Protriptyline (BioDeep_00000002057)

 

Secondary id: BioDeep_00000408796

human metabolite blood metabolite


代谢物信息卡片


methyl(3-{tricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,9,11,13-heptaen-2-yl}propyl)amine

化学式: C19H21N (263.1674)
中文名称: 普罗替林
谱图信息: 最多检出来源 Viridiplantae(plant) 45.83%

分子结构信息

SMILES: CNCCCC1C2=CC=CC=C2C=CC2=CC=CC=C12
InChI: InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3

描述信息

Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Protriptyline may be used for the treatment of depression.
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AA - Non-selective monoamine reuptake inhibitors
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D049990 - Membrane Transport Modulators

同义名列表

15 个代谢物同义名

methyl(3-{tricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,9,11,13-heptaen-2-yl}propyl)amine; 3-(5H-Dibenzo[a,D]cyclohepten-5-yl)-N-methyl-1-propanamine; 7-(3-Methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene; 5-(3-Methylaminopropyl)-5H-dibenzo[a,D]cycloheptene; N-Methyl-5H-dibenzo[a,D]cycloheptene-5-propylamine; N-Methyl-5H-dibenzo[a,D]cycloheptene-5-propanamine; Odyssey brand OF protriptyline hydrochloride; Hydrochloride, protriptyline; Protriptyline hydrochloride; protriptyline; Protryptyline; Amimetilina; Vivactil; Protriptyline; Protriptyline



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ADRA2A, AXIN2, BDNF, CA3, CENPJ, EDN1, GFAP, MAPT
Peripheral membrane protein 1 MAPT
Endosome membrane 1 SLC6A4
Endoplasmic reticulum membrane 1 HSP90B1
Nucleus 4 AXIN2, HSP90B1, MAPT, PLCZ1
cytosol 8 AXIN2, CA3, CENPJ, GFAP, HSP90B1, LEP, MAPT, PLCZ1
dendrite 3 BDNF, KCNB1, MAPT
centrosome 2 AXIN2, CENPJ
nucleoplasm 2 PLCZ1, SCN5A
Cell membrane 7 ADRA2A, KCNB1, KCNH2, MAPT, SCN5A, SLC6A2, SLC6A4
Cytoplasmic side 1 MAPT
Cell projection, axon 2 KCNB1, MAPT
Multi-pass membrane protein 6 ADRA2A, KCNB1, KCNH2, SCN5A, SLC6A2, SLC6A4
Synapse 3 KCNB1, SLC6A4, TAC1
cell junction 1 SCN5A
cell surface 4 KCNB1, KCNH2, SCN5A, SLC6A2
glutamatergic synapse 1 ADRA2A
Golgi membrane 1 INS
growth cone 1 MAPT
neuronal cell body 3 ADRA2A, MAPT, TAC1
presynaptic membrane 2 SLC6A2, SLC6A4
sarcolemma 2 KCNB1, SCN5A
smooth endoplasmic reticulum 1 HSP90B1
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 1 MAPT
Presynapse 1 SLC6A4
plasma membrane 9 ADRA2A, AXIN2, BCHE, KCNB1, KCNH2, MAPT, SCN5A, SLC6A2, SLC6A4
synaptic vesicle membrane 1 SLC6A2
Membrane 7 BDNF, HSP90B1, KCNB1, KCNH2, SCN5A, SLC6A2, SLC6A4
apical plasma membrane 1 KCNB1
axon 5 BDNF, KCNB1, MAPT, SLC6A2, TAC1
basolateral plasma membrane 1 ADRA2A
caveola 1 SCN5A
extracellular exosome 1 HSP90B1
endoplasmic reticulum 2 HSP90B1, SCN5A
extracellular space 7 BCHE, BDNF, CCL2, EDN1, INS, LEP, TAC1
perinuclear region of cytoplasm 6 BDNF, HSP90B1, KCNB1, KCNH2, PLCZ1, SCN5A
intercalated disc 1 SCN5A
mitochondrion 1 MAPT
protein-containing complex 1 HSP90B1
pronucleus 1 PLCZ1
Secreted 7 BCHE, BDNF, CCL2, EDN1, INS, LEP, MAPT
extracellular region 9 BCHE, BDNF, CCL2, EDN1, HSP90B1, INS, LEP, MAPT, TAC1
astrocyte end-foot 1 GFAP
basal part of cell 1 EDN1
neuronal cell body membrane 2 KCNB1, SLC6A2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CENPJ
dendritic spine 1 MAPT
T-tubule 1 SCN5A
perikaryon 1 KCNB1
Z disc 1 SCN5A
beta-catenin destruction complex 1 AXIN2
microtubule cytoskeleton 1 MAPT
nucleolus 2 PLCZ1, SCN5A
axon cytoplasm 1 MAPT
midbody 1 HSP90B1
postsynaptic membrane 2 KCNB1, SLC6A4
presynaptic active zone membrane 1 ADRA2A
Cell membrane, sarcolemma 1 KCNB1
Cytoplasm, perinuclear region 2 PLCZ1, SCN5A
Membrane raft 2 MAPT, SLC6A4
Cell junction, focal adhesion 1 SLC6A4
Cytoplasm, cytoskeleton 1 MAPT
focal adhesion 2 HSP90B1, SLC6A4
microtubule 2 CENPJ, MAPT
axolemma 1 MAPT
GABA-ergic synapse 1 ADRA2A
collagen-containing extracellular matrix 1 HSP90B1
intermediate filament 1 GFAP
lateral plasma membrane 2 KCNB1, SCN5A
nuclear speck 1 MAPT
Postsynaptic cell membrane 1 KCNB1
receptor complex 1 ADRA2A
Cell projection, neuron projection 1 SLC6A4
neuron projection 2 MAPT, SLC6A4
ciliary basal body 1 CENPJ
cell projection 1 GFAP
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole 1 CENPJ
centriole 1 CENPJ
cytoplasmic ribonucleoprotein granule 1 MAPT
blood microparticle 1 BCHE
Endomembrane system 1 SLC6A4
endosome lumen 1 INS
monoatomic ion channel complex 1 KCNH2
Cell projection, dendrite 2 KCNB1, MAPT
Melanosome 1 HSP90B1
cell body 2 GFAP, MAPT
sperm plasma membrane 1 HSP90B1
intermediate filament cytoskeleton 1 GFAP
Cell membrane, sarcolemma, T-tubule 1 SCN5A
inward rectifier potassium channel complex 1 KCNH2
voltage-gated potassium channel complex 2 KCNB1, KCNH2
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 BCHE, BDNF, HSP90B1, INS
axon terminus 1 ADRA2A
procentriole replication complex 1 CENPJ
transport vesicle 2 EDN1, INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 ADRA2A
nuclear envelope lumen 1 BCHE
Sarcoplasmic reticulum lumen 1 HSP90B1
Synapse, synaptosome 1 KCNB1
Lateral cell membrane 1 KCNB1
postsynaptic specialization membrane 1 KCNB1
dopaminergic synapse 1 ADRA2A
dendrite membrane 1 KCNB1
somatodendritic compartment 1 MAPT
voltage-gated sodium channel complex 1 SCN5A
nuclear periphery 1 MAPT
cytoplasmic side of lysosomal membrane 1 GFAP
glial cell projection 1 MAPT
cholinergic synapse 1 KCNB1
endocytic vesicle lumen 1 HSP90B1
rough endoplasmic reticulum lumen 1 EDN1
sperm head 1 PLCZ1
Weibel-Palade body 1 EDN1
neurofibrillary tangle 1 MAPT
endoplasmic reticulum chaperone complex 1 HSP90B1
main axon 1 MAPT
tubulin complex 1 MAPT
proximal dendrite 1 KCNB1
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
serotonergic synapse 1 SLC6A4
gamma-tubulin small complex 1 CENPJ


文献列表

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