Trihexyphenidyl (BioDeep_00000002363)

 

Secondary id: BioDeep_00001867882

human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds natural product


代谢物信息卡片


Pharmaceutical associates brand OF trihexyphenidyl hydrochloride

化学式: C20H31NO (301.2405516)
中文名称: 苯海索
谱图信息: 最多检出来源 Viridiplantae(plant) 2.72%

分子结构信息

SMILES: C1CCC(CC1)C(CCN2CCCCC2)(C3=CC=CC=C3)O
InChI: InChI=1S/C20H31NO/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2

描述信息

Trihexyphenidyl is only found in individuals that have used or taken this drug. It is one of the centrally acting muscarinic antagonists used for treatment of parkinsonian disorders and drug-induced extrapyramidal movement disorders and as an antispasmodic. [PubChem]Trihexyphenidyl is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). Trihexyphenidyl partially blocks cholinergic activity in the CNS, which is responsible for the symptoms of Parkinsons disease. It is also thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth control of voluntary muscle movement.
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
N - Nervous system > N04 - Anti-parkinson drugs > N04A - Anticholinergic agents > N04AA - Tertiary amines
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
C78272 - Agent Affecting Nervous System > C38149 - Antiparkinsonian Agent

同义名列表

38 个代谢物同义名

Pharmaceutical associates brand OF trihexyphenidyl hydrochloride; 1-cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol; Liquipharm brand OF trihexyphenidyl hydrochloride; Psicofarma brand OF trihexyphenidyl hydrochloride; Lederle brand OF trihexyphenidyl hydrochloride; Cypress brand OF trihexyphenidyl hydrochloride; Schrein brand OF trihexyphenidyl hydrochloride; Aventis brand OF trihexyphenidyl hydrochloride; Apotex brand OF trihexyphenidyl hydrochloride; Hexal brand OF trihexyphenidyl hydrochloride; Wyeth brand OF trihexyphenidyl hydrochloride; Rugby brand OF trihexyphenidyl hydrochloride; Eisai brand OF trihexyphenidyl hydrochloride; AHP brand OF trihexyphenidyl hydrochloride; Trihexyphenidyl hydrochloride elixir; Wyeth brand OF trihexyphenidyl; Trihexyphenidyl hydrochloride; Trihexyphenidyl wyeth brand; Trihexidyl hydrochloride; Trihexylphenidyle; Trihexyphenidyle; Trihexylphenidyl; Trihexylphenizyl; Trihexylphenedyl; trihexyphenidyl; Triphenidyl; Apo-trihex; apo Trihex; ApoTrihex; Benzhexol; Parkinane; Hipokinon; Trihexane; Cyclodol; Parkopan; Artane; Trihexyphenidyl; Trihexyphenidyl



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

64 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

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  • Xiaoxia Chen, Junmei Zhang, Yue Li, Suqin Han. Chemiluminescence of copper nanoclusters and its application for trihexyphenidyl hydrochloride detection. Luminescence : the journal of biological and chemical luminescence. 2018 Aug; 33(5):962-967. doi: 10.1002/bio.3496. [PMID: 29785806]
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