Nimodipine (BioDeep_00000002103)
Secondary id: BioDeep_00000398962
human metabolite blood metabolite
代谢物信息卡片
2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester
化学式: C21H26N2O7 (418.174)
中文名称: 尼莫地平
谱图信息:
最多检出来源 Homo sapiens(blood) 34.12%
分子结构信息
SMILES: CC(C)OC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCOC)C
InChI: InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
描述信息
Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Compared to other calcium channel blocking agents, nimodipine exhibits greater effects on cerebral circulation than on peripheral circulation. Nimodipine is used to as an adjunct to improve the neurologic outcome following subarachnoid hemorrhage from ruptured intracranial aneurysm.
C - Cardiovascular system > C08 - Calcium channel blockers > C08C - Selective calcium channel blockers with mainly vascular effects > C08CA - Dihydropyridine derivatives
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
同义名列表
44 个代谢物同义名
2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester; 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-b-methoxyethyl ester 5-isopropyl ester; 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-methoxyethyl ester 5-isopropyl ester; 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 3-beta-methoxyethyl ester 5-isopropyl ester; 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 3-β-methoxyethyl ester 5-isopropyl ester; 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 3-b-methoxyethyl ester 5-isopropyl ester; 3-(2-methoxyethyl) 5-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid; Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylic acid; Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate; Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate; Andromaco brand OF nimodipine; Cantabria brand OF nimodipine; Alpharma brand OF nimodipine; Almirall brand OF nimodipine; Bayvit brand OF nimodipine; Esteve brand OF nimodipine; Hexal brand OF nimodipine; Bayer brand OF nimodipine; Elan brand OF nimodipine; Vita brand OF nimodipine; Bayvit, nimodipino; Nimodipino bayvit; Hexal, nimodipin; Nimodipin hexal; Nimodipin isis; Nimodipin-isis; NimodipinISIS; 9736, Bay e; Nimodipinum; e 9736, Bay; Nimodipino; BAY e 9736; nimodipine; Remontal; Nymalize; Periplum; Kenesil; Brainal; Nimotop; Calnit; Admon; Modus; Nimodipine
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:7575
- KEGG: C07267
- KEGGdrug: D00438
- PubChem: 4497
- HMDB: HMDB0014537
- Metlin: METLIN1541
- DrugBank: DB00393
- ChEMBL: CHEMBL3197349
- Wikipedia: Nimodipine
- MeSH: Nimodipine
- chemspider: 4341
- CAS: 66085-59-4
- PMhub: MS000001839
- PubChem: 9476
- NIKKAJI: J19.052G
- RefMet: Nimodipine
- KNApSAcK: 7575
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- J-F Zhang, N Ma, W-S Zhang, G-J Cheng, L Lv, L Zhang, R-M Li. Current management of subarachnoid hemorrhage in a northern urban Chinese population: a multi-center surveillance study.
European review for medical and pharmacological sciences.
2023 Feb; 27(3):1007-1015. doi:
10.26355/eurrev_202302_31195. [PMID: 36808346] - Hai-Dong Chen, Ming-Zhao Jiang, Ying-Ying Zhao, Xin Li, Hai Lan, Wan-Qi Yang, Yong Lai. Effects of breviscapine on cerebral ischemia-reperfusion injury and intestinal flora imbalance by regulating the TLR4/MyD88/NF-κB signaling pathway in rats.
Journal of ethnopharmacology.
2023 Jan; 300(?):115691. doi:
10.1016/j.jep.2022.115691. [PMID: 36087844] - Jirakhamon Sengking, Chio Oka, Nuttapong Yawoot, Jiraporn Tocharus, Waraluck Chaichompoo, Apichart Suksamrarn, Chainarong Tocharus. Protective Effect of Neferine in Permanent Cerebral Ischemic Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms.
Neurotoxicity research.
2022 Oct; 40(5):1348-1359. doi:
10.1007/s12640-022-00568-6. [PMID: 36018507] - Qiang Yang, Jia Liu, Kai-Lin Huang, Guang-Yao Wang, Mi-Yuan Wang, Ai-Hua Tan, Si-Miao Ran. A systematic review of the efficacy of donepezil hydrochloride combined with nimodipine on treating vascular dementia.
Medicine.
2022 Aug; 101(31):e29307. doi:
10.1097/md.0000000000029307. [PMID: 35945739] - Xianxin Meng, Guanjun Nan, Yunzhe Li, Yan Du, Hongwen Zhao, Hongxia Zheng, Wanlu Li, Henglin Liu, Yiping Li, Guangde Yang. Study on the interaction between nimodipine and five proteinases and the effects of naringin and vitamin C on these interactions by spectroscopic and molecular docking methods.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2022 May; 272(?):120982. doi:
10.1016/j.saa.2022.120982. [PMID: 35139470] - Zhi-Jia Liu, Cun-Ping Wang, Bin Yang, Nan Wang, Qin Wang, Jian Gu, Rui Tan. [Protective effect and mechanism of Ershiwuwei Zhenzhu Pills on cerebral apoplexy rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Apr; 47(8):2064-2073. doi:
10.19540/j.cnki.cjcmm.20211216.705. [PMID: 35531722] - Xiaojun Zhao, Jingjing Liu, Lingling Yang, Yang Niu, Ruru Ren, Chao Su, Yingli Wang, Jianyu Chen, Xueqin Ma. Beneficial effects of mijianchangpu decoction on ischemic stroke through components accessing to the brain based on network pharmacology.
Journal of ethnopharmacology.
2022 Mar; 285(?):114882. doi:
10.1016/j.jep.2021.114882. [PMID: 34848358] - Xin-Yu Zhang, Song-Song Jing, Ou Qiao, Xiao-Ying Han, Wen-Zhe Wang, Hai-Xia Ji, Yi Zhang, Xia Li, Juan Wang, Shu-Li Man, Chang-Xiao Liu, Wen-Yuan Gao. Cerebralcare Granule® combined with nimodipine improves cognitive impairment in bilateral carotid artery occlusion rats by reducing lipocalin-2.
Life sciences.
2021 Dec; 286(?):120048. doi:
10.1016/j.lfs.2021.120048. [PMID: 34655604] - D Viderman, A Sarria-Santamera, F Bilotta. Side effects of continuous intra-arterial infusion of nimodipine for management of resistant cerebral vasospasm in subarachnoid hemorrhage patients: A systematic review.
Neuro-Chirurgie.
2021 Sep; 67(5):461-469. doi:
10.1016/j.neuchi.2021.02.005. [PMID: 33652066] - Tarab Mansoor, Ali A Alsarah, Hossein Mousavi, Javed Khader Eliyas, Tarun Girotra, Omar Hussein. COVID-19 Associated Reversible Cerebral Vasoconstriction Syndrome Successfully Treated with Nimodipine and Aspirin.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.
2021 Jul; 30(7):105822. doi:
10.1016/j.jstrokecerebrovasdis.2021.105822. [PMID: 33895426] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Wenwen Zhang, Jianxia Wen, Yinxiao Jiang, Qichao Hu, Jian Wang, Shizhang Wei, Haotian Li, Xiao Ma. l-Borneol ameliorates cerebral ischaemia by downregulating the mitochondrial calcium uniporter-induced apoptosis cascade in pMCAO rats.
The Journal of pharmacy and pharmacology.
2021 Mar; 73(2):272-280. doi:
10.1093/jpp/rgaa028. [PMID: 33793797] - Yuanyuan Wang, Hao Ma, Jiaxuan Huang, Zhengguang Yao, Jianqiang Yu, Wannian Zhang, Lichao Zhang, Zhibin Wang, Chunlin Zhuang. Discovery of bardoxolone derivatives as novel orally active necroptosis inhibitors.
European journal of medicinal chemistry.
2021 Feb; 212(?):113030. doi:
10.1016/j.ejmech.2020.113030. [PMID: 33248849] - Fadumo Ahmed Isse, Tyson Le, Sherif Hanafy Mahmoud. Enantioselective assay of nimodipine in human plasma using liquid chromatography-tandem mass spectrometry.
Biomedical chromatography : BMC.
2021 Feb; 35(2):e4971. doi:
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BMJ case reports.
2021 Jan; 14(1):. doi:
10.1136/bcr-2019-233877. [PMID: 33509852] - Marco Zattoni, Chiara Garrovo, Elena Xerxa, Giada Spigolon, Gilberto Fisone, Krister Kristensson, Giuseppe Legname. NMDA Receptor and L-Type Calcium Channel Modulate Prion Formation.
Cellular and molecular neurobiology.
2021 Jan; 41(1):191-198. doi:
10.1007/s10571-020-00834-1. [PMID: 32239389] - L-N Pei, X-H Liu, H Zhang, J Zhu, Z Gao, M-Z Bi. Clinical efficacy of mouse nerve growth factor plus nimodipine in neonatal intracranial hemorrhage and its effect on plasma PAF, CNP, MMP-2, and neurological function.
European review for medical and pharmacological sciences.
2021 01; 25(1):215-221. doi:
10.26355/eurrev_202101_24387. [PMID: 33506910] - Kagan Kamasak, Kagan Basarslan, Ahmet Turan Dagli, Mustafa Ogden, Ulas Alabalik, Adnan Ekinci, Adnan Ceviz. Effects of Nimodipine and Nigella sativa on Oxidative Stress and Apoptosis in Serum and Brain Tissue of Rats with Experimental Head Trauma.
Turkish neurosurgery.
2021; 31(1):8-17. doi:
10.5137/1019-5149.jtn.25523-19.3. [PMID: 31124573] - R Loch Macdonald, Daniel Hänggi, Nerissa U Ko, Tim E Darsaut, Andrew P Carlson, George K Wong, Nima Etminan, Stephan A Mayer, E Francois Aldrich, Michael N Diringer, David Ng, Poul Strange, Thomas Bleck, Robert Grubb, Jose I Suarez. NEWTON-2 Cisternal (Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage): A Phase 2, Multicenter, Randomized, Open-Label Safety Study of Intracisternal EG-1962 in Aneurysmal Subarachnoid Hemorrhage.
Neurosurgery.
2020 12; 88(1):E13-E26. doi:
10.1093/neuros/nyaa430. [PMID: 32985652] - Xingwang Chen, Zhijun Yao, Xian Peng, Long Wu, Huachu Wu, Yuantong Ou, Jianbo Lai. Eupafolin alleviates cerebral ischemia/reperfusion injury in rats via blocking the TLR4/NF‑κB signaling pathway.
Molecular medicine reports.
2020 Dec; 22(6):5135-5144. doi:
10.3892/mmr.2020.11637. [PMID: 33173992] - Weiping Wang, Pengyan Li, Mengna Fang, Xiaoting Li, Yu Zhang, Tianhong Zhang. SFC-MS/MS method for simultaneous determination of nimodipine and 3-n-butylphthalide in beagle plasma: application to pharmacokinetic interaction study.
Bioanalysis.
2020 Nov; 12(21):1509-1519. doi:
10.4155/bio-2020-0229. [PMID: 33078962] - Karim Mohsen, Hassan M E Azzazy, Nageh K Allam, Emad B Basalious. Intranasal lipid nanocapsules for systemic delivery of nimodipine into the brain: In vitro optimization and in vivo pharmacokinetic study.
Materials science & engineering. C, Materials for biological applications.
2020 Nov; 116(?):111236. doi:
10.1016/j.msec.2020.111236. [PMID: 32806316] - Chunyan Fu, Qian Wu, Zhimin Zhang, Zian Xia, Zhaoying Liu, Hongmei Lu, Yang Wang, Gang Huang. Development of a sensitive and rapid UHPLC-MS/MS method for simultaneous quantification of nine compounds in rat plasma and application in a comparative pharmacokinetic study after oral administration of Xuefu Zhuyu Decoction and nimodipine.
Biomedical chromatography : BMC.
2020 Sep; 34(9):e4872. doi:
10.1002/bmc.4872. [PMID: 32358897] - Fang Li, Qingsong Fei, Dan Mao, Qiaoyun Si, Manman Dai, Qun Ma, Huimin Zhang, Luyu Bai, Ning He. Comparative Pharmacokinetics of Nimodipine in Rat Plasma and Tissues Following Intraocular, Intragastric, and Intravenous Administration.
AAPS PharmSciTech.
2020 Aug; 21(6):234. doi:
10.1208/s12249-020-01772-3. [PMID: 32794077] - Weilin Wu, Chenfeng Qiu, Xuewen Feng, Xiaoxiao Tao, Qian Zhu, Zhengjun Chen, Xiaomin Ma, Jinwei Yang, Xianjun Bao. Protective Effect of Paeoniflorin on Acute Cerebral Infarction in Rats.
Current pharmaceutical biotechnology.
2020; 21(8):702-709. doi:
10.2174/1389201021666191224151634. [PMID: 31884927] - Jelena Ristic, Marko Folic, Katarina Radonjic, Milenko I Rosic, Sergey Bolevich, Omarov Israpil Alisultanovich, Nevena Draginic, Marijana Andjic, Jovana Jeremic, Isidora Milosavljevic, Vladimir Zivkovic, Vladimir Jakovljevic. Preconditioning with PDE1 Inhibitors and Moderate-Intensity Training Positively Affect Systemic Redox State of Rats.
Oxidative medicine and cellular longevity.
2020; 2020(?):6361703. doi:
10.1155/2020/6361703. [PMID: 32104536] - Saixu Huang, Zhiyong Huang, Zhiqin Fu, Yamin Shi, Qi Dai, Shuyan Tang, Yongwei Gu, Youfa Xu, Jianming Chen, Xin Wu, Fuzheng Ren. A Novel Drug Delivery Carrier Comprised of Nimodipine Drug Solution and a Nanoemulsion: Preparation, Characterization, in vitro, and in vivo Studies.
International journal of nanomedicine.
2020; 15(?):1161-1172. doi:
10.2147/ijn.s226591. [PMID: 32110014] - Xuanwei Liu, Na'na Zhao, Kexue Zeng, Peng Xiao, Pengjie Sheng, Xun Luo, Yulong Wang. Effects of nimodipine combined with betahistine on CRP and other inflammatory cytokines and vascular endothelial function in patients with hypertensive cerebral vasospasm.
Clinical hemorheology and microcirculation.
2020; 75(3):279-289. doi:
10.3233/ch-190589. [PMID: 32280080] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Roberto Riva, Marianna Pegoli, Manuela Contin, Alessandro Perrone, Susan Mohamed, Marco Zanello. Cerebrospinal Fluid Concentrations of Nimodipine Correlate With Long-term Outcome in Aneurysmal Subarachnoid Hemorrhage: Pilot Study.
Clinical neuropharmacology.
2019 Sep; 42(5):157-162. doi:
10.1097/wnf.0000000000000356. [PMID: 31306217] - Fangcheng Luo, Liangmiao Wu, Zhixiang Zhang, Zeyu Zhu, Zheng Liu, Baojian Guo, Ning Li, Jun Ju, Qiang Zhou, Shupeng Li, Xifei Yang, Shinghung Mak, Yifan Han, Yewei Sun, Yuqiang Wang, Gaoxiao Zhang, Zaijun Zhang. The dual-functional memantine nitrate MN-08 alleviates cerebral vasospasm and brain injury in experimental subarachnoid haemorrhage models.
British journal of pharmacology.
2019 09; 176(17):3318-3335. doi:
10.1111/bph.14763. [PMID: 31180578] - Martin Kieninger, Michael Gruber, Isabella Knott, Katja Dettmer, Peter J Oefner, Sylvia Bele, Christina Wendl, Simon Tuemmler, Bernhard Graf, Christoph Eissnert. Incidence of Arterial Hypotension in Patients Receiving Peroral or Continuous Intra-arterial Nimodipine After Aneurysmal or Perimesencephalic Subarachnoid Hemorrhage.
Neurocritical care.
2019 08; 31(1):32-39. doi:
10.1007/s12028-019-00676-w. [PMID: 30725331] - Weiping Wang, Pengyan Li, Fengying Wu, Zhen Wang, Tianhong Zhang. Development and optimization of a supercritical fluid chromatography tandem mass spectrometry method for the high-throughput determination of nimodipine in beagle plasma.
Journal of separation science.
2019 Jun; 42(12):2179-2186. doi:
10.1002/jssc.201900134. [PMID: 30993887] - Fang Li, Dan Mao, Man Man Dai, Hui Min Zhang, Qun Ma, Lu Yu Bai, Ning He. [Pharmacokinetics of Nimodipine after Intraocular Administration in Rats].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.
2019 Feb; 41(1):57-62. doi:
10.3881/j.issn.1000-503x.10536. [PMID: 30837043] - Weizhuo Lu, Ling Xv, Jiyue Wen. Protective effect of extract of the Camellia japonica L. on cerebral ischemia-reperfusion injury in rats.
Arquivos de neuro-psiquiatria.
2019 01; 77(1):39-46. doi:
10.1590/0004-282x20180146. [PMID: 30758441] - Zaijin Teng, Miao Yu, Yang Ding, Huaqing Zhang, Yan Shen, Menglao Jiang, Peixin Liu, Yaw Opoku-Damoah, Thomas J Webster, Jianping Zhou. Preparation and characterization of nimodipine-loaded nanostructured lipid systems for enhanced solubility and bioavailability.
International journal of nanomedicine.
2019; 14(?):119-133. doi:
10.2147/ijn.s186899. [PMID: 30613141] - Alaadin Alayoubi, Mohammad Sabir Aqueel, Celia N Cruz, Muhammad Ashraf, Ahmed S Zidan. Application of in vitro lipolysis for the development of oral self-emulsified delivery system of nimodipine.
International journal of pharmaceutics.
2018 Dec; 553(1-2):441-453. doi:
10.1016/j.ijpharm.2018.10.066. [PMID: 30385374] - Wei Liu, Ruya Wang, Fan Hu, Pinping Wu, Tao Huang, Meriem Fizir, Hua He. Novel mixed hemimicelles based on nonionic surfactant-imidazolium ionic liquid and magnetic halloysite nanotubes as efficient approach for analytical determination.
Analytical and bioanalytical chemistry.
2018 Nov; 410(28):7357-7371. doi:
10.1007/s00216-018-1348-4. [PMID: 30294762] - Chaoyue Zhao, Jiulong Zhang, Haiyang Hu, Mingxi Qiao, Dawei Chen, Xiuli Zhao, Chunrong Yang. Design of lactoferrin modified lipid nano-carriers for efficient brain-targeted delivery of nimodipine.
Materials science & engineering. C, Materials for biological applications.
2018 Nov; 92(?):1031-1040. doi:
10.1016/j.msec.2018.02.004. [PMID: 30184727] - Qin-Mei Zhou, Ming-Hua Chen, Xiao-Hong Li, Cheng Peng, Da-Sheng Lin, Xiao-Nian Li, Yang He, Liang Xiong. Absolute Configurations and Bioactivities of Guaiane-Type Sesquiterpenoids Isolated from Pogostemon cablin.
Journal of natural products.
2018 09; 81(9):1919-1927. doi:
10.1021/acs.jnatprod.7b00690. [PMID: 30188125] - Fiqry Fadhlillah, Shashank Patil. Pharmacological and mechanical management of calcium channel blocker toxicity.
BMJ case reports.
2018 Aug; 2018(?):. doi:
10.1136/bcr-2018-225324. [PMID: 30150339] - Yan Chen, Zhenli Guo, Xingming Peng, Wenting Xie, Lizhu Chen, Zihu Tan. Nimodipine represses AMPK phosphorylation and excessive autophagy after chronic cerebral hypoperfusion in rats.
Brain research bulletin.
2018 06; 140(?):88-96. doi:
10.1016/j.brainresbull.2018.03.019. [PMID: 29625150] - Heran Li, Haiting Li, Chen Wei, Jia Ke, Jing Li, Lu Xu, Hongzhuo Liu, YangYang, Sanming Li, Mingshi Yang. Biomimetic synthesis and evaluation of histidine-derivative templated chiral mesoporous silica for improved oral delivery of the poorly water-soluble drug, nimodipine.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2018 May; 117(?):321-330. doi:
10.1016/j.ejps.2018.03.013. [PMID: 29530545] - Feixue Li, Huihui Ma, Jing Liu. Pyrethroid Insecticide Cypermethrin Modulates Gonadotropin Synthesis via Calcium Homeostasis and ERK1/2 Signaling in LβT2 Mouse Pituitary Cells.
Toxicological sciences : an official journal of the Society of Toxicology.
2018 03; 162(1):43-52. doi:
10.1093/toxsci/kfx248. [PMID: 29149324] - Martin Kieninger, Julia Flessa, Nicole Lindenberg, Sylvia Bele, Andreas Redel, André Schneiker, Gerhard Schuierer, Christina Wendl, Bernhard Graf, Vera Silbereisen. Side Effects of Long-Term Continuous Intra-arterial Nimodipine Infusion in Patients with Severe Refractory Cerebral Vasospasm after Subarachnoid Hemorrhage.
Neurocritical care.
2018 02; 28(1):65-76. doi:
10.1007/s12028-017-0428-1. [PMID: 28685393] - Zihu Tan, Yan Chen, Wenting Xie, Xi Liu, Yuanyue Zhu, Yan Zhu. Nimodipine attenuates tau phosphorylation at Ser396 via miR-132/GSK-3β pathway in chronic cerebral hypoperfusion rats.
European journal of pharmacology.
2018 Jan; 819(?):1-8. doi:
10.1016/j.ejphar.2017.10.027. [PMID: 29042207] - Yu-Xing Fei, Tian-Hong Zhang, Jing Zhao, He Ren, Ya-Nan Du, Chun-Ling Yu, Qiang Wang, Shu Li, Ting-Lin Ren, Qiang Jian, Shu-Yang Fei, Zhen-Qing Zhang, Yi Zhang. In vitro and in vivo evaluation of hypothermia on pharmacokinetics and pharmacodynamics of nimodipine in rabbits.
The Journal of international medical research.
2018 Jan; 46(1):335-347. doi:
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The Cochrane database of systematic reviews.
2017 12; 12(?):CD012057. doi:
10.1002/14651858.cd012057.pub2. [PMID: 29197180] - C E Terrillion, D T Dao, R Cachope, M K Lobo, A C Puche, J F Cheer, T D Gould. Reduced levels of Cacna1c attenuate mesolimbic dopamine system function.
Genes, brain, and behavior.
2017 06; 16(5):495-505. doi:
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World neurosurgery.
2017 Jun; 102(?):459-465. doi:
10.1016/j.wneu.2017.03.062. [PMID: 28344178] - Jun Chen, Michael J Sanderson. Store-operated calcium entry is required for sustained contraction and Ca2+ oscillations of airway smooth muscle.
The Journal of physiology.
2017 05; 595(10):3203-3218. doi:
10.1113/jp272694. [PMID: 27396568] - Fan Yang, De Chen, Zhe-Fei Guo, Yong-Ming Zhang, Yi Liu, Sean Askin, Duncan Q M Craig, Min Zhao. The application of novel nano-thermal and imaging techniques for monitoring drug microstructure and distribution within PLGA microspheres.
International journal of pharmaceutics.
2017 Apr; 522(1-2):34-49. doi:
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Journal of ethnopharmacology.
2017 Apr; 202(?):138-146. doi:
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African journal of traditional, complementary, and alternative medicines : AJTCAM.
2017; 14(2):241-252. doi:
10.21010/ajtcam.v14i2.26. [PMID: 28573241] - Wen-Jie He, Qian Hong, Jing Liang, Xiao-Wei He, Feng-Jia Zhu. [Pharmacokinetics and brain distribution of NMD/TMP-nanoparticles].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2016 Nov; 41(22):4254-4258. doi:
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BMC complementary and alternative medicine.
2016 Sep; 16(?):361. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Aug; 1028(?):94-99. doi:
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Neuroscience letters.
2016 08; 628(?):105-9. doi:
10.1016/j.neulet.2016.03.054. [PMID: 27038516] - Jie Xiao, Tianyang Wang, Pei Li, Ran Liu, Qing Li, Kaishun Bi. Development of two step liquid-liquid extraction tandem UHPLC-MS/MS method for the simultaneous determination of Ginkgo flavonoids, terpene lactones and nimodipine in rat plasma: Application to the pharmacokinetic study of the combination of Ginkgo biloba dispersible tablets and Nimodipine tablets.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Aug; 1028(?):33-41. doi:
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Toxicology and applied pharmacology.
2016 06; 301(?):50-60. doi:
10.1016/j.taap.2016.04.008. [PMID: 27095094] - Janne Koskimäki, Miikka Tarkia, Tuula Ahtola-Sätilä, Lasse Saloranta, Aki Laakso, Janek Frantzén. Absorption, elimination and cerebrospinal fluid concentrations of nimodipine in healthy beagle dogs receiving human intravenous and oral formulation.
European journal of drug metabolism and pharmacokinetics.
2016 Jun; 41(3):295-300. doi:
10.1007/s13318-015-0258-5. [PMID: 25652785] - Daniel Hänggi, Nima Etminan, Hans Jakob Steiger, Mark Johnson, M Melissa Peet, Tom Tice, Kevin Burton, Bruce Hudson, Michele Turner, Angela Stella, Parissa Heshmati, Cara Davis, Herbert J Faleck, R Loch Macdonald. A Site-Specific, Sustained-Release Drug Delivery System for Aneurysmal Subarachnoid Hemorrhage.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.
2016 Apr; 13(2):439-49. doi:
10.1007/s13311-016-0424-8. [PMID: 26935204] - Jing-Wen Luo, Zhi-Rong Zhang, Tao Gong, Yao Fu. One-step self-assembled nanomicelles for improving the oral bioavailability of nimodipine.
International journal of nanomedicine.
2016; 11(?):1051-65. doi:
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Neurocritical care.
2015 Oct; 23(2):274-84. doi:
10.1007/s12028-015-0112-2. [PMID: 25678453] - Emad B Basalious, Rehab N Shamma. Novel self-assembled nano-tubular mixed micelles of Pluronics P123, Pluronic F127 and phosphatidylcholine for oral delivery of nimodipine: In vitro characterization, ex vivo transport and in vivo pharmacokinetic studies.
International journal of pharmaceutics.
2015 Sep; 493(1-2):347-56. doi:
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Pharmaceutical research.
2015 Jul; 32(7):2372-83. doi:
10.1007/s11095-015-1630-5. [PMID: 25609013] - Tammam Abboud, Hilke Andresen, Johannes Koeppen, Patrick Czorlich, Lasse Duehrsen, Justus Stenzig, Manfred Westphal, Jan Regelsberger. Serum levels of nimodipine in enteral and parenteral administration in patients with aneurysmal subarachnoid hemorrhage.
Acta neurochirurgica.
2015 May; 157(5):763-7. doi:
10.1007/s00701-015-2369-9. [PMID: 25701099] - Kirti Singhal, Rajat Sandhir. L-type calcium channel blocker ameliorates diabetic encephalopathy by modulating dysregulated calcium homeostasis.
Journal of neuroscience research.
2015 Feb; 93(2):296-308. doi:
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Neuroscience letters.
2015 Jan; 585(?):38-42. doi:
10.1016/j.neulet.2014.11.025. [PMID: 25445375] - Janne Koskimäki, Miikka Tarkia, Tuula Ahtola-Sätilä, Lasse Saloranta, Outi Simola, Ari-Pekka Forsback, Aki Laakso, Janek Frantzén. Intracranial biodegradable silica-based nimodipine drug release implant for treating vasospasm in subarachnoid hemorrhage in an experimental healthy pig and dog model.
BioMed research international.
2015; 2015(?):715752. doi:
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2015; 149(?):934-40. doi:
10.1016/j.saa.2015.05.026. [PMID: 26005990] - P Ortega, M R Custódio, F P Zanotto. Characterization of cadmium plasma membrane transport in gills of a mangrove crab Ucides cordatus.
Aquatic toxicology (Amsterdam, Netherlands).
2014 Dec; 157(?):21-9. doi:
10.1016/j.aquatox.2014.09.006. [PMID: 25456216] - Wei Xiao, Xian-bao Zhang, Hui-xing Hu, Zhen Wang, Xiao-li Guo. [Acupuncture and drug for subcortical ischemic vascular disease complicated with depression: a randomized controlled trial].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2014 Nov; 34(11):1051-6. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2014 Oct; 63(?):187-98. doi:
10.1016/j.ejps.2014.07.007. [PMID: 25063034] - Chia-Wen Hsu, Jinghua Zhao, Ruili Huang, Jui-Hua Hsieh, Jon Hamm, Xiaoqing Chang, Keith Houck, Menghang Xia. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor.
Scientific reports.
2014 Sep; 4(?):6437. doi:
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Journal of neurological surgery. Part A, Central European neurosurgery.
2014 Jul; 75(4):251-8. doi:
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Pharmacology, biochemistry, and behavior.
2014 Jul; 122(?):61-73. doi:
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International journal of pharmaceutics.
2014 Apr; 464(1-2):1-9. doi:
10.1016/j.ijpharm.2014.01.020. [PMID: 24456674] - Chun Wu, Qiongfeng Liao, Meicun Yao, Xinjun Xu, Yuting Zhou, Xueying Hou, Zhiyong Xie. Effect of natural borneol on the pharmacokinetics and distribution of nimodipine in mice.
European journal of drug metabolism and pharmacokinetics.
2014 Mar; 39(1):17-24. doi:
10.1007/s13318-013-0135-z. [PMID: 23673491] - Christian Scheller, Andreas Wienke, Franziska Wurm, Anne-Sophie Vogel, Sebastian Simmermacher, Julian Prell, Jens Rachinger, Gershom Koman, Christian Strauss, Konstanze Scheller. Enteral or parenteral nimodipine treatment: a comparative pharmacokinetic study.
Journal of neurological surgery. Part A, Central European neurosurgery.
2014 Mar; 75(2):84-90. doi:
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Eksperimental'naia i klinicheskaia farmakologiia.
2014; 77(3):3-8. doi:
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Journal of ethnopharmacology.
2014; 151(1):228-36. doi:
10.1016/j.jep.2013.10.015. [PMID: 24161430] - Hui Li, Xue Yang, Wei Shi, Zhao Ma, Guangshen Feng, Qinzhou Wang, Li Shen, Chunli Xie. Protective effects of nimodipine on cerebrovascular function in chronic alcoholic encephalopathy.
International journal of molecular medicine.
2014 Jan; 33(1):201-8. doi:
10.3892/ijmm.2013.1540. [PMID: 24173596] - Andreas Krämer, Torben Mentrup, Bertrand Kleizen, Eric Rivera-Milla, Daniela Reichenbach, Christoph Enzensperger, Richard Nohl, Eric Täuscher, Helmar Görls, Aspasia Ploubidou, Christoph Englert, Oliver Werz, Hans-Dieter Arndt, Christoph Kaether. Small molecules intercept Notch signaling and the early secretory pathway.
Nature chemical biology.
2013 Nov; 9(11):731-8. doi:
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Brain research bulletin.
2013 Oct; 99(?):13-8. doi:
10.1016/j.brainresbull.2013.09.002. [PMID: 24070657] - Jianping Zhang, Hua Cao, Ying Zhang, Yuanyuan Zhang, Juanjuan Ma, Jiangyan Wang, Yonggang Gao, Xuan Zhang, Fenghua Zhang, Li Chu. Nephroprotective effect of calcium channel blockers against toxicity of lead exposure in mice.
Toxicology letters.
2013 Apr; 218(3):273-80. doi:
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Biomedical chromatography : BMC.
2013 Apr; 27(4):515-9. doi:
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Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society.
2013 Mar; 13(1):29-34. doi:
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AAPS PharmSciTech.
2013 Mar; 14(1):332-8. doi:
10.1208/s12249-013-9924-6. [PMID: 23319300] - Dan Nayot, Shany Klachook, Robert F Casper. Nimodipine, a calcium channel blocker, delays the spontaneous LH surge in women with regular menstrual cycles: a prospective pilot study.
Reproductive biology and endocrinology : RB&E.
2013 Feb; 11(?):7. doi:
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Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2012 Dec; 32(12):1667-70. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
2012 Oct; 129(2):346-62. doi:
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American journal of physiology. Renal physiology.
2012 Sep; 303(6):F790-9. doi:
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Indian journal of pharmacology.
2012 Sep; 44(5):624-8. doi:
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Colloids and surfaces. B, Biointerfaces.
2012 Sep; 97(?):109-16. doi:
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Journal of neurosurgical sciences.
2012 Sep; 56(3):247-53. doi:
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Molecular medicine reports.
2012 08; 6(2):371-4. doi:
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Journal of ethnopharmacology.
2012 Jul; 142(2):488-95. doi:
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Journal of neurological surgery. Part A, Central European neurosurgery.
2012 May; 73(3):153-9. doi:
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