Paraoxon (BioDeep_00000002359)

 

Secondary id: BioDeep_00000405977

human metabolite Endogenous Chemicals and Drugs Volatile Flavor Compounds natural product


代谢物信息卡片


O,O-Diethyl O-p-nitrophenyl phosphoric acid

化学式: C10H14NO6P (275.0558714)
中文名称: 对硫磷(乙基对硫磷)
谱图信息: 最多检出来源 Homo sapiens(blood) 0.46%

分子结构信息

SMILES: CCOP(=O)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-]
InChI: InChI=1S/C10H14NO6P/c1-3-15-18(14,16-4-2)17-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3

描述信息

Paraoxon is an acetylcholinesterase inhibitor. It is an organophosphate oxon, and the active metabolite of the insecticide parathion. It is also used as an opthamological drug against glaucoma. Paraoxon is one of the most potent acetylcholinesterase-inhibiting insecticides available, around 70\\% as potent as the nerve agent sarin, and so is now rarely used as an insecticide due to the risk of poisoning to humans and other animals. It is easily absorbed through skin, and was used as an assassination weapon by the apartheid-era South African chemical weapons program Project Coast. [HMDB]
Paraoxon is an acetylcholinesterase inhibitor. It is an organophosphate oxon, and the active metabolite of the insecticide parathion. It is also used as an opthamological drug against glaucoma. Paraoxon is one of the most potent acetylcholinesterase-inhibiting insecticides available, around 70\\% as potent as the nerve agent sarin, and so is now rarely used as an insecticide due to the risk of poisoning to humans and other animals. It is easily absorbed through skin, and was used as an assassination weapon by the apartheid-era South African chemical weapons program Project Coast.
S - Sensory organs > S01 - Ophthalmologicals > S01E - Antiglaucoma preparations and miotics > S01EB - Parasympathomimetics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D010575 - Pesticides > D007306 - Insecticides
D004791 - Enzyme Inhibitors
D016573 - Agrochemicals

同义名列表

22 个代谢物同义名

O,O-Diethyl O-p-nitrophenyl phosphoric acid; Phosphoric acid diethyl 4-nitrophenyl ester; O,O-Diethyl-O-p-nitrophenylphosphoric acid; p-Nitrophenyl diethyl phosphoric acid; Phosphate diethyl 4-nitrophenyl ester; Diethyl p-nitrophenyl phosphoric acid; O,O-Diethyl O-p-nitrophenyl phosphate; O,O-Diethyl-O-p-nitrophenylphosphate; diethyl (4-nitrophenyl) phosphate; Phosphate, diethyl-P-nitrophenyl; Diethyl P nitrophenyl phosphate; Diethyl-P-nitrophenyl phosphate; diethyl 4-nitrophenyl phosphate; Diethyl p-nitrophenyl phosphate; p-Nitrophenyl diethyl phosphate; Diethyl paraoxon; Ethyl paraoxon; Phosphacol; Fosfakol; PARAOXON; Paraoxon; Paraoxon



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

6 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(6)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

15 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hessameddin Mortazavi, Hossein Omidi-Ardali, Seyed Asadollah Amini, Javad Saffari-Chaleshtori, Keihan Ghatreh Samani. In vivo/in silico insight into the effect of titanium dioxide nanoparticle on serum paraoxonase 1 activity in rat. Journal of biomolecular structure & dynamics. 2022 07; 40(11):4961-4971. doi: 10.1080/07391102.2020.1864662. [PMID: 33459188]
  • Mai Luo, Ling Chen, Jinchao Wei, Xiping Cui, Zehua Cheng, Ting Wang, Incheng Chao, Yunyang Zhao, Hao Gao, Peng Li. A two-step strategy for simultaneous dual-mode detection of methyl-paraoxon and Ni (Ⅱ). Ecotoxicology and environmental safety. 2022 Jul; 239(?):113668. doi: 10.1016/j.ecoenv.2022.113668. [PMID: 35623151]
  • Praveen Kumar Gopi, Duy Ba Ngo, Shen-Ming Chen, Chandan Hunsur Ravikumar, Werasak Surareungchai. High-performance electrochemical sensing of hazardous pesticide Paraoxon using BiVO4 nano dendrites equipped catalytic strips. Chemosphere. 2022 Feb; 288(Pt 2):132511. doi: 10.1016/j.chemosphere.2021.132511. [PMID: 34688713]
  • Ashima Thakur, Jayant Patwa, Abha Sharma, Swaran Jeet Singh Flora. Synthesis, Molecular Docking, BSA, and In Vitro Reactivation Study of Imidazopyridine Oximes Against Paraoxon Inhibited Acetylcholinesterase. Medicinal chemistry (Shariqah (United Arab Emirates)). 2022; 18(2):273-287. doi: 10.2174/1573406417666210208223240. [PMID: 33563155]
  • Vladislav E Sobolev, Margarita O Sokolova, Richard O Jenkins, Nikolay V Goncharov. Nephrotoxic Effects of Paraoxon in Three Rat Models of Acute Intoxication. International journal of molecular sciences. 2021 Dec; 22(24):. doi: 10.3390/ijms222413625. [PMID: 34948422]
  • Balthazar Toussaint, Hervé Hillaireau, Emmanuel Jaccoulet, Catherine Cailleau, Pauline Legrand, Yves Ambroise, Elias Fattal. Interspecies comparison of plasma metabolism and sample stabilization for quantitative bioanalyses: Application to (R)-CE3F4 in preclinical development, including metabolite identification by high-resolution mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Oct; 1183(?):122943. doi: 10.1016/j.jchromb.2021.122943. [PMID: 34666890]
  • Lambert K Sørensen, Jørgen B Hasselstrøm, Jesper D Gunst, Ole S Søgaard, Mads Kjolby. Determination of camostat and its metabolites in human plasma - Preservation of samples and quantification by a validated UHPLC-MS/MS method. Clinical biochemistry. 2021 Oct; 96(?):56-62. doi: 10.1016/j.clinbiochem.2021.07.007. [PMID: 34252447]
  • Royce H Nichols, Janice E Chambers. Reactivation of organophosphate-inhibited serum butyrylcholinesterase by novel substituted phenoxyalkyl pyridinium oximes and traditional oximes. Toxicology. 2021 03; 452(?):152719. doi: 10.1016/j.tox.2021.152719. [PMID: 33592259]
  • Laxmikant S Deshpande, Robert E Blair, Matthew Halquist, Leon Kosmider, Robert J DeLorenzo. Intramuscular atenolol and levetiracetam reduce mortality in a rat model of paraoxon-induced status epilepticus. Annals of the New York Academy of Sciences. 2020 11; 1480(1):219-232. doi: 10.1111/nyas.14500. [PMID: 32961584]
  • Lin Zhang, Ziyu Liu, Shanjie Zha, Guangxu Liu, Wenyue Zhu, Qingji Xie, Yanbin Li, Yibin Ying, Yingchun Fu. Bio-/Nanoimmobilization Platform Based on Bioinspired Fibrin-Bone@Polydopamine-Shell Adhesive Composites for Biosensing. ACS applied materials & interfaces. 2019 Dec; 11(50):47311-47319. doi: 10.1021/acsami.9b15376. [PMID: 31742992]
  • Giovanni Paolo Cetrangolo, Carla Gori, Janis Rusko, Sara Terreri, Giuseppe Manco, Amelia Cimmino, Ferdinando Febbraio. Determination of Picomolar Concentrations of Paraoxon in Human Urine by Fluorescence-Based Enzymatic Assay. Sensors (Basel, Switzerland). 2019 Nov; 19(22):. doi: 10.3390/s19224852. [PMID: 31703397]
  • Kirstin P Hester, Krishna Bhattarai, Haobo Jiang, Pratul K Agarwal, Carey Pope. Engineering Dynamic Surface Peptide Networks on ButyrylcholinesteraseG117H for Enhanced Organophosphosphorus Anticholinesterase Catalysis. Chemical research in toxicology. 2019 09; 32(9):1801-1810. doi: 10.1021/acs.chemrestox.9b00146. [PMID: 31411024]
  • Amna Iqbal, Shahrukh Malik, Syed M Nurulain, Kamil Musilek, Kamil Kuca, Huba Kalasz, M Qaiser Fatmi. Reactivation potency of two novel oximes (K456 and K733) against paraoxon-inhibited acetyl and butyrylcholinesterase: In silico and in vitro models. Chemico-biological interactions. 2019 Sep; 310(?):108735. doi: 10.1016/j.cbi.2019.108735. [PMID: 31276662]
  • Yvonne Rosenberg, James Fink, Ronan MacLoughlin, Tara Ooms-Konecny, Dennis Sullivan, William Gerk, Lingjun Mao, Xiaoming Jiang, Jonathan Lees, Lori Urban, Narayanan Rajendran. Aerosolized recombinant human butyrylcholinesterase delivered by a nebulizer provides long term protection against inhaled paraoxon in macaques. Chemico-biological interactions. 2019 Aug; 309(?):108712. doi: 10.1016/j.cbi.2019.06.025. [PMID: 31201777]
  • Erez Hanael, Ronel Veksler, Alon Friedman, Guy Bar-Klein, Vladimir V Senatorov, Daniela Kaufer, Lilach Konstantin, Maria Elkin, Orit Chai, Dana Peery, Merav H Shamir. Blood-brain barrier dysfunction in canine epileptic seizures detected by dynamic contrast-enhanced magnetic resonance imaging. Epilepsia. 2019 05; 60(5):1005-1016. doi: 10.1111/epi.14739. [PMID: 31032909]
  • Ahmed Samir, Ayano Kage, Kayoko Ohura, Teruko Imai. Development of simultaneous quantification method of loteprednol etabonate (LE) and its acidic metabolites, and analysis of LE metabolism in rat. Xenobiotica; the fate of foreign compounds in biological systems. 2019 May; 49(5):569-576. doi: 10.1080/00498254.2018.1479803. [PMID: 29781759]
  • Zohreh Zare, Mohsen Tehrani, Noorollah Rezaei, Babak Dana Ghalebarzand, Moslem Mohammadi. Anxiolytic activity of paraoxon is associated with alterations in rat brain glutamatergic system. Neurotoxicology and teratology. 2019 Jan; 71(?):32-40. doi: 10.1016/j.ntt.2018.12.001. [PMID: 30576762]
  • Tatiana N Pashirova, Anissa Braïki, Irina V Zueva, Konstantin A Petrov, Vasily M Babaev, Evgenia A Burilova, Darya A Samarkina, Ildar Kh Rizvanov, Eliana B Souto, Ludovic Jean, Pierre-Yves Renard, Patrick Masson, Lucia Ya Zakharova, Oleg G Sinyashin. Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection. Journal of controlled release : official journal of the Controlled Release Society. 2018 11; 290(?):102-111. doi: 10.1016/j.jconrel.2018.10.010. [PMID: 30308259]
  • Miriam González-González, Jorge Estévez, Eva Del Río, Eugenio Vilanova, Miguel A Sogorb. Hydrolyzing activities of phenyl valerate sensitive to organophosphorus compounds paraoxon and mipafox in human neuroblastoma SH-SY5Y cells. Toxicology. 2018 08; 406-407(?):123-128. doi: 10.1016/j.tox.2018.07.016. [PMID: 30118792]
  • Anna Bizoń, Halina Milnerowicz. The effect of divalent metal chelators and cadmium on serum phosphotriesterase, lactonase and arylesterase activities of paraoxonase 1. Environmental toxicology and pharmacology. 2018 Mar; 58(?):77-83. doi: 10.1016/j.etap.2017.12.019. [PMID: 29306821]
  • Xiangkun Meng, Xixia Xu, Haibo Bao, Jianjun Wang, Zewen Liu. Characterization of the Fifth Putative Acetylcholinesterase in the Wolf Spider, Pardosa pseudoannulata. Molecules (Basel, Switzerland). 2017 Jul; 22(7):. doi: 10.3390/molecules22071118. [PMID: 28696352]
  • Vladislav E Sobolev, Richard O Jenkins, Nikolay V Goncharov. Sulfated glycosaminoglycans in bladder tissue and urine of rats after acute exposure to paraoxon and cyclophosphamide. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 2017 Jul; 69(6):339-347. doi: 10.1016/j.etp.2017.02.007. [PMID: 28259532]
  • Nahit Gençer, Emre Yavuz. An alternative purification method for human serum paraoxonase 1 and its interaction with methidathion. Archives of physiology and biochemistry. 2017 Jul; 123(3):159-164. doi: 10.1080/13813455.2017.1279632. [PMID: 28276711]
  • Zohreh Zare, Mohsen Tehrani, Alireza Rafiei, Reza Valadan, Moslem Mohammadi. Differential expression of glutamate transporters in cerebral cortex of paraoxon-treated rats. Neurotoxicology and teratology. 2017 Jul; 62(?):20-26. doi: 10.1016/j.ntt.2017.06.001. [PMID: 28603072]
  • Tatiana N Pashirova, Irina V Zueva, Konstantin A Petrov, Vasily M Babaev, Svetlana S Lukashenko, Ildar Kh Rizvanov, Eliana B Souto, Evgeny E Nikolsky, Lucia Ya Zakharova, Patrick Masson, Oleg G Sinyashin. Nanoparticle-Delivered 2-PAM for Rat Brain Protection against Paraoxon Central Toxicity. ACS applied materials & interfaces. 2017 May; 9(20):16922-16932. doi: 10.1021/acsami.7b04163. [PMID: 28504886]
  • Anna Wysocka, Marek Cybulski, Henryk Berbeć, Andrzej Wysokiński, Janusz Stążka, Jadwiga Daniluk, Tomasz Zapolski. Dynamic changes of paraoxonase 1 activity towards paroxon and phenyl acetate during coronary artery surgery. BMC cardiovascular disorders. 2017 04; 17(1):92. doi: 10.1186/s12872-017-0528-z. [PMID: 28376720]
  • Hasan Bagheri, Abbas Afkhami, Hosein Khoshsafar, Ali Hajian, Alireza Shahriyari. Protein capped Cu nanoclusters-SWCNT nanocomposite as a novel candidate of high performance platform for organophosphates enzymeless biosensor. Biosensors & bioelectronics. 2017 Mar; 89(Pt 2):829-836. doi: 10.1016/j.bios.2016.10.003. [PMID: 27818050]
  • David Blaha-Nelson, Dennis M Krüger, Klaudia Szeler, Moshe Ben-David, Shina Caroline Lynn Kamerlin. Active Site Hydrophobicity and the Convergent Evolution of Paraoxonase Activity in Structurally Divergent Enzymes: The Case of Serum Paraoxonase 1. Journal of the American Chemical Society. 2017 01; 139(3):1155-1167. doi: 10.1021/jacs.6b10801. [PMID: 28026940]
  • Marta Rusek, Jolanta Elżbieta Pastryk, Jerzy Bełtowski. Modulation of paraoxonase 1 (PON1) activity and protein N-homocysteinylation by bisphosphonates in rats. Chemico-biological interactions. 2016 Nov; 259(Pt B):401-406. doi: 10.1016/j.cbi.2016.07.002. [PMID: 27387541]
  • Jolanta Elżbieta Pastryk, Marta Rusek, Jerzy Bełtowski. Effects of antiretroviral treatment on paraoxonase 1 (PON1) activity in rats. Chemico-biological interactions. 2016 Nov; 259(Pt B):407-412. doi: 10.1016/j.cbi.2016.06.031. [PMID: 27378623]
  • Valentina Bušić, Maja Katalinić, Goran Šinko, Zrinka Kovarik, Dajana Gašo-Sokač. Pyridoxal oxime derivative potency to reactivate cholinesterases inhibited by organophosphorus compounds. Toxicology letters. 2016 Nov; 262(?):114-122. doi: 10.1016/j.toxlet.2016.09.015. [PMID: 27693733]
  • Jean Froment, Kevin V Thomas, Knut Erik Tollefsen. Automated high-throughput in vitro screening of the acetylcholine esterase inhibiting potential of environmental samples, mixtures and single compounds. Ecotoxicology and environmental safety. 2016 Aug; 130(?):74-80. doi: 10.1016/j.ecoenv.2016.04.005. [PMID: 27085000]
  • Qiqi Zheng, Yonghua Yu, Kai Fan, Feng Ji, Jian Wu, Yibin Ying. A nano-silver enzyme electrode for organophosphorus pesticide detection. Analytical and bioanalytical chemistry. 2016 Aug; 408(21):5819-5827. doi: 10.1007/s00216-016-9694-6. [PMID: 27342792]
  • Erin Gallagher, Il Minn, Janice E Chambers, Peter C Searson. In vitro characterization of pralidoxime transport and acetylcholinesterase reactivation across MDCK cells and stem cell-derived human brain microvascular endothelial cells (BC1-hBMECs). Fluids and barriers of the CNS. 2016 Jul; 13(1):10. doi: 10.1186/s12987-016-0035-0. [PMID: 27396356]
  • Peng Zhang, Priyesh Jain, Caroline Tsao, Andrew Sinclair, Fang Sun, Hsiang-Chieh Hung, Tao Bai, Kan Wu, Shaoyi Jiang. Butyrylcholinesterase nanocapsule as a long circulating bioscavenger with reduced immune response. Journal of controlled release : official journal of the Controlled Release Society. 2016 05; 230(?):73-8. doi: 10.1016/j.jconrel.2016.04.008. [PMID: 27063423]
  • Alper Coban, Russell L Carr, Howard W Chambers, Kenneth O Willeford, Janice E Chambers. Comparison of inhibition kinetics of several organophosphates, including some nerve agent surrogates, using human erythrocyte and rat and mouse brain acetylcholinesterase. Toxicology letters. 2016 Apr; 248(?):39-45. doi: 10.1016/j.toxlet.2016.03.002. [PMID: 26965078]
  • Olusegun K Afolabi, Adedoja D Wusu, Olufunmilayo O Ogunrinola, Esther O Abam, David O Babayemi, Oluwatosin A Dosumu, Okechukwu B Onunkwor, Elizabeth A Balogun, Olusegun O Odukoya, Oladipo Ademuyiwa. Paraoxonase 1 activity in subchronic low-level inorganic arsenic exposure through drinking water. Environmental toxicology. 2016 Feb; 31(2):154-62. doi: 10.1002/tox.22030. [PMID: 25082665]
  • Rezeda V Shamagsumova, Dmitry N Shurpik, Pavel L Padnya, Ivan I Stoikov, Gennady A Evtugyn. Acetylcholinesterase biosensor for inhibitor measurements based on glassy carbon electrode modified with carbon black and pillar[5]arene. Talanta. 2015 Nov; 144(?):559-68. doi: 10.1016/j.talanta.2015.07.008. [PMID: 26452862]
  • Stanislav Terekhov, Ivan Smirnov, Tatiana Bobik, Olga Shamborant, Marina Zenkova, Elena Chernolovskaya, Danil Gladkikh, Arkadii Murashev, Igor Dyachenko, Viktor Palikov, Yulia Palikova, Vera Knorre, Alexey Belogurov, Natalie Ponomarenko, G Michael Blackburn, Patrick Masson, Alexander Gabibov. A novel expression cassette delivers efficient production of exclusively tetrameric human butyrylcholinesterase with improved pharmacokinetics for protection against organophosphate poisoning. Biochimie. 2015 Nov; 118(?):51-9. doi: 10.1016/j.biochi.2015.07.028. [PMID: 26239905]
  • Gabriele Horn, Timo Wille, Kamil Musilek, Kamil Kuca, Horst Thiermann, Franz Worek. Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase. Archives of toxicology. 2015 Mar; 89(3):405-14. doi: 10.1007/s00204-014-1288-5. [PMID: 24912784]
  • Karel Ondracek, Hana Bandouchova, Klara Hilscherova, Veronika Kovacova, Petr Linhart, Miroslava Miksikova, Veronika Mlcakova, Jitka Osickova, Miroslav Pohanka, Hana Skochova, Jiri Pikula. Mixture toxicity of microcystin-LR, paraoxon and bromadiolone in Xenopus laevis embryos. Neuro endocrinology letters. 2015; 36 Suppl 1(?):114-9. doi: . [PMID: 26757121]
  • Feng Jiang, Yixi Zhang, Huahua Sun, Xiangkun Meng, Haibo Bao, Jichao Fang, Zewen Liu. Identification of polymorphisms in Cyrtorhinus lividipennis RDL subunit contributing to fipronil sensitivity. Pesticide biochemistry and physiology. 2015 Jan; 117(?):62-7. doi: 10.1016/j.pestbp.2014.10.010. [PMID: 25619913]
  • Yamina Belabassi, Chih-Kai Chao, Ryan Holly, Kathleen M George, Jon O Nagy, Charles M Thompson. Preparation and characterization of diethoxy- and monoethoxy phosphylated ('aged') serine haptens and use in the production of monoclonal antibodies. Chemico-biological interactions. 2014 Nov; 223(?):134-40. doi: 10.1016/j.cbi.2014.09.010. [PMID: 25261769]
  • Matthew K Ross, Abdolsamad Borazjani, Lee C Mangum, Ran Wang, J Allen Crow. Effects of toxicologically relevant xenobiotics and the lipid-derived electrophile 4-hydroxynonenal on macrophage cholesterol efflux: silencing carboxylesterase 1 has paradoxical effects on cholesterol uptake and efflux. Chemical research in toxicology. 2014 Oct; 27(10):1743-56. doi: 10.1021/tx500221a. [PMID: 25250848]
  • Mustafa Sagit, Bahadir Sarli, Sabri Guler, Mehmet Namuslu, Huseyin Tugrul Celik, Serkan Kurtul, Ferhat Korkmaz, Mehmet Akif Somdas. Assessment of early atherosclerotic findings in patients with nasal polyposis. Auris, nasus, larynx. 2014 Apr; 41(2):179-84. doi: 10.1016/j.anl.2013.07.013. [PMID: 24148525]
  • Yvonne J Rosenberg, Jeffery Gearhart, Lingjun Mao, Xiaoming Jiang, Segundo Hernandez-Abanto. Protection against paraoxon toxicity by an intravenous pretreatment with polyethylene-glycol-conjugated recombinant butyrylcholinesterase in macaques. Chemico-biological interactions. 2014 Mar; 210(?):20-5. doi: 10.1016/j.cbi.2013.12.010. [PMID: 24384224]
  • Xiangjiang Tang, Bo Liang, Tuyong Yi, Giuseppe Manco, Ilaria Palchetti, Ilariapalchetti, Aihua Liu. Cell surface display of organophosphorus hydrolase for sensitive spectrophotometric detection of p-nitrophenol substituted organophosphates. Enzyme and microbial technology. 2014 Feb; 55(?):107-12. doi: 10.1016/j.enzmictec.2013.10.006. [PMID: 24411452]
  • Syed M Nurulain, Georg Petroianu, Mohamed Shafiullah, Huba Kalász, Murat Oz, Tariq Saeed, Abdu Adem, Ernest Adeghate. Sub-chronic exposure to paraoxon neither induces nor exacerbates diabetes mellitus in Wistar rat. Journal of applied toxicology : JAT. 2013 Oct; 33(10):1036-43. doi: 10.1002/jat.2794. [PMID: 22886793]
  • Çiğdem Bilen, Serap Beyaztaş, Oktay Arslan, Özen Özensoy Güler. Investigation of heavy metal effects on immobilized paraoxanase by glutaraldehyde. Journal of enzyme inhibition and medicinal chemistry. 2013 Jun; 28(3):440-6. doi: 10.3109/14756366.2011.647007. [PMID: 22233542]
  • Claudia Huesca-Gómez, María Elena Soto, Vicente Castrejón-Téllez, Oscar Pérez-Méndez, Ricardo Gamboa. PON1 gene polymorphisms and plasma PON1 activities in Takayasu's arteritis disease. Immunology letters. 2013 Apr; 152(1):77-82. doi: 10.1016/j.imlet.2013.04.005. [PMID: 23628180]
  • Elena Porzio, Spartaco Di Gennaro, Achille Palma, Giuseppe Manco. Mn2+ modulates the kinetic properties of an archaeal member of the PLL family. Chemico-biological interactions. 2013 Mar; 203(1):251-6. doi: 10.1016/j.cbi.2012.11.003. [PMID: 23174457]
  • Yvonne J Rosenberg, Beth Laube, Lingjun Mao, Xiaoming Jiang, Segundo Hernandez-Abanto, Keunmyoung D Lee, Robert Adams. Pulmonary delivery of an aerosolized recombinant human butyrylcholinesterase pretreatment protects against aerosolized paraoxon in macaques. Chemico-biological interactions. 2013 Mar; 203(1):167-71. doi: 10.1016/j.cbi.2012.11.004. [PMID: 23178380]
  • Guozhen Liu, Dandan Song, Fengjuan Chen. Towards the fabrication of a label-free amperometric immunosensor using SWNTs for direct detection of paraoxon. Talanta. 2013 Jan; 104(?):103-8. doi: 10.1016/j.talanta.2012.11.039. [PMID: 23597895]
  • Abdolkarim Mahrooz, Ghorban Gohari, Mohammad-Bagher Hashemi, Mehryar Zargari, Hadis Musavi, Mahmoud Abedini, Ahad Alizadeh. R-carrying genotypes of serum paraoxonase (PON1) 192 polymorphism and higher activity ratio are related to susceptibility against ischemic stroke. Molecular biology reports. 2012 Dec; 39(12):11177-85. doi: 10.1007/s11033-012-2027-8. [PMID: 23054002]
  • Mahvash Jafari, Maryam Salehi, Alireza Asgari, Sediq Ahmadi, Maryam Abbasnezhad, Reza Hajihoosani, Mansoure Hajigholamali. Effects of paraoxon on serum biochemical parameters and oxidative stress induction in various tissues of Wistar and Norway rats. Environmental toxicology and pharmacology. 2012 Nov; 34(3):876-87. doi: 10.1016/j.etap.2012.08.011. [PMID: 23021855]
  • Mahmut Erzengin, Ismet Basaran, Umit Cakir, Aynur Aybey, Selma Sinan. In vitro inhibition effect of some dihydroxy coumarin compounds on purified human serum paraoxonase 1 (PON1). Applied biochemistry and biotechnology. 2012 Nov; 168(6):1540-8. doi: 10.1007/s12010-012-9876-4. [PMID: 22971832]
  • J Allen Crow, Victoria Bittles, Abdolsamad Borazjani, Philip M Potter, Matthew K Ross. Covalent inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by the carbamates JZL184 and URB597. Biochemical pharmacology. 2012 Nov; 84(9):1215-22. doi: 10.1016/j.bcp.2012.08.017. [PMID: 22943979]
  • Ferenc Sztanek, Ildikó Seres, Mariann Harangi, Lajos Lőcsey, János Padra, György J R Paragh, László Asztalos, György Paragh. Decreased paraoxonase 1 (PON1) lactonase activity in hemodialyzed and renal transplanted patients. A novel cardiovascular biomarker in end-stage renal disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2012 Jul; 27(7):2866-72. doi: 10.1093/ndt/gfr753. [PMID: 22247228]
  • Naiyu Zheng, Eliza N Fung, Adela Buzescu, Mark E Arnold, Jianing Zeng. Esterase inhibitors as ester-containing drug stabilizers and their hydrolytic products: potential contributors to the matrix effects on bioanalysis by liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2012 Jun; 26(11):1291-304. doi: 10.1002/rcm.6230. [PMID: 22555922]
  • Uma K Aryal, Chiann-Tso Lin, Jong-Seo Kim, Tyler H Heibeck, Jun Wang, Wei-Jun Qian, Yuehe Lin. Identification of phosphorylated butyrylcholinesterase in human plasma using immunoaffinity purification and mass spectrometry. Analytica chimica acta. 2012 Apr; 723(?):68-75. doi: 10.1016/j.aca.2012.02.023. [PMID: 22444575]
  • Alireza Javadzadeh, Amir Ghorbanihaghjo, Elham Bahreini, Nadereh Rashtchizadeh, Hassan Argani, Samira Alizadeh. Serum paraoxonase phenotype distribution in exudative age-related macular degeneration and its relationship to homocysteine and oxidized low-density lipoprotein. Retina (Philadelphia, Pa.). 2012 Apr; 32(4):658-66. doi: 10.1097/iae.0b013e31822529b1. [PMID: 22030834]
  • Hong-Bo Jiang, Wei Dou, Pei-An Tang, Jin-Jun Wang. Transcription and induction profiles of three novel P450 genes in Liposcelis bostrychophila (Psocoptera: Liposcelididae). Journal of economic entomology. 2012 Apr; 105(2):560-72. doi: 10.1603/ec11324. [PMID: 22606828]
  • Ilona Petrikovics, Melinda Wales, Marianna Budai, Jorn C C Yu, Mária Szilasi. Nano-intercalated organophosphorus-hydrolyzing enzymes in organophosphorus antagonism. AAPS PharmSciTech. 2012 Mar; 13(1):112-7. doi: 10.1208/s12249-011-9728-5. [PMID: 22160885]
  • Uta Kuepper, Frank Herbstreit, Jürgen Peters, Burkhard Madea, Frank Musshoff. Degradation and elimination of succinylcholine and succinylmonocholine and definition of their respective detection windows in blood and urine for forensic purposes. International journal of legal medicine. 2012 Mar; 126(2):259-69. doi: 10.1007/s00414-011-0623-0. [PMID: 21947675]
  • Ellen G Duysen, John R Cashman, Lawrence M Schopfer, Florian Nachon, Patrick Masson, Oksana Lockridge. Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran. Chemico-biological interactions. 2012 Feb; 195(3):189-98. doi: 10.1016/j.cbi.2011.12.006. [PMID: 22209767]
  • Sabrina Nickel, Farnusch Kaschani, Tom Colby, Renier A L van der Hoorn, Markus Kaiser. A para-nitrophenol phosphonate probe labels distinct serine hydrolases of Arabidopsis. Bioorganic & medicinal chemistry. 2012 Jan; 20(2):601-6. doi: 10.1016/j.bmc.2011.06.041. [PMID: 21763150]
  • O Hussein, J Zidan, K Abu Jabal, I Shams, S Szvalb, M Grozovski, I Bersudsky, R Karry, M Aviram. Paraoxonase activity and expression is modulated by therapeutics in experimental rat nonalcoholic Fatty liver disease. International journal of hepatology. 2012; 2012(?):265305. doi: 10.1155/2012/265305. [PMID: 22536512]
  • T Scott Pinkerton, James R Wild, John A Howard. Organophosphorus hydrolase: a multifaceted plant genetic marker which is selectable, scorable, and quantifiable in whole seed. Methods in molecular biology (Clifton, N.J.). 2012; 847(?):11-23. doi: 10.1007/978-1-61779-558-9_2. [PMID: 22350995]
  • Kazunobu Ishikawa, Mohamad Navab, Aldons J Lusis. Vasculitis, Atherosclerosis, and Altered HDL Composition in Heme-Oxygenase-1-Knockout Mice. International journal of hypertension. 2012; 2012(?):948203. doi: 10.1155/2012/948203. [PMID: 22518297]
  • Jordi Camps, Anabel García-Heredia, Anna Rull, Carlos Alonso-Villaverde, Gerard Aragonès, Raúl Beltrán-Debón, Esther Rodríguez-Gallego, Jorge Joven. PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways. PPAR research. 2012; 2012(?):616371. doi: 10.1155/2012/616371. [PMID: 22315585]
  • Nicola Martinelli, Roberta Micaglio, Letizia Consoli, Patrizia Guarini, Elisa Grison, Francesca Pizzolo, Simonetta Friso, Elisabetta Trabetti, Pier Franco Pignatti, Roberto Corrocher, Oliviero Olivieri, Domenico Girelli. Low levels of serum paraoxonase activities are characteristic of metabolic syndrome and may influence the metabolic-syndrome-related risk of coronary artery disease. Experimental diabetes research. 2012; 2012(?):231502. doi: 10.1155/2012/231502. [PMID: 21960992]
  • Gianna Ferretti, Tiziana Bacchetti, Letizia Saturni, Nicola Manzella, Cinzia Candelaresi, Antonio Benedetti, Antonio Di Sario. Lipid peroxidation and paraoxonase-1 activity in celiac disease. Journal of lipids. 2012; 2012(?):587479. doi: 10.1155/2012/587479. [PMID: 22536510]
  • Karel Ondracek, Hana Bandouchova, Veronika Damkova, Klara Hilscherova, Jiri Kral, Jitka Osickova, Veronika Mlcakova, Miroslav Pohanka, Hana Skochova, Frantisek Vitula, Frantisek Treml, Jiri Pikula. Risk of combined exposure of birds to cyanobacterial biomass containing microcystins, acetylcholinesterase inhibitor and anticoagulant. Neuro endocrinology letters. 2012; 33 Suppl 3(?):155-60. doi: . [PMID: 23353860]
  • R H Alasbahi, M F Melzig. Forskolin and derivatives as tools for studying the role of cAMP. Die Pharmazie. 2012 Jan; 67(1):5-13. doi: . [PMID: 22393824]
  • Ahmed Djeghader, Gerard Aragonès, Nune Darbinian, Mikael Elias, Daniel Gonzalez, Anabel García-Heredia, Raúl Beltrán-Debón, Rafal Kaminski, Guillaume Gotthard, Julien Hiblot, Anna Rull, Olivier Rohr, Christian Schwartz, Carlos Alonso-Villaverde, Jorge Joven, Jordi Camps, Eric Chabriere. The level of DING proteins is increased in HIV-infected patients: in vitro and in vivo studies. PloS one. 2012; 7(3):e33062. doi: 10.1371/journal.pone.0033062. [PMID: 22427948]
  • Alejandro Gugliucci, Kazuhiko Kotani, Satoshi Kimura. Paraoxonase 1 in chronic kidney failure. Journal of lipids. 2012; 2012(?):726048. doi: 10.1155/2012/726048. [PMID: 22523692]
  • Elad Cohen, Michael Aviram, Soliman Khatib, Asaf Rabin, Dalit Mannheim, Ron Karmeli, Jacob Vaya. Increased Levels of Human Carotid Lesion Linoleic Acid Hydroperoxide in Symptomatic and Asymptomatic Patients Is Inversely Correlated with Serum HDL and Paraoxonase 1 Activity. Journal of lipids. 2012; 2012(?):762560. doi: 10.1155/2012/762560. [PMID: 22690338]
  • Su Jeong Ban, Catherine W Rico, In Chul Um, Mi Young Kang. Antihyperglycemic and antioxidative effects of Hydroxyethyl Methylcellulose (HEMC) and Hydroxypropyl Methylcellulose (HPMC) in mice fed with a high fat diet. International journal of molecular sciences. 2012; 13(3):3738-3750. doi: 10.3390/ijms13033738. [PMID: 22489179]
  • Helle R Andersen, Christine Wohlfahrt-Veje, Christine Dalgård, Lene Christiansen, Katharina M Main, Christine Nellemann, Katsuyuki Murata, Tina K Jensen, Niels E Skakkebæk, Philippe Grandjean. Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age. PloS one. 2012; 7(5):e36830. doi: 10.1371/journal.pone.0036830. [PMID: 22615820]
  • R Hunter Coombes, J Allen Crow, MaryBeth Dail, Howard W Chambers, Robert W Wills, Janice E Chambers. Relationship of human paraoxonase-1 serum activity and genotype with atherosclerosis in individuals from the Deep South. Pharmacogenetics and genomics. 2011 Dec; 21(12):867-875. doi: 10.1097/fpc.0b013e32834cebc6. [PMID: 21960140]
  • Khadija Amine, Abdelouahed Atouk, Samya Moussamih, Rachid Saile, Afaf Mikou, Anass Kettani. [Paraoxonase-1 (PON1) activity in patients with coronary artery diseases and in diabetic patients]. Annales de biologie clinique. 2011 Nov; 69(6):671-7. doi: 10.1684/abc.2011.0648. [PMID: 22123566]
  • Abdolkarim Mahrooz, Mohammad-Reza Rashidi, Mohammad Nouri. Naringenin is an inhibitor of human serum paraoxonase (PON1): an in vitro study. Journal of clinical laboratory analysis. 2011 Nov; 25(6):395-401. doi: 10.1002/jcla.20490. [PMID: 22086792]
  • Durdu Altuner, Ilker Ates, Sinan H Suzen, Gonul Varan Koc, Yalcin Aral, Asuman Karakaya. The relationship of PON1 QR 192 and LM 55 polymorphisms with serum paraoxonase activities of Turkish diabetic patients. Toxicology and industrial health. 2011 Nov; 27(10):873-8. doi: 10.1177/0748233711399317. [PMID: 21505009]
  • Maureen McMahon, Brian J Skaggs, Lori Sahakian, Jennifer Grossman, John FitzGerald, Nagesh Ragavendra, Christina Charles-Schoeman, Marissa Chernishof, Alan Gorn, Joseph L Witztum, Weng Kee Wong, Michael Weisman, Daniel J Wallace, Antonio La Cava, Bevra H Hahn. High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids. Annals of the rheumatic diseases. 2011 Sep; 70(9):1619-24. doi: 10.1136/ard.2010.142737. [PMID: 21670088]
  • Ancha Baranova, Priyanka Lal, Aybike Birerdinc, Zobair M Younossi. Non-invasive markers for hepatic fibrosis. BMC gastroenterology. 2011 Aug; 11(?):91. doi: 10.1186/1471-230x-11-91. [PMID: 21849046]
  • Saad A Noeman, Hala E Hamooda, Amal A Baalash. Biochemical study of oxidative stress markers in the liver, kidney and heart of high fat diet induced obesity in rats. Diabetology & metabolic syndrome. 2011 Aug; 3(1):17. doi: 10.1186/1758-5996-3-17. [PMID: 21812977]
  • Pierre Ayotte, Antoine Carrier, Nathalie Ouellet, Véronique Boiteau, Belkacem Abdous, Elhadji Anassour Laouan Sidi, Marie-Ludivine Château-Degat, Éric Dewailly. Relation between methylmercury exposure and plasma paraoxonase activity in inuit adults from Nunavik. Environmental health perspectives. 2011 Aug; 119(8):1077-83. doi: 10.1289/ehp.1003296. [PMID: 21543280]
  • Mireille Ouimet, Vivian Franklin, Esther Mak, Xianghai Liao, Ira Tabas, Yves L Marcel. Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase. Cell metabolism. 2011 Jun; 13(6):655-67. doi: 10.1016/j.cmet.2011.03.023. [PMID: 21641547]
  • Sang-Yong Eom, Yun-Sik Kim, Chung-Jong Lee, Chul-Ho Lee, Yong-Dae Kim, Heon Kim. Effects of intronic and exonic polymorphisms of paraoxonase 1 (PON1) gene on serum PON1 activity in a Korean population. Journal of Korean medical science. 2011 Jun; 26(6):720-5. doi: 10.3346/jkms.2011.26.6.720. [PMID: 21655055]
  • Manojkumar Valiyaveettil, Yonas Alamneh, Lionel Biggemann, Iswarduth Soojhawon, Heba A Farag, Prashasthi Agrawal, Bhupendra P Doctor, Madhusoodana P Nambiar. In vitro efficacy of paraoxonase 1 from multiple sources against various organophosphates. Toxicology in vitro : an international journal published in association with BIBRA. 2011 Jun; 25(4):905-13. doi: 10.1016/j.tiv.2011.02.012. [PMID: 21382471]
  • Kai Lüersen, Constance Schmelzer, Christine Boesch-Saadatmandi, Christine Kohl, Gerald Rimbach, Frank Döring. Paraoxonase 1 polymorphism Q192R affects the pro-inflammatory cytokine TNF-alpha in healthy males. BMC research notes. 2011 May; 4(?):141. doi: 10.1186/1756-0500-4-141. [PMID: 21569287]
  • Jelena Martinović, Violeta Dopsaj, Jelena Kotur-Stevuljević, Milivoj Dopsaj, Ana Vujović, Aleksandra Stefanović, Goran Nešić. Oxidative stress biomarker monitoring in elite women volleyball athletes during a 6-week training period. Journal of strength and conditioning research. 2011 May; 25(5):1360-7. doi: 10.1519/jsc.0b013e3181d85a7f. [PMID: 21157395]
  • Tomás Meroño, Leonardo Gómez, Leonardo G Rosso, Patricia Sorroche, Laura Boero, Jorge Arbelbide, Fernando Brites. High risk of cardiovascular disease in iron overload patients. European journal of clinical investigation. 2011 May; 41(5):479-86. doi: 10.1111/j.1365-2362.2010.02429.x. [PMID: 21128934]
  • Na-Na Wang, Li Yuan, Heng Dai, Zhen-Kun Han, Min Zhao. Effect of PON1 on dichlorvos toxicokinetics. Emergency medicine journal : EMJ. 2011 Apr; 28(4):313-5. doi: 10.1136/emj.2009.088500. [PMID: 20581384]
  • Maya Kayouka, Pascal Houzé, Frederic J Baud, Salvatore Cisternino, Marcel Debray, Patricia Risède, Alfred H Schinkel, Jean-Michel Warnet. Does modulation of organic cation transporters improve pralidoxime activity in an animal model of organophosphate poisoning?. Critical care medicine. 2011 Apr; 39(4):803-11. doi: 10.1097/ccm.0b013e318206d52f. [PMID: 21242797]
  • Darko Stefanovski, Joyce M Richey, Orison Woolcott, Maya Lottati, Dan Zheng, Lisa N Harrison, Viorica Ionut, Stella P Kim, Isabel Hsu, Richard N Bergman. Consistency of the disposition index in the face of diet induced insulin resistance: potential role of FFA. PloS one. 2011 Mar; 6(3):e18134. doi: 10.1371/journal.pone.0018134. [PMID: 21479217]
  • J Martinović, V Dopsaj, J Kotur-Stevuljević, M Dopsaj, A Vujović, A Stefanović, G Nesić. Proxidant* antioxidant balance in supplemented elite female volleyball athletes during a six week training period. The Journal of sports medicine and physical fitness. 2011 Mar; 51(1):145-52. doi: . [PMID: 21297574]
  • Luísa Veiga, José Silva-Nunes, Alice Melão, Ana Oliveira, Leone Duarte, Miguel Brito. Q192R polymorphism of the paraoxonase-1 gene as a risk factor for obesity in Portuguese women. European journal of endocrinology. 2011 Feb; 164(2):213-8. doi: 10.1530/eje-10-0825. [PMID: 21078685]
  • Jorge Estévez, Adolfo García-Pérez, José Barril, Eugenio Vilanova. Inhibition with spontaneous reactivation of carboxyl esterases by organophosphorus compounds: paraoxon as a model. Chemical research in toxicology. 2011 Jan; 24(1):135-43. doi: 10.1021/tx100346c. [PMID: 21155548]