Methotrexate (BioDeep_00000002040)

 

Secondary id: BioDeep_00000398440

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid

化学式: C20H22N8O5 (454.1713082)
中文名称: 甲氨蝶呤 水合物, 二水合氨甲嘌呤
谱图信息: 最多检出来源 Homo sapiens(blood) 4.35%

分子结构信息

SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
InChI: InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)

描述信息

Methotrexate is only found in individuals that have used or taken this drug. It is an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. [PubChem]Methotrexate anti-tumor activity is a result of the inhibition of folic acid reductase, leading to inhibition of DNA synthesis and inhibition of cellular replication. The mechanism involved in its activity against rheumatoid arthritis is not known.
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01B - Antimetabolites > L01BA - Folic acid analogues
L - Antineoplastic and immunomodulating agents > L04 - Immunosuppressants > L04A - Immunosuppressants
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
D012102 - Reproductive Control Agents > D000019 - Abortifacient Agents
C471 - Enzyme Inhibitor > C2153 - Dihydrofolate Reductase Inhibitor
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D004791 - Enzyme Inhibitors > D005493 - Folic Acid Antagonists
CONFIDENCE standard compound; INTERNAL_ID 2730
D009676 - Noxae > D000963 - Antimetabolites
D000970 - Antineoplastic Agents
D018501 - Antirheumatic Agents
D003879 - Dermatologic Agents
Corona-virus
KEIO_ID M048
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

42 个代谢物同义名

(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid; N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid; N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate; 4-Amino-N(10)-methylpteroylglutamic acid; 4-Amino-N(10)-methylpteroylglutamate; N-Bismethylpteroylglutamic acid; 4-Amino-10-methylfolic acid; Methotrexate, dicesium salt; Methotrexate, disodium salt; Dicesium salt methotrexate; Methotrexate, sodium salt; Methotrexate, (DL)-isomer; L(+)-Amethopterin hydrate; Methotrexate, (D)-isomer; 4-Amino-10-methylfolate; Hydrate, methotrexate; Methotrexate hydrate; Sodium, methotrexate; Methylaminopterinum; Methotrexate sodium; Methylaminopterin; Ledertrexic acid; Methotrexic acid; L-Amethopterin; Methotextrate; Amethopterine; Methotrexatum; Ledertrexate; Emtexic acid; Methotrexate; Amethopterin; Metotrexato; Methotrexat; Methopterin; Rheumatrex; Emtexate; Trexall; Otrexup; Xatmep; Mexate; HDMTX; MTX



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wenlu Hu, Yanxia Ding, Kelei Guan, Panpan Zhang, Jingbo Su, Chunyi Zhang, Wei Li, Chaofeng Lian, Qihua Yang, Shengyun Liu, Tianfang Li. Changes in metabolic parameters and serum YKL-40 levels in Chinese rheumatoid arthritis patients during tocilizumab therapy. Clinical rheumatology. 2024 Jun; 43(6):1845-1853. doi: 10.1007/s10067-024-06982-9. [PMID: 38696116]
  • Raghuraj Singh, Krishna Jadhav, Rohit Kamboj, Hitesh Malhotra, Eupa Ray, Agrim Jhilta, Varun Dhir, Rahul Kumar Verma. Self-actuating inflammation responsive hydrogel microsphere formulation for controlled drug release in rheumatoid arthritis (RA): Animal trials and study in human fibroblast like synoviocytes (hFLS) of RA patients. Biomaterials advances. 2024 Jun; 160(?):213853. doi: 10.1016/j.bioadv.2024.213853. [PMID: 38636119]
  • Yi Zhou, Yantao Ding, Mengxing Cui, Yuanjing Zhang, Mengwei Wang, Feiran Zhou, Yi Su, Bo Liang, Fusheng Zhou. Metabolomic Alterations in Methotrexate Treatment of Moderate-to-Severe Psoriasis. Medical science monitor : international medical journal of experimental and clinical research. 2024 May; 30(?):e943360. doi: 10.12659/msm.943360. [PMID: 38715343]
  • Raisa Kraaijvanger, Montse Janssen Bonás, Jan C Grutters, Ioanna Paspali, Marcel Veltkamp, Dominique P V de Kleijn, Coline H M van Moorsel. Decreased serpin C1 in extracellular vesicles predicts response to methotrexate treatment in patients with pulmonary sarcoidosis. Respiratory research. 2024 Apr; 25(1):166. doi: 10.1186/s12931-024-02809-y. [PMID: 38627696]
  • Shengyang Chen, Lifeng Huang, Weikun Huang, You Zheng, Li Shen, Maobai Liu, Wansheng Chen, Xuemei Wu. External Evaluation of Population Pharmacokinetic Models for High-Dose Methotrexate in Adult Patients with Hematological Tumors. Journal of clinical pharmacology. 2024 04; 64(4):437-448. doi: 10.1002/jcph.2392. [PMID: 38081138]
  • Huan Meng, Steven H Lam, Ho So, Lai-Shan Tam. Incidence and risk factors of major cardiovascular events in rheumatoid arthritis and psoriatic arthritis: A population-based cohort study. Seminars in arthritis and rheumatism. 2024 Apr; 65(?):152416. doi: 10.1016/j.semarthrit.2024.152416. [PMID: 38368730]
  • Jianyang Liu, Helena Idborg, Marina Korotkova, Kristina Lend, Ronald van Vollenhoven, Jon Lampa, Anna Rudin, Dan Nordström, Bjorn Gudbjornsson, Gerdur Gröndal, Till Uhlig, Kim Hørslev-Petersen, Merete Lund Hetland, Mikkel Østergaard, Michael Nurmohamed, Per-Johan Jakobsson. Urinary prostanoids are elevated by anti-TNF and anti-IL6 receptor disease-modifying antirheumatic drugs but are not predictive of response to treatment in early rheumatoid arthritis. Arthritis research & therapy. 2024 Mar; 26(1):61. doi: 10.1186/s13075-024-03295-9. [PMID: 38444034]
  • Maria C Schneeweiss, Denys Shay, Sophia Ly, Richard Wyss, Sebastian Schneeweiss, Robert J Glynn, Arash Mostaghimi. Prevalence of Pretreatment Testing Recommended for Patients With Chronic Inflammatory Skin Diseases. JAMA dermatology. 2024 Mar; 160(3):334-340. doi: 10.1001/jamadermatol.2023.5895. [PMID: 38294794]
  • Kai-Xin Du, Hao-Rui Shen, Bi-Hui Pan, Sibusiso Luthuli, Li Wang, Jin-Hua Liang, Yue Li, Hua Yin, Jian-Yong Li, Jia-Zhu Wu, Wei Xu. Prognostic value of POD18 combined with improved IELSG in primary central nervous system lymphoma. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2024 Mar; 26(3):720-731. doi: 10.1007/s12094-023-03292-5. [PMID: 37558851]
  • Xin-Zhuo Zhang, Xiao-Hui Su, Shi-Qi Kang, Bei Yuan, Jing-Hang Yang, Na Lin, Xiang-Ying Kong, Feng Huang. [Effect and mechanism of aqueous extract of Strychni Semen on bone destruction in rats with type Ⅱ collagen-induced rheumatoid arthritis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Mar; 49(6):1421-1428. doi: 10.19540/j.cnki.cjcmm.20231206.401. [PMID: 38621925]
  • Roberta Avila-Tavares, Luciano Gibran, Luiz Gustavo Oliveira Brito, Thauany Martins Tavoni, Manoel Orlando Gonçalves, Edmund Chada Baracat, Raul Cavalcante Maranhão, Sergio Podgaec. Pilot study of treatment of patients with deep infiltrative endometriosis with methotrexate carried in lipid nanoparticles. Archives of gynecology and obstetrics. 2024 02; 309(2):659-667. doi: 10.1007/s00404-023-07246-8. [PMID: 37987824]
  • R Matloob, Z Althanoon, S Algburi, M Salih, M Merkhan. UPDATE ON THE USE OF METHOTREXATE IN THE MANAGEMENT OF RHEUMATOID ARTHRITIS. Georgian medical news. 2024 Feb; ?(347):28-33. doi: ". [PMID: 38609109]
  • Nan Zhang, Liu-Bo Zhang, Zihan Wang, Tian-Yi Lan, Jin-Ping Wang, Cheng Xiao, Qing-Wen Tao, Yuan Xu. Efficacy and safety of the modified Zhiwang decoction combined with methotrexate in early rheumatoid arthritis: study protocol for a randomised controlled trial. BMJ open. 2024 01; 14(1):e076571. doi: 10.1136/bmjopen-2023-076571. [PMID: 38238175]
  • Zhihao Duan, Can Jin, Shuai Ma, Jinlang Liu, Shigang Li, You Zhou. Exploring the potential molecular mechanism of Gualou Guizhi decoction in the treatment of rheumatoid arthritis based on network pharmacology and molecular docking. Medicine. 2024 Jan; 103(1):e36844. doi: 10.1097/md.0000000000036844. [PMID: 38181229]
  • Riyadh S Almalki. The Protective Effect of Roflumilast Against Acute Hepatotoxicity Caused by Methotrexate in Wistar Rats: In vivo Evaluation. Drug design, development and therapy. 2024; 18(?):453-462. doi: 10.2147/dddt.s438703. [PMID: 38374827]
  • Xiuying Li, Xin Wang, Xiuwu Qu, Ningning Shi, Qinqing Li, Zhifang Yan, Yandong Li, Yingli Wang. Microenvironmental Enzyme-Responsive Methotrexate Modified Quercetin Micelles for the Treatment of Rheumatoid Arthritis. International journal of nanomedicine. 2024; 19(?):3259-3273. doi: 10.2147/ijn.s457004. [PMID: 38601347]
  • Feng Luo, Shuo-Yan Gau, Yu-Xia Wu, Hou-Li Liao, Fang Tang, Qin Zhong, Ying Huang, Lei Hou, Zheng-Qi Liu, Jin-Long Cai, Yue-Peng Cao, Dao-Min Lu, Yang An, Wei-Ya Lan, Can Liu, Chang-Ming Chen, Er-Tao Jia, Xue-Ming Yao, James Cheng-Chung Wei, Wu-Kai Ma. Efficacy of adalimumab combined with Tripterygium wilfordii Hook F in the treatment of patient with rheumatoid arthritis: A multicenter, open-label, randomized-controlled trial. International journal of rheumatic diseases. 2024 Jan; 27(1):e15031. doi: 10.1111/1756-185x.15031. [PMID: 38287544]
  • Olexander M Semenenko, Victoria V Lipson, Alina O Sadchenko, Olga V Vashchenko, Natalia A Kasian, Liliia V Sviechnikova, Longin M Lisetski, Mykola L Babak, Volodymyr M Vakula, Oleksandr V Borysov, Yuliia V Holota, Sergey O Zozulya, Petro O Borysko, Olexander V Mazepa. Synthesis of methotrexate-betulonic acid hybrids and evaluation of their effect on artificial and Caco-2 cell membranes. Steroids. 2024 Jan; 201(?):109332. doi: 10.1016/j.steroids.2023.109332. [PMID: 37939980]
  • Sushmita Negi, Nikunj Tandel, Neeraj K Garg, Prakriti Sharma, Rajinder Kumar, Praveen Sharma, Reetesh Kumar, Sheetal Saini, Aman Sharma, Rajeev K Tyagi. Co-Delivery of Aceclofenac and Methotrexate Nanoparticles Presents an Effective Treatment for Rheumatoid Arthritis. International journal of nanomedicine. 2024; 19(?):2149-2177. doi: 10.2147/ijn.s439359. [PMID: 38482519]
  • Li Li, Jianfeng Ju, Xiuping Zhuang, Shuming Li, Rui Ma, Ji Li, Ming Ding, Chuanjiang Ma, Xin Wang, Baoqing Zhang. Chemistry of Bairui granules and its mechanisms in the protective effect against methotrexate-induced liver injury. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155158. doi: 10.1016/j.phymed.2023.155158. [PMID: 37935081]
  • Chayakamon Niyasom, Sirisucha Soponkanaporn, Soamarat Vilaiyuk, Chatmanee Lertudomphonwanit, Songpon Getsuwan, Pornthep Tanpawpong, Piyaporn Kaewduang, Abhasnee Sobhonslidsuk. Use of transient elastography to assess hepatic steatosis and fibrosis in patients with juvenile idiopathic arthritis during methotrexate treatment. Clinical rheumatology. 2024 Jan; 43(1):423-433. doi: 10.1007/s10067-023-06835-x. [PMID: 38062311]
  • Maroua Slouma, Wided Lahmar, Ghanem Mohamed, Omar Dhrif, Rim Dhahri, Hedia Bellali, Imen Gharsallah, Nabil Ebdelli. Associated factors with liver fibrosis in rheumatoid arthritis patients treated with methotrexate. Clinical rheumatology. 2023 Dec; ?(?):. doi: 10.1007/s10067-023-06847-7. [PMID: 38159207]
  • Fengyue Yin, Xiao Xu, Julia Qi, Mengyu Guo, Yubo Wang, Yun Wang, Roumei Ye, Qian Lin, Daowei Yang, Xuan Zhu, Jinling Wang. DSPE-PEG2000-methotrexate nanoparticles encapsulating phenobarbital sodium kill cancer cells by inducing pyroptosis. Journal of molecular medicine (Berlin, Germany). 2023 Dec; ?(?):. doi: 10.1007/s00109-023-02403-7. [PMID: 38047923]
  • Wessam M El-Refaie, Mostafa S Ghazy, Fady A Ateyya, Eman Sheta, Mohanad Y Shafek, Mahmoud S Ibrahim, Mahmoud Ma Ismail, Mennatallah A Gowayed. Rhein methotrexate-decorated solid lipid nanoparticles altering adjuvant arthritis progression through endoplasmic reticulum stress-mediated apoptosis. Inflammopharmacology. 2023 Dec; 31(6):3127-3142. doi: 10.1007/s10787-023-01295-w. [PMID: 37526838]
  • Suxia Huo, Liang Shen, Ying Ju, Keke Liu, Wei Liu. Treatments for cesarean scar pregnancy: 11-year experience at a medical center. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2023 Dec; 36(1):2162818. doi: 10.1080/14767058.2022.2162818. [PMID: 36597830]
  • Ning Tan, Chi-Jen Hsu, Han-You Mo, Xiuyan Yang, James Cheng-Chung Wei. Methotrexate injection: An old drug with a newly developing landscape. International journal of rheumatic diseases. 2023 Dec; 26(12):2366-2370. doi: 10.1111/1756-185x.14879. [PMID: 38041651]
  • Yuchun Wang, Han Xie, Xuan Huang, Keyuan Chen, Yizhun Zhu, Genhong Yao. Retrospective analysis and preliminary laboratory validation of treatment efficacy and blood lipid levels in patients with rheumatoid arthritis. Clinical rheumatology. 2023 Dec; 42(12):3213-3223. doi: 10.1007/s10067-023-06683-9. [PMID: 37488372]
  • Wenyuan Li, Chuanzhu Yan, Dongqing Du, Yuxia Ma. Bibliometric analysis of trends in research of Tripterygium wilfordii Hook F for treating rheumatoid arthritis. Medicine. 2023 Nov; 102(47):e36338. doi: 10.1097/md.0000000000036338. [PMID: 38013265]
  • Ammara Saleem, Huma Khalid, Muhammad Furqan Akhtar, Alam Zeb. Appraisal of anti-arthritic potential of Coronopus didymus (L.) Sm. aqueous extract and its safety study in Wistar rats. Inflammopharmacology. 2023 Nov; ?(?):. doi: 10.1007/s10787-023-01374-y. [PMID: 37962695]
  • Ruofei Huang, Ruya Li, Jun Chen, Meiyan Lv, Xiangwei Xu. Network pharmacology analysis of the pharmacological mechanism of Artemisia lavandulaefolia DC. in rheumatoid arthritis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Sep; 118(?):154905. doi: 10.1016/j.phymed.2023.154905. [PMID: 37348247]
  • Tsz On Lam, Isaac T Cheng, Steven H Lam, Chi Chiu Mok, Carmen T Ho, Tommy T Cheung, Virginia W Lao, Hin Ting Pang, Chi Hung To, Cheuk Wan Yim, Alexandra Ng, Kitty Y Kwok, Ka Lai Lee, Shirley K Ying, Man Choi Wan, Jolly M Lee, Lai-Shan Tam. Five-year cardiovascular event risk in early rheumatoid arthritis patients who received treat-to-target management: a case-control study. Rheumatology (Oxford, England). 2023 09; 62(9):2998-3005. doi: 10.1093/rheumatology/kead039. [PMID: 36707997]
  • Yujie Li, Nannan Zhang, Xin Peng, Wukai Ma, Yuanxing Qin, Xueming Yao, Cong Huang, Xudong Zhang. Network pharmacology analysis and clinical verification of Jishe Qushi capsules in rheumatoid arthritis treatment. Medicine. 2023 Aug; 102(34):e34883. doi: 10.1097/md.0000000000034883. [PMID: 37653836]
  • Z Y Shen, X C Chen, H R Shan, T Jia, W Y Gu, F Wang, Q L Teng, L Wang, C L Wang, Y Y Shi, H Zhang, Y Q Miao, T G Zhu, C Y Ji, J J Ye, M Z Zhang, X D Zhang, L Wang, K L Xu, W Sang. [Analysis of prognostic factors of extranodal NK/T-cell lymphoma treated with pegaspargase/L-asparaginase: a multicenter retrospective study]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi. 2023 Aug; 44(8):642-648. doi: 10.3760/cma.j.issn.0253-2727.2023.08.005. [PMID: 37803837]
  • Wang Bei, Jiang Qian, Qu Zilu, Chen Kai, Jiang Ruili, Hu Feng, Chen Liuqing. Comparing four immunosuppressive agents for chronic spontaneous urticaria-A network meta-analysis. International immunopharmacology. 2023 Aug; 123(?):110577. doi: 10.1016/j.intimp.2023.110577. [PMID: 37567010]
  • Ruiyuan Zhang, Fang Liu, Qian Zhang, Luping Yang, Xinlian Hou, Taoming Du, Jie Fan, Huiling Hu, Hongdan Deng, Li Hao, Li Guo, Chaomei Fu. Intra-articular delivery system of methotrexate for rheumatoid arthritis therapy: An in-suit thermosensitive comprehensive gel of polysaccharide from Aconitum carmichaelii Debx. International journal of biological macromolecules. 2023 Jul; 244(?):124822. doi: 10.1016/j.ijbiomac.2023.124822. [PMID: 37257527]
  • Cameron Adams, Nisha Nair, Darren Plant, Suzanne M M Verstappen, Hong L Quach, Diana L Quach, Alex Carvidi, Joanne Nititham, Mary Nakamura, Jonathan Graf, Anne Barton, Lindsey A Criswell, Lisa F Barcellos. Identification of Cell-Specific Differential DNA Methylation Associated With Methotrexate Treatment Response in Rheumatoid Arthritis. Arthritis & rheumatology (Hoboken, N.J.). 2023 07; 75(7):1088-1097. doi: 10.1002/art.42464. [PMID: 36716083]
  • Zhihua Yang, Qi Liang, Huasheng Liang, Wenying Chen, Chuanning Li, Yunting Xiao, Youbang Liang, Maojie Wang, Xi Tan, Xiaodong Wu, Yanzhao Lin, Xiumin Chen, Qingchun Huang, Zehuai Wen, Runyue Huang. Single-cell RNA transcriptomic and plasma Lipidomic reveal the potential mechanisms of a Methotrexate-based therapy against Rheumatoid Arthritis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jul; 115(?):154816. doi: 10.1016/j.phymed.2023.154816. [PMID: 37094424]
  • Sara M Radwan, Mustafa Alqulaly, Magdy Y Elsaeed, Shimaa Z Elshora, Asmaa H Atwa, Eman F Wasfey. L-carnitine reverses methotrexate-induced nephrotoxicity in experimental rat model: Insight on SIRT1/PGC-1α/Nrf2/HO-1 axis. Journal of applied toxicology : JAT. 2023 Jun; ?(?):. doi: 10.1002/jat.4503. [PMID: 37312617]
  • Bo Yu, Xiaoxue Lang, Xiangtao Wang, Lijuan Ding, Meihua Han, Yifei Guo, Zhengqi Dong. Effects of different conformations of polylysine on the anti-tumor efficacy of methotrexate nanoparticles. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jun; 162(?):114662. doi: 10.1016/j.biopha.2023.114662. [PMID: 37037095]
  • Yijun Luo, Xiaoxiao Hou, Anran Xi, Mengxian Luo, Keer Wang, Zhenghao Xu. Tripterygium wilfordii Hook F combination therapy with methotrexate for rheumatoid arthritis: An updated meta-analysis. Journal of ethnopharmacology. 2023 May; 307(?):116211. doi: 10.1016/j.jep.2023.116211. [PMID: 36706936]
  • Aya M Abosrea, Heba S Aboul Ezz, Sahar M Mahmoud, Mohamed R Mousa, Nawal A Ahmed. The potential role of pumpkin seeds oil on methotrexate-induced lung toxicity. Scientific reports. 2023 May; 13(1):7321. doi: 10.1038/s41598-023-34143-6. [PMID: 37147356]
  • Z Dogan, D D Ergun, S Durmus, H Sahin, G E Senturk, R Gelisgen, A Senyigit, H Uzun. Empagliflozin and sacubitril/valsartan reverse methotrexate cardiotoxicity by repressing oxidative stress and hypoxia in heart embryonic H9c2 cardiomyocytes - the role of morphology of mitochondria observed on electron microscopy. European review for medical and pharmacological sciences. 2023 05; 27(9):3979-3992. doi: 10.26355/eurrev_202305_32304. [PMID: 37203822]
  • Nusaiba Al-Nemrawi, Yazan Wahsheh, Karem H Alzoubi. Transdermal Delivery of Methotrexate Loaded in Chitosan Nanoparticles to Treat Rheumatoid Arthritis. Current drug delivery. 2023 Apr; ?(?):. doi: 10.2174/1567201820666230428124346. [PMID: 37132147]
  • Afnan Afnan, Ammara Saleem, Muhammad Furqan Akhtar. Chrysin, a 5,7-dihydroxyflavone restrains inflammatory arthritis in rats via subsiding oxidative stress biomarkers and inflammatory cytokines. Inflammopharmacology. 2023 Apr; ?(?):. doi: 10.1007/s10787-023-01229-6. [PMID: 37083920]
  • Shan-Shan Jie, Hui-Juan Sun, Jian-Xin Liu, Yan Gao, Dong Bai, Liu-Luan Zhu, Hong-Yan Zhao, Hui Zeng, Ya-Luan Ma. Simiao Yong'an decoction ameliorates murine collagen-induced arthritis by modulating neutrophil activities: An in vitro and in vivo study. Journal of ethnopharmacology. 2023 Apr; 305(?):116119. doi: 10.1016/j.jep.2022.116119. [PMID: 36596398]
  • Jyoti Rathee, Rohini Kanwar, Laxmi Kumari, Sandip V Pawar, Shikha Sharma, Md Ehesan Ali, Deepak B Salunke, Surinder Kumar Mehta. Development of nanostructured lipid carriers as a promising tool for methotrexate delivery: physicochemical and in vitro evaluation. Journal of biomolecular structure & dynamics. 2023 04; 41(7):2747-2758. doi: 10.1080/07391102.2022.2037465. [PMID: 35238266]
  • Jia Xu, Lu Zhang, Yanping Xu, Jiahui Yu, Lianyu Zhao, Hui Deng, Meiling Li, Mingying Zhang, Xujie Lei, Congqi Hu, Wei Jiao, Zhao Dai, Lijuan Liu, Guangxing Chen. Effectiveness of Yishen Tongbi decoction versus methotrexate in patients with active rheumatoid arthritis: A double-blind, randomized, controlled, non-inferiority trial. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Apr; 112(?):154704. doi: 10.1016/j.phymed.2023.154704. [PMID: 36796186]
  • Elif Tufan, Güzin Göksun Sivas, Begüm Gürel-Gökmen, Sümeyye Yılmaz-Karaoğlu, Ercan Dursun, Esin Çalışkan-Ak, Aleyna Muhan, Dilek Özbeyli, Göksel Şener, Tuğba Tunali-Akbay. Whey protein concentrate ameliorates the methotrexate-induced liver and kidney damage. The British journal of nutrition. 2023 Mar; ?(?):1-8. doi: 10.1017/s0007114523000752. [PMID: 36950976]
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