D-Mannitol (BioDeep_00000231048)

Main id: BioDeep_00000000355

Secondary id: BioDeep_00000017597

natural product PANOMIX_OTCML-2023


代谢物信息卡片


D-glycero-Hexitol

化学式: C6H14O6 (182.0790344)
中文名称: 甘露醇, 甘露糖
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 0.07%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

D-Mannitol. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/d-mannitol (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000231048). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C(C(C(C(CO)O)O)O)O)O
InChI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

描述信息

Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid. On October 30, 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of pulmonary symptoms associated with cystic fibrosis in adult patients and is currently marketed for this indication under the name BRONCHITOL® by Chiesi USA Inc.

Mannitol, a type of sugar alcohol, serves several important biological functions:

Osmotic Diuretic: Mannitol is used medically as an osmotic diuretic to reduce intracranial and intraocular pressure. By increasing urine production, it helps to draw excess fluid from the brain and eyes, which is beneficial in conditions like cerebral edema and glaucoma.
Sweetener and Sugar Substitute: In the food industry, mannitol is used as a sweetener and sugar substitute. It provides sweetness without contributing to tooth decay and is often used in products for diabetics because it has a minimal impact on blood sugar levels.
Preservative: Mannitol’s hygroscopic properties make it useful as a preservative in various products, including pharmaceuticals and foods, to prevent moisture absorption and maintain product stability.
Laxative: In high concentrations, mannitol can act as a laxative due to its osmotic effect in the intestine, drawing water into the bowel and stimulating bowel movements.
Tissue Protectant: In cryopreservation, mannitol is used to protect tissues from damage caused by freezing and thawing processes.
Cell Culture Medium Component: Mannitol is often included in cell culture media to maintain osmotic balance and provide a stable environment for cell growth.
Pharmaceutical Excipient: It is used as an excipient in the pharmaceutical industry, helping to enhance the stability and bioavailability of drugs.

Mannitol. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=69-65-8 (retrieved 2024-07-01) (CAS RN: 69-65-8). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
DL-Mannitol is obtained by combining D-mannitol with a sample of Lmannitol obtained by reduction of L-mannono-1, Clactone[1].
DL-Mannitol is obtained by combining D-mannitol with a sample of Lmannitol obtained by reduction of L-mannono-1, Clactone[1].
D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells[1][2][3][4][5][6][7].
D-Mannitol is an osmotic diuretic with weak renal vasodilatory activity.
D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells[1][2][3][4][5][6][7].
D-Mannitol is an osmotic diuretic with weak renal vasodilatory activity.

同义名列表

5 个代谢物同义名

Mannitol; D-mannitol; D-glycero-Hexitol; DL-Mannitol; Mannite



数据库引用编号

52 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(6)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

293 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wei-Bo Xu, Qian-Huan Guo, Peng Liu, Shuang Dai, Chang-Ai Wu, Guo-Dong Yang, Jin-Guang Huang, Shi-Zhong Zhang, Jian-Min Song, Cheng-Chao Zheng, Kang Yan. A long non-coding RNA functions as a competitive endogenous RNA to modulate TaNAC018 by acting as a decoy for tae-miR6206. Plant molecular biology. 2024 Apr; 114(3):36. doi: 10.1007/s11103-024-01448-7. [PMID: 38598012]
  • Samilly A Ribeiro, Enock Lr Braga, Marcus L Queiroga, Marco A Clementino, Xhaulla Mqc Fonseca, Mônica O Belém, Lyvia Mvc Magalhães, José K de Sousa, Thiago M de Freitas, Herlice N Veras, Cristiane C de Aquino, Alan Dc Santos, Flávio Rm de Moura, Armênio A Dos Santos, Alexandre Havt, Bruna Ll Maciel, Aldo Am Lima. A New Murine Undernutrition Model Based on Complementary Feeding of Undernourished Children Causes Damage to the Morphofunctional Intestinal Epithelium Barrier. The Journal of nutrition. 2024 Apr; 154(4):1232-1251. doi: 10.1016/j.tjnut.2024.02.001. [PMID: 38346539]
  • Shirong Li, He Xiao, Mingfei Liu, Qingguo Wang, Chenghong Sun, Jingchun Yao, Ningning Cao, Haifang Zhang, Guimin Zhang, Xuefeng Xiao. Network pharmacology and experimental verification to explore the anti-superficial thrombophlebitis mechanism of Mailuo shutong pill. Journal of ethnopharmacology. 2024 Mar; 322(?):117668. doi: 10.1016/j.jep.2023.117668. [PMID: 38159829]
  • Zhe Li, Xiaosui Luo, Qiong Li, Zhengji Jin, Abid Naeem, Weifeng Zhu, Lihua Chen, Yi Feng, Liangshan Ming. The Fabrication, Drug Loading, and Release Behavior of Porous Mannitol. Molecules (Basel, Switzerland). 2024 Feb; 29(3):. doi: 10.3390/molecules29030715. [PMID: 38338458]
  • Valeria Cornelius, Linda Droessler, Salah Amasheh. Quercetin Improves Barrier Properties in Porcine Small Intestine but Not in Peyer's Patches. International journal of molecular sciences. 2024 Jan; 25(3):. doi: 10.3390/ijms25031530. [PMID: 38338808]
  • Sandhya Neupane, Lisa Alexander, Fulya Baysal-Gurel. Evaluation of Hydrangea Cultivars for Tolerance Against Root Rot Caused by Fusarium oxysporum. Plant disease. 2023 Dec; 107(12):3967-3974. doi: 10.1094/pdis-11-22-2712-re. [PMID: 37392028]
  • Leru Liu, Shaoming Xu, Lu Tian, Xuelian Qin, Guojiang Wu, Huawu Jiang, Yaping Chen. Functional characterization of polyol/monosaccharide transporter 1 in Lotus japonicus. Journal of plant physiology. 2023 Nov; 292(?):154146. doi: 10.1016/j.jplph.2023.154146. [PMID: 38043244]
  • Hai-Zhen Duan, Xin Zhou, Quan Hu, Meng-Long Liu, Shu-Hong Wang, Ji Zhang, Xu-Heng Jiang, Tian-Xi Zhang, An-Yong Yu. Mannitol inhibits the proliferation of neural stem cell by a p38 mitogen-activated protein kinase-dependent signaling pathway. Chinese journal of traumatology = Zhonghua chuang shang za zhi. 2023 Nov; ?(?):. doi: 10.1016/j.cjtee.2023.10.004. [PMID: 37953130]
  • Hye-Yeon Seok, Sun-Young Lee, Swarnali Sarker, Md Bayzid, Yong-Hwan Moon. Genome-Wide Analysis of Stress-Responsive Genes and Alternative Splice Variants in Arabidopsis Roots under Osmotic Stresses. International journal of molecular sciences. 2023 Sep; 24(19):. doi: 10.3390/ijms241914580. [PMID: 37834024]
  • Ashish Sarode, Priyal Patel, Natalia Vargas-Montoya, Ayed Allawzi, Alisa Zhilin-Roth, Saswata Karmakar, Lianne Boeglin, Hongfeng Deng, Shrirang Karve, Frank DeRosa. Inhalable dry powder product (DPP) of mRNA lipid nanoparticles (LNPs) for pulmonary delivery. Drug delivery and translational research. 2023 Aug; ?(?):. doi: 10.1007/s13346-023-01402-y. [PMID: 37526881]
  • Maria Belikova, Mamdoh Al-Ameri, Ann-Charlotte Orre, Jesper Säfholm. Defining the contractile prostanoid component in hyperosmolar-induced bronchoconstriction in human small airways. Prostaglandins & other lipid mediators. 2023 Jun; ?(?):106761. doi: 10.1016/j.prostaglandins.2023.106761. [PMID: 37336434]
  • Michele Linsalata, Francesco Russo, Giuseppe Riezzo, Benedetta D'Attoma, Laura Prospero, Antonella Orlando, Antonia Ignazzi, Martina Di Chito, Annamaria Sila, Sara De Nucci, Roberta Rinaldi, Gianluigi Giannelli, Giovanni De Pergola. The Effects of a Very-Low-Calorie Ketogenic Diet on the Intestinal Barrier Integrity and Function in Patients with Obesity: A Pilot Study. Nutrients. 2023 May; 15(11):. doi: 10.3390/nu15112561. [PMID: 37299524]
  • Benshuai Liang, Jiahui Cao, Ruilin Wang, Chenjie Fan, Wei Wang, Xiuli Hu, Rui He, Fuju Tai. ZmCIPK32 positively regulates germination of stressed seeds via gibberellin signal. Plant physiology and biochemistry : PPB. 2023 Apr; 199(?):107716. doi: 10.1016/j.plaphy.2023.107716. [PMID: 37116226]
  • Venkateswarlu Korthikunta, Rohit Singh, Rohit Srivastava, Jyotsana Pandey, Atul Srivastava, Upma Chaturvedi, Akansha Mishra, Arvind K Srivastava, Akhilesh K Tamrakar, Narender Tadigoppula. Design, synthesis, and evaluation of benzofuran-based chromenochalcones for antihyperglycemic and antidyslipidemic activities. RSC medicinal chemistry. 2023 Mar; 14(3):470-481. doi: 10.1039/d2md00341d. [PMID: 36970150]
  • Frank B Lake, Leo S van Overbeek, Johan J P Baars, Tjakko Abee, Heidy M W den Besten. Variability in growth and biofilm formation of Listeria monocytogenes in Agaricus bisporus mushroom products. Food research international (Ottawa, Ont.). 2023 03; 165(?):112488. doi: 10.1016/j.foodres.2023.112488. [PMID: 36869500]
  • Sara Sangi, Geovanna Vitória Olimpio, Fernanda Silva Coelho, Camilla R Alexandrino, Maura Da Cunha, Clícia Grativol. Flagellin and mannitol modulate callose biosynthesis and deposition in soybean seedlings. Physiologia plantarum. 2023 Feb; ?(?):e13877. doi: 10.1111/ppl.13877. [PMID: 36811487]
  • Arun Narota, Ranjit Singh, Ranju Bansal, Ashwani Kumar, Amarjit S Naura. Isolation & identification of anti-inflammatory constituents of Randia dumetorum lamk. fruit: Potential beneficial effects against acute lung injury. Journal of ethnopharmacology. 2023 Jan; 301(?):115759. doi: 10.1016/j.jep.2022.115759. [PMID: 36216197]
  • Qian Chen, Lu Peng, Anhu Wang, Lingzhi Yu, Yu Liu, Xinrong Zhang, Ruolin Wang, Xiaoyi Li, Yi Yang, Xufeng Li, Jianmei Wang. An R2R3-MYB FtMYB11 from Tartary buckwheat has contrasting effects on abiotic tolerance in Arabidopsis. Journal of plant physiology. 2023 Jan; 280(?):153842. doi: 10.1016/j.jplph.2022.153842. [PMID: 36434991]
  • Hao Zhang, Ke Zhang, Tongtong Liu, Ying Zhang, Ziyan Tang, Jingao Dong, Fengru Wang. The characterization and expression analysis under stress conditions of PCST1 in Arabidopsis. Plant signaling & behavior. 2022 Dec; 17(1):2134675. doi: 10.1080/15592324.2022.2134675. [PMID: 36281762]
  • Vinay Kumar Bari, Dharmendra Singh, Jackline Abu Nassar, Radi Aly. Silencing of a mannitol transport gene in Phelipanche aegyptiaca by the tobacco rattle virus system reduces the parasite germination on the host root. Plant signaling & behavior. 2022 12; 17(1):2139115. doi: 10.1080/15592324.2022.2139115. [PMID: 36420997]
  • Kelly M Winter, Rachel G Webb, Denese C Marks. Red cells manufactured from lipaemic whole blood donations: Do they have higher haemolysis?. Vox sanguinis. 2022 Dec; 117(12):1351-1359. doi: 10.1111/vox.13366. [PMID: 36214384]
  • Ying-Ying Liu, Wen-Sen Shi, Yu Liu, Xue-Meng Gao, Bo Hu, Hao-Ran Sun, Xiao-Yi Li, Yi Yang, Xu-Feng Li, Zhi-Bin Liu, Jian-Mei Wang. MdPP2C24/37, Protein Phosphatase Type 2Cs from Apple, Interact with MdPYL2/12 to Negatively Regulate ABA Signaling in Transgenic Arabidopsis. International journal of molecular sciences. 2022 Nov; 23(22):. doi: 10.3390/ijms232214375. [PMID: 36430851]
  • María Del Mar Contreras, Irene Gómez-Cruz, Anouar Feriani, Saleh Alwasel, Abdel Halim Harrath, Inmaculada Romero, Eulogio Castro, Nizar Tlili. Hepatopreventive properties of hydroxytyrosol and mannitol-rich extracts obtained from exhausted olive pomace using green extraction methods. Food & function. 2022 Nov; 13(22):11915-11928. doi: 10.1039/d2fo00888b. [PMID: 36321712]
  • Nicoline Dorothea Jakobsen, Katharina Kaiser, Morten Frendø Ebbesen, Line Lauritsen, Morten Frier Gjerstorff, Judith Kuntsche, Jonathan R Brewer. The ROC skin model: A robust skin equivalent for permeation and live cell imaging studies. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2022 Nov; 178(?):106282. doi: 10.1016/j.ejps.2022.106282. [PMID: 35995349]
  • Weijia Shi, Xiaojing Wang, Huan Liu, Zian Cai, Cunfu Lu, Yuzhen Chen. A novel ABA-insensitive mutant in Arabidopsis reveals molecular network of ABA-induced anthocyanin accumulation and abiotic stress tolerance. Journal of plant physiology. 2022 Nov; 278(?):153810. doi: 10.1016/j.jplph.2022.153810. [PMID: 36162212]
  • Wenliang Feng, Xuebin Jiang, Rujiang Zhang, Zhendong Guo, Daiquan Gao. Diagnosis of an Acinetobacter pittii from a patient in China with a multiplex PCR-based targeted gene sequencing platform of the cerebrospinal fluid: A case report with literature review. Medicine. 2022 Oct; 101(42):e31130. doi: 10.1097/md.0000000000031130. [PMID: 36281177]
  • Modou Jobe, Schadrac C Agbla, Marijana Todorcevic, Bakary Darboe, Ebrima Danso, Jean-Paul Pais de Barros, Laurent Lagrost, Fredrik Karpe, Andrew M Prentice. Possible mediators of metabolic endotoxemia in women with obesity and women with obesity-diabetes in The Gambia. International journal of obesity (2005). 2022 10; 46(10):1892-1900. doi: 10.1038/s41366-022-01193-1. [PMID: 35933445]
  • Maya Giridhar, Bastian Meier, Jafargholi Imani, Karl-Heinz Kogel, Edgar Peiter, Ute C Vothknecht, Fatima Chigri. Comparative analysis of stress-induced calcium signals in the crop species barley and the model plant Arabidopsis thaliana. BMC plant biology. 2022 Sep; 22(1):447. doi: 10.1186/s12870-022-03820-5. [PMID: 36114461]
  • Hongzhi Liu, Long Yuan, Wei Guo, Wei Wu. Transcription factor TERF1 promotes seed germination under osmotic conditions by activating gibberellin acid signaling. Plant science : an international journal of experimental plant biology. 2022 Sep; 322(?):111350. doi: 10.1016/j.plantsci.2022.111350. [PMID: 35709980]
  • Cíntia Tomaz Sant'Ana, Ariane Dias de Amorim, Ana Paula Gava, Carla Mora Aguilar, Nayana Garcia Silva, Líllian Duarte Machado, Mirelle Lomar Viana, Daniela da Silva Oliveira, Pollyanna Ibrahim Silva, Neuza Maria Brunoro Costa, André Gustavo Vasconcelos Costa. Brown and golden flaxseed reduce intestinal permeability and endotoxemia, and improve the lipid profile in perimenopausal overweight women. International journal of food sciences and nutrition. 2022 Sep; 73(6):829-840. doi: 10.1080/09637486.2022.2052820. [PMID: 35311432]
  • Pedro García-Caparrós, Lara Vogelsang, Marcus Persicke, Markus Wirtz, Vijay Kumar, Karl-Josef Dietz. Differential sensitivity of metabolic pathways in sugar beet roots to combined salt, heat, and light stress. Physiologia plantarum. 2022 Sep; 174(5):e13786. doi: 10.1111/ppl.13786. [PMID: 36169530]
  • Kristin D Gerson, Nancy Yang, Lauren Anton, Maayan Levy, Jacques Ravel, Michal A Elovitz, Heather H Burris. Second trimester short cervix is associated with decreased abundance of cervicovaginal lipid metabolites. American journal of obstetrics and gynecology. 2022 08; 227(2):273.e1-273.e18. doi: 10.1016/j.ajog.2022.04.031. [PMID: 35469813]
  • Jinzhi Li, Zhe Li, Hongsheng Ruan, Yating Gao, Yanlong Hong, Lan Shen, Xiao Lin. Improved direct compression properties of Gardeniae fructus water extract powders via fluid bed-mediated surface engineering. Pharmaceutical development and technology. 2022 Jul; 27(6):725-739. doi: 10.1080/10837450.2022.2109671. [PMID: 35920696]
  • Jaswin S Sawhney, George Kasotakis, Anna Goldenberg, Stuart Abramson, Christopher Dodgion, Nimitt Patel, Mansoor Khan, John J Como. Management of rhabdomyolysis: A practice management guideline from the Eastern Association for the Surgery of Trauma. American journal of surgery. 2022 07; 224(1 Pt A):196-204. doi: 10.1016/j.amjsurg.2021.11.022. [PMID: 34836603]
  • Ozkan Ates, Ibrahim Yilmaz, Numan Karaarslan, Emel Ersoz, Fatma Bahar Hacioglu Kasim, Mustafa Dogan, Hanefi Ozbek. Coexistence of SARS-CoV-2 and cerebrovascular diseases: does COVID-19 positivity trigger cerebrovascular pathologies?. Journal of infection in developing countries. 2022 Jun; 16(6):981-992. doi: 10.3855/jidc.15800. [PMID: 35797292]
  • João Francisco Câmara Neto, Matheus da Silva Campelo, Gilberto Santos Cerqueira, João Antônio Leal de Miranda, Jhonyson Arruda Carvalho Guedes, Raimundo Rafael de Almeida, Sandra de Aguiar Soares, Nilce Viana Gramosa, Guilherme Julião Zocolo, Ícaro Gusmão Pinto Vieira, Nágila Maria Pontes Silva Ricardo, Maria Elenir Nobre Pinho Ribeiro. Gastroprotective effect of hydroalcoholic extract from Agaricus blazei Murill against ethanol-induced gastric ulcer in mice. Journal of ethnopharmacology. 2022 Jun; 292(?):115191. doi: 10.1016/j.jep.2022.115191. [PMID: 35292374]
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  • Amanpreet Kaur, Gurudutt Dubey, Nisha Sharma, Rajat Pant, Prasad V Bharatam, Kulbhushan Tikoo, Arvind K Bansal. High dose nanocrystalline solid dispersion powder of voriconazole for inhalation. International journal of pharmaceutics. 2022 Jun; 622(?):121827. doi: 10.1016/j.ijpharm.2022.121827. [PMID: 35589006]
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  • Matheus Garbuio, Lucas D Dias, Larissa M de Souza, Thaila Q Corrêa, Natasha F Mezzacappo, Kate C Blanco, Kleber T de Oliveira, Natalia M Inada, Vanderlei S Bagnato. Formulations of curcumin and d-mannitol as a photolarvicide against Aedes aegypti larvae: Sublethal photolarvicidal action, toxicity, residual evaluation, and small-scale field trial. Photodiagnosis and photodynamic therapy. 2022 Jun; 38(?):102740. doi: 10.1016/j.pdpdt.2022.102740. [PMID: 35101624]
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  • Juan Gilberto Martínez-Miranda, Isaac Chairez, Enrique Durán-Páramo. Mannitol Production by Heterofermentative Lactic Acid Bacteria: a Review. Applied biochemistry and biotechnology. 2022 Jun; 194(6):2762-2795. doi: 10.1007/s12010-022-03836-5. [PMID: 35195836]
  • Hao Kong, Yu-Xiu Zhang, Peng-Cheng Ye, Jia-Hui Ma, Jian Gao, Jie Guan. Intraoperative Intravenous Mannitol Administration Failed to Provide Added Value on Renal Functional Preservation After Partial Nephrectomy in Patients with Chronic Kidney Disease: A Matched Cohort Study. Journal of endourology. 2022 05; 36(5):626-633. doi: 10.1089/end.2021.0620. [PMID: 34913722]
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  • Ivana R Sequeira, Marlena C Kruger, Roger D Hurst, Roger G Lentle. A Simple, Robust, and Convenient HPLC Assay for Urinary Lactulose and Mannitol in the Dual Sugar Absorption Test. Molecules (Basel, Switzerland). 2022 Apr; 27(9):. doi: 10.3390/molecules27092677. [PMID: 35566024]
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