Protopanaxadiol (BioDeep_00000230281)

 

Secondary id: BioDeep_00000000017

PANOMIX_OTCML-2023 Cytotoxicity natural product


代谢物信息卡片


(3S,5R,8R,9R,10R,12R,13R,14R,17S)-17-[(2R)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol

化学式: C30H52O3 (460.3916242)
中文名称: (20R)-原人参二醇, 20(R)-原人参二醇, 原人参二醇, 20 (S)-原人参二醇, S-原人参二醇
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.07%

分子结构信息

SMILES: C1C[C@]2(C)[C@@]3([H])C[C@@H](O)[C@]4([H])[C@@]([H])([C@@](O)(C)CC/C=C(\C)/C)CC[C@@]4(C)[C@]3(C)CC[C@@]2([H])C(C)(C)[C@H]1O
InChI: InChI=1S/C30H52O3/c1-19(2)10-9-14-30(8,33)20-11-16-29(7)25(20)21(31)18-23-27(5)15-13-24(32)26(3,4)22(27)12-17-28(23,29)6/h10,20-25,31-33H,9,11-18H2,1-8H3/t20-,21+,22-,23+,24-,25-,27-,28+,29+,30+/m0/s1

描述信息

(20R)-protopanaxadiol is a diastereomer of protopanaxadiol in which the 20-hydroxy substituent has been introduced at the pro-R position.
20(R)-Protopanaxadiol is a natural product found in Panax ginseng with data available.
A diastereomer of protopanaxadiol in which the 20-hydroxy substituent has been introduced at the pro-R position.
(20S)-protopanaxadiol is a diastereomer of protopanaxadiol in which the 20-hydroxy substituent has been introduced at the pro-S position.
(20S)-Protopanaxadiol is a natural product found in Gynostemma pentaphyllum, Panax ginseng, and Aralia elata with data available.
A diastereomer of protopanaxadiol in which the 20-hydroxy substituent has been introduced at the pro-S position.
(20R)-Protopanaxadiol is a triterpenoid saponin metabolite of 20(R)-ginsenoside Rg3 in black ginseng. (20R)-Protopanaxadiol exhibits anti-tumor activity and cytotoxicity, and potently inhibits the growth of Helicobacter pylori[1][2][3].
(20R)-Protopanaxadiol is a triterpenoid saponin metabolite of 20(R)-ginsenoside Rg3 in black ginseng. (20R)-Protopanaxadiol exhibits anti-tumor activity and cytotoxicity, and potently inhibits the growth of Helicobacter pylori[1][2][3].
20S-protopanaxadiol (aPPD) is a metabolite of ginseng saponins, inhibits Akt activity and induces apoptosis in various tumor cells[1].
20S-protopanaxadiol (aPPD) is a metabolite of ginseng saponins, inhibits Akt activity and induces apoptosis in various tumor cells[1].

同义名列表

40 个代谢物同义名

(3S,5R,8R,9R,10R,12R,13R,14R,17S)-17-[(2R)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol; (3S,8R,10R,12R,14R)-17-((R)-1-Hydroxy-1,5-dimethyl-hex-4-enyl)-4,4,8,10,14-pentamethyl-hexadecahydro-cyclopenta[a]phenanthrene-3,12-diol; dammar-24-ene-3beta, 6alpha, 12beta, 20-tetrol, (20s)-; DAMMAR-24-ENE-3,12,20-TRIOL, (3.BETA.,12.BETA.,20R)-; DAMMAR-24-ENE-3,12,20-TRIOL, (3.BETA.,12.BETA.,2R)-; Dammar-24-ene-3,12,20-triol, (3beta,12beta,20R)-; (3beta,12beta,20R)-dammar-24-ene-3,12,20-triol; protopanaxadiol, (3beta,12beta)-isomer; dammar-24-ene-3beta,12beta,20R-triol; ethyl2-m-tolylthiazole-4-carboxylate; 24-Dammarene-3beta,12beta-20S-triol; 24-dammarene-3beta,12beta,20R-triol; 20(S)-Protopanaxadiol; 20(R)-Protopanaxadiol; (20R)-Protopanaxadiol; 20(R)-Protopanaxdiol; (20R)-Protopanaxdiol; 20R-Protopanaxadiol; protopanaxadiol; (3S,5R,8R,9R,10R,12R,13R,14R,17S)-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol; (3S,8R,10R,12R,14R)-17-((S)-1-Hydroxy-1,5-dimethyl-hex-4-enyl)-4,4,8,10,14-pentamethyl-hexadecahydro-cyclopenta[a]phenanthrene-3,12-diol; DAMMAR-24-ENE-3,12,20-TRIOL, (3.BETA.,12.BETA.)-; (20S)-protopanaxadiol-type ginsenoside aglycone; (3.BETA.,12.BETA.)-DAMMAR-24-ENE-3,12,20-TRIOL; Dammar-24-ene-3,12,20-triol, (3beta,12beta)-; (3beta,12beta)-dammar-24-ene-3,12,20-triol; DAMMAR-24-ENE-3.BETA.,12.BETA.,20-TRIOL; dammar-24-ene-3beta,12beta,20S-triol; Protopanaxadiol, analytical standard; dammar-24-ene-3beta,12beta,20-triol; 24-dammarene-3beta,12beta,20S-triol; (20S)-Protopanaxadiol [INCI]; PYXFVCFISTUSOO-HKUCOEKDSA-N; (20S)-Protopanaxadiol; 20-Epiprotopanaxadiol; (20S)-Protopanaxdiol; UNII-MR8AEF5T1N; Protopanasadiol; MR8AEF5T1N; 20(S)-APPD



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

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BioCyc(1)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

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26 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yang Ruan, Guoqing Ren, Mingchun Wang, Weichao Lv, Kuniyoshi Shimizu, Chaofeng Zhang. The dual role of 20(S)-protopanaxadiol in alleviating pulmonary fibrosis through the gut-lung axis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155699. doi: 10.1016/j.phymed.2024.155699. [PMID: 38733907]
  • Zhu Zhu, Yao Cheng, Xu Han, Tiantian Wang, Hantao Zhang, Qi Yao, Feiyan Chen, Ling Gu, Dongqing Yang, Lin Chen, Yunan Zhao. 20(S)-Protopanaxadiol Exerts Antidepressive Effects in Chronic Corticosterone-Induced Rodent Animal Models as an Activator of Brain-Type Creatine Kinase. Journal of agricultural and food chemistry. 2024 May; 72(18):10376-10390. doi: 10.1021/acs.jafc.4c00415. [PMID: 38661058]
  • Kang-Xi Zhang, Yue Zhu, Shu-Xia Song, Qing-Yun Bu, Xiao-Yan You, Hong Zou, Guo-Ping Zhao. Ginsenoside Rb1, Compound K and 20(S)-Protopanaxadiol Attenuate High-Fat Diet-Induced Hyperlipidemia in Rats via Modulation of Gut Microbiota and Bile Acid Metabolism. Molecules (Basel, Switzerland). 2024 Mar; 29(5):. doi: 10.3390/molecules29051108. [PMID: 38474620]
  • Yanyan Li, Ke Yang, Linxian Zhao, Chunyi Xu, Weiling Zhou, Zhanguo Wang, Huiling Hu, Yu You. Effects of schisandra lignans on the absorption of protopanaxadiol-type ginsenosides mediated by P-glycoprotein and protopanaxatriol-type ginsenosides mediated by CYP3A4. Journal of ethnopharmacology. 2023 Aug; 318(Pt B):117057. doi: 10.1016/j.jep.2023.117057. [PMID: 37597677]
  • Likang Lu, Hui Ao, Jingxin Fu, Manzhen Li, Yaoyao Guo, Yifei Guo, Meihua Han, Rongxing Shi, Xiangtao Wang. Ginsenoside Rb1 stabilized and paclitaxel / protopanaxadiol co-loaded nanoparticles for synergistic treatment of breast tumor. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jul; 163(?):114870. doi: 10.1016/j.biopha.2023.114870. [PMID: 37187019]
  • Shangkun Qiu, Lars M Blank. Recent Advances in Yeast Recombinant Biosynthesis of the Triterpenoid Protopanaxadiol and Glycosylated Derivatives Thereof. Journal of agricultural and food chemistry. 2023 Feb; 71(5):2197-2210. doi: 10.1021/acs.jafc.2c06888. [PMID: 36696911]
  • Yiping Li, Yang Liu, Zhiwei Chen, Kaiyue Tang, Lili Yang, Yuwei Jiang, Jue Wang, Ping Huang, Jianyi Wang, Peiyong Zheng, Haiyan Song. Protopanaxadiol ameliorates NAFLD by regulating hepatocyte lipid metabolism through AMPK/SIRT1 signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jan; 160(?):114319. doi: 10.1016/j.biopha.2023.114319. [PMID: 36724639]
  • Hong-Ping Wang, Zi-Jian Wang, Jing Du, Zhao-Zhou Lin, Chen Zhao, Run Zhang, Qiong Yin, Chun-Lan Fan, Ping Peng, Zhi-Bin Wang. Comprehensive Identification of Ginsenosides in the Roots and Rhizomes of Panax ginseng Based on Their Molecular Features-Oriented Precursor Ions Selection and Targeted MS/MS Analysis. Molecules (Basel, Switzerland). 2023 Jan; 28(3):. doi: 10.3390/molecules28030941. [PMID: 36770610]
  • Yuan Zhu, Jianxiu Li, Longyun Peng, Lijun Meng, Mengxue Diao, Shuiyuan Jiang, Jianbin Li, Nengzhong Xie. High-yield production of protopanaxadiol from sugarcane molasses by metabolically engineered Saccharomyces cerevisiae. Microbial cell factories. 2022 Nov; 21(1):230. doi: 10.1186/s12934-022-01949-4. [PMID: 36335407]
  • Chaiwat Monmai, Jin-Suk Kim, So-Hyeon Baek. Transgenic Rice Seed Extracts Exert Immunomodulatory Effects by Modulating Immune-Related Biomarkers in RAW264.7 Macrophage Cells. Nutrients. 2022 Oct; 14(19):. doi: 10.3390/nu14194143. [PMID: 36235795]
  • Ye-Wei Huang, Meng Zhang, Li-Tian Wang, Yan Nie, Jin-Bo Yang, Wen-Luer Meng, Xuan-Jun Wang, Jun Sheng. 20(S)-Protopanaxadiol decreases atherosclerosis in ApoE KO mice by increasing the levels of LDLR and inhibiting its binding with PCSK9. Food & function. 2022 Jul; 13(13):7020-7028. doi: 10.1039/d2fo00392a. [PMID: 35723202]
  • He Zhang, Yuyao Zhang, Xiaolei Tang, Wenjie Su, Chunhui Yang, Daian Pan, Daqing Zhao, Bin Qi, Xiangyan Li. Hemostatic Effect of 20(S)-Panaxadiol by Induced Platelet Aggregation Depending on Calcium Signaling Pathway. BioMed research international. 2022; 2022(?):8265898. doi: 10.1155/2022/8265898. [PMID: 36177062]
  • Su-Nyeong Jang, So-Young Park, Hyunyoung Lee, Hyojin Jeong, Ji-Hyeon Jeon, Im-Sook Song, Mi Jeong Kwon, Kwang-Hyeon Liu. In vitro modulatory effects of ginsenoside compound K, 20(S)-protopanaxadiol and 20(S)-protopanaxatriol on uridine 5'-diphospho-glucuronosyltransferase activity and expression. Xenobiotica; the fate of foreign compounds in biological systems. 2021 Oct; 51(10):1087-1094. doi: 10.1080/00498254.2021.1963503. [PMID: 34338601]
  • Se-A Kim, Eun-Bi Jeong, Deok-Kun Oh. Complete Bioconversion of Protopanaxadiol-Type Ginsenosides to Compound K by Extracellular Enzymes from the Isolated Strain Aspergillus tubingensis. Journal of agricultural and food chemistry. 2021 Jan; 69(1):315-324. doi: 10.1021/acs.jafc.0c07424. [PMID: 33372793]
  • Zhen-Zhen Lai, Hui-Li Yang, Jia-Wei Shi, Hui-Hui Shen, Yan Wang, Kai-Kai Chang, Tao Zhang, Jiang-Feng Ye, Jian-Song Sun, Xue-Min Qiu, Ming-Qing Li. Protopanaxadiol improves endometriosis associated infertility and miscarriage in sex hormones receptors-dependent and independent manners. International journal of biological sciences. 2021; 17(8):1878-1894. doi: 10.7150/ijbs.58657. [PMID: 34131393]
  • Eun-Bi Jeong, Se-A Kim, Kyung-Chul Shin, Deok-Kun Oh. Biotransformation of Protopanaxadiol-Type Ginsenosides in Korean Ginseng Extract into Food-Available Compound K by an Extracellular Enzyme from Aspergillus niger. Journal of microbiology and biotechnology. 2020 Oct; 30(10):1560-1567. doi: 10.4014/jmb.2007.07003. [PMID: 32807754]
  • Jingya Ruan, Fan Sun, Ying Zhang, Dandan Zheng, Guilin Xiang, Wei Zhao, Yi Zhang, Tao Wang. New 20(S)-protopanaxadiol type saponins from the leaves of Panax notoginseng and their potential anti-inflammatory activities. Steroids. 2020 10; 162(?):108696. doi: 10.1016/j.steroids.2020.108696. [PMID: 32649999]
  • Dan Zhang, Wei Li, Zhong-Jian Chen, Fu-Gang Wei, Yun-Long Liu, Li-Zhi Gao. SMRT- and Illumina-based RNA-seq analyses unveil the ginsinoside biosynthesis and transcriptomic complexity in Panax notoginseng. Scientific reports. 2020 09; 10(1):15310. doi: 10.1038/s41598-020-72291-1. [PMID: 32943706]
  • Yao Cheng, Ruimei Li, Zixuan Lin, Feiyan Chen, Jianguo Dai, Zhu Zhu, Lin Chen, Yunan Zhao. Structure-activity relationship analysis of dammarane-type natural products as muscle-type creatine kinase activators. Bioorganic & medicinal chemistry letters. 2020 09; 30(17):127364. doi: 10.1016/j.bmcl.2020.127364. [PMID: 32738969]
  • Di Sun, Shi-Yan Guo, Li Yang, Ya-Ru Wang, Xiao-Hui Wei, Sha Song, Yi-Wei Yang, Yong Gan, Zheng-Tao Wang. Silicone elastomer gel impregnated with 20(S)-protopanaxadiol-loaded nanostructured lipid carriers for ordered diabetic ulcer recovery. Acta pharmacologica Sinica. 2020 Jan; 41(1):119-128. doi: 10.1038/s41401-019-0288-7. [PMID: 31534201]
  • Ning Jiang, Jing-Wei Lv, Hai-Xia Wang, Qiong Wang, Cong Lu, Yu-Jie Yang, Hong Huang, Tian-Ji Xia, Guang-Hua Lv, Xin-Min Liu. Antidepressant-like effects of 20(S)-protopanaxadiol in a mouse model of chronic social defeat stress and the related mechanisms. Phytotherapy research : PTR. 2019 Oct; 33(10):2726-2736. doi: 10.1002/ptr.6446. [PMID: 31353678]
  • Jung Yeon Han, So-Hyeon Baek, Hye Jeong Jo, Do Won Yun, Yong Eui Choi. Genetically modified rice produces ginsenoside aglycone (protopanaxadiol). Planta. 2019 Oct; 250(4):1103-1110. doi: 10.1007/s00425-019-03204-4. [PMID: 31168665]
  • Hui Zhang, Hongbing Liu, Pan Qi, Silin Wang, Haibin Hu, Jingxin Gou, Yu Zhang, Haibing He, Xing Tang, Tian Yin, Yue Yuan. Enhanced the Bioavailability of Sterile 20(S)-Protopanaxadiol Nanocrystalline Suspension Coated by Bovine Serum Albumin for Intramuscular Injection: In Vitro and In Vivo Evaluation. AAPS PharmSciTech. 2019 Sep; 20(7):305. doi: 10.1208/s12249-019-1498-5. [PMID: 31506831]
  • Tiehua Zhang, Yuan Liang, Peng Zuo, Mi Yan, Siyuan Jing, Tiezhu Li, Yongjun Wang, Jie Zhang, Zhengyi Wei. Identification of 20(R, S)-protopanaxadiol and 20(R, S)-protopanaxatriol for potential selective modulation of glucocorticoid receptor. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2019 Sep; 131(?):110642. doi: 10.1016/j.fct.2019.110642. [PMID: 31247261]
  • Chang-Hao Cui, Byeong-Min Jeon, Yaoyao Fu, Wan-Taek Im, Sun-Chang Kim. High-density immobilization of a ginsenoside-transforming β-glucosidase for enhanced food-grade production of minor ginsenosides. Applied microbiology and biotechnology. 2019 Sep; 103(17):7003-7015. doi: 10.1007/s00253-019-09951-4. [PMID: 31289903]
  • Liying Zhang, Congcong Xu, Jingjing Mao, Weiwei Wang, Han Han, Yiqiong Pu, Tong Zhang. Formulation and Characterization of Novel Dry Suspension and Dry Emulsion of 20(S)-Protopanaxadiol. AAPS PharmSciTech. 2019 Aug; 20(7):275. doi: 10.1208/s12249-019-1487-8. [PMID: 31388863]
  • Chuhe Liu, Hongli Li, Zhenyu Zhou, Junxiao Li, Hui Chen, Yalei Liu, Cheng Huang, Shengjie Fan. Protopanaxadiol alleviates obesity in high-fat diet-fed mice via activation of energy-sensing neuron in the paraventricular nucleus of hypothalamus. Biochemical and biophysical research communications. 2019 06; 513(4):1092-1099. doi: 10.1016/j.bbrc.2019.04.031. [PMID: 31010683]
  • Zhihua Wang, Unchol Kim, Yanting Jiao, Chaowen Li, Yingying Guo, Xiaoyao Ma, Min Jiang, Zhihong Jiang, Yuanyuan Hou, Gang Bai. Quantitative Proteomics Combined with Affinity MS Revealed the Molecular Mechanism of Ginsenoside Antitumor Effects. Journal of proteome research. 2019 05; 18(5):2100-2108. doi: 10.1021/acs.jproteome.8b00972. [PMID: 30860844]
  • Jian Li, Lan Ma, Shuting Zhang, Cailian Zuo, Na Song, Shusheng Zhu, Jinsong Wu. Transcriptome analysis of 1- and 3-year-old Panax notoginseng roots and functional characterization of saponin biosynthetic genes DS and CYP716A47-like. Planta. 2019 Apr; 249(4):1229-1237. doi: 10.1007/s00425-018-03083-1. [PMID: 30607503]
  • Xue Wang, Hua-Ying Xia, Hong-You Qin, Xiang-Ping Kang, Hai-Yan Hu, Jing Zheng, Jia-Ye Jiang, Ling-Ai Yao, Yan-Wu Xu, Tong Zhang, Xue-Li Zhang. 20(S)-protopanaxadiol induces apoptosis in human umbilical vein endothelial cells by activating the PERK-eIF2alpha-ATF4 signaling pathway. Journal of cellular biochemistry. 2019 04; 120(4):5085-5096. doi: 10.1002/jcb.27785. [PMID: 30259568]
  • Mohamed Ben-Eltriki, Mohamed Hassona, Gray Meckling, Hans Adomat, Subrata Deb, Emma S Tomlinson Guns. Pharmacokinetic interaction of calcitriol with 20(S)-protopanaxadiol in mice: Determined by LC/MS analysis. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2019 Mar; 130(?):173-180. doi: 10.1016/j.ejps.2019.01.016. [PMID: 30654110]
  • Li Yang, Chun-Yang Wang, Xiao-Nv Xie, Yi-Cheng Wang, Jing-Bo Peng, Wei-Hua Huang, Yao Chen, Dong-Sheng Ouyang, Zhi-Rong Tan. LC-MS/MS determination of ginsenoside compound K and its metabolite 20 (S)-protopanaxadiol in human plasma and urine: applications in a clinical study. Bioanalysis. 2019 Mar; 11(5):365-380. doi: 10.4155/bio-2018-0185. [PMID: 30873858]
  • Hong Ri Jin, Charles H Du, Chong-Zhi Wang, Chun-Su Yuan, Wei Du. Ginseng metabolite protopanaxadiol interferes with lipid metabolism and induces endoplasmic reticulum stress and p53 activation to promote cancer cell death. Phytotherapy research : PTR. 2019 Mar; 33(3):610-617. doi: 10.1002/ptr.6249. [PMID: 30537241]
  • Jianqiang Zhang, Qian Zhang, Yangrong Xu, Huixiang Li, Fenglan Zhao, Chaoming Wang, Zhi Liu, Pan Liu, Yanan Liu, Qingguo Meng, Feng Zhao. Synthesis and In Vitro Anti-inflammatory Activity of C20 Epimeric Ocotillol-Type Triterpenes and Protopanaxadiol. Planta medica. 2019 Mar; 85(4):292-301. doi: 10.1055/a-0770-0994. [PMID: 30380571]
  • Min-Hwan Kim, Ki-Taek Kim, Seo-Yeon Sohn, Jae-Young Lee, Chang Hyung Lee, Hee Yang, Bo Kyung Lee, Ki Won Lee, Dae-Duk Kim. Formulation And Evaluation Of Nanostructured Lipid Carriers (NLCs) Of 20(S)-Protopanaxadiol (PPD) By Box-Behnken Design. International journal of nanomedicine. 2019; 14(?):8509-8520. doi: 10.2147/ijn.s215835. [PMID: 31749618]
  • Kyo Bin Kang, Murukarthick Jayakodi, Yun Sun Lee, Van Binh Nguyen, Hyun-Seung Park, Hyun Jo Koo, Ik Young Choi, Dae Hyun Kim, You Jin Chung, Byeol Ryu, Dong Young Lee, Sang Hyun Sung, Tae-Jin Yang. Identification of candidate UDP-glycosyltransferases involved in protopanaxadiol-type ginsenoside biosynthesis in Panax ginseng. Scientific reports. 2018 08; 8(1):11744. doi: 10.1038/s41598-018-30262-7. [PMID: 30082711]
  • Jin-Qi Li, Jia-Feng Wang, Jie Li, Shu-Han Zhang, Dan He, Rong-Sheng Tong, Shu-Ya She. Simultaneous determination of 20(S)-protopanaxadiol and its three metabolites in rat plasma by LC-MS/MS: application to their pharmacokinetic studies. Biomedical chromatography : BMC. 2018 Aug; 32(8):e4252. doi: 10.1002/bmc.4252. [PMID: 29607527]
  • Guangfei Wei, Fugang Wei, Can Yuan, Zhongjian Chen, Yong Wang, Jiang Xu, Yongqing Zhang, Linlin Dong, Shilin Chen. Integrated Chemical and Transcriptomic Analysis Reveals the Distribution of Protopanaxadiol- and Protopanaxatriol-Type Saponins in Panax notoginseng. Molecules (Basel, Switzerland). 2018 Jul; 23(7):. doi: 10.3390/molecules23071773. [PMID: 30029488]
  • Kyung-Chul Shin, Tae-Hun Kim, Ji-Hyeon Choi, Deok-Kun Oh. Complete Biotransformation of Protopanaxadiol-Type Ginsenosides to 20- O-β-Glucopyranosyl-20( S)-protopanaxadiol Using a Novel and Thermostable β-Glucosidase. Journal of agricultural and food chemistry. 2018 Mar; 66(11):2822-2829. doi: 10.1021/acs.jafc.7b06108. [PMID: 29468877]
  • Cong Lu, Jingwei Lv, Liming Dong, Ning Jiang, Yan Wang, Bei Fan, Fengzhong Wang, Xinmin Liu. The protective effect of 20(S)-protopanaxadiol (PPD) against chronic sleep deprivation (CSD)-induced memory impairments in mice. Brain research bulletin. 2018 03; 137(?):249-256. doi: 10.1016/j.brainresbull.2017.12.012. [PMID: 29287793]
  • Lin Dai, Weiyan Zhu, Chuanling Si, Jiandu Lei. 'Nano-Ginseng' for Enhanced Cytotoxicity AGAINST Cancer Cells. International journal of molecular sciences. 2018 Feb; 19(2):. doi: 10.3390/ijms19020627. [PMID: 29473838]
  • Xiu-Wei Yang, Li-Yuan Ma, Qi-Le Zhou, Wei Xu, You-Bo Zhang. SIRT1 activator isolated from artificial gastric juice incubate of total saponins in stems and leaves of Panax ginseng. Bioorganic & medicinal chemistry letters. 2018 02; 28(3):240-243. doi: 10.1016/j.bmcl.2017.12.067. [PMID: 29317167]
  • Cong Lu, Liming Dong, Jingwei Lv, Yan Wang, Bei Fan, Fengzhong Wang, Xinmin Liu. 20(S)-protopanaxadiol (PPD) alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of Egr-1, c-Fos and c-Jun in mice. Chemico-biological interactions. 2018 Jan; 279(?):64-72. doi: 10.1016/j.cbi.2017.11.008. [PMID: 29133030]
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