Niflumic Acid (BioDeep_00000002102)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


2-[[3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid

化学式: C13H9F3N2O2 (282.0616)
中文名称: 尼氟酸
谱图信息: 最多检出来源 Homo sapiens(blood) 27.03%

分子结构信息

SMILES: C1=CC(=CC(=C1)NC2=C(C=CC=N2)C(=O)O)C(F)(F)F
InChI: InChI=1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20)

描述信息

Niflumic Acid is only found in individuals that have used or taken this drug. It is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis. [PubChem]Niflumic acid is able to inhibit both phospholipase A2 as well as COX-2, thereby acting as an antiinflamatory and pain reduction agent.
M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3691
CONFIDENCE standard compound; INTERNAL_ID 1154
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors

同义名列表

25 个代谢物同义名

2-[[3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid; 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylic acid; 2-[(3-Trifluoromethyl)phenyl]amino-3-pyridine-carboxylic acid; 2-(alpha,alpha,alpha-Trifluoro-m-toluidino)nicotinic acid; 2-(3-(Trifluoromethyl)-phenyl)aminonicotinic acid; 2-(3-Trifluoromethyl-phenylamino)-nicotinic acid; 2-(3-(Trifluoromethyl)anilino)nicotinic acid; 2-[3-(Trifluoromethyl)anilino]nicotinic acid; UPSA conseil brand OF niflumic acid; Upsamedica brand OF niflumic acid; UPSA brand 2 OF niflumic acid; UPSA brand 1 OF niflumic acid; Nifluminic acid; Acid, niflumic; niflumic acid; Lopac-N-0630; Niflactol; Niflumate; Nifluril; Donalgin; Niflugel; Flunir; NFA; NFL; Niflumic acid



数据库引用编号

39 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ALB, CASP3, IL13, NPPB, PTGS1, PTGS2, S100A9, TNK1
Peripheral membrane protein 5 CLCA1, PTGS1, PTGS2, S100A9, TNK1
Endosome membrane 2 CLCN3, CLCN5
Endoplasmic reticulum membrane 4 PTGS1, PTGS2, UGT1A1, UGT1A9
Nucleus 3 ALB, CASP3, S100A9
cytosol 6 ALB, CASP3, CLC, CLCN5, PRKCQ, S100A9
phagocytic vesicle 1 CLCN3
centrosome 1 ALB
nucleoplasm 2 ANO1, CASP3
Cell membrane 6 ANO1, CLCA1, CLCN3, CLCN5, GLRA2, S100A9
ruffle membrane 1 CLCN3
Cytoplasmic granule 1 CLC
Early endosome membrane 1 CLCN3
Multi-pass membrane protein 6 ANO1, CACNA1I, CLCN3, CLCN5, CLCNKA, GLRA2
Golgi apparatus membrane 1 CLCN5
Synapse 1 GLRA2
cell surface 1 CLCN3
glutamatergic synapse 2 CASP3, CLCN3
Golgi apparatus 4 ALB, CLCN3, CLCN5, PTGS1
Golgi membrane 2 CLCN3, CLCN5
lysosomal membrane 2 CLCN3, CLCN5
neuronal cell body 1 CASP3
synaptic vesicle 2 CLCN3, CLCN5
Cytoplasm, cytosol 1 CLC
Presynapse 1 ANO1
plasma membrane 12 ANO1, CACNA1I, CLCA1, CLCN3, CLCN5, CLCNKA, GLRA2, MUC5AC, PRKCQ, S100A9, TNK1, UGT1A1
synaptic vesicle membrane 1 CLCN3
Membrane 8 ANO1, CACNA1I, CLCN3, CLCN5, GLRA2, TNK1, UGT1A1, UGT1A9
apical plasma membrane 1 ANO1
basolateral plasma membrane 1 CLCNKA
caveola 1 PTGS2
extracellular exosome 5 ALB, ANO1, MUC5AC, PTGS1, S100A9
Lysosome membrane 1 CLCN3
endoplasmic reticulum 4 ALB, PTGS2, UGT1A1, UGT1A9
extracellular space 6 ALB, CLC, IL13, MUC5AC, NPPB, S100A9
perinuclear region of cytoplasm 1 UGT1A1
protein-containing complex 3 ALB, NPPB, PTGS2
intracellular membrane-bounded organelle 3 CLCN3, GLRA2, PTGS1
Microsome membrane 2 PTGS1, PTGS2
postsynaptic density 1 CASP3
Secreted 4 ALB, CLC, IL13, MUC5AC
extracellular region 7 ALB, CLC, CLCA1, IL13, MUC5AC, NPPB, S100A9
Single-pass membrane protein 2 UGT1A1, UGT1A9
Extracellular side 1 CLCA1
anchoring junction 1 ALB
centriolar satellite 1 PRKCQ
photoreceptor outer segment 1 PTGS1
external side of plasma membrane 2 CLCN3, IL13
cytoplasmic vesicle 1 CLCN3
Early endosome 2 CLCN3, CLCN5
apical part of cell 1 CLCN5
recycling endosome 1 CLCN3
Apical cell membrane 1 ANO1
Cell projection, ruffle membrane 1 CLCN3
Cytoplasm, perinuclear region 1 UGT1A1
Cytoplasm, cytoskeleton 1 S100A9
GABA-ergic synapse 2 CLCN3, GLRA2
extracellular matrix 1 MUC5AC
collagen-containing extracellular matrix 2 CLC, S100A9
secretory granule 1 CLCN3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Postsynaptic cell membrane 1 GLRA2
Late endosome 1 CLCN3
Zymogen granule membrane 1 CLCA1
neuron projection 3 GLRA2, PTGS1, PTGS2
ciliary basal body 1 ALB
Late endosome membrane 1 CLCN3
cell projection 2 ANO1, GLRA2
cytoskeleton 1 S100A9
centriole 1 ALB
Secreted, extracellular space 1 CLCA1
spindle pole 1 ALB
blood microparticle 1 ALB
transmembrane transporter complex 1 GLRA2
Basolateral cell membrane 1 CLCNKA
Endomembrane system 1 PTGS1
microvillus 1 CLCA1
chloride channel complex 3 ANO1, CLCNKA, GLRA2
specific granule 1 CLCN3
secretory granule lumen 1 S100A9
Golgi lumen 1 MUC5AC
endoplasmic reticulum lumen 2 ALB, PTGS2
platelet alpha granule lumen 1 ALB
axon terminus 1 CLCN3
voltage-gated calcium channel complex 1 CACNA1I
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
vesicle membrane 1 CLCN3
death-inducing signaling complex 1 CASP3
postsynaptic specialization membrane 1 GLRA2
mucus layer 1 MUC5AC
CRLF-CLCF1 complex 1 CLC
glycinergic synapse 1 GLRA2
calprotectin complex 1 S100A9
S100A9 complex 1 S100A9
endoplasmic reticulum chaperone complex 1 UGT1A1
[NT-proBNP]: Secreted 1 NPPB
[proBNP(3-108)]: Secreted 1 NPPB
[Brain natriuretic peptide 32]: Secreted 1 NPPB
[BNP(3-32)]: Secreted 1 NPPB
[Isoform 2]: Golgi apparatus membrane 1 CLCN3
cytochrome complex 1 UGT1A1
CNTFR-CLCF1 complex 1 CLC
[Isoform 1]: Early endosome membrane 1 CLCN3
ciliary transition fiber 1 ALB


文献列表

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