Testosterone Propionate (BioDeep_00000002308)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

(1S,2R,10R,11S,14S,15S)-2,15-dimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-14-yl propanoate

化学式: C22H32O3 (344.23513219999995)
中文名称: 丙酸睾丸素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(=O)OC1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
InChI: InChI=1S/C22H32O3/c1-4-20(24)25-19-8-7-17-16-6-5-14-13-15(23)9-11-21(14,2)18(16)10-12-22(17,19)3/h13,16-19H,4-12H2,1-3H3/t16-,17-,18-,19-,21-,22-/m0/s1

描述信息

Testosterone Propionate is only found in individuals that have used or taken this drug. It is an ester of testosterone with a propionate substitution at the 17-beta position. [PubChem]The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5α-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5α-reductase. DHT binds to the same androgen receptor even more strongly than T, so that its androgenic potency is about 2.5 times that of T. The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C2360 - Anabolic Steroid
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

13 个代谢物同义名

(1S,2R,10R,11S,14S,15S)-2,15-dimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-14-yl propanoate; 17-propionyl-17beta-hydroxyandrost-4-en-3-one; Eifelfango brand OF testosterone propionate; Ferring brand OF testosterone propionate; Propionat eifelfango, testosteron; Eifelfango, testosteron propionat; Testosteron propionat eifelfango; Testosterone propionic acid; Testosterone propionate; ChemDiv1_020720; Virormone; Agovirin; Testex

数据库引用编号

18 个数据库交叉引用编号

ChEBI: CHEBI:9466
KEGG: C08158
KEGGdrug: D00959
PubChem: 5410
PubChem: 5995
HMDB: HMDB0015489
Metlin: METLIN2783
DrugBank: DB01420
ChEMBL: CHEMBL1170
Wikipedia: Testosterone propionate
MeSH: Testosterone Propionate
chemspider: 5774
CAS: 57-85-2
PMhub: MS000002318
PubChem: 10358
LipidMAPS: LMST02020076
3DMET: B02149
NIKKAJI: J4.584E

分类词条

Steroid esters

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Shedrach C Kanu, Fidelis E Ejezie, Chioma S Ejezie, Chinedum O Eleazu. Effect of methanol extract of Plectranthus esculentus N.E.Br tuber and its fractions on indices of benign prostatic hyperplasia in Wistar rats. Journal of ethnopharmacology. 2024 Sep; 331(?):118301. doi: 10.1016/j.jep.2024.118301. [PMID: 38735419]
Young-Jin Choi, Nishala Erandi Wedamulla, Seok-Hee Kim, Mirae Oh, Kang Sik Seo, Jeong Su Han, Eun Joo Lee, Young Ho Park, Young Jin Park, Eun-Kyung Kim. Salvia miltiorrhiza Bunge Ameliorates Benign Prostatic Hyperplasia through Regulation of Oxidative Stress via Nrf-2/HO-1 Activation. Journal of microbiology and biotechnology. 2024 May; 34(5):1059-1072. doi: 10.4014/jmb.2308.08053. [PMID: 37994101]
Seong Min Lee, Sang Mok Lee, Jungbin Song. Effects of Taraxaci Herba (Dandelion) on Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats. Nutrients. 2024 Apr; 16(8):. doi: 10.3390/nu16081189. [PMID: 38674879]
Misaki Kojima, Masakuni Degawa. Causes of Sex Differences in Serum Cholesterol and Triglyceride Levels in Meishan Pigs. Biological & pharmaceutical bulletin. 2024; 47(3):606-610. doi: 10.1248/bpb.b23-00895. [PMID: 38462492]
Y Y Han, Q H Zhang, W S Chen, Z L Li, D Xie, S L Zhang, H Lu, L W Wang, Z H Xu, L Z Zhang. Fermented rape pollen powder can alleviate benign prostatic hyperplasia in rats by reducing hormone content and changing gut microbiota. Beneficial microbes. 2023 Nov; 14(5):503-524. doi: 10.1163/18762891-20230039. [PMID: 38656098]
Guo-Yu Gong, Sheng-Yan Xi, Cheng-Chen Li, Wen-Li Tang, Xue-Ming Fu, Yuan-Peng Huang. Bushen Tongluo formula ameliorated testosterone propionate-induced benign prostatic hyperplasia in rats. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Aug; 120(?):155048. doi: 10.1016/j.phymed.2023.155048. [PMID: 37651753]
Shanshan Wang, Wenjiang He, Wenzhi Li, Jin-Rong Zhou, Zhiyun Du. Combination of Lycopene and Curcumin Synergistically Alleviates Testosterone-Propionate-Induced Benign Prostatic Hyperplasia in Sprague Dawley Rats via Modulating Inflammation and Proliferation. Molecules (Basel, Switzerland). 2023 Jun; 28(13):. doi: 10.3390/molecules28134900. [PMID: 37446563]
Deusdedit Tusubira, Patrick M Aja, Jonasi Munezero, Frank Ssedyabane, Nathim Namale, Josiah E Ifie, Peter C Agu, Clement O Ajayi, Joash Okoboi. Safety profile of colocasia esculenta tuber extracts in benign prostate hyperplasia. BMC complementary medicine and therapies. 2023 Jun; 23(1):187. doi: 10.1186/s12906-023-04018-4. [PMID: 37286957]
Jie Kang, Jixing Yan, Wensheng Yan. Testosterone ameliorated the behavioural deficits of gonadectomised rats and counteracted free radicals in a dosage-dependent manner. Behavioural brain research. 2023 May; 450(?):114501. doi: 10.1016/j.bbr.2023.114501. [PMID: 37207980]
Akansha Bisht, Ritika Gururani, Smita Jain, Rahul Shukla, Jaya Dwivedi, Swapnil Sharma. Cedrus deodara (Roxb. ex D.Don) G.Don bark fraction ameliorates metabolic, endocrine and ovarian dynamics in rats experiencing polycystic ovarian syndrome. Journal of ethnopharmacology. 2023 Apr; 306(?):116206. doi: 10.1016/j.jep.2023.116206. [PMID: 36690306]
Ebenezer O Farombi, Babajide O Ajayi, Edward K Opata, Abisoye O Fafioye, Adetomilola T Akinade. Kolaviron modulates angiogenesis, apoptosis and inflammatory signaling in rat model of testosterone propionate-induced benign prostate hyperplasia. Inflammopharmacology. 2023 Mar; ?(?):. doi: 10.1007/s10787-023-01171-7. [PMID: 36881348]
Myunghee Kim, Phuong Tran, Jun Yin, Jungbin Song, Hocheol Kim. Cinnamomum cassia and Rosa laevigata Mixture Improves Benign Prostatic Hyperplasia in Rats by Regulating Androgen Receptor Signaling and Apoptosis. Nutrients. 2023 Feb; 15(4):. doi: 10.3390/nu15040818. [PMID: 36839177]
Young-Jin Choi, Meiqi Fan, Nishala Erandi Wedamulla, Yujiao Tang, Sung Mun Bae, Ji-Young Hwang, Eun-Kyung Kim. Inhibitory effects of Centella asiatica (L.) Urban on enlarged prostate through androgen receptor and PI3K/Akt signaling pathways. Food & function. 2022 Oct; 13(19):10235-10247. doi: 10.1039/d2fo00841f. [PMID: 36124918]
Ja Yeon Park, Woo Yong Park, Jinbong Park, Kwang Seok Ahn, Jun Hee Lee, Hyun Jeong Kwak, Jae-Young Um. Therapeutic role of Glycyrrhiza Uralensis fisher on benign prostatic hyperplasia through 5 alpha reductase regulation and apoptosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Oct; 105(?):154371. doi: 10.1016/j.phymed.2022.154371. [PMID: 35964456]
Kate Eleazu, Patrick Maduabuchi Aja, Chinedum Ogbonnaya Eleazu. Cocoyam (Colocasia esculenta) modulates some parameters of testosterone propionate-induced rat model of benign prostatic hyperplasia. Drug and chemical toxicology. 2022 Sep; 45(5):1923-1933. doi: 10.1080/01480545.2021.1892956. [PMID: 33641553]
Woo Yong Park, Gahee Song, Ja Yeon Park, Kwang Seok Ahn, Hyun Jeong Kwak, Jinbong Park, Jun Hee Lee, Jae-Young Um. Ellagic acid improves benign prostate hyperplasia by regulating androgen signaling and STAT3. Cell death & disease. 2022 06; 13(6):554. doi: 10.1038/s41419-022-04995-3. [PMID: 35715415]
Hyo-Jung Kim, Byung-Hak Kim, Bo-Ram Jin, Sang Jae Park, Hyo-Jin An. Purple Corn Extract Improves Benign Prostatic Hyperplasia by Regulating Prostate Cell Proliferation and Apoptosis. Journal of agricultural and food chemistry. 2022 May; 70(18):5561-5569. doi: 10.1021/acs.jafc.1c07955. [PMID: 35466676]
Basma H Marghani, Alaa Fehaid, Ahmed I Ateya, Mohamed Aboul Ezz, Rasha M Saleh. Photothermal therapeutic potency of plasmonic silver nanoparticles for apoptosis and anti-angiogenesis in testosterone induced benign prostate hyperplasia in rats. Life sciences. 2022 Feb; 291(?):120240. doi: 10.1016/j.lfs.2021.120240. [PMID: 34942164]
Thuy Doan Minh, Tuan Nguyen Thanh Ha, Thuan Nguyen Duy, Ngan Nguyen Hoang, Dung PhamTien, Hung Pham Thai, Hoa Nguyen Thi, Phuong Dang Thi Lan, Binh Pham Quoc, D Y Ivkin, M N Povydysh, Bang Nguyen Cong, M V Krasnova. Linh Phu Khang Tue Tinh inhibited prostate proliferation in rats induced benign prostatic hyperplasia by testosterone propionate. Journal of ethnopharmacology. 2021 Oct; 279(?):114388. doi: 10.1016/j.jep.2021.114388. [PMID: 34224813]
Linghe Zang, Yuwei Zhang, Jing Zhao, Yunxia Yuan, Yi Wen, Jiaxin Lian, Shuailong Chen, Yiran Chen, Weiyi Liu, Ze Niu, Xinyue Wang, Chunlin Peng, Wenxin Zhang, Zhaoqing Meng, Jincai Lu. A metabolomics study of Qianliexin capsule treatment of benign prostatic hyperplasia induced by testosterone propionate in the rat model. Analytical biochemistry. 2021 09; 628(?):114258. doi: 10.1016/j.ab.2021.114258. [PMID: 34081927]
Hyo-Jung Kim, Bo-Ram Jin, Hyo-Jin An. Psoralea corylifolia L. extract ameliorates benign prostatic hyperplasia by regulating prostate cell proliferation and apoptosis. Journal of ethnopharmacology. 2021 Jun; 273(?):113844. doi: 10.1016/j.jep.2021.113844. [PMID: 33485982]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Fangfang Wang, Ningning Xie, Yan Wu, Qing Zhang, Yuhang Zhu, Minchen Dai, Jue Zhou, Jiexue Pan, Mengling Tang, Qi Cheng, Biwei Shi, Qinyuan Guo, Xinling Li, Lifeng Xie, Bing Wang, Dongxia Yang, Qing Weng, Lanzhong Guo, Jisheng Ye, Mingwo Pan, Shuyi Zhang, Hua Zhou, Cailan Zhen, Ping Liu, Ke Ning, Lisa Brackenridge, Paul J Hardiman, Fan Qu. Association between circadian rhythm disruption and polycystic ovary syndrome. Fertility and sterility. 2021 03; 115(3):771-781. doi: 10.1016/j.fertnstert.2020.08.1425. [PMID: 33358334]
Patience N Ogbu, Lawrence U S Ezeanyika, Victor N Eji Ogugua, Ikechukwu M Ogbu, Chinyere Aloke, Gertrude N Ony. Sphenostylis stenocarpa Seed Extract Attenuates Dyslipidemia in Testosterone Propionate-induced Benign Prostatic Hyperplasia in Rats. Pakistan journal of biological sciences : PJBS. 2021 Jan; 24(1):151-157. doi: 10.3923/pjbs.2021.151.157. [PMID: 33683042]
Misaki Kojima, Masakuni Degawa. Androgen-Dependent Differences in the Amounts of CYP mRNAs in the Pig Kidney. Biological & pharmaceutical bulletin. 2021; 44(8):1120-1128. doi: 10.1248/bpb.b21-00333. [PMID: 34334497]
Asmaa Mohamed Abdel-Aziz, Nashwa Fathy Gamal El-Tahawy, Medhat Atta Salah Abdel Haleem, Mostafa Mouard Mohammed, Ahmed Issam Ali, Yasmine F Ibrahim. Amelioration of testosterone-induced benign prostatic hyperplasia using febuxostat in rats: The role of VEGF/TGFβ and iNOS/COX-2. European journal of pharmacology. 2020 Dec; 889(?):173631. doi: 10.1016/j.ejphar.2020.173631. [PMID: 33031799]
Patience N Ogbu, Evelyn O Ugota, Rita U Onwuka, Ikechukwu M Ogbu, Chinyere Aloke. Effect of acetogenin fraction of Annona muricata leaves on antioxidant status and some indices of benign prostatic hyperplasia in rats. Redox report : communications in free radical research. 2020 Dec; 25(1):80-86. doi: 10.1080/13510002.2020.1804711. [PMID: 32878595]
Diego G Rocha, Mary Ane G Lana, Débora C S de Assis, Rodinei Augusti, Adriana F Faria. Determination of Steroids in Bovine Serum: Validation of a Reliable LC-MS/MS Method and In Vivo Studies with Boldenone Undecylenate and Testosterone Propionate. Journal of agricultural and food chemistry. 2020 Oct; 68(41):11545-11552. doi: 10.1021/acs.jafc.0c03621. [PMID: 32960588]
Eman M Elbaz, Hebat Allah A Amin, Ahmed S Kamel, Sherehan M Ibrahim, Hebatullah S Helmy. Immunomodulatory effect of diallyl sulfide on experimentally-induced benign prostate hyperplasia via the suppression of CD4+T/IL-17 and TGF-β1/ERK pathways. Inflammopharmacology. 2020 Oct; 28(5):1407-1420. doi: 10.1007/s10787-020-00743-1. [PMID: 32785828]
Diego G Rocha, Mary Ane G Lana, Débora C S de Assis, Silvana V Cançado, Rodinei Augusti, Adriana F Faria. Determination of steroids in bovine hair: Validation of a microwave-assisted chemical derivatization method using liquid chromatography-tandem mass spectrometry and in vivo studies. Drug testing and analysis. 2020 Aug; 12(8):1078-1086. doi: 10.1002/dta.2815. [PMID: 32384229]
Jinhyung Rho, Chang-Seob Seo, Hee-Seon Park, Hye-Yun Jeong, Og-Sung Moon, Young-Won Seo, Hwa-Young Son, Young-Suk Won, Hyo-Jung Kwun. Asteris Radix et Rhizoma suppresses testosterone-induced benign prostatic hyperplasia in rats by regulating apoptosis and inflammation. Journal of ethnopharmacology. 2020 Jun; 255(?):112779. doi: 10.1016/j.jep.2020.112779. [PMID: 32209388]
Xi Jin, Tianhai Lin, Guang Yang, Huawei Cai, Bo Tang, Xinyang Liao, Huifang Li, Xiaoting Chen, Lina Gong, Hang Xu, Yi Sun, Ping Tan, Jianqiong Yin, Hongwen Ma, Jianzhong Ai, Kunjie Wang, Qiang Wei, Lu Yang, Hong Li. Use of Tregs as a cell-based therapy via CD39 for benign prostate hyperplasia with inflammation. Journal of cellular and molecular medicine. 2020 05; 24(9):5082-5096. doi: 10.1111/jcmm.15137. [PMID: 32191396]
Shanika Karunasagara, Geum-Lan Hong, Da-Young Jung, Kyung-Hyun Kim, Kyoungwon Cho, Ju-Young Jung. Protective effects of combination of Stauntonia hexaphylla and Cornus officinalis on testosterone-induced benign prostatic hyperplasia through inhibition of 5α- reductase type 2 and induced cell apoptosis. PloS one. 2020; 15(8):e0236879. doi: 10.1371/journal.pone.0236879. [PMID: 32790676]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
XiangJun Kong, Jun Jiang, Bo Cheng, Rui Jiang. Effect of low androgen status on the expression of adenosine A2A and A2B receptors in rat penile corpus cavernosum. Andrologia. 2019 Oct; 51(9):e13344. doi: 10.1111/and.13344. [PMID: 31206753]
Oluwaseun A Adeyanju, Timothy O Falodun, Oyesanmi A Fabunmi, Lawrence A Olatunji, Ayodele O Soladoye. Very low dose spironolactone protects experimentally-induced polycystic ovarian syndrome from insulin-resistant metabolic disturbances by suppressing elevated circulating testosterone. Chemico-biological interactions. 2019 Sep; 310(?):108742. doi: 10.1016/j.cbi.2019.108742. [PMID: 31295448]
Mamdouh M Hegazy, Manar S Elmehankar, Manar S Azab, Nora L El-Tantawy, Azza Abdel-Aziz. Sex dichotomy in the course of experimental latent toxoplasmosis. Experimental parasitology. 2019 Jul; 202(?):15-21. doi: 10.1016/j.exppara.2019.05.003. [PMID: 31078550]
Ri-Na Su, Rong-Rui Wei, Wei-Zao Luo, Ji-Xiao Zhu, Lu Wang, Guo-Yue Zhong. [Study on effect of extract from Tibetan medicine Urtica hyperborean on anti-prostatic hyperplasia]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 May; 44(9):1953-1959. doi: 10.19540/j.cnki.cjcmm.20190304.004. [PMID: 31342726]
Jinhyung Rho, Chang-Seob Seo, Hee-Seon Park, Charith Ub Wijerathne, Hye-Yun Jeong, Og-Sung Moon, Young-Won Seo, Hwa-Young Son, Young-Suk Won, Hyo-Jung Kwun. Ulmus macrocarpa Hance improves benign prostatic hyperplasia by regulating prostatic cell apoptosis. Journal of ethnopharmacology. 2019 Apr; 233(?):115-122. doi: 10.1016/j.jep.2018.11.042. [PMID: 30508623]
Junyi Li, Robert B Gibbs. Detection of estradiol in rat brain tissues: Contribution of local versus systemic production. Psychoneuroendocrinology. 2019 04; 102(?):84-94. doi: 10.1016/j.psyneuen.2018.11.037. [PMID: 30529907]
Hee-Seon Park, Chang-Seob Seo, Charith Ub Wijerathne, Hye-Yun Jeong, Og-Sung Moon, Young-Won Seo, Young-Suk Won, Hwa-Young Son, Jong-Hwan Lim, Hyo-Jung Kwun. Effect of Veratrum maackii on Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats. Biological & pharmaceutical bulletin. 2019 Jan; 42(1):1-9. doi: 10.1248/bpb.b18-00313. [PMID: 30381617]
Seonung Lim, Wonwoo Lee, Doo Suk Lee, In-Jeong Nam, Nayoung Yun, Yoonseon Jeong, Taewoong Rho, Sunyoung Kim. Botanical Formulation HX109 Ameliorates TP-Induced Benign Prostate Hyperplasia in Rat Model and Inhibits Androgen Receptor Signaling by Upregulating Ca2+/CaMKKβ and ATF3 in LNCaP Cells. Nutrients. 2018 Dec; 10(12):. doi: 10.3390/nu10121946. [PMID: 30544543]
Joabel Tonellotto Dos Santos, Jandui Escarião da Nóbrega, Lady Katerine Serrano Mujica, Carolina Dos Santos Amaral, Fabrício Amadori Machado, Manuela W Manta, Tiele Medianeira Rizzetti, Renato Zanella, Rafael Fighera, Alfredo Quites Antoniazzi, Paulo Bayard Dias Gonçalves, Fabio Vasconcellos Comim. Prenatal Androgenization of Ewes as a Model of Hirsutism in Polycystic Ovary Syndrome. Endocrinology. 2018 12; 159(12):4056-4064. doi: 10.1210/en.2018-00781. [PMID: 30376052]
Ming-Yi Liu, Ning-Juan Chi, Juan Feng, Xiao-Peng Shi, Ai-Dong Wen. [Ruyi Jinhuang Plaster suppresses BPH by reducing the expressions of P38, JNK2, NF-кBP65 and STAT3 in the prostate tissue of rats]. Zhonghua nan ke xue = National journal of andrology. 2018 Dec; 24(12):1116-1121. doi: ". [PMID: 32212493]
Lawrence A Olatunji, Emmanuel D Areola, Olufunto O Badmus. Endoglin inhibition by sodium acetate and flutamide ameliorates cardiac defective G6PD-dependent antioxidant defense in gestational testosterone-exposed rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Nov; 107(?):1641-1647. doi: 10.1016/j.biopha.2018.08.133. [PMID: 30257382]
Sonnet S Jonker, Samantha Louey, Charles E Roselli. Cardiac myocyte proliferation and maturation near term is inhibited by early gestation maternal testosterone exposure. American journal of physiology. Heart and circulatory physiology. 2018 11; 315(5):H1393-H1401. doi: 10.1152/ajpheart.00314.2018. [PMID: 30095996]
Bo-Ram Jin, Hyo-Jung Kim, Sang-Kyun Park, Myoung-Seok Kim, Kwang-Ho Lee, Il-Joo Yoon, Hyo-Jin An. Anti-Proliferative Effects of HBX-5 on Progression of Benign Prostatic Hyperplasia. Molecules (Basel, Switzerland). 2018 Oct; 23(10):. doi: 10.3390/molecules23102638. [PMID: 30322186]
Guoliang Zhang, Yunxiao Kang, Chenming Zhou, Rui Cui, Min Jia, Shen Hu, Xiaoming Ji, Jiayu Yuan, Huixian Cui, Geming Shi. Amelioratory Effects of Testosterone Propionate on Age-related Renal Fibrosis via Suppression of TGF-β1/Smad Signaling and Activation of Nrf2-ARE Signaling. Scientific reports. 2018 Jul; 8(1):10726. doi: 10.1038/s41598-018-29023-3. [PMID: 30013094]
Tatiana Dib, Jonathan Martínez-Pinto, Miguel Reyes-Parada, Gonzalo E Torres, Ramón Sotomayor-Zárate. Neonatal programming with testosterone propionate reduces dopamine transporter expression in nucleus accumbens and methylphenidate-induced locomotor activity in adult female rats. Behavioural brain research. 2018 07; 346(?):80-85. doi: 10.1016/j.bbr.2017.12.001. [PMID: 29221813]
W T Farmer, G W Louis, A R Buckalew, D R Hallinger, T E Stoker. Evaluation of triclosan in the Hershberger and H295R steroidogenesis assays. Toxicology letters. 2018 Jul; 291(?):194-199. doi: 10.1016/j.toxlet.2018.03.001. [PMID: 29501854]
Irene Paterniti, Michela Campolo, Marika Cordaro, Rosalba Siracusa, Antonio Filippone, Emanuela Esposito, Salvatore Cuzzocrea. Effects of different natural extracts in an experimental model of benign prostatic hyperplasia (BPH). Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2018 Jul; 67(7):617-626. doi: 10.1007/s00011-018-1152-9. [PMID: 29679313]
Chun-Bin Lu, Ping-le Qiu, Qi-Jun Kong, Bei-Bei Zhu, Chun-Meng Li, Biao Liu. [Effects of alcohol on benign prostate hyperplasia induced by testosterone propionate in mice]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 2018 Jun; 34(6):501-506. doi: 10.12047/j.cjap.5686.2018.112. [PMID: 31032584]
Katarzyna Knapczyk-Stwora, Malgorzata Grzesiak, Renata E Ciereszko, Elzbieta Czaja, Marek Koziorowski, Maria Slomczynska. The impact of sex steroid agonists and antagonists on folliculogenesis in the neonatal porcine ovary via cell proliferation and apoptosis. Theriogenology. 2018 Jun; 113(?):19-26. doi: 10.1016/j.theriogenology.2018.02.008. [PMID: 29452853]
Ana Lambertos, Bruno Ramos-Molina, David Cerezo, Andrés J López-Contreras, Rafael Peñafiel. The mouse Gm853 gene encodes a novel enzyme: Leucine decarboxylase. Biochimica et biophysica acta. General subjects. 2018 Mar; 1862(3):365-376. doi: 10.1016/j.bbagen.2017.11.007. [PMID: 29108956]
Charith Ub Wijerathne, Hee-Seon Park, Hye-Yun Jeong, Ji-Won Song, Og-Sung Moon, Young-Won Seo, Young-Suk Won, Hwa-Young Son, Jong-Hwan Lim, Sung-Hum Yeon, Hyo-Jung Kwun. Quisqualis indica Improves Benign Prostatic Hyperplasia by Regulating Prostate Cell Proliferation and Apoptosis. Biological & pharmaceutical bulletin. 2017 Dec; 40(12):2125-2133. doi: 10.1248/bpb.b17-00468. [PMID: 28943529]
Aruna L Hugar, Amarvani P Kanjikar, Ramesh L Londonkar. A Novel Potential Reproductive Effects of Pterocarpus marsupium Methanolic Extract on Testosterone Propionate Induced Polycystic Ovary Syndrome in Female Albino Rats. Endocrine, metabolic & immune disorders drug targets. 2017 Nov; 17(4):317-323. doi: 10.2174/1871530317666170912153934. [PMID: 28901866]
Gulzar Ahmed, Walter Elger, Frederick Meece, Hareesh B Nair, Birgitt Schneider, Ralf Wyrwa, Klaus Nickisch. A prodrug design for improved oral absorption and reduced hepatic interaction. Bioorganic & medicinal chemistry. 2017 10; 25(20):5569-5575. doi: 10.1016/j.bmc.2017.08.027. [PMID: 28886996]
E Domonkos, V Borbélyová, L Kolátorová, T Chlupáčová, D Ostatníková, J Hodosy, L Stárka, P Celec. Sex differences in the effect of prenatal testosterone exposure on steroid hormone production in adult rats. Physiological research. 2017 09; 66(Suppl 3):S367-S374. doi: 10.33549/physiolres.933722. [PMID: 28948821]
Woo-Young Jeon, Ohn Soon Kim, Chang-Seob Seo, Seong Eun Jin, Jung-Ae Kim, Hyeun-Kyoo Shin, Yong-Ung Kim, Mee-Young Lee. Inhibitory effects of Ponciri Fructus on testosterone-induced benign prostatic hyperplasia in rats. BMC complementary and alternative medicine. 2017 Aug; 17(1):384. doi: 10.1186/s12906-017-1877-y. [PMID: 28774334]
Ying Zou, Waleed Aboshora, Jing Li, Tiancun Xiao, Lianfu Zhang. Protective Effects of Lepidium meyenii (Maca) Aqueous Extract and Lycopene on Testosterone Propionate-Induced Prostatic Hyperplasia in Mice. Phytotherapy research : PTR. 2017 Aug; 31(8):1192-1198. doi: 10.1002/ptr.5838. [PMID: 28635053]
Zhan-di Wang, Ying Feng, Li-Yi Ma, Xian Li, Wei-Feng Ding, Xiao-Ming Chen. Hair growth promoting effect of white wax and policosanol from white wax on the mouse model of testosterone-induced hair loss. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 May; 89(?):438-446. doi: 10.1016/j.biopha.2017.02.036. [PMID: 28249244]
Karen Y Kwok, Timmy L S Choi, Wai Him Kwok, Jenny K Y Wong, Terence S M Wan. Detection of anabolic and androgenic steroids and/or their esters in horse hair using ultra-high performance liquid chromatography-high resolution mass spectrometry. Journal of chromatography. A. 2017 Apr; 1493(?):76-86. doi: 10.1016/j.chroma.2017.03.007. [PMID: 28314523]
Olubukola Oyebimpe Akanni, Olusoji John Abiola, Oluwatosin Adekunle Adaramoye. Methyl Jasmonate Ameliorates Testosterone Propionate-induced Prostatic Hyperplasia in Castrated Wistar Rats. Phytotherapy research : PTR. 2017 Apr; 31(4):647-656. doi: 10.1002/ptr.5778. [PMID: 28211173]
Martina Rejtharová, Libor Rejthar, Katarína Čačková. Determination of testosterone esters and estradiol esters in bovine and porcine blood serum. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2017 Apr; 34(4):477-481. doi: 10.1080/19440049.2016.1268272. [PMID: 27915587]
An-Xi Wang, Xiao-Yu Zhu, Ting Huang, Jin Yang, Yi-Dong Cheng, Yu-Feng Xu. [Effects of Kudzu Root plus Cinnamon Granules on prostatic hyperplasia in mice]. Zhonghua nan ke xue = National journal of andrology. 2017 Apr; 23(4):353-360. doi: ". [PMID: 29714422]
Sebastian T Soukup, Dennis R Müller, Anne Kurrat, Patrick Diel, Sabine E Kulling. Influence of testosterone on phase II metabolism and availability of soy isoflavones in male Wistar rats. Archives of toxicology. 2017 Apr; 91(4):1649-1661. doi: 10.1007/s00204-016-1853-1. [PMID: 27743010]
Nirja K Chaudhari, Laxmipriya P Nampoothiri. Neurotransmitter alteration in a testosterone propionate-induced polycystic ovarian syndrome rat model. Hormone molecular biology and clinical investigation. 2017 Feb; 29(2):71-77. doi: 10.1515/hmbci-2016-0035. [PMID: 27802175]
Guo-Ping Xie, Ji-Yi Xia, Jun Liu, Rui Jiang. [Molecular mechanisms of androgens regulating the eNOS expression in rat corpus cavernosum]. Zhonghua nan ke xue = National journal of andrology. 2017 Jan; 23(1):11-20. doi: NULL. [PMID: 29658231]
Isabel Moreno-Indias, Lidia Sánchez-Alcoholado, Miguel Ángel Sánchez-Garrido, Gracia María Martín-Núñez, Francisco Pérez-Jiménez, Manuel Tena-Sempere, Francisco J Tinahones, María Isabel Queipo-Ortuño. Neonatal Androgen Exposure Causes Persistent Gut Microbiota Dysbiosis Related to Metabolic Disease in Adult Female Rats. Endocrinology. 2016 Dec; 157(12):4888-4898. doi: 10.1210/en.2016-1317. [PMID: 27700135]
M Zügel, S Qiu, R Laszlo, E Bosnyák, C Weigt, D Müller, P Diel, J M Steinacker, U Schumann. The role of sex, adiposity, and gonadectomy in the regulation of irisin secretion. Endocrine. 2016 Oct; 54(1):101-110. doi: 10.1007/s12020-016-0913-x. [PMID: 27055554]
Po-Han Lin, Cai-Yun Jian, Jou-Chun Chou, Chien-Wei Chen, Chih-Chieh Chen, Christina Soong, Sindy Hu, Fu-Kong Lieu, Paulus S Wang, Shyi-Wu Wang. Induction of renal senescence marker protein-30 (SMP30) expression by testosterone and its contribution to urinary calcium absorption in male rats. Scientific reports. 2016 08; 6(?):32085. doi: 10.1038/srep32085. [PMID: 27553527]
Hyun-Myung Choi, Yunu Jung, Jinbong Park, Hye-Lin Kim, Dong-Hyun Youn, JongWook Kang, Mi-Young Jeong, Jong-Hyun Lee, Woong Mo Yang, Seok-Geun Lee, Kwang Seok Ahn, Jae-Young Um. Cinnamomi Cortex (Cinnamomum verum) Suppresses Testosterone-induced Benign Prostatic Hyperplasia by Regulating 5α-reductase. Scientific reports. 2016 08; 6(?):31906. doi: 10.1038/srep31906. [PMID: 27549514]
Li Wang, Yunxiao Kang, Guoliang Zhang, Yingbo Zhang, Rui Cui, Wensheng Yan, Huibing Tan, Shuangcheng Li, Baiyila Wu, Huixian Cui, Geming Shi. Deficits in coordinated motor behavior and in nigrostriatal dopaminergic system ameliorated and VMAT2 expression up-regulated in aged male rats by administration of testosterone propionate. Experimental gerontology. 2016 Jun; 78(?):1-11. doi: 10.1016/j.exger.2016.03.003. [PMID: 26956479]
Misaki Kojima, Masakuni Degawa. Sex differences in constitutive mRNA levels of CYP2B22, CYP2C33, CYP2C49, CYP3A22, CYP3A29 and CYP3A46 in the pig liver: Comparison between Meishan and Landrace pigs. Drug metabolism and pharmacokinetics. 2016 Jun; 31(3):185-92. doi: 10.1016/j.dmpk.2016.02.001. [PMID: 27080814]
Na Wang, Ying Xu, Xian-Qing Zhou, Yan-Hua Wu, Sheng-Li Li, Xin Qiao, Yan-Bo Li, Zhi-Wei Sun. Protective effects of testosterone propionate on reproductive toxicity caused by Endosulfan in male mice. Environmental toxicology. 2016 Feb; 31(2):142-53. doi: 10.1002/tox.22029. [PMID: 25077688]
Dennis R Müller, Fabian Basso, Anne Kurrat, Sebastian T Soukup, Anja Niehoff, Sabine E Kulling, Patrick Diel. Dose-dependent effects of isoflavone exposure during early lifetime on development and androgen sensitivity in male Wistar rats. Molecular nutrition & food research. 2016 Feb; 60(2):325-36. doi: 10.1002/mnfr.201500559. [PMID: 26573877]
Jun-rong Li, Ting Shen, Yan-li Wang, Quan-wei Wei, Fang-xiong Shi. Expression of matrix metalloproteinases and ovarian morphological changes in androgenized cyclic female guinea pigs. Tissue & cell. 2016 Feb; 48(1):72-80. doi: 10.1016/j.tice.2015.10.003. [PMID: 26710991]
Amar S More, Jay S Mishra, Kathirvel Gopalakrishnan, Chellakkan S Blesson, Gary D Hankins, Kunju Sathishkumar. Prenatal Testosterone Exposure Leads to Gonadal Hormone-Dependent Hyperinsulinemia and Gonadal Hormone-Independent Glucose Intolerance in Adult Male Rat Offspring. Biology of reproduction. 2016 Jan; 94(1):5. doi: 10.1095/biolreprod.115.133157. [PMID: 26586841]
Michael J Wilson, Jeremy Lind, Akhouri A Sinha. Induction of a heparin-stimulated serine proteinase in sex accessory gland tumors of the Lobund-Wistar rat. Experimental and molecular pathology. 2015 Aug; 99(1):39-43. doi: 10.1016/j.yexmp.2015.04.008. [PMID: 25913327]
Qinmei Xiong, Xiao Liu, Yang Shen, Peng Yu, Sisi Chen, Jinzhu Hu, Jianhua Yu, Juxiang Li, Hong-Sheng Wang, Xiaoshu Cheng, Kui Hong. Elevated serum Bisphenol A level in patients with dilated cardiomyopathy. International journal of environmental research and public health. 2015 May; 12(5):5329-37. doi: 10.3390/ijerph120505329. [PMID: 25996886]
M Abdel-Raouf, H A Hussein. Effect of long-term testosterone propionate or human chorionic gonadotrophin administration on reproductive glands in adult male rabbits. Andrologia. 2015 May; 47(4):455-63. doi: 10.1111/and.12288. [PMID: 24811403]
Ruwei Wang, Yuta Kobayashi, Yu Lin, Hans Wilhelm Rauwald, Ling Fang, Hongxiang Qiao, Kenny Kuchta. A phytosterol enriched refined extract of Brassica campestris L. pollen significantly improves benign prostatic hyperplasia (BPH) in a rat model as compared to the classical TCM pollen preparation Qianlie Kang Pule'an Tablets. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2015 Jan; 22(1):145-52. doi: 10.1016/j.phymed.2014.10.001. [PMID: 25636883]
Mahmoud M Said, Nahla S Hassan, Michael J Schlicht, Maarten C Bosland. Flaxseed suppressed prostatic epithelial proliferation in a rat model of benign prostatic hyperplasia. Journal of toxicology and environmental health. Part A. 2015; 78(7):453-65. doi: 10.1080/15287394.2014.993779. [PMID: 25785559]
Fiona Connolly, Michael T Rae, Katharina Späth, Lyndsey Boswell, Alan S McNeilly, W Colin Duncan. In an Ovine Model of Polycystic Ovary Syndrome (PCOS) Prenatal Androgens Suppress Female Fetal Renal Gluconeogenesis. PloS one. 2015; 10(7):e0132113. doi: 10.1371/journal.pone.0132113. [PMID: 26148093]
Duojia Zhang, Jing Cong, Huanhuan Shen, Qi Wu, Xiaoke Wu. Genome-wide identification of aberrantly methylated promoters in ovarian tissue of prenatally androgenized rats. Fertility and sterility. 2014 Nov; 102(5):1458-67. doi: 10.1016/j.fertnstert.2014.07.1203. [PMID: 25150387]
Jean-François Bisson, Sophie Hidalgo, Rudy Simons, Marian Verbruggen. Preventive effects of lignan extract from flax hulls on experimentally induced benign prostate hyperplasia. Journal of medicinal food. 2014 Jun; 17(6):650-6. doi: 10.1089/jmf.2013.0046. [PMID: 24460407]
Eugene L Piatnitski Chekler, Rayomond Unwalla, Taukeer A Khan, Raghuram S Tangirala, Mark Johnson, Michael St Andre, James T Anderson, Thomas Kenney, Sue Chiparri, Chris McNally, Edward Kilbourne, Catherine Thompson, Sunil Nagpal, Gregory Weber, Scott Schelling, Jane Owens, Carl A Morris, Dennis Powell, Patrick R Verhoest, Adam M Gilbert. 1-(2-Hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile derivatives as potent and tissue selective androgen receptor modulators. Journal of medicinal chemistry. 2014 Mar; 57(6):2462-71. doi: 10.1021/jm401625b. [PMID: 24527807]
Yan-Zhi Zhao, Jing Jia, Yan-Bo Li, Cai-Xia Guo, Xian-Qing Zhou, Zhi-Wei Sun. Effects of endosulfan on the immune function of erythrocytes, and potential protection by testosterone propionate. The Journal of toxicological sciences. 2014; 39(5):701-10. doi: 10.2131/jts.39.701. [PMID: 25242399]
Prawarisa Wasutrasawat, Hisham Al-Obaidi, Simon Gaisford, M Jayne Lawrence, Warangkana Warisnoicharoen. Drug solubilisation in lipid nanoparticles containing high melting point triglycerides. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2013 Nov; 85(3 Pt A):365-71. doi: 10.1016/j.ejpb.2013.04.020. [PMID: 23688806]
E Sadowska-Krepa, B Klapcinska, S Jagsz, M Chalimoniuk, S J Chrapusta, A Wanke, P Grieb, J Langfort. Diverging oxidative damage and heat shock protein 72 responses to endurance training and chronic testosterone propionate treatment in three striated muscle types of adolescent male rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2013 Oct; 64(5):639-47. doi: ". [PMID: 24304577]
Renata Walczak-Jędrzejowska, Katarzyna Marchlewska, Elżbieta Oszukowska, Eliza Filipiak, Jolanta Słowikowska-Hilczer, Krzysztof Kula. Estradiol and testosterone inhibit rat seminiferous tubule development in a hormone-specific way. Reproductive biology. 2013 Sep; 13(3):243-50. doi: 10.1016/j.repbio.2013.07.005. [PMID: 24011196]
Aydogan Aydogdu, Erol Bolu, Alper Sonmez, Ilker Tasci, Cem Haymana, Ramazan Acar, Coskun Meric, Abdullah Taslipinar, Taner Ozgurtas, Omer Azal. Effects of three different medications on metabolic parameters and testicular volume in patients with hypogonadotropic hypogonadism: 3-year experience. Clinical endocrinology. 2013 Aug; 79(2):243-51. doi: 10.1111/cen.12135. [PMID: 23278834]
Z Kaabia, G Dervilly-Pinel, F Hanganu, N Cesbron, E Bichon, M A Popot, Y Bonnaire, B Le Bizec. Ultra high performance liquid chromatography/tandem mass spectrometry based identification of steroid esters in serum and plasma: an efficient strategy to detect natural steroids abuse in breeding and racing animals. Journal of chromatography. A. 2013 Apr; 1284(?):126-40. doi: 10.1016/j.chroma.2013.02.010. [PMID: 23484650]
Delyan P Delev, Delyana P Davcheva, Ilia D Kostadinov, Ivanka I Kostadinova. Effect of testosterone propionate on erythropoiesis after experimental orchiectomy. Folia medica. 2013 Apr; 55(2):51-7. doi: 10.2478/folmed-2013-0017. [PMID: 24191399]
Haiyin Zheng, Wei Xu, Jiumao Lin, Jun Peng, Zhenfeng Hong. Qianliening capsule treats benign prostatic hyperplasia via induction of prostatic cell apoptosis. Molecular medicine reports. 2013 Mar; 7(3):848-54. doi: 10.3892/mmr.2013.1265. [PMID: 23314795]
Haijiang Zhang, Yi Jing, Guotai Wu. Inhibitory effects of crude polysaccharides from Semen vaccariae on benign prostatic hyperplasia in mice. Journal of ethnopharmacology. 2013 Jan; 145(2):667-9. doi: 10.1016/j.jep.2012.11.027. [PMID: 23202245]
Rebecca W Persky, Fudong Liu, Yan Xu, Gillian Weston, Stephanie Levy, Charles E Roselli, Louise D McCullough. Neonatal testosterone exposure protects adult male rats from stroke. Neuroendocrinology. 2013; 97(3):271-82. doi: 10.1159/000343804. [PMID: 23051877]
Mick Rae, Cathal Grace, Kirsten Hogg, Lisa Marie Wilson, Sophie L McHaffie, Seshadri Ramaswamy, Janis MacCallum, Fiona Connolly, Alan S McNeilly, Colin Duncan. The pancreas is altered by in utero androgen exposure: implications for clinical conditions such as polycystic ovary syndrome (PCOS). PloS one. 2013; 8(2):e56263. doi: 10.1371/journal.pone.0056263. [PMID: 23457541]
Sherri Lee Jones, Nafissa Ismail, Leonora King, James G Pfaus. The effects of chronic administration of testosterone propionate with or without estradiol on the sexual behavior and plasma steroid levels of aged female rats. Endocrinology. 2012 Dec; 153(12):5928-39. doi: 10.1210/en.2012-1578. [PMID: 23070545]