Glycyrrhizin (BioDeep_00000230658)

Main id: BioDeep_00000003388

 

natural product PANOMIX_OTCML-2023 Chemicals and Drugs


代谢物信息卡片


(2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxy-tetrahydropyran-3-yl]oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid

化学式: C42H62O16 (822.4038)
中文名称: 甘草皂甙, 甘草皂苷, 甘草酸, 强力宁, 甘草甜素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C[C@H](O[C@H]2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(=O)O)O3)[C@@H](O)[C@H](O)[C@@H](C(=O)O)O2)[C@@](C)(C)[C@]2([H])CC[C@@]3(C)[C@@]4(C)C([C@@]5([H])[C@](C)(CC[C@](C)(C(O)=O)C5)CC4)=CC(=O)[C@]3([H])[C@@]12C
InChI: InChI=1S/C42H62O16/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54)/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35+,38+,39-,40-,41+,42+/m0/s1

描述信息

Glycyrrhizinic acid is a triterpenoid saponin that is the glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid. It has a role as an EC 3.4.21.5 (thrombin) inhibitor and a plant metabolite. It is a glucosiduronic acid, a tricarboxylic acid, a pentacyclic triterpenoid, an enone and a triterpenoid saponin. It is a conjugate acid of a glycyrrhizinate(3-).
Glycyrrhizic acid is extracted from the root of the licorice plant; Glycyrrhiza glabra. It is a triterpene glycoside with glycyrrhetinic acid that possesses a wide range of pharmacological and biological activities. When extracted from the plant, it can be obtained in the form of ammonium glycyrrhizin and mono-ammonium glycyrrhizin. Glycyrrhizic acid has been developed in Japan and China as a hepatoprotective drug in cases of chronic hepatitis. From January 2014, glycyrrhizic acid as part of the licorice extract was approved by the FDA as an existing food sweetener. It was approved by Health Canada to be used in over-the-counter products but all the products are currently on the status canceled post marketed.
Glycyrrhizic acid is a natural product found in Hypomontagnella monticulosa, Abrus precatorius, and other organisms with data available.
Glycyrrhizin is a saponin-like compound that provides the main sweet flavor for Glycyrrhiza glabra (licorice), with potential immunomodulating, anti-inflammatory, hepato- and neuro-protective, and antineoplastic activities. Glycyrrhizin modulates certain enzymes involved in inflammation and oxidative stress, and downregulates certain pro-inflammatory mediators, thereby protecting against inflammation- and reactive oxygen species (ROS)-induced damage. Glycerrhizin may also suppress the growth of susceptible tumor cells.
Glycyrrhyzin is a metabolite found in or produced by Saccharomyces cerevisiae.
A widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to GLYCYRRHETINIC ACID, which inhibits 11-BETA-HYDROXYSTEROID DEHYDROGENASES and other enzymes involved in the metabolism of CORTICOSTEROIDS. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system.
See also: Enoxolone (has active moiety); Glycyrrhizinate Dipotassium (active moiety of); Glycyrrhiza uralensis Root (part of) ... View More ...
A - Alimentary tract and metabolism > A05 - Bile and liver therapy > A05B - Liver therapy, lipotropics > A05BA - Liver therapy
A triterpenoid saponin that is the glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid.
C1907 - Drug, Natural Product > C28269 - Phytochemical > C1905 - Triterpenoid Compound
C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product
D000893 - Anti-Inflammatory Agents
Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities.
Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities.

同义名列表

76 个代谢物同义名

(2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxy-tetrahydropyran-3-yl]oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid; (2S,3S,4S,5R,6S)-6-{[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl]oxy}-5-{[(2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy}-3,4-dihydroxyoxane-2-carboxylic acid; (2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylicacid; (3.beta.,20.beta.)-20-Carboxy-11-oxo-30-norlean-12-en-3-yl-2-O-.beta.-1- 7-glucopyranuronosyl-.alpha.-D-glucopyranosiduronic acid; (3.BETA.,20.BETA.)-20-CARBOXY-11-OXO-30-NOROLEAN-12-EN-3-YL 2-O-.BETA.-D-GLUCOPYRANURONOSYL-.ALPHA.-D-GLUCOPYRANOSIDURONIC ACID; alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norlean-12-en-3-yl-2-O-beta-1- 7-glucopyranuronosyl-; alpha-D-glucopyranosiduronic acid, (3 beta,20 beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-; alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norlean-12-en-3-yl-2-O-beta-1-7-glucopyranuronosyl-; alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl-2-O-beta-D-glucopyranuron osyl-; alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-; (3beta,20beta)-20-Carboxy-11-oxo-30-norlean-12-en-3-yl-2-O-beta-1- 7-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid; (3beta,20beta)-20-Carboxy-11-oxo-30-norlean-12-en-3-yl-2-O-beta-1-7-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid; (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid; (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl-2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid; 30-hydroxy-11,30-dioxoolean-12-en-3beta-yl (2-O-beta-D-glucopyranosyluronic acid)-alpha-D-glucopyranosiduronic acid; 20BETA-CARBOXY-11-OXO-30-NOROLEAN-12-EN-3BETA-YL-2-O-BE TA-D-GLUCOPYRANURONOSYL-ALPHA-D-GLUCOPYRANOSIDURONIC ACID; 20beta-Carboxy-11-oxo-30-norolean-12-en-3beta-yl-2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid; Glycyrrhizic Acid, Pharmaceutical Secondary Standard; Certified Reference Material; Glycyrrhizic acid, United States Pharmacopeia (USP) Reference Standard; GLYCYRRHIZIC ACID (GLYCYRRHIZIN) (CONSTITUENT OF LICORICE) [DSC]; GLYCYRRHIZIC ACID (GLYCYRRHIZIN) (CONSTITUENT OF LICORICE); 4-18-00-05156 (Beilstein Handbook Reference); Glycyrrhizin (Glycyrrhizic Acid); Glycyrrhetinic acid glycoside; Glycyrrhizinate, Dipotassium; Dipotassium Glycyrrhizinate; LPLVUJXQOOQHMX-QWBHMCJMSA-N; Glycyrrhizinate, Diammonium; GLYCYRRHIZIC ACID [WHO-DD]; GLYCYRRHIZIC ACID [USP-RS]; GLYCYRRHIZIC ACID (USP-RS); Diammonium Glycyrrhizinate; 18.beta.-glycyrrhizic acid; Rizinsan K2 A2 (free acid); GLYCYRRHIZIC ACID (MART.); GLYCYRRHIZIC ACID [MART.]; 18-beta-Glycyrrhizic acid; ammonium-glycyrrhizinate; beta-Glycyrrhizinic acid; GLYCYRRHIZIC ACID [INCI]; 18beta-Glycyrrhizic acid; GLYCYRRHIZIC ACID [MI]; Glycyrrhizic acid, 2K; Acid, Glycyrrhizinic; Glycyrrhizate, Zinc; .beta.-glycyrrhizin; Glycyrrhizinic acid; GLYCYRRHIZIN [HSDB]; Acid, Glycyrrhizic; Glycyrrhizin [JAN]; Zinc Glycyrrhizate; GLYCYRRHIZIN (II); beta-Glycyrrhizin; GLYCYRRHIZIN [II]; Glycyrrhizic acid; UNII-6FO62043WK; Glycyrrhizinate; glycyrrhizate; Tox21_113426; Glycyrrhizin; Glycyrrhitin; Tox21_111520; Tox21_303493; Glycyrrhizic; glyzyrrhizin; Glycyrrizin; 6FO62043WK; potenlini; Dermacrin; Liquorice; Glycyron; Glycyram; Neo-Umor; Glizigen; 30-hydroxy-11,30-dioxoolean-12-en-3beta-yl 2-O-beta-D-glucopyranuronosyl-beta-D-glucopyranosiduronic acid; Glycyrrhizinate



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

78 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ABCB1, ACE2, ANG, CYP3A4, MAPK14, NR3C2, PIK3CA, PTGS2, RB1, STAT3, TLR2, TLR4, VEGFA
Peripheral membrane protein 2 CYP1B1, PTGS2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 5 CYP1B1, CYP3A4, HMGCR, NR3C2, PTGS2
Nucleus 6 ANG, MAPK14, NR3C2, RB1, STAT3, VEGFA
cytosol 6 ANG, MAPK14, NR3C2, PIK3CA, RB1, STAT3
nucleoplasm 4 MAPK14, NR3C2, RB1, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 3 ABCB1, ACE2, TLR4
lamellipodium 1 PIK3CA
Multi-pass membrane protein 3 ABCB1, ABCC2, HMGCR
cell junction 1 AGER
cell surface 7 ABCB1, ABCC2, ACE2, AGER, TLR2, TLR4, VEGFA
glutamatergic synapse 1 MAPK14
Golgi apparatus 2 TLR2, VEGFA
growth cone 1 ANG
neuronal cell body 1 ANG
postsynapse 1 AGER
plasma membrane 8 ABCB1, ABCC2, ACE2, AGER, PIK3CA, STAT3, TLR2, TLR4
Membrane 10 ABCB1, ABCC2, ACE2, AGER, CYP1B1, CYP3A4, HMGCR, TLR2, TLR4, VEGFA
apical plasma membrane 4 ABCB1, ABCC2, ACE2, AGER
axon 1 CCK
caveola 1 PTGS2
extracellular exosome 2 ABCB1, ACE2
endoplasmic reticulum 3 HMGCR, PTGS2, VEGFA
extracellular space 6 ACE2, ANG, CCK, IL10, IL4, VEGFA
perinuclear region of cytoplasm 2 PIK3CA, TLR4
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
intercellular canaliculus 1 ABCC2
mitochondrion 2 CYP1B1, MAPK14
protein-containing complex 1 PTGS2
intracellular membrane-bounded organelle 2 CYP1B1, CYP3A4
Microsome membrane 3 CYP1B1, CYP3A4, PTGS2
Single-pass type I membrane protein 4 ACE2, AGER, TLR2, TLR4
Secreted 6 ACE2, ANG, CCK, IL10, IL4, VEGFA
extracellular region 8 ACE2, AGER, ANG, CCK, IL10, IL4, MAPK14, VEGFA
transcription regulator complex 1 STAT3
Cell projection, cilium 1 ACE2
external side of plasma membrane 1 TLR4
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
nucleolus 1 ANG
Early endosome 1 TLR4
Apical cell membrane 3 ABCB1, ABCC2, ACE2
Membrane raft 2 ACE2, TLR2
spindle 1 RB1
extracellular matrix 1 VEGFA
basement membrane 1 ANG
peroxisomal membrane 1 HMGCR
PML body 1 RB1
secretory granule 1 VEGFA
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 3 NR3C2, TLR2, TLR4
neuron projection 1 PTGS2
cilium 1 ACE2
chromatin 3 NR3C2, RB1, STAT3
Cytoplasmic vesicle, phagosome membrane 1 TLR2
cell projection 1 TLR2
phagocytic cup 1 TLR4
phagocytic vesicle membrane 1 TLR2
Chromosome 1 ANG
brush border membrane 1 ACE2
Nucleus, nucleolus 1 ANG
spindle pole 1 MAPK14
fibrillar center 1 AGER
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
cell body 1 TLR2
Peroxisome membrane 1 HMGCR
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
secretory granule membrane 1 TLR2
endoplasmic reticulum lumen 2 ACE2, PTGS2
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle membrane 1 ACE2
endocytic vesicle 1 ANG
SWI/SNF complex 1 RB1
external side of apical plasma membrane 1 ABCB1
[Isoform 1]: Cell membrane 1 AGER
Toll-like receptor 1-Toll-like receptor 2 protein complex 1 TLR2
Toll-like receptor 2-Toll-like receptor 6 protein complex 1 TLR2
angiogenin-PRI complex 1 ANG
chromatin lock complex 1 RB1
Rb-E2F complex 1 RB1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[Isoform 10]: Cell membrane 1 AGER
[Processed angiotensin-converting enzyme 2]: Secreted 1 ACE2
[Isoform 2]: Apical cell membrane 1 ACE2


文献列表

  • Sijue Chen, Wei Cao, Xianjun Xiao, Lu Wang, Renhong Wan, Zihao Zou, Qian Yang, Ying Li. A systematic review and meta-analysis of efficacy and safety of compound glycyrrhizin combined with second-generation non-sedated antihistamine for the treatment of chronic urticaria. The Journal of dermatological treatment. 2024 Dec; 35(1):2299597. doi: 10.1080/09546634.2023.2299597. [PMID: 38166511]
  • Jialing Sun, Mengqing Ma, Xin Zhong, Jing Li, Jinyu Yi, Renjie Zhang, Xingning Liu, Lanfen Peng, Xinfeng Sun, Wenxing Feng, Rui Hu, Qi Huang, Minling Lv, Kongli Fan, Xiaozhou Zhou. Investigating the molecular mechanism of Qizhu anticancer prescription in inhibiting hepatocellular carcinoma based on high-resolution mass spectrometry and network pharmacology. Journal of ethnopharmacology. 2024 Jun; 328(?):117985. doi: 10.1016/j.jep.2024.117985. [PMID: 38417600]
  • Shanbo Ma, Ye Chong, Rui Zhang, Wei Quan, Jiayue Gui, Long Li, Jin Wang, Shan Miao, Xiaopeng Shi, Minggao Zhao, Kun Zhang. Glycyrrhizic acid treatment ameliorates anxiety-like behaviour via GLT1 and Per1/2-dependent pathways. Journal of ethnopharmacology. 2024 Jun; 328(?):118013. doi: 10.1016/j.jep.2024.118013. [PMID: 38453099]
  • Kai Chen, Yan-Yan Hu, Shan-Shan Qian, Jin-Zhao Wu, Li-Juan Cao, Lin-Lin Wang, Meng Li, Yu-Xin Xia, Qian Jiang, Hong-Ying Chen, Liu-Qing Chen, Dong-Sheng Li. A novel glycyrrhizic acid-based dressing effectively improved photodynamic therapy-caused skin barrier damage in port-wine stains. Journal of cosmetic dermatology. 2024 Jun; 23(6):2301-2303. doi: 10.1111/jocd.16250. [PMID: 38410871]
  • Yiting Hu, Zhongfei Luo, Siyi Cai, Qinfen Xie, Shusen Zheng. Glycyrrhizic acid attenuates sorafenib resistance by inducing ferroptosis via targeting mTOR signaling in hepatocellular carcinoma. Scandinavian journal of gastroenterology. 2024 Jun; 59(6):730-736. doi: 10.1080/00365521.2024.2315317. [PMID: 38426342]
  • Hassan Esmaeili, Mohammad Hossein Mirjalili, Akbar Karami, Samad Nejad Ebrahimi. Introducing the glycyrrhizic acid and glabridin rich genotypes from the cultivated Iranian licorice (Glycyrrhiza glabra L.) populations to exploit in production systems. Scientific reports. 2024 05; 14(1):11034. doi: 10.1038/s41598-024-61711-1. [PMID: 38744977]
  • Lingfeng Du, Chunfang Ma, Bingnan Liu, Wei Liu, Yue Zhu, Zuhua Wang, Teng Chen, Luqi Huang, Yuxin Pang. Green Synthesis of Blumea balsamifera Oil Nanoemulsions Stabilized by Natural Emulsifiers and Its Effect on Wound Healing. Molecules (Basel, Switzerland). 2024 Apr; 29(9):. doi: 10.3390/molecules29091994. [PMID: 38731484]
  • Wenjing Su, Anna V Mastova, Maya A Ul'yanova, Polina A Kononova, Olga Yu Selyutina, Veronika I Evseenko, Elizaveta S Meteleva, Alexander V Dushkin, Weike Su, Nikolay E Polyakov. NMR Study of Water-Soluble Carotenoid Crocin: Formation of Mixed Micelles, Interaction with Lipid Membrane and Antioxidant Activity. International journal of molecular sciences. 2024 Mar; 25(6):. doi: 10.3390/ijms25063194. [PMID: 38542168]
  • José Bryan García-Cambrón, José Luis Cerriteño-Sánchez, Rocío Lara-Romero, David Quintanar-Guerrero, Gerardo Blancas-Flores, Brenda L Sánchez-Gaytán, Irma Herrera-Camacho, Julieta Sandra Cuevas-Romero. Development of Glycyrrhizinic Acid-Based Lipid Nanoparticle (LNP-GA) as An Adjuvant That Improves the Immune Response to Porcine Epidemic Diarrhea Virus Spike Recombinant Protein. Viruses. 2024 03; 16(3):. doi: 10.3390/v16030431. [PMID: 38543796]
  • Longyue Zhou, Shankang Chen, Yuanyi Wei, Yihui Sun, Yifan Yang, Bingqi Lin, Yuhao Li, Chunxia Wang. Glycyrrhizic acid restores the downregulated hepatic ACE2 signaling in the attenuation of mouse steatohepatitis. European journal of pharmacology. 2024 Feb; ?(?):176365. doi: 10.1016/j.ejphar.2024.176365. [PMID: 38316247]
  • Liangliang Chen, Lin Zhao, Ju Han, Ping Xiao, Mingzhe Zhao, Sen Zhang, Jinao Duan. Biosynthesis of Chryseno[2,1,c]oxepin-12-Carboxylic Acid from Glycyrrhizic Acid in Aspergillus terreus TMZ05-2, and Analysis of Its Anti-inflammatory Activity. Journal of microbiology (Seoul, Korea). 2024 Feb; 62(2):113-124. doi: 10.1007/s12275-024-00105-4. [PMID: 38411880]
  • Liu Zhou, Yifei Yang, Xiaotong Fu, Bing Xia, Chun Li, Chenna Lu, Ying Qi, Haijing Zhang, Ting Liu. The protective effect and molecular mechanism of glycyrrhizic acid glycosides against Tripterygium glycosides induced nephrotoxicity based on the RhoA/ROCK1 signalling pathway. Journal of ethnopharmacology. 2024 Jan; 319(Pt 1):117100. doi: 10.1016/j.jep.2023.117100. [PMID: 37648177]
  • Rui Zhang, Aiminuer Asikaer, Qi Chen, Fang Wang, Junjie Lan, Yang Liu, Linfang Hu, Huaye Zhao, Hongtao Duan. Network pharmacology and in vitro experimental verification unveil glycyrrhizin from glycyrrhiza glabra alleviates acute pancreatitis via modulation of MAPK and STAT3 signaling pathways. BMC complementary medicine and therapies. 2024 Jan; 24(1):58. doi: 10.1186/s12906-024-04372-x. [PMID: 38280993]
  • Peter Fischer, Viviane Lutz-Bueno. Glycyrrhizic acid aggregates seen from a synthetic surfactant perspective. Physical chemistry chemical physics : PCCP. 2024 Jan; 26(4):2806-2814. doi: 10.1039/d3cp04835g. [PMID: 38196347]
  • Xuecheng Wang, Xiaohui Wang, Yutian Zhang, Yaqi Wang, Yuanhui Li, Yaokun Xiong, Ming Yang, Xiaorong Luo, Zhenfeng Wu. Effects of ultrasonic power on drying kinetics and product quality of licorice extract during ultrasound-assisted vacuum drying. Journal of the science of food and agriculture. 2024 Jan; ?(?):. doi: 10.1002/jsfa.13283. [PMID: 38252708]
  • Yaoyao Xiao, Lele Zhou, Wenkang Tao, Xuan Yang, Junying Li, Rulin Wang, Yanan Zhao, Can Peng, Caiyun Zhang. Preparation of paeoniflorin-glycyrrhizic acid complex transethosome gel and its preventive and therapeutic effects on melasma. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2024 Jan; 192(?):106664. doi: 10.1016/j.ejps.2023.106664. [PMID: 38061662]
  • Yu Mou, Wenhao Liao, Yuchen Li, Lina Wan, Jingwen Liu, Xialing Luo, Hongping Shen, Qin Sun, Jing Wang, Jianyuan Tang, Zhilei Wang. Glycyrrhizin and the Related Preparations: An Inspiring Resource for the Treatment of Liver Diseases. The American journal of Chinese medicine. 2024; 52(2):315-354. doi: 10.1142/s0192415x24500149. [PMID: 38553799]
  • Kavita J Lanjekar, Virendra K Rathod. Recovery and separation of glycyrrhizic acid from Natural Deep Eutectic Solvent (NADES) extract by macroporous resin: adsorption kinetics and isotherm studies. Preparative biochemistry & biotechnology. 2024 Jan; 54(1):39-48. doi: 10.1080/10826068.2023.2204485. [PMID: 37204086]
  • Naoki Chiyo, Hikaru Seki, Takuya Kanamoto, Hiroshi Ueda, Mareshige Kojoma, Toshiya Muranaka. Glycyrrhizin Production in Licorice Hairy Roots Based on Metabolic Redirection of Triterpenoid Biosynthetic Pathway by Genome Editing. Plant & cell physiology. 2023 Dec; ?(?):. doi: 10.1093/pcp/pcad161. [PMID: 38153756]
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