Methotrexate (BioDeep_00000002040)

 

Secondary id: BioDeep_00000398440

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid

化学式: C20H22N8O5 (454.1713)
中文名称: 二水合氨甲嘌呤, 甲氨蝶呤, 甲氨蝶呤 水合物
谱图信息: 最多检出来源 Rattus norvegicus(blood) 12.8%

分子结构信息

SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
InChI: InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)

描述信息

Methotrexate is only found in individuals that have used or taken this drug. It is an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. [PubChem]Methotrexate anti-tumor activity is a result of the inhibition of folic acid reductase, leading to inhibition of DNA synthesis and inhibition of cellular replication. The mechanism involved in its activity against rheumatoid arthritis is not known.
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01B - Antimetabolites > L01BA - Folic acid analogues
L - Antineoplastic and immunomodulating agents > L04 - Immunosuppressants > L04A - Immunosuppressants
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
D012102 - Reproductive Control Agents > D000019 - Abortifacient Agents
C471 - Enzyme Inhibitor > C2153 - Dihydrofolate Reductase Inhibitor
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D004791 - Enzyme Inhibitors > D005493 - Folic Acid Antagonists
CONFIDENCE standard compound; INTERNAL_ID 2730
D009676 - Noxae > D000963 - Antimetabolites
D000970 - Antineoplastic Agents
D018501 - Antirheumatic Agents
D003879 - Dermatologic Agents
Corona-virus
KEIO_ID M048
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

43 个代谢物同义名

(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid; N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid; N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate; 4-Amino-N(10)-methylpteroylglutamic acid; 4-Amino-N(10)-methylpteroylglutamate; N-Bismethylpteroylglutamic acid; 4-Amino-10-methylfolic acid; Methotrexate, dicesium salt; Methotrexate, disodium salt; Dicesium salt methotrexate; Methotrexate, sodium salt; Methotrexate, (DL)-isomer; L(+)-Amethopterin hydrate; Methotrexate, (D)-isomer; 4-Amino-10-methylfolate; Hydrate, methotrexate; Methotrexate hydrate; Sodium, methotrexate; Methylaminopterinum; Methotrexate sodium; Methylaminopterin; Ledertrexic acid; Methotrexic acid; L-Amethopterin; Methotextrate; Amethopterine; Methotrexatum; Ledertrexate; Emtexic acid; Methotrexate; Amethopterin; Metotrexato; Methotrexat; Methopterin; Rheumatrex; Emtexate; Trexall; Otrexup; Xatmep; Mexate; HDMTX; MTX; Methotrexate



数据库引用编号

33 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ACE, CD34, ERBB2, MME, TNFRSF8, TNK1, TYMS
Peripheral membrane protein 1 TNK1
Endosome membrane 2 ERBB2, HLA-A
Endoplasmic reticulum membrane 1 HLA-A
Nucleus 2 ERBB2, TYMS
cytosol 2 ERBB2, TYMS
dendrite 1 MME
trans-Golgi network 1 MME
nucleoplasm 2 ERBB2, TNFRSF8
Cell membrane 11 ACE, CD19, CD79A, CD8A, ERBB2, HLA-A, IL6R, MME, SLC19A1, SLCO1B1, TNF
ruffle membrane 1 ERBB2
Early endosome membrane 1 HLA-A
Multi-pass membrane protein 4 ATP4A, SLC19A1, SLC22A8, SLCO1B1
Synapse 1 MME
cell surface 3 HLA-A, MME, TNF
Golgi apparatus 1 HLA-A
Golgi membrane 2 HLA-A, INS
lysosomal membrane 1 HLA-A
mitochondrial inner membrane 1 TYMS
neuromuscular junction 1 ERBB2
neuronal cell body 2 MME, TNF
presynaptic membrane 1 ERBB2
synaptic vesicle 1 MME
Lysosome 2 ACE, CD34
Presynapse 1 MME
endosome 1 ACE
plasma membrane 17 ACE, ATP4A, CD19, CD34, CD79A, CD8A, ERBB2, HLA-A, IGHE, IL6R, MME, SLC19A1, SLC22A8, SLCO1B1, TNF, TNFRSF8, TNK1
Membrane 11 ACE, ATP4A, CD19, CD34, ERBB2, HLA-A, IL6R, MME, SLC19A1, SLCO1B1, TNK1
apical plasma membrane 6 ATP4A, CD34, ERBB2, IL6R, SLC19A1, SLC22A8
axon 1 MME
basolateral plasma membrane 4 ERBB2, SLC19A1, SLC22A8, SLCO1B1
brush border 1 MME
extracellular exosome 7 ACE, CD19, CPVL, HLA-A, MME, SLC22A8, TNFRSF8
Lysosome membrane 1 HLA-A
endoplasmic reticulum 1 HLA-A
extracellular space 7 ACE, ATP4A, HLA-A, IGHE, IL6R, INS, TNF
perinuclear region of cytoplasm 2 CD34, ERBB2
mitochondrion 1 TYMS
protein-containing complex 1 CD19
Single-pass type I membrane protein 10 ACE, CD19, CD34, CD79A, CD8A, ERBB2, HLA-A, IGHE, IL6R, TNFRSF8
Secreted 2 ACE, INS
extracellular region 8 ACE, CD34, CD8A, ERBB2, IGHE, IL6R, INS, TNF
Single-pass membrane protein 1 HLA-A
[Isoform 2]: Secreted 2 CD8A, IL6R
Mitochondrion matrix 1 TYMS
mitochondrial matrix 1 TYMS
external side of plasma membrane 8 ACE, CD19, CD34, CD79A, CD8A, HLA-A, IL6R, TNF
multivesicular body 1 CD79A
cytoplasmic vesicle 2 ERBB2, MME
Early endosome 2 ERBB2, MME
recycling endosome 1 TNF
Single-pass type II membrane protein 2 MME, TNF
Apical cell membrane 2 ATP4A, SLC19A1
Cell projection, ruffle membrane 1 ERBB2
Cytoplasm, perinuclear region 1 ERBB2
Mitochondrion inner membrane 1 TYMS
Membrane raft 4 CD19, CD79A, MME, TNF
focal adhesion 1 MME
lateral plasma membrane 1 SLC22A8
receptor complex 3 CD8A, ERBB2, IL6R
IgE immunoglobulin complex 1 IGHE
phagocytic cup 1 TNF
phagocytic vesicle membrane 1 HLA-A
brush border membrane 2 ACE, SLC19A1
sperm midpiece 1 ACE
Basolateral cell membrane 3 SLC19A1, SLC22A8, SLCO1B1
[Isoform 2]: Cell membrane 1 IGHE
intercellular bridge 1 CD34
Recycling endosome membrane 1 HLA-A
endosome lumen 1 INS
myelin sheath 1 ERBB2
basal plasma membrane 4 ACE, CD34, ERBB2, SLCO1B1
plasma membrane raft 1 CD8A
secretory granule lumen 1 INS
secretory granule membrane 1 MME
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
endoplasmic reticulum exit site 1 HLA-A
ER to Golgi transport vesicle membrane 1 HLA-A
semaphorin receptor complex 1 ERBB2
[Isoform 2]: Cytoplasm 1 TNFRSF8
Basal cell membrane 1 SLCO1B1
lumenal side of endoplasmic reticulum membrane 1 HLA-A
MHC class I peptide loading complex 1 HLA-A
[Isoform 1]: Cell membrane 4 CD8A, ERBB2, IL6R, TNFRSF8
[Isoform 3]: Cell membrane 1 IGHE
Golgi medial cisterna 1 HLA-A
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD8A
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
IgM B cell receptor complex 1 CD79A
MHC class I protein complex 1 HLA-A
MHC class II protein complex 1 HLA-A
ERBB3:ERBB2 complex 1 ERBB2
interleukin-6 receptor complex 1 IL6R
neuron projection terminus 1 MME
[Soluble interleukin-6 receptor subunit alpha]: Secreted 1 IL6R
ciliary neurotrophic factor receptor complex 1 IL6R
B cell receptor complex 1 CD79A
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
potassium:proton exchanging ATPase complex 1 ATP4A
glomerular endothelium fenestra 1 CD34
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Wenlu Hu, Yanxia Ding, Kelei Guan, Panpan Zhang, Jingbo Su, Chunyi Zhang, Wei Li, Chaofeng Lian, Qihua Yang, Shengyun Liu, Tianfang Li. Changes in metabolic parameters and serum YKL-40 levels in Chinese rheumatoid arthritis patients during tocilizumab therapy. Clinical rheumatology. 2024 Jun; 43(6):1845-1853. doi: 10.1007/s10067-024-06982-9. [PMID: 38696116]
  • Raghuraj Singh, Krishna Jadhav, Rohit Kamboj, Hitesh Malhotra, Eupa Ray, Agrim Jhilta, Varun Dhir, Rahul Kumar Verma. Self-actuating inflammation responsive hydrogel microsphere formulation for controlled drug release in rheumatoid arthritis (RA): Animal trials and study in human fibroblast like synoviocytes (hFLS) of RA patients. Biomaterials advances. 2024 Jun; 160(?):213853. doi: 10.1016/j.bioadv.2024.213853. [PMID: 38636119]
  • Yi Zhou, Yantao Ding, Mengxing Cui, Yuanjing Zhang, Mengwei Wang, Feiran Zhou, Yi Su, Bo Liang, Fusheng Zhou. Metabolomic Alterations in Methotrexate Treatment of Moderate-to-Severe Psoriasis. Medical science monitor : international medical journal of experimental and clinical research. 2024 May; 30(?):e943360. doi: 10.12659/msm.943360. [PMID: 38715343]
  • Raisa Kraaijvanger, Montse Janssen Bonás, Jan C Grutters, Ioanna Paspali, Marcel Veltkamp, Dominique P V de Kleijn, Coline H M van Moorsel. Decreased serpin C1 in extracellular vesicles predicts response to methotrexate treatment in patients with pulmonary sarcoidosis. Respiratory research. 2024 Apr; 25(1):166. doi: 10.1186/s12931-024-02809-y. [PMID: 38627696]
  • Shengyang Chen, Lifeng Huang, Weikun Huang, You Zheng, Li Shen, Maobai Liu, Wansheng Chen, Xuemei Wu. External Evaluation of Population Pharmacokinetic Models for High-Dose Methotrexate in Adult Patients with Hematological Tumors. Journal of clinical pharmacology. 2024 04; 64(4):437-448. doi: 10.1002/jcph.2392. [PMID: 38081138]
  • Huan Meng, Steven H Lam, Ho So, Lai-Shan Tam. Incidence and risk factors of major cardiovascular events in rheumatoid arthritis and psoriatic arthritis: A population-based cohort study. Seminars in arthritis and rheumatism. 2024 Apr; 65(?):152416. doi: 10.1016/j.semarthrit.2024.152416. [PMID: 38368730]
  • Jianyang Liu, Helena Idborg, Marina Korotkova, Kristina Lend, Ronald van Vollenhoven, Jon Lampa, Anna Rudin, Dan Nordström, Bjorn Gudbjornsson, Gerdur Gröndal, Till Uhlig, Kim Hørslev-Petersen, Merete Lund Hetland, Mikkel Østergaard, Michael Nurmohamed, Per-Johan Jakobsson. Urinary prostanoids are elevated by anti-TNF and anti-IL6 receptor disease-modifying antirheumatic drugs but are not predictive of response to treatment in early rheumatoid arthritis. Arthritis research & therapy. 2024 Mar; 26(1):61. doi: 10.1186/s13075-024-03295-9. [PMID: 38444034]
  • Maria C Schneeweiss, Denys Shay, Sophia Ly, Richard Wyss, Sebastian Schneeweiss, Robert J Glynn, Arash Mostaghimi. Prevalence of Pretreatment Testing Recommended for Patients With Chronic Inflammatory Skin Diseases. JAMA dermatology. 2024 Mar; 160(3):334-340. doi: 10.1001/jamadermatol.2023.5895. [PMID: 38294794]
  • Kai-Xin Du, Hao-Rui Shen, Bi-Hui Pan, Sibusiso Luthuli, Li Wang, Jin-Hua Liang, Yue Li, Hua Yin, Jian-Yong Li, Jia-Zhu Wu, Wei Xu. Prognostic value of POD18 combined with improved IELSG in primary central nervous system lymphoma. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2024 Mar; 26(3):720-731. doi: 10.1007/s12094-023-03292-5. [PMID: 37558851]
  • Xin-Zhuo Zhang, Xiao-Hui Su, Shi-Qi Kang, Bei Yuan, Jing-Hang Yang, Na Lin, Xiang-Ying Kong, Feng Huang. [Effect and mechanism of aqueous extract of Strychni Semen on bone destruction in rats with type Ⅱ collagen-induced rheumatoid arthritis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Mar; 49(6):1421-1428. doi: 10.19540/j.cnki.cjcmm.20231206.401. [PMID: 38621925]
  • Roberta Avila-Tavares, Luciano Gibran, Luiz Gustavo Oliveira Brito, Thauany Martins Tavoni, Manoel Orlando Gonçalves, Edmund Chada Baracat, Raul Cavalcante Maranhão, Sergio Podgaec. Pilot study of treatment of patients with deep infiltrative endometriosis with methotrexate carried in lipid nanoparticles. Archives of gynecology and obstetrics. 2024 02; 309(2):659-667. doi: 10.1007/s00404-023-07246-8. [PMID: 37987824]
  • R Matloob, Z Althanoon, S Algburi, M Salih, M Merkhan. UPDATE ON THE USE OF METHOTREXATE IN THE MANAGEMENT OF RHEUMATOID ARTHRITIS. Georgian medical news. 2024 Feb; ?(347):28-33. doi: ". [PMID: 38609109]
  • Nan Zhang, Liu-Bo Zhang, Zihan Wang, Tian-Yi Lan, Jin-Ping Wang, Cheng Xiao, Qing-Wen Tao, Yuan Xu. Efficacy and safety of the modified Zhiwang decoction combined with methotrexate in early rheumatoid arthritis: study protocol for a randomised controlled trial. BMJ open. 2024 01; 14(1):e076571. doi: 10.1136/bmjopen-2023-076571. [PMID: 38238175]
  • Zhihao Duan, Can Jin, Shuai Ma, Jinlang Liu, Shigang Li, You Zhou. Exploring the potential molecular mechanism of Gualou Guizhi decoction in the treatment of rheumatoid arthritis based on network pharmacology and molecular docking. Medicine. 2024 Jan; 103(1):e36844. doi: 10.1097/md.0000000000036844. [PMID: 38181229]
  • Riyadh S Almalki. The Protective Effect of Roflumilast Against Acute Hepatotoxicity Caused by Methotrexate in Wistar Rats: In vivo Evaluation. Drug design, development and therapy. 2024; 18(?):453-462. doi: 10.2147/dddt.s438703. [PMID: 38374827]
  • Xiuying Li, Xin Wang, Xiuwu Qu, Ningning Shi, Qinqing Li, Zhifang Yan, Yandong Li, Yingli Wang. Microenvironmental Enzyme-Responsive Methotrexate Modified Quercetin Micelles for the Treatment of Rheumatoid Arthritis. International journal of nanomedicine. 2024; 19(?):3259-3273. doi: 10.2147/ijn.s457004. [PMID: 38601347]
  • Feng Luo, Shuo-Yan Gau, Yu-Xia Wu, Hou-Li Liao, Fang Tang, Qin Zhong, Ying Huang, Lei Hou, Zheng-Qi Liu, Jin-Long Cai, Yue-Peng Cao, Dao-Min Lu, Yang An, Wei-Ya Lan, Can Liu, Chang-Ming Chen, Er-Tao Jia, Xue-Ming Yao, James Cheng-Chung Wei, Wu-Kai Ma. Efficacy of adalimumab combined with Tripterygium wilfordii Hook F in the treatment of patient with rheumatoid arthritis: A multicenter, open-label, randomized-controlled trial. International journal of rheumatic diseases. 2024 Jan; 27(1):e15031. doi: 10.1111/1756-185x.15031. [PMID: 38287544]
  • Olexander M Semenenko, Victoria V Lipson, Alina O Sadchenko, Olga V Vashchenko, Natalia A Kasian, Liliia V Sviechnikova, Longin M Lisetski, Mykola L Babak, Volodymyr M Vakula, Oleksandr V Borysov, Yuliia V Holota, Sergey O Zozulya, Petro O Borysko, Olexander V Mazepa. Synthesis of methotrexate-betulonic acid hybrids and evaluation of their effect on artificial and Caco-2 cell membranes. Steroids. 2024 Jan; 201(?):109332. doi: 10.1016/j.steroids.2023.109332. [PMID: 37939980]
  • Sushmita Negi, Nikunj Tandel, Neeraj K Garg, Prakriti Sharma, Rajinder Kumar, Praveen Sharma, Reetesh Kumar, Sheetal Saini, Aman Sharma, Rajeev K Tyagi. Co-Delivery of Aceclofenac and Methotrexate Nanoparticles Presents an Effective Treatment for Rheumatoid Arthritis. International journal of nanomedicine. 2024; 19(?):2149-2177. doi: 10.2147/ijn.s439359. [PMID: 38482519]
  • Li Li, Jianfeng Ju, Xiuping Zhuang, Shuming Li, Rui Ma, Ji Li, Ming Ding, Chuanjiang Ma, Xin Wang, Baoqing Zhang. Chemistry of Bairui granules and its mechanisms in the protective effect against methotrexate-induced liver injury. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155158. doi: 10.1016/j.phymed.2023.155158. [PMID: 37935081]
  • Chayakamon Niyasom, Sirisucha Soponkanaporn, Soamarat Vilaiyuk, Chatmanee Lertudomphonwanit, Songpon Getsuwan, Pornthep Tanpawpong, Piyaporn Kaewduang, Abhasnee Sobhonslidsuk. Use of transient elastography to assess hepatic steatosis and fibrosis in patients with juvenile idiopathic arthritis during methotrexate treatment. Clinical rheumatology. 2024 Jan; 43(1):423-433. doi: 10.1007/s10067-023-06835-x. [PMID: 38062311]
  • Maroua Slouma, Wided Lahmar, Ghanem Mohamed, Omar Dhrif, Rim Dhahri, Hedia Bellali, Imen Gharsallah, Nabil Ebdelli. Associated factors with liver fibrosis in rheumatoid arthritis patients treated with methotrexate. Clinical rheumatology. 2023 Dec; ?(?):. doi: 10.1007/s10067-023-06847-7. [PMID: 38159207]
  • Fengyue Yin, Xiao Xu, Julia Qi, Mengyu Guo, Yubo Wang, Yun Wang, Roumei Ye, Qian Lin, Daowei Yang, Xuan Zhu, Jinling Wang. DSPE-PEG2000-methotrexate nanoparticles encapsulating phenobarbital sodium kill cancer cells by inducing pyroptosis. Journal of molecular medicine (Berlin, Germany). 2023 Dec; ?(?):. doi: 10.1007/s00109-023-02403-7. [PMID: 38047923]
  • Wessam M El-Refaie, Mostafa S Ghazy, Fady A Ateyya, Eman Sheta, Mohanad Y Shafek, Mahmoud S Ibrahim, Mahmoud Ma Ismail, Mennatallah A Gowayed. Rhein methotrexate-decorated solid lipid nanoparticles altering adjuvant arthritis progression through endoplasmic reticulum stress-mediated apoptosis. Inflammopharmacology. 2023 Dec; 31(6):3127-3142. doi: 10.1007/s10787-023-01295-w. [PMID: 37526838]
  • Suxia Huo, Liang Shen, Ying Ju, Keke Liu, Wei Liu. Treatments for cesarean scar pregnancy: 11-year experience at a medical center. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2023 Dec; 36(1):2162818. doi: 10.1080/14767058.2022.2162818. [PMID: 36597830]
  • Ning Tan, Chi-Jen Hsu, Han-You Mo, Xiuyan Yang, James Cheng-Chung Wei. Methotrexate injection: An old drug with a newly developing landscape. International journal of rheumatic diseases. 2023 Dec; 26(12):2366-2370. doi: 10.1111/1756-185x.14879. [PMID: 38041651]
  • Yuchun Wang, Han Xie, Xuan Huang, Keyuan Chen, Yizhun Zhu, Genhong Yao. Retrospective analysis and preliminary laboratory validation of treatment efficacy and blood lipid levels in patients with rheumatoid arthritis. Clinical rheumatology. 2023 Dec; 42(12):3213-3223. doi: 10.1007/s10067-023-06683-9. [PMID: 37488372]
  • Wenyuan Li, Chuanzhu Yan, Dongqing Du, Yuxia Ma. Bibliometric analysis of trends in research of Tripterygium wilfordii Hook F for treating rheumatoid arthritis. Medicine. 2023 Nov; 102(47):e36338. doi: 10.1097/md.0000000000036338. [PMID: 38013265]
  • Ammara Saleem, Huma Khalid, Muhammad Furqan Akhtar, Alam Zeb. Appraisal of anti-arthritic potential of Coronopus didymus (L.) Sm. aqueous extract and its safety study in Wistar rats. Inflammopharmacology. 2023 Nov; ?(?):. doi: 10.1007/s10787-023-01374-y. [PMID: 37962695]
  • Ruofei Huang, Ruya Li, Jun Chen, Meiyan Lv, Xiangwei Xu. Network pharmacology analysis of the pharmacological mechanism of Artemisia lavandulaefolia DC. in rheumatoid arthritis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Sep; 118(?):154905. doi: 10.1016/j.phymed.2023.154905. [PMID: 37348247]
  • Tsz On Lam, Isaac T Cheng, Steven H Lam, Chi Chiu Mok, Carmen T Ho, Tommy T Cheung, Virginia W Lao, Hin Ting Pang, Chi Hung To, Cheuk Wan Yim, Alexandra Ng, Kitty Y Kwok, Ka Lai Lee, Shirley K Ying, Man Choi Wan, Jolly M Lee, Lai-Shan Tam. Five-year cardiovascular event risk in early rheumatoid arthritis patients who received treat-to-target management: a case-control study. Rheumatology (Oxford, England). 2023 09; 62(9):2998-3005. doi: 10.1093/rheumatology/kead039. [PMID: 36707997]
  • Yujie Li, Nannan Zhang, Xin Peng, Wukai Ma, Yuanxing Qin, Xueming Yao, Cong Huang, Xudong Zhang. Network pharmacology analysis and clinical verification of Jishe Qushi capsules in rheumatoid arthritis treatment. Medicine. 2023 Aug; 102(34):e34883. doi: 10.1097/md.0000000000034883. [PMID: 37653836]
  • Z Y Shen, X C Chen, H R Shan, T Jia, W Y Gu, F Wang, Q L Teng, L Wang, C L Wang, Y Y Shi, H Zhang, Y Q Miao, T G Zhu, C Y Ji, J J Ye, M Z Zhang, X D Zhang, L Wang, K L Xu, W Sang. [Analysis of prognostic factors of extranodal NK/T-cell lymphoma treated with pegaspargase/L-asparaginase: a multicenter retrospective study]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi. 2023 Aug; 44(8):642-648. doi: 10.3760/cma.j.issn.0253-2727.2023.08.005. [PMID: 37803837]
  • Wang Bei, Jiang Qian, Qu Zilu, Chen Kai, Jiang Ruili, Hu Feng, Chen Liuqing. Comparing four immunosuppressive agents for chronic spontaneous urticaria-A network meta-analysis. International immunopharmacology. 2023 Aug; 123(?):110577. doi: 10.1016/j.intimp.2023.110577. [PMID: 37567010]
  • Ruiyuan Zhang, Fang Liu, Qian Zhang, Luping Yang, Xinlian Hou, Taoming Du, Jie Fan, Huiling Hu, Hongdan Deng, Li Hao, Li Guo, Chaomei Fu. Intra-articular delivery system of methotrexate for rheumatoid arthritis therapy: An in-suit thermosensitive comprehensive gel of polysaccharide from Aconitum carmichaelii Debx. International journal of biological macromolecules. 2023 Jul; 244(?):124822. doi: 10.1016/j.ijbiomac.2023.124822. [PMID: 37257527]
  • Cameron Adams, Nisha Nair, Darren Plant, Suzanne M M Verstappen, Hong L Quach, Diana L Quach, Alex Carvidi, Joanne Nititham, Mary Nakamura, Jonathan Graf, Anne Barton, Lindsey A Criswell, Lisa F Barcellos. Identification of Cell-Specific Differential DNA Methylation Associated With Methotrexate Treatment Response in Rheumatoid Arthritis. Arthritis & rheumatology (Hoboken, N.J.). 2023 07; 75(7):1088-1097. doi: 10.1002/art.42464. [PMID: 36716083]
  • Zhihua Yang, Qi Liang, Huasheng Liang, Wenying Chen, Chuanning Li, Yunting Xiao, Youbang Liang, Maojie Wang, Xi Tan, Xiaodong Wu, Yanzhao Lin, Xiumin Chen, Qingchun Huang, Zehuai Wen, Runyue Huang. Single-cell RNA transcriptomic and plasma Lipidomic reveal the potential mechanisms of a Methotrexate-based therapy against Rheumatoid Arthritis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jul; 115(?):154816. doi: 10.1016/j.phymed.2023.154816. [PMID: 37094424]
  • Sara M Radwan, Mustafa Alqulaly, Magdy Y Elsaeed, Shimaa Z Elshora, Asmaa H Atwa, Eman F Wasfey. L-carnitine reverses methotrexate-induced nephrotoxicity in experimental rat model: Insight on SIRT1/PGC-1α/Nrf2/HO-1 axis. Journal of applied toxicology : JAT. 2023 Jun; ?(?):. doi: 10.1002/jat.4503. [PMID: 37312617]
  • Bo Yu, Xiaoxue Lang, Xiangtao Wang, Lijuan Ding, Meihua Han, Yifei Guo, Zhengqi Dong. Effects of different conformations of polylysine on the anti-tumor efficacy of methotrexate nanoparticles. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jun; 162(?):114662. doi: 10.1016/j.biopha.2023.114662. [PMID: 37037095]
  • Yijun Luo, Xiaoxiao Hou, Anran Xi, Mengxian Luo, Keer Wang, Zhenghao Xu. Tripterygium wilfordii Hook F combination therapy with methotrexate for rheumatoid arthritis: An updated meta-analysis. Journal of ethnopharmacology. 2023 May; 307(?):116211. doi: 10.1016/j.jep.2023.116211. [PMID: 36706936]
  • Aya M Abosrea, Heba S Aboul Ezz, Sahar M Mahmoud, Mohamed R Mousa, Nawal A Ahmed. The potential role of pumpkin seeds oil on methotrexate-induced lung toxicity. Scientific reports. 2023 May; 13(1):7321. doi: 10.1038/s41598-023-34143-6. [PMID: 37147356]
  • Z Dogan, D D Ergun, S Durmus, H Sahin, G E Senturk, R Gelisgen, A Senyigit, H Uzun. Empagliflozin and sacubitril/valsartan reverse methotrexate cardiotoxicity by repressing oxidative stress and hypoxia in heart embryonic H9c2 cardiomyocytes - the role of morphology of mitochondria observed on electron microscopy. European review for medical and pharmacological sciences. 2023 05; 27(9):3979-3992. doi: 10.26355/eurrev_202305_32304. [PMID: 37203822]
  • Nusaiba Al-Nemrawi, Yazan Wahsheh, Karem H Alzoubi. Transdermal Delivery of Methotrexate Loaded in Chitosan Nanoparticles to Treat Rheumatoid Arthritis. Current drug delivery. 2023 Apr; ?(?):. doi: 10.2174/1567201820666230428124346. [PMID: 37132147]
  • Afnan Afnan, Ammara Saleem, Muhammad Furqan Akhtar. Chrysin, a 5,7-dihydroxyflavone restrains inflammatory arthritis in rats via subsiding oxidative stress biomarkers and inflammatory cytokines. Inflammopharmacology. 2023 Apr; ?(?):. doi: 10.1007/s10787-023-01229-6. [PMID: 37083920]
  • Shan-Shan Jie, Hui-Juan Sun, Jian-Xin Liu, Yan Gao, Dong Bai, Liu-Luan Zhu, Hong-Yan Zhao, Hui Zeng, Ya-Luan Ma. Simiao Yong'an decoction ameliorates murine collagen-induced arthritis by modulating neutrophil activities: An in vitro and in vivo study. Journal of ethnopharmacology. 2023 Apr; 305(?):116119. doi: 10.1016/j.jep.2022.116119. [PMID: 36596398]
  • Jyoti Rathee, Rohini Kanwar, Laxmi Kumari, Sandip V Pawar, Shikha Sharma, Md Ehesan Ali, Deepak B Salunke, Surinder Kumar Mehta. Development of nanostructured lipid carriers as a promising tool for methotrexate delivery: physicochemical and in vitro evaluation. Journal of biomolecular structure & dynamics. 2023 04; 41(7):2747-2758. doi: 10.1080/07391102.2022.2037465. [PMID: 35238266]
  • Jia Xu, Lu Zhang, Yanping Xu, Jiahui Yu, Lianyu Zhao, Hui Deng, Meiling Li, Mingying Zhang, Xujie Lei, Congqi Hu, Wei Jiao, Zhao Dai, Lijuan Liu, Guangxing Chen. Effectiveness of Yishen Tongbi decoction versus methotrexate in patients with active rheumatoid arthritis: A double-blind, randomized, controlled, non-inferiority trial. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Apr; 112(?):154704. doi: 10.1016/j.phymed.2023.154704. [PMID: 36796186]
  • Elif Tufan, Güzin Göksun Sivas, Begüm Gürel-Gökmen, Sümeyye Yılmaz-Karaoğlu, Ercan Dursun, Esin Çalışkan-Ak, Aleyna Muhan, Dilek Özbeyli, Göksel Şener, Tuğba Tunali-Akbay. Whey protein concentrate ameliorates the methotrexate-induced liver and kidney damage. The British journal of nutrition. 2023 Mar; ?(?):1-8. doi: 10.1017/s0007114523000752. [PMID: 36950976]
  • Somayeh Shahani, Nasrin Mehraban, Fereshteh Talebpour Amiri, Seyed Mohammad Abedi, Zohreh Noaparast, Salam Mohammadinia. Melissa Officinalis L. aqueous extract pretreatment decreases methotrexate-induced hepatotoxicity at lower dose and increases 99mTc-phytate liver uptake, as a probe of liver toxicity assessment, in rats. Annals of nuclear medicine. 2023 Mar; 37(3):166-175. doi: 10.1007/s12149-022-01813-w. [PMID: 36469234]
  • Selvaraj Sengottiyan, Alicja Mikolajczyk, Tomasz Puzyn. How Does the Study MD of pH-Dependent Exposure of Nanoparticles Affect Cellular Uptake of Anticancer Drugs?. International journal of molecular sciences. 2023 Feb; 24(4):. doi: 10.3390/ijms24043479. [PMID: 36834890]
  • Adil Aldhahrani. Paullinia cupana seed extract ameliorated methotrexate-induced testicular dysfunction through the regulation of antioxidants, inflammatory, apoptosis/anti-apoptosis, and steroidogenesis-associated genes. Environmental science and pollution research international. 2023 Feb; 30(6):15115-15127. doi: 10.1007/s11356-022-22698-2. [PMID: 36168017]
  • Sa-Sa Zhang, Yi-Jin Wu, Shu Pan, Qi-Hai Wang, Wen-Gang Chen, Zhong-Fang Wang, Jin-Ying Xu, Jian Zuo, Qin Yin. Xanthones from securidaca inappendiculata antagonizes the anti-rheumatic effect of methotrexate by inhibiting reduced folate carrier 1. Immunopharmacology and immunotoxicology. 2023 Feb; 45(1):16-25. doi: 10.1080/08923973.2022.2103707. [PMID: 35850595]
  • Jia Tian, Tao Chen, Baoxuan Huang, Yang Liu, Chao Wang, Zepeng Cui, Hao Xu, Qiang Li, Weian Zhang, Qianqian Liang. Inflammation specific environment activated methotrexate-loaded nanomedicine to treat rheumatoid arthritis by immune environment reconstruction. Acta biomaterialia. 2023 02; 157(?):367-380. doi: 10.1016/j.actbio.2022.12.007. [PMID: 36513249]
  • Graziela S Gomes, Luiza A Frank, Renata V Contri, Maria S Longhi, Adriana R Pohlmann, Silvia S Guterres. Nanotechnology-based alternatives for the topical delivery of immunosuppressive agents in psoriasis. International journal of pharmaceutics. 2023 Jan; 631(?):122535. doi: 10.1016/j.ijpharm.2022.122535. [PMID: 36566826]
  • Rahul Kumar, Vinish Ranjan Srivastava, Supratim Mahapatra, Daphika S Dkhar, Rohini Kumari, Kumari Prerna, Vikash Kumar Dubey, Pranjal Chandra. Drug Encapsulated Lipid-Polymeric Nanohybrid as a Chemo-therapeutic Platform of Cancer. Nanotheranostics. 2023; 7(2):167-175. doi: 10.7150/ntno.81173. [PMID: 36793351]
  • Adel Sadeq, Asim Ahmed Elnour, Azza Ramadan, Israa Yousif Kidir, Judit Don, Abdulla Al Amoodi, Nadia Al Mazrouei, Mohamed A Baraka, Farah Hamad Farah, Maisoun Alkaabi. Randomized Clinical Trials on the Efficacy and Safety of Tocilizumab in Subjects with Rheumatoid Arthritis: A Systematic Review. Current reviews in clinical and experimental pharmacology. 2023; 18(1):64-87. doi: 10.2174/2772432817666220202115623. [PMID: 35114930]
  • Jinying Fang, Mingxuan Liu, Zhenghui Huang, Yucao Ma, Yiwen Wang, Xiaojia Zheng, Liu Lv, Chunpin Liu, Wei Li, Zhenghong Zhu, Huachao Zhu, Jie Hu, Yonghong Wang, Hailong Wang. Efficacy and safety of TCMs with anti-inflammatory effect in patients with rheumatoid arthritis: A network meta-analysis. Frontiers in immunology. 2023; 14(?):1114930. doi: 10.3389/fimmu.2023.1114930. [PMID: 36969172]
  • Qian Rui, Jun Gao, Zheng-Zhi Yin, Junyao Li, Wenrong Cai, Datong Wu, Yong Kong. A biodegradable pH and glutathione dual-triggered drug delivery system based on mesoporous silica, carboxymethyl chitosan and oxidized pullulan. International journal of biological macromolecules. 2023 Jan; 224(?):1294-1302. doi: 10.1016/j.ijbiomac.2022.10.215. [PMID: 36306897]
  • Hiroki Ueno, Narumi Ohno, Takafumi Abe, Kazuki Kimoto, Chika Matsuoka, Mayumi Giga, Hiroyuki Naito, Tomoyuki Kono, Miyuki Takasu, Naoya Kidani, Rie Yamasaki, Koichi Ichimura, Eiichi Nomura. Prognosis Prediction Using Magnetic Resonance Spectroscopy and Oligoclonal Bands in Central Nervous System Methotrexate-associated Lymphoproliferative Disorder. Internal medicine (Tokyo, Japan). 2022 Dec; 61(24):3733-3738. doi: 10.2169/internalmedicine.9296-21. [PMID: 35598995]
  • Megan Sutcliffe, Nisha Nair, James Oliver, Ann W Morgan, John D Isaacs, Anthony G Wilson, Suzanne M M Verstappen, Sebastien Viatte, Kimme L Hyrich, Andrew P Morris, Anne Barton, Darren Plant. Pre-defined gene co-expression modules in rheumatoid arthritis transition towards molecular health following anti-TNF therapy. Rheumatology (Oxford, England). 2022 11; 61(12):4935-4944. doi: 10.1093/rheumatology/keac204. [PMID: 35377444]
  • Aveek Samanta, Saptadipa Banerjee, Tilak Raj Maity, Jangala Jahnavi, Siraj Datta. Towards establishment of a plant-based model to assess the novel anti-cancerous lead molecule(s): An in silico, in vivo and in vitro assessment of some potential anti-cancerous drugs on Lathyrus sativus L. Protoplasma. 2022 Nov; 259(6):1455-1466. doi: 10.1007/s00709-022-01745-2. [PMID: 35195768]
  • Mei Li, Jun Liang, Wenyou Pan, Lin Liu, Min Wu, Fuwan Ding, Huaixia Hu, Xiang Ding, Hua Wei, Yaohong Zou, Xian Qian, Meimei Wang, Jian Wu, Juan Tao, Jun Tan, Zhanyun Da, Miaojia Zhang, Jing Li, Xuebing Feng, Lihui Wen, Huayong Zhang, Lingyun Sun. Predictors of improvement in disease activity in first hospitalized patients with systemic lupus erythematosus: a multicenter retrospective study of a Chinese cohort. Clinical rheumatology. 2022 Nov; 41(11):3355-3362. doi: 10.1007/s10067-022-06289-7. [PMID: 35849245]
  • Jesica Ramírez-Santos, Fernando Calzada, Jessica Elena Mendieta-Wejebe, Rosa María Ordoñez-Razo, Rubria Marlen Martinez-Casares, Miguel Valdes. Understanding the Antilymphoma Activity of Annona macroprophyllata Donn and Its Acyclic Terpenoids: In Vivo, In Vitro, and In Silico Studies. Molecules (Basel, Switzerland). 2022 Oct; 27(20):. doi: 10.3390/molecules27207123. [PMID: 36296714]
  • Ahram Jang, Boryana Petrova, Taek-Chin Cheong, Miriam E Zawadzki, Jill K Jones, Andrew J Culhane, Frederick B Shipley, Roberto Chiarle, Eric T Wong, Naama Kanarek, Maria K Lehtinen. Choroid plexus-CSF-targeted antioxidant therapy protects the brain from toxicity of cancer chemotherapy. Neuron. 2022 10; 110(20):3288-3301.e8. doi: 10.1016/j.neuron.2022.08.009. [PMID: 36070751]
  • Nida Iftikhar, Ammara Saleem, Muhammad Furqan Akhtar, Ghulam Abbas, Shahid Shah, Shabana Bibi, Ghulam Md Ashraf, Badrah S Alghamdi, Turki S Abujamel. In Vitro and In Vivo Anti-Arthritic Potential of Caralluma tuberculata N. E. Brown. and Its Chemical Characterization. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196323. [PMID: 36234860]
  • Reda F A Abdelhameed, Shaimaa A Fattah, Eman T Mehanna, Dina M Hal, Sarah M Mosaad, Maged S Abdel-Kader, Amany K Ibrahim, Safwat A Ahmed, Jihan M Badr, Enas E Eltamany. Zygo-Albuside A: New Saponin from Zygophyllum album L. with Significant Antioxidant, Anti-Inflammatory and Antiapoptotic Effects against Methotrexate-Induced Testicular Damage. International journal of molecular sciences. 2022 Sep; 23(18):. doi: 10.3390/ijms231810799. [PMID: 36142712]
  • Jianbin Xu, Lianbo Xiao, Jie Zhu, Qiu Qin, Yuedie Fang, Jin-An Zhang. Methotrexate use reduces mortality risk in rheumatoid arthritis: A systematic review and meta-analysis of cohort studies. Seminars in arthritis and rheumatism. 2022 08; 55(?):152031. doi: 10.1016/j.semarthrit.2022.152031. [PMID: 35671648]
  • Noboru Hokama, Nobuyuki Hyakuna, Satoru Hamada, Hideo Shiohira, Koichi Nakanishi, Katsunori Nakamura. High-dose methotrexate therapy for a child with B-cell precursor acute lymphoblastic leukemia and congenital solitary kidney. Pediatric blood & cancer. 2022 08; 69(8):e29567. doi: 10.1002/pbc.29567. [PMID: 35084099]
  • Satoru Mitsuboshi, Takahiro Niimura, Masaya Kanda, Shunsuke Ishida, Yoshito Zamami, Keisuke Ishizawa. Risk of Hematologic Events With Coadministration of Methotrexate and the Breast Cancer Resistance Protein Inhibitor Febuxostat. The Annals of pharmacotherapy. 2022 08; 56(8):910-915. doi: 10.1177/10600280211055794. [PMID: 34726078]
  • Shima Ourani-Pourdashti, Esmaeil Mirzaei, Reza Heidari, Hajar Ashrafi, Amir Azadi. Preparation and evaluation of niosomal chitosan-based in situ gel formulation for direct nose-to-brain methotrexate delivery. International journal of biological macromolecules. 2022 Jul; 213(?):1115-1126. doi: 10.1016/j.ijbiomac.2022.06.031. [PMID: 35691430]
  • Heba S Zaky, Somaia A Abdel-Sattar, Albatoul Allam, Hebatalla I Ahmed. Further insights into the impact of rebamipide on gentamicin-induced nephrotoxicity in rats: modulation of SIRT1 and β-catenin/cyclin D1 pathways. Drug and chemical toxicology. 2022 Jul; ?(?):1-13. doi: 10.1080/01480545.2022.2104867. [PMID: 35899710]
  • Yugo Horiuchi, Kenichi Hashimoto, Hideyuki Horikoshi, Azusa Sano, Yusuke Kawamura, Naoya Fujita, Motohiro Kimata, Yosuke Ono, Yasuhiro Obuchi, Arisa Makino, Mayuko Kaneko, Fumihiko Kimura, Kenji Itoh, Yuji Tanaka. Fulminant elderly adult-onset Still disease effectively treated with tocilizumab and methotrexate: A case report. Medicine. 2022 Jul; 101(28):e29354. doi: 10.1097/md.0000000000029354. [PMID: 35839054]
  • Amira Akacha, Riadh Badraoui, Tarek Rebai, Lazhar Zourgui. Effect of Opuntia ficus indica extract on methotrexate-induced testicular injury: a biochemical, docking and histological study. Journal of biomolecular structure & dynamics. 2022 Jul; 40(10):4341-4351. doi: 10.1080/07391102.2020.1856187. [PMID: 33305699]
  • Yashika Mirchandani, Vandana B Patravale, S Brijesh. Hyaluronic acid-coated solid lipid nanoparticles enhance antirheumatic activity and reduce toxicity of methotrexate. Nanomedicine (London, England). 2022 07; 17(16):1099-1114. doi: 10.2217/nnm-2022-0009. [PMID: 36178114]
  • Koichi Sugihara, Risa Wakiya, Hiromi Shimada, Tomohiro Kameda, Shusaku Nakashima, Mikiya Kato, Taichi Miyagi, Mao Mizusaki, Rina Mino, Yumi Nomura, Masayuki Inoo, Norimitsu Kadowaki, Hiroaki Dobashi. Immunogenicity against the BNT162b2 mRNA COVID-19 Vaccine in Rheumatic Disease Patients Receiving Immunosuppressive Therapy. Internal medicine (Tokyo, Japan). 2022 Jul; 61(13):1953-1958. doi: 10.2169/internalmedicine.9223-21. [PMID: 35466168]
  • Jonathan Aldridge, Anna-Carin Lundell, Kerstin Andersson, Linda Mark, Merete Lund Hetland, Mikkel Østergaard, Till Uhlig, Marte Schrumpf Heiberg, Espen A Haavardsholm, Michael Nurmohamed, Jon Lampa, Dan Nordström, Kim Hørslev-Petersen, Bjorn Gudbjornsson, Gerdur Gröndal, Ronald van Vollenhoven, Anna Rudin. Blood chemokine levels are markers of disease activity but not predictors of remission in early rheumatoid arthritis. Clinical and experimental rheumatology. 2022 Jul; 40(7):1393-1402. doi: 10.55563/clinexprheumatol/idogmj. [PMID: 34796837]
  • Anne Grosen, Emanuelle Bellaguarda, Jacob Nersting, Christian Lodberg Hvas, Ingela Liljeqvist-Soltic, Adam Stein, Lisbet Ambrosius Christensen, Eric M Ruderman, Calvin R Brown, Kjeld Schmiegelow, John X Zhang, Jens Kelsen, Stephen B Hanauer. Low-dose Methotrexate Therapy Does Not Affect Semen Parameters and Sperm DNA. Inflammatory bowel diseases. 2022 07; 28(7):1012-1018. doi: 10.1093/ibd/izab205. [PMID: 34463329]
  • Xinran Chen, Liying Du, Mingfeng Liu. Development, validation, and application of an UPLC-MS/MS method for vancomycin, norvancomycin, methotrexate, paclitaxel, and imatinib analysis in human plasma. Annals of clinical biochemistry. 2022 07; 59(4):253-263. doi: 10.1177/00045632221077183. [PMID: 35209719]
  • Iman O Sherif, Nora H Al-Shaalan. Hepatoprotective effect of Ginkgo biloba extract against methotrexate-induced hepatotoxicity via targeting STAT3/miRNA-21 axis. Drug and chemical toxicology. 2022 Jul; 45(4):1723-1731. doi: 10.1080/01480545.2020.1862859. [PMID: 33349067]
  • David Banji, Otilia J F Banji, Shaik Rashida, Saeed Alshahrani, Saad S Alqahtani. Bioavailability, anti-inflammatory and anti-arthritic effect of Acetyl Keto Boswellic acid and its combination with methotrexate in an arthritic animal model. Journal of ethnopharmacology. 2022 Jun; 292(?):115200. doi: 10.1016/j.jep.2022.115200. [PMID: 35306043]
  • Fujian Zheng, Lei You, Wangshu Qin, Runze Ouyang, Wangjie Lv, Lei Guo, Xin Lu, Enyou Li, Xinjie Zhao, Guowang Xu. MetEx: A Targeted Extraction Strategy for Improving the Coverage and Accuracy of Metabolite Annotation in Liquid Chromatography-High-Resolution Mass Spectrometry Data. Analytical chemistry. 2022 Jun; 94(24):8561-8569. doi: 10.1021/acs.analchem.1c04783. [PMID: 35670335]
  • Ayan Pradhan, Shilpa Sengupta, Ritika Sengupta, Mitali Chatterjee. Attenuation of methotrexate induced hepatotoxicity by epigallocatechin 3-gallate. Drug and chemical toxicology. 2022 Jun; ?(?):1-9. doi: 10.1080/01480545.2022.2085738. [PMID: 35698845]
  • Habib MotieGhader, Parinaz Tabrizi-Nezhadi, Mahshid Deldar Abad Paskeh, Behzad Baradaran, Ahad Mokhtarzadeh, Mehrdad Hashemi, Hossein Lanjanian, Seyed Mehdi Jazayeri, Masoud Maleki, Ehsan Khodadadi, Sajjad Nematzadeh, Farzad Kiani, Mazaher Maghsoudloo, Ali Masoudi-Nejad. Drug repositioning in non-small cell lung cancer (NSCLC) using gene co-expression and drug-gene interaction networks analysis. Scientific reports. 2022 06; 12(1):9417. doi: 10.1038/s41598-022-13719-8. [PMID: 35676421]
  • Hainan Xu, Dali Cheng, Qing Yang, Dandan Wang. Multidisciplinary treatment of retroperitoneal ectopic pregnancy: a case report and literature review. BMC pregnancy and childbirth. 2022 Jun; 22(1):472. doi: 10.1186/s12884-022-04799-5. [PMID: 35672717]
  • Ammara Saleem, Huma Khalid, Muhammad Furqan Akhtar, Alam Zeb. HPLC -DAD analysis, anti-inflammatory and anti-arthritic potentials of Coronopus didymus (L.) Sm. extracts: effects on pro- and anti-inflammatory cytokines, COX-2, I-κβ, NF-κβ and oxidative stress biomarkers. Food & function. 2022 Jun; 13(11):6244-6258. doi: 10.1039/d2fo00207h. [PMID: 35587790]
  • Martin Feuchtenberger, Magdolna Szilvia Kovacs, Anna Eder, Axel Nigg, Arne Schäfer. Methotrexate significantly reduces the humoral vaccination response against SARS-CoV-2 in older but not younger patients with rheumatoid arthritis. Rheumatology international. 2022 06; 42(6):959-966. doi: 10.1007/s00296-022-05123-2. [PMID: 35429290]
  • Miao Li, Xiao-Yan Kong, Shu-Mei Wang. Analysis of the frequency distribution of five single-nucleotide polymorphisms of the MTRRgene in a Chinese pediatric population with acute lymphoblastic leukemia. Pharmacotherapy. 2022 06; 42(6):442-452. doi: 10.1002/phar.2685. [PMID: 35434830]
  • Carlo Scognamiglio Renner Araujo, Ana Cristina Medeiros-Ribeiro, Carla G S Saad, Karina Rossi Bonfiglioli, Diogo Souza Domiciano, Andrea Yukie Shimabuco, Matheus Santos Rodrigues Silva, Emily Figueiredo Neves Yuki, Sandra Gofinet Pasoto, Tatiana Pedrosa, Leonard de Vinci Kanda Kupa, Gioanna Zou, Rosa M R Pereira, Clóvis Artur Silva, Nádia Emi Aikawa, Eloisa Bonfa. Two-week methotrexate discontinuation in patients with rheumatoid arthritis vaccinated with inactivated SARS-CoV-2 vaccine: a randomised clinical trial. Annals of the rheumatic diseases. 2022 06; 81(6):889-897. doi: 10.1136/annrheumdis-2021-221916. [PMID: 35193873]
  • Khalaf Kridin, Yochai Schonmann, Arie Solomon, Giovanni Damiani, Dana Tzur Bitan, Erez Onn, Orly Weinstein, Arnon Dov Cohen. Risk of COVID-19 infection, hospitalization, and mortality in patients with psoriasis treated by interleukin-17 inhibitors. The Journal of dermatological treatment. 2022 Jun; 33(4):2014-2020. doi: 10.1080/09546634.2021.1905766. [PMID: 33759683]
  • J Hiltunen, P Parmanne, T Sokka, T Lamberg, P Isomäki, O Kaipiainen-Seppänen, R Peltomaa, T Uutela, L Pirilä, K Taimen, M J Kauppi, T Yli-Kerttula, R Tuompo, H Relas, S Kortelainen, K Paalanen, J Asikainen, P Ekman, A Santisteban, K-L Vidqvist, K Tadesse, M Romu, J Borodina, P Elfving, H Valleala, M Leirisalo-Repo, V Rantalaiho, H Kautiainen, T S Jokiranta, K K Eklund. Immunogenicity of subcutaneous TNF inhibitors and its clinical significance in real-life setting in patients with spondyloarthritis. Rheumatology international. 2022 06; 42(6):1015-1025. doi: 10.1007/s00296-021-04955-8. [PMID: 34357455]
  • Weiyan Zhou, Yuhang Deng, Chao Zhang, Zhenni Liu, Jiangtao Zhang, Li Zhou, Lijun Shao, Chuanbao Zhang. Current status of therapeutic drug monitoring for methotrexate, imatinib, paclitaxel in China. Clinical biochemistry. 2022 Jun; 104(?):44-50. doi: 10.1016/j.clinbiochem.2022.03.005. [PMID: 35331753]
  • Amanthi Nadira Arumahandi de Silva, Leonie Maria Frommert, Fredrik N Albach, Jens Klotsche, Veronika Scholz, Lara Maria Jeworowski, Tatjana Schwarz, Alexander Ten Hagen, Jan Zernicke, Victor Max Corman, Christian Drosten, Gerd-Rüdiger Burmester, Robert Biesen. Pausing methotrexate improves immunogenicity of COVID-19 vaccination in elderly patients with rheumatic diseases. Annals of the rheumatic diseases. 2022 06; 81(6):881-888. doi: 10.1136/annrheumdis-2021-221876. [PMID: 35288376]
  • Daniel H Kwon, Jose Cadena, Sam Nguyen, Kwan Ho Ryan Chan, Braden Soper, Amy L Gryshuk, Julian C Hong, Priyadip Ray, Franklin W Huang. COVID-19 outcomes in patients with cancer: Findings from the University of California health system database. Cancer medicine. 2022 Jun; 11(11):2204-2215. doi: 10.1002/cam4.4604. [PMID: 35261195]
  • Danielle G Creamer, Chad W Schmiedt, Anna Claire Bullington, Courtney M Caster, Jennifer M Schmiedt, David J Hurley, Roy D Berghaus. Influence of exposure to microbial ligands, immunosuppressive drugs and chronic kidney disease on endogenous immunomodulatory gene expression in feline adipose-derived mesenchymal stem cells. Journal of feline medicine and surgery. 2022 06; 24(6):e43-e56. doi: 10.1177/1098612x221083074. [PMID: 35302413]
  • Elif Tufan, Güzin Göksun Sivas, Begüm Gürel-Gökmen, Sümeyye Yılmaz-Karaoğlu, Dursun Ercan, Dilek Özbeyli, Göksel Şener, Tuğba Tunali-Akbay. Inhibitory effect of whey protein concentrate on SARS-CoV-2-targeted furin activity and spike protein-ACE2 binding in methotrexate-induced lung damage. Journal of food biochemistry. 2022 06; 46(6):e14039. doi: 10.1111/jfbc.14039. [PMID: 34981557]
  • Qi-Hai Wang, Shu Pan, Kui Yang, Yi-Jin Wu, Xiu-Ping Cheng, Opeyemi Joshua Olatunji, Qingcheng Mao, Jian Zuo. Glycolysis aggravates methotrexate toxicity by fueling RFC1-controlled intestinal absorption in rheumatic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):113067. doi: 10.1016/j.biopha.2022.113067. [PMID: 35658235]
  • Haixiao Wu, Guijun Xu, Zhijun Li, Yao Xu, Yile Lin, Vladimir P Chekhonin, Karl Peltzer, Jun Wang, Shu Li, Huiyang Li, Jin Zhang, Yuan Xue, Wenjuan Ma, Xin Wang, Chao Zhang. Nomogram predicting leukopenia in osteosarcoma after high-dose methotrexate chemotherapy. Aging. 2022 05; 14(12):5023-5033. doi: 10.18632/aging.203978. [PMID: 35640086]
  • Zahra Golsanamlou, Houman Kholafazad-Kordasht, Jafar Soleymani, Abolghasem Jouyban. Quantification of methotrexate in plasma samples using highly fluorescent nanoparticles. Journal of pharmaceutical and biomedical analysis. 2022 May; 214(?):114716. doi: 10.1016/j.jpba.2022.114716. [PMID: 35390574]
  • Cebrail Gursul, Adalet Ozcicek, Mustafa Ozkaraca, Ali Sefa Mendil, Taha Abdulkadir Coban, Aynur Arslan, Fatih Ozcicek, Halis Suleyman. Amelioration of oxidative damage parameters by carvacrol on methanol-induced liver injury in rats. Experimental animals. 2022 May; 71(2):224-230. doi: 10.1538/expanim.21-0143. [PMID: 34911876]