2005 Oct; 40(10):1013-21. doi: 10.1016/j.ejmech.2005.04.016. [PMID: 16009468]
  • K H Chan, R T F Cheung, K M Au-Yeung, W Mak, T S Cheng, S L Ho. Wilson's disease with depression and parkinsonism. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2005 Apr; 12(3):303-5. doi: 10.1016/j.jocn.2004.09.005. [PMID: 15851088]
  • Xiaocui Zhao, Tianyan You, Jifeng Liu, Xiuhua Sun, Jilin Yan, Xiurong Yang, Erkang Wang. Drug-human serum albumin binding studied by capillary electrophoresis with electrochemiluminescence detection. Electrophoresis. 2004 Oct; 25(20):3422-6. doi: 10.1002/elps.200305930. [PMID: 15490448]
  • Kamal A Hadidi. Development of a screening method for the most commonly abused anticholinergic drugs in Jordan; trihexyphenidyl, procyclidine and biperiden. Legal medicine (Tokyo, Japan). 2004 Oct; 6(4):233-41. doi: 10.1016/j.legalmed.2004.06.001. [PMID: 15363448]
  • Nunzio Pomara, Lisa M Willoughby, Keith Wesnes, John J Sidtis. Increased anticholinergic challenge-induced memory impairment associated with the APOE-epsilon4 allele in the elderly: a controlled pilot study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2004 Feb; 29(2):403-9. doi: 10.1038/sj.npp.1300305. [PMID: 14735126]
  • Maria Bozi, Kailash P Bhatia. Paroxysmal exercise-induced dystonia as a presenting feature of young-onset Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. 2003 Dec; 18(12):1545-7. doi: 10.1002/mds.10597. [PMID: 14673897]
  • S K Guthrie, L Manzey, D Scott, B Giordani, R Tandon. Comparison of central and peripheral pharmacologic effects of biperiden and trihexyphenidyl in human volunteers. Journal of clinical psychopharmacology. 2000 Feb; 20(1):77-83. doi: 10.1097/00004714-200002000-00013. [PMID: 10653212]
  • F J DiMario. Childhood head tremor. Journal of child neurology. 2000 Jan; 15(1):22-5. doi: 10.1177/088307380001500105. [PMID: 10641605]
  • V Cápka, Y Xu, Y H Chen. Stereoselective determination of trihexyphenidyl in human serum by LC-ESI-MS. Journal of pharmaceutical and biomedical analysis. 1999 Nov; 21(3):507-17. doi: 10.1016/s0731-7085(99)00116-8. [PMID: 10701417]
  • J Ishizaki, K Yokogawa, E Nakashima, S Ohkuma, F Ichimura. Influence of ammonium chloride on the tissue distribution of anticholinergic drugs in rats. The Journal of pharmacy and pharmacology. 1998 Jul; 50(7):761-6. doi: 10.1111/j.2042-7158.1998.tb07137.x. [PMID: 9720625]
  • G Vargas, J Havel, L Babácková, J Patocka. Determination of drugs used as anti-Parkinson's disease drugs in urine and serum by capillary electrophoresis. Journal of capillary electrophoresis. 1998 May; 5(3-4):153-8. doi: . [PMID: 10797881]
  • J Ishizaki, K Yokogawa, E Nakashima, S Ohkuma, F Ichimura. Characteristic subcellular distribution, in brain, heart and lung, of biperiden, trihexyphenidyl, and (-)-quinuclidinyl benzylate in rats. Biological & pharmaceutical bulletin. 1998 Jan; 21(1):67-71. doi: 10.1248/bpb.21.67. [PMID: 9477171]
  • A H Battah, K A Hadidi. Stability of trihexyphenidyl in stored blood and urine specimens. International journal of legal medicine. 1998; 111(3):111-4. doi: 10.1007/s004140050129. [PMID: 9587791]
  • K A Hadidi. Solid-phase extraction of benzhexol from blood and urine. Science & justice : journal of the Forensic Science Society. 1997 Oct; 37(4):265-8. doi: 10.1016/s1355-0306(97)72201-9. [PMID: 9519541]
  • K Otani, M Ishida, N Yasui, T Kondo, K Mihara, A Suzuki, S Kaneko, Y Inoue, M Shibata, K Ikeda. No effect of the anticholinergic drugs trihexyphenidyl and biperiden on the plasma concentrations of bromperidol and its reduced metabolite. Therapeutic drug monitoring. 1997 Apr; 19(2):165-8. doi: 10.1097/00007691-199704000-00008. [PMID: 9108644]
  • J Kassa, J Bajgar. The influence of pharmacological pretreatment on efficacy of HI-6 oxime in combination with benactyzine in soman poisoning in rats. Human & experimental toxicology. 1996 May; 15(5):383-8. doi: 10.1177/096032719601500503. [PMID: 8735460]
  • J Roberts, D G Waller, A G von Renwick, N O'Shea, B S Macklin, M Bulling. The effects of co-administration of benzhexol on the peripheral pharmacokinetics of oral levodopa in young volunteers. British journal of clinical pharmacology. 1996 Apr; 41(4):331-7. doi: 10.1046/j.1365-2125.1996.32311.x. [PMID: 8730980]
  • H He, G McKay, B Wirshing, K K Midha. Development and application of a specific and sensitive radioimmunoassay for trihexyphenidyl to a pharmacokinetic study in humans. Journal of pharmaceutical sciences. 1995 May; 84(5):561-7. doi: 10.1002/jps.2600840509. [PMID: 7658345]
  • T Hineno, M Mizobuchi, O Nishimatsu, J Horiguchi, Y Kakimoto. Day-night variation of urine volume in Parkinson's disease. The Japanese journal of psychiatry and neurology. 1994 Sep; 48(3):583-7. doi: 10.1111/j.1440-1819.1994.tb03018.x. [PMID: 7891422]
  • E Urbańska, M Dziki, S J Czuczwar, Z Kleinrok, W A Turski. Antiparkinsonian drugs memantine and trihexyphenidyl potentiate the anticonvulsant activity of valproate against maximal electroshock-induced seizures. Neuropharmacology. 1992 Oct; 31(10):1021-6. doi: 10.1016/0028-3908(92)90103-v. [PMID: 1436383]
  • A Valevski, I Gil-Ad, I Modai, A Apter, S Tyano, Z Laron, A Weizman. Neuroendocrine response to trihexyphenidyl in depressed patients. Clinical neuropharmacology. 1992 Feb; 15(1):27-33. doi: 10.1097/00002826-199202000-00004. [PMID: 1576596]
  • M Desage, M Rousseau-Tsangaris, D Lecompte, J L Brazier. Quantitation of trihexyphenidyl from plasma using a mass-selective detector and electron-impact ionization. Journal of chromatography. 1991 Nov; 571(1-2):250-6. doi: 10.1016/0378-4347(91)80452-i. [PMID: 1810953]
  • L Rockland, T Cooper, F Schwartz, D Weber, T Sullivan. Effects of trihexyphenidyl on plasma chlorpromazine in young schizophrenics. Canadian journal of psychiatry. Revue canadienne de psychiatrie. 1990 Oct; 35(7):604-7. doi: 10.1177/070674379003500708. [PMID: 2268840]
  • M E Strauss, K S Reynolds, G Jayaram, L E Tune. Effects of anticholinergic medication on memory in schizophrenia. Schizophrenia research. 1990 Mar; 3(2):127-9. doi: 10.1016/0920-9964(90)90045-9. [PMID: 1980611]
  • B T Darras, M G Ampola, W H Dietz, H E Gilmore. Intermittent dystonia in Hartnup disease. Pediatric neurology. 1989 Mar; 5(2):118-20. doi: 10.1016/0887-8994(89)90038-6. [PMID: 2712944]
  • P Kintz, B Godelar, P Mangin, A J Chaumont, A A Lugnier. Identification and quantification of trihexyphenidyl and its hydroxylated metabolite by gas chromatography with nitrogen-phosphorus detection. Journal of analytical toxicology. 1989 Jan; 13(1):47-9. doi: 10.1093/jat/13.1.47. [PMID: 2709827]
  • W K Cheung, S S Stravinski, S I Engel, L L Sia, A Yacobi, B M Silber. Pharmacokinetic evaluation of a sustained-release formulation of trihexyphenidyl in healthy volunteers. Journal of pharmaceutical sciences. 1988 Sep; 77(9):748-50. doi: 10.1002/jps.2600770905. [PMID: 3225767]
  • P Rinieris, J Hatzimanolis, M Markianos, C Stefanis. Effects of 4 weeks treatment with chlorpromazine and/or trihexyphenidyl on the pituitary-gonadal axis in male paranoid schizophrenics. European archives of psychiatry and neurological sciences. 1988; 237(4):189-93. doi: 10.1007/bf00449905. [PMID: 3203697]
  • Y Watahiki, S Narita, K Kurahashi, T Tanaka, M Matsunaga. [Akinetic mutism from recurrent hydrocephalus: successful treatment with levodopa, bromocriptine and trihexyphenidyl]. No to shinkei = Brain and nerve. 1987 Oct; 39(10):977-82. doi: . [PMID: 3435688]
  • A Hitri, R B Craft, R Sethi, D Sinha. Drug levels and antiparkinsonian drugs in neuroleptic-treated schizophrenic patients. Clinical neuropharmacology. 1987 Jun; 10(3):261-71. doi: 10.1097/00002826-198706000-00007. [PMID: 2900683]
  • S Ueno, M Takahashi, K Kajiyama, N Okahisa, T Hazama, S Yorifuji, S Tarui. Parkinson's disease and myasthenia gravis: adverse effect of trihexyphenidyl on neuromuscular transmission. Neurology. 1987 May; 37(5):832-3. doi: 10.1212/wnl.37.5.832. [PMID: 3033545]
  • A Hitri, R B Craft, J Fallon, R Sethi, D Sinha. Serum neuroleptic and anticholinergic activity in relationship to cognitive toxicity of antiparkinsonian agents in schizophrenic patients. Psychopharmacology bulletin. 1987; 23(1):33-7. doi: NULL. [PMID: 2885890]
  • K Yokogawa, E Nakashima, F Ichimura, T Yamana. Simultaneous microdetermination of biperiden, haloperidol, and trihexyphenidyl in plasma and its application to pharmacokinetic analysis after concomitant intravenous administration of the drugs to rabbits. Chemical & pharmaceutical bulletin. 1985 Oct; 33(10):4581-6. doi: 10.1248/cpb.33.4581. [PMID: 4092273]
  • R E Burke, S Fahn. Pharmacokinetics of trihexyphenidyl after short-term and long-term administration to dystonic patients. Annals of neurology. 1985 Jul; 18(1):35-40. doi: 10.1002/ana.410180107. [PMID: 4037749]
  • R E Burke, S Fahn. Serum trihexyphenidyl levels in the treatment of torsion dystonia. Neurology. 1985 Jul; 35(7):1066-9. doi: 10.1212/wnl.35.7.1066. [PMID: 4010950]
  • U Goswami, S M Channabasavanna. Is akathisia a forerunner of tardive dyskinesia? A clinical report with brief review of literature. Clinical neurology and neurosurgery. 1984; 86(2):107-10. doi: 10.1016/0303-8467(84)90074-x. [PMID: 6329575]
  • S Garbarg, J P Devissaguet, M Prost, Y Bogaievsky. [Pharmacoclinical comparison of 2 dosage forms of trihexyphenidyl]. L'Encephale. 1983; 9(2):167-74. doi: . [PMID: 6641617]
  • G M Simpson, T B Cooper, N Bark, I Sud, J H Lee. Effect of antiparkinsonian medication on plasma levels of chlorpromazine. Archives of general psychiatry. 1980 Feb; 37(2):205-8. doi: 10.1001/archpsyc.1980.01780150095010. [PMID: 7352851]
  • G B Burnett, A J Prange, I C Wilson, L A Jolliff, I C Creese, S H Synder. Adverse effects of anticholinergic antiparkinsonian drugs in tardive dyskinesia. An investigation of mechanism. Neuropsychobiology. 1980; 6(2):109-20. doi: 10.1159/000117742. [PMID: 6101910]
  • R L Nation, E J Triggs, J Vine. Metabolism and urinary excretion of benzhexol in humans. Xenobiotica; the fate of foreign compounds in biological systems. 1978 Mar; 8(3):165-9. doi: 10.3109/00498257809060395. [PMID: 654310]
  • T Kolakowska, D H Wiles, M G Gelder, A S McNeilly. Clinical significance of plasma chlorpromazine levels. II. Plasma levels of the drug, some of its metabolites and prolactin in patients receiving long-term phenothiazine treatment. Psychopharmacology. 1976 Aug; 49(1):101-7. doi: NULL. [PMID: 8814]
  • L Rivera-Calimlim, H Nasrallah, J Strauss, L Lasagna. Clinical response and plasma levels: effect of dose, dosage schedules, and drug interactions on plasma chlorpromazine levels. The American journal of psychiatry. 1976 Jun; 133(6):646-52. doi: 10.1176/ajp.133.6.646. [PMID: 5901]
  • L Rivera-Calimlim. Impaired absorption of chlorpromazine in rats given trihexyphenidyl. British journal of pharmacology. 1976 Mar; 56(3):301-5. doi: 10.1111/j.1476-5381.1976.tb07642.x. [PMID: 1260174]
  • S Algeri, C Cerletti, M Curcio, P L Morselli, L Bonollo, G Buniva, M Minazzi, G Minoli. Effect of anticholinergic drugs on gastro-intestinal absorption of L-dopa in rats and in man. European journal of pharmacology. 1976 Feb; 35(2):293-9. doi: 10.1016/0014-2999(76)90231-4. [PMID: 1248506]
  • N Allen, W Knopp. Hereditary Parkinsonism-dystonia with sustained control by L-DOPA and anticholinergic medication. Advances in neurology. 1976; 14(?):201-13. doi: NULL. [PMID: 942621]
  • A Barbeau, G Campanella, R F Butterworth, K Yamada. Uptake and efflux of 14-C-dopamine in platelets: evidence for a generalized defect in Parkinson's disease. Neurology. 1975 Jan; 25(1):1-9. doi: 10.1212/wnl.25.1.1. [PMID: 234181]
  • P R Andersen, P Gibbs, H Kubinski. Effects of neuropharmacological agents on in vitro formation of complexes between nucleic acids and proteins. Neuropharmacology. 1974 Feb; 13(2):111-7. doi: 10.1016/0028-3908(74)90028-8. [PMID: 4595677]
  • F S Messiha, W Knopp. Metabolic patterns and clinical response to levedopa therapy in Parkinson's disease. Clinical pharmacology and therapeutics. 1973 Jul; 14(4):565-71. doi: 10.1002/cpt1973144part1565. [PMID: 4541856]
  • P S Papavasiliou, G C Cotzias, W H Lawrence. Levodopa and dopamine in cerebrospinal fluid. Neurology. 1973 Jul; 23(7):756-9. doi: 10.1212/wnl.23.7.756. [PMID: 4736493]
  • H Kihara, M Valente, M T Porter, A L Fluharty. Hyperdibasicaminoaciduria in a mentally retarded homozygote with a peculiar response to phenothiazines. Pediatrics. 1973 Feb; 51(2):223-9. doi: NULL. [PMID: 4144453]
  • C Anding, R Heintz, G Ourisson. [Comparative cyclization of 2,3 epoxide of methylene-22-dihydro-22-squalene in cell-free systems extracted from animal and higher plant tissues]. Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles. 1973 Jan; 276(2):205-7. doi: ". [PMID: 4632903]
  • G B Muscettola, M Giovannucci, R Montanini, P L Morselli, S Garattini. Relationship between desipramine plasma levels and the effect in Parkinson's syndrome. Revue europeenne d'etudes cliniques et biologiques. European journal of clinical and biological research. 1972 Apr; 17(4):375-9. doi: NULL. [PMID: 5079227]
  • J Dreyfuss, B Beer, D D Devine, B F Roberts, E C Schreiber. Fluphenazine-induced parkinsonism in the baboon: pharmacological and metabolic studies. Neuropharmacology. 1972 Mar; 11(2):223-30. doi: 10.1016/0028-3908(72)90094-9. [PMID: 4623662]
  • A P Ridges, P Harper. Pink spot--is it a drug artefact?. Psychiatria clinica. 1970; 3(2):101-7. doi: 10.1159/000278596. [PMID: 5424765]
  • D A Stephens. Psychotoxic effects of benzhexol hydrochloride (Artane). The British journal of psychiatry : the journal of mental science. 1967 Feb; 113(495):213-8. doi: 10.1192/bjp.113.495.213. [PMID: 6032482]