Sulfisoxazole (BioDeep_00000002005)

 

Secondary id: BioDeep_00000398997

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


4-amino-N-(dimethyl-1,2-oxazol-5-yl)benzene-1-sulfonamide

化学式: C11H13N3O3S (267.06775880000004)
中文名称: 磺胺二甲异唑
谱图信息: 最多检出来源 Mus musculus(blood) 33.33%

分子结构信息

SMILES: CC1=C(ON=C1C)NS(=O)(=O)C2=CC=C(C=C2)N
InChI: InChI=1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3

描述信息

Sulfisoxazole is only found in individuals that have used or taken this drug. It is a short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. [PubChem]Sulfisoxazole is a competitive inhibitor of the enzyme dihydropteroate synthetase. It inhibits bacterial synthesis of dihydrofolic acid by preventing the condensation of the pteridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3072; ORIGINAL_PRECURSOR_SCAN_NO 3068
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6520; ORIGINAL_PRECURSOR_SCAN_NO 6519
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3077; ORIGINAL_PRECURSOR_SCAN_NO 3073
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6493; ORIGINAL_PRECURSOR_SCAN_NO 6491
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6549; ORIGINAL_PRECURSOR_SCAN_NO 6547
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3096; ORIGINAL_PRECURSOR_SCAN_NO 3094
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3126; ORIGINAL_PRECURSOR_SCAN_NO 3125
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6542; ORIGINAL_PRECURSOR_SCAN_NO 6539
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6522; ORIGINAL_PRECURSOR_SCAN_NO 6521
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6555; ORIGINAL_PRECURSOR_SCAN_NO 6553
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3083; ORIGINAL_PRECURSOR_SCAN_NO 3080
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3067; ORIGINAL_PRECURSOR_SCAN_NO 3065
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01E - Sulfonamides and trimethoprim > J01EB - Short-acting sulfonamides
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AB - Sulfonamides
C254 - Anti-Infective Agent > C29739 - Sulfonamide Anti-Infective Agent
D000890 - Anti-Infective Agents > D013424 - Sulfanilamides
CONFIDENCE standard compound; INTERNAL_ID 1013
Sulfisoxazole (Sulfafurazole) is an orally active endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole is a sulfonamide antibacterial agent with an oxazole substituent. Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A[1][2].

同义名列表

74 个代谢物同义名

4-amino-N-(dimethyl-1,2-oxazol-5-yl)benzene-1-sulfonamide; 4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulphonamide; 4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide; 5-(p-Aminobenzenesulphonamido)-3,4-dimethylisoxazole; 5-(p-Aminobenzenesulfonamido)-3,4-dimethylisoxazole; 5-(4-Aminophenylsulphonamido)-3,4-dimethylisoxazole; 5-(4-Aminophenylsulfonamido)-3,4-dimethylisoxazole; N(1)-(3,4-Dimethyl-5-isoxazolyl)sulphanilamide; N(1)-(3,4-Dimethyl-5-isoxazolyl)sulfanilamide; Sulfisoxazole, monosodium, monomesylate salt; N-(3,4)dimethylisoxazol-5-yl-sulphanilamide; N-(3,4)dimethylisoxazol-5-yl-sulfanilamide; 5-Sulphanilamido-3,4-dimethyl-isoxazole; 5-Sulfanilamido-3,4-dimethyl-isoxazole; 3,4-Dimethylisoxazole-5-sulphanilamide; 5-Sulphanilamido-3,4-dimethylisoxazole; Roche brand OF sulfisoxazole diolamine; 3,4-Dimethyl-5-sulphanilamidoisoxazole; 5-Sulfanilamido-3,4-dimethylisoxazole; 3,4-Dimethylisoxazole-5-sulfanilamide; 3,4-Dimethyl-5-sulfanilamidoisoxazole; Roche brand OF sulfisoxazole acetate; 3,4-Dimethyl-5-sulphonamidoisoxazole; 3,4-Dimethyl-5-sulfonamidoisoxazole; Sulfisoxazole, triammonium salt; Sulfisoxazole, monolithium salt; Vangard brand OF sulfisoxazole; Monolithium salt sulfisoxazole; Sulfisoxazole, monosodium salt; Triammonium salt sulfisoxazole; Monosodium salt sulfisoxazole; Zenith brand OF sulfisoxazole; Roche brand OF sulfisoxazole; Sulfisoxazole, ammonium salt; Ammonium salt sulfisoxazole; FNA brand OF sulfisoxazole; Sulfisoxazole roche brand; Diolamine, sulfisoxazole; Sulfisoxazole dialamine; Sulphadimethylisoxazole; Sulfisoxazole diolamine; Sulfadimethylisoxazole; Pediatric, gantrisin; Sulfadimethyloxazole; Gantrisin pediatric; Sulfafurazol fna; Sulphaisoxazole; Sulphafurazolum; Sulphisonazole; Sulphisoxazole; Sulfaisoxazole; Sulphofurazole; Sulphisoxasole; Sulfafurazolum; Sulphasoxazole; Sulphafurazole; Sulfisonazole; sulfisoxazole; Sulfasoxizole; Sulphafurazol; Sulfasoxazole; Sulfafurazole; Sulfofurazole; Sulphisoxazol; Sulfisoxasole; Sulfafurazol; Sulfisoxazol; Gantrisin; Neoxazoi; TL Azole; TL-Azole; ganda; V-Sul; V Sul



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hyun-Ju Song, Dong Chan Moon, Su-Jeong Kim, Abraham Fikru Mechesso, Ji-Hyun Choi, Naila Boby, Hee Young Kang, Seok-Hyeon Na, Soon-Seek Yoon, Suk-Kyung Lim. Antimicrobial Resistance Profiles and Molecular Characteristics of Extended-Spectrum β-Lactamase-Producing Escherichia coli Isolated from Healthy Cattle and Pigs in Korea. Foodborne pathogens and disease. 2023 01; 20(1):7-16. doi: 10.1089/fpd.2022.0051. [PMID: 36577050]
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  • Bai Wei, Ke Shang, Se-Yeoun Cha, Jun-Feng Zhang, Hyung-Kwan Jang, Min Kang. Clonal dissemination of Salmonella enterica serovar albany with concurrent resistance to ampicillin, chloramphenicol, streptomycin, sulfisoxazole, tetracycline, and nalidixic acid in broiler chicken in Korea. Poultry science. 2021 Jul; 100(7):101141. doi: 10.1016/j.psj.2021.101141. [PMID: 34089935]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Ayanna Glaize, Eduardo Gutierrez-Rodriguez, Irene Hanning, Sandra Díaz-Sánchez, Chris Gunter, Arnoud H M van Vliet, Wes Watson, Siddhartha Thakur. Transmission of antimicrobial resistant non-O157 Escherichia coli at the interface of animal-fresh produce in sustainable farming environments. International journal of food microbiology. 2020 Apr; 319(?):108472. doi: 10.1016/j.ijfoodmicro.2019.108472. [PMID: 31901751]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Cynthia N Schreiner, Charles E Ahlfors, Ronald J Wong, David K Stevenson, Diana F Clarke, Mark Mirochnick. In Vitro Study on the Effect of Maraviroc or Dolutegravir on Bilirubin to Albumin Binding. The Pediatric infectious disease journal. 2018 09; 37(9):908-909. doi: 10.1097/inf.0000000000002011. [PMID: 29561509]
  • Zuhal Alim, Deryanur Kilic, Zeynep Koksal, Sukru Beydemir, Hasan Ozdemir. Assessment of the inhibitory effects and molecular docking of some sulfonamides on human serum paraoxonase 1. Journal of biochemical and molecular toxicology. 2017 Oct; 31(10):. doi: 10.1002/jbt.21950. [PMID: 28665493]
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  • Hanne Tegnander Soligard, Dag Bratlid, Chunyu Cao, Aihua Liang, Odd Georg Nilsen. Displacement of bilirubin from albumin in plasma from jaundiced newborns. An in vitro study of purified Chinese herbal constituents and sulfisoxazole. Phytotherapy research : PTR. 2011 Jul; 25(7):1068-72. doi: 10.1002/ptr.3402. [PMID: 21280114]
  • Jang-Gi Choi, Ok-Hwa Kang, Young-Seob Lee, Hee-Sung Chae, You-Chang Oh, Obiang-Obounou Brice, Min-San Kim, Dong-Hwan Sohn, Hun-Soo Kim, Hyun Park, Dong-Won Shin, Jung-Rae Rho, Dong-Yeul Kwon. In Vitro and In Vivo Antibacterial Activity of Punica granatum Peel Ethanol Extract against Salmonella. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):690518. doi: 10.1093/ecam/nep105. [PMID: 19687188]
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  • Paolo Ascenzi, Alessandro Bolli, Francesca Gullotta, Gabriella Fanali, Mauro Fasano. Drug binding to Sudlow's site I impairs allosterically human serum heme-albumin-catalyzed peroxynitrite detoxification. IUBMB life. 2010 Oct; 62(10):776-80. doi: 10.1002/iub.381. [PMID: 20979209]
  • Hanne T Soligard, Odd G Nilsen, Dag Bratlid. Displacement of bilirubin from albumin by ibuprofen in vitro. Pediatric research. 2010 Jun; 67(6):614-8. doi: 10.1203/pdr.0b013e3181da7578. [PMID: 20216106]
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  • M Aslam, K Stanford, T A McAllister. Characterization of antimicrobial resistance and seasonal prevalence of Escherichia coli O157:H7 recovered from commercial feedlots in Alberta, Canada. Letters in applied microbiology. 2010 Mar; 50(3):320-6. doi: 10.1111/j.1472-765x.2010.02798.x. [PMID: 20102509]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
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  • Mohammad Jahangir Alam, David Renter, Ethel Taylor, Diana Mina, Rodney Moxley, David Smith. Antimicrobial susceptibility profiles of Salmonella enterica serotypes recovered from pens of commercial feedlot cattle using different types of composite samples. Current microbiology. 2009 Apr; 58(4):354-9. doi: 10.1007/s00284-008-9347-x. [PMID: 19219500]
  • Csaba Varga, Andrijana Rajić, Margaret E McFall, Richard J Reid-Smith, Anne E Deckert, Sylvia L Checkley, Scott A McEwen. Associations between reported on-farm antimicrobial use practices and observed antimicrobial resistance in generic fecal Escherichia coli isolated from Alberta finishing swine farms. Preventive veterinary medicine. 2009 Mar; 88(3):185-92. doi: 10.1016/j.prevetmed.2008.10.002. [PMID: 19041147]
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  • Charles E Ahlfors. Effect of ibuprofen on bilirubin-albumin binding. The Journal of pediatrics. 2004 Mar; 144(3):386-8. doi: 10.1016/j.jpeds.2003.11.027. [PMID: 15001951]
  • Hisao Oka, Yuko Ito, Tomomi Goto, Tamae Minami, Isao Yamamoto, Hiroshi Matsumoto, Yoshihisa Mizuno, Masukiyo Tsuruta, Itsuki Hayashi. Survey of residual tetracycline antibiotics and sulfa drugs in kidneys of diseased animals in the Aichi Prefecture, Japan (1995-1999). Journal of AOAC International. 2003 May; 86(3):494-500. doi: 10.1093/jaoac/86.3.494. [PMID: 12852565]
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