Paraoxon (BioDeep_00000002359)
Secondary id: BioDeep_00000405977
human metabolite Endogenous Chemicals and Drugs natural product
代谢物信息卡片
O,O-Diethyl O-p-nitrophenyl phosphoric acid
化学式: C10H14NO6P (275.0559)
中文名称: 对硫磷(乙基对硫磷)
谱图信息:
最多检出来源 Homo sapiens(natural_products) 8.05%
分子结构信息
SMILES: CCOP(=O)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-]
InChI: InChI=1S/C10H14NO6P/c1-3-15-18(14,16-4-2)17-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3
描述信息
Paraoxon is an acetylcholinesterase inhibitor. It is an organophosphate oxon, and the active metabolite of the insecticide parathion. It is also used as an opthamological drug against glaucoma. Paraoxon is one of the most potent acetylcholinesterase-inhibiting insecticides available, around 70\\% as potent as the nerve agent sarin, and so is now rarely used as an insecticide due to the risk of poisoning to humans and other animals. It is easily absorbed through skin, and was used as an assassination weapon by the apartheid-era South African chemical weapons program Project Coast. [HMDB]
Paraoxon is an acetylcholinesterase inhibitor. It is an organophosphate oxon, and the active metabolite of the insecticide parathion. It is also used as an opthamological drug against glaucoma. Paraoxon is one of the most potent acetylcholinesterase-inhibiting insecticides available, around 70\\% as potent as the nerve agent sarin, and so is now rarely used as an insecticide due to the risk of poisoning to humans and other animals. It is easily absorbed through skin, and was used as an assassination weapon by the apartheid-era South African chemical weapons program Project Coast.
S - Sensory organs > S01 - Ophthalmologicals > S01E - Antiglaucoma preparations and miotics > S01EB - Parasympathomimetics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D010575 - Pesticides > D007306 - Insecticides
D004791 - Enzyme Inhibitors
D016573 - Agrochemicals
同义名列表
22 个代谢物同义名
O,O-Diethyl O-p-nitrophenyl phosphoric acid; Phosphoric acid diethyl 4-nitrophenyl ester; O,O-Diethyl-O-p-nitrophenylphosphoric acid; p-Nitrophenyl diethyl phosphoric acid; Phosphate diethyl 4-nitrophenyl ester; Diethyl p-nitrophenyl phosphoric acid; O,O-Diethyl O-p-nitrophenyl phosphate; O,O-Diethyl-O-p-nitrophenylphosphate; diethyl (4-nitrophenyl) phosphate; Phosphate, diethyl-P-nitrophenyl; Diethyl P nitrophenyl phosphate; Diethyl-P-nitrophenyl phosphate; diethyl 4-nitrophenyl phosphate; Diethyl p-nitrophenyl phosphate; p-Nitrophenyl diethyl phosphate; Diethyl paraoxon; Ethyl paraoxon; Phosphacol; Fosfakol; PARAOXON; Paraoxon; Paraoxon
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:27827
- KEGG: C06606
- KEGGdrug: D10529
- PubChem: 9395
- HMDB: HMDB0013035
- Metlin: METLIN44800
- DrugBank: DB13495
- ChEMBL: CHEMBL23838
- Wikipedia: Paraoxon
- MeSH: Paraoxon
- foodb: FDB029261
- chemspider: 9026
- CAS: 311-45-5
- PMhub: MS000002420
- PubChem: 8832
- NIKKAJI: J5.657J
- KNApSAcK: 27827
- LOTUS: LTS0215580
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
6 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(6)
- paraoxon degradation:
H2O + paraoxon ⟶ 4-nitrophenol + H+ + diethylphosphate - paraoxon degradation:
H2O + paraoxon ⟶ 4-nitrophenol + H+ + diethylphosphate - paraoxon degradation:
H2O + paraoxon ⟶ 4-nitrophenol + H+ + diethylphosphate - paraoxon degradation:
H2O + paraoxon ⟶ 4-nitrophenol + H+ + diethylphosphate - paraoxon degradation:
H2O + paraoxon ⟶ 4-nitrophenol + H+ + diethylphosphate - paraoxon degradation:
H2O + paraoxon ⟶ 4-nitrophenol + H+ + diethylphosphate
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
15 个相关的物种来源信息
- 7458 - Apidae: LTS0215580
- 7459 - Apis: LTS0215580
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 7461 - Apis cerana: LTS0215580
- 6656 - Arthropoda: LTS0215580
- 7711 - Chordata: LTS0215580
- 2759 - Eukaryota: LTS0215580
- 9606 - Homo sapiens: -
- 50557 - Insecta: LTS0215580
- 40674 - Mammalia: LTS0215580
- 33208 - Metazoa: LTS0215580
- 10066 - Muridae: LTS0215580
- 10088 - Mus: LTS0215580
- 10090 - Mus musculus: LTS0215580
- 10090 - Mus musculus: NA
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hessameddin Mortazavi, Hossein Omidi-Ardali, Seyed Asadollah Amini, Javad Saffari-Chaleshtori, Keihan Ghatreh Samani. In vivo/in silico insight into the effect of titanium dioxide nanoparticle on serum paraoxonase 1 activity in rat.
Journal of biomolecular structure & dynamics.
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10.1080/07391102.2020.1864662. [PMID: 33459188] - Mai Luo, Ling Chen, Jinchao Wei, Xiping Cui, Zehua Cheng, Ting Wang, Incheng Chao, Yunyang Zhao, Hao Gao, Peng Li. A two-step strategy for simultaneous dual-mode detection of methyl-paraoxon and Ni (Ⅱ).
Ecotoxicology and environmental safety.
2022 Jul; 239(?):113668. doi:
10.1016/j.ecoenv.2022.113668. [PMID: 35623151] - Praveen Kumar Gopi, Duy Ba Ngo, Shen-Ming Chen, Chandan Hunsur Ravikumar, Werasak Surareungchai. High-performance electrochemical sensing of hazardous pesticide Paraoxon using BiVO4 nano dendrites equipped catalytic strips.
Chemosphere.
2022 Feb; 288(Pt 2):132511. doi:
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Medicinal chemistry (Shariqah (United Arab Emirates)).
2022; 18(2):273-287. doi:
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International journal of molecular sciences.
2021 Dec; 22(24):. doi:
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Molecular biology reports.
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Environmental toxicology and pharmacology.
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Applied biochemistry and biotechnology.
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Retina (Philadelphia, Pa.).
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International journal of legal medicine.
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Chemico-biological interactions.
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Bioorganic & medicinal chemistry.
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PloS one.
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Toxicology and industrial health.
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Annals of the rheumatic diseases.
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Environmental health perspectives.
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Critical care medicine.
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