TOLYLFLUANID (BioDeep_00000001968)

   


代谢物信息卡片


dichloro-N-[(dimethylamino)sulphonyl]fluoro-N-(p-tolyl)methanesulphenamide

化学式: C10H13Cl2FN2O2S2 (345.978)
中文名称: 甲苯氟磺胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC=C(C=C1)N(SC(F)(Cl)Cl)S(=O)(=O)N(C)C
InChI: InChI=1S/C10H13Cl2FN2O2S2/c1-8-4-6-9(7-5-8)15(18-10(11,12)13)19(16,17)14(2)3/h4-7H,1-3H3



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ADIG, AKT1, IRS1, MTOR, NR3C1, PIK3C3, PPARG, TSC22D3
Peripheral membrane protein 1 MTOR
Endosome membrane 1 INSR
Endoplasmic reticulum membrane 1 MTOR
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 8 ADIG, AKT1, IRS1, MPC2, MTOR, NR3C1, PPARG, TSC22D3
autophagosome 1 PIK3C3
cytosol 9 AKT1, IRS1, LEP, MTOR, NR3C1, PIK3C3, PPARG, TAT, TSC22D3
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
centrosome 1 NR3C1
nucleoplasm 5 AKT1, IRS1, MTOR, NR3C1, PPARG
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 2 AKT1, INSR
Cytoplasmic side 1 MTOR
lamellipodium 1 AKT1
Multi-pass membrane protein 1 MPC2
Golgi apparatus membrane 1 MTOR
Synapse 1 NR3C1
cell cortex 1 AKT1
cell surface 1 ADIPOQ
glutamatergic synapse 2 AKT1, PIK3C3
Golgi membrane 2 INS, MTOR
lysosomal membrane 1 MTOR
mitochondrial inner membrane 1 MPC2
postsynapse 1 AKT1
Lysosome 2 INSR, MTOR
endosome 1 PIK3C3
plasma membrane 3 AKT1, INSR, IRS1
Membrane 6 ADIG, AKT1, INSR, MTOR, NR3C1, PIK3C3
axon 1 INSR
caveola 2 INSR, IRS1
extracellular exosome 1 INSR
Lysosome membrane 1 MTOR
endoplasmic reticulum 1 ADIPOQ
extracellular space 3 ADIPOQ, INS, LEP
perinuclear region of cytoplasm 1 PPARG
mitochondrion 3 MPC2, NR3C1, PCK2
protein-containing complex 2 AKT1, NR3C1
intracellular membrane-bounded organelle 2 IRS1, PPARG
Microsome membrane 1 MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 INSR
Secreted 4 ADIG, ADIPOQ, INS, LEP
extracellular region 4 ADIG, ADIPOQ, INS, LEP
Mitochondrion outer membrane 1 MTOR
Single-pass membrane protein 1 ADIG
mitochondrial outer membrane 1 MTOR
neuronal cell body membrane 1 INSR
mitochondrial matrix 2 NR3C1, PCK2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 NR3C1
external side of plasma membrane 1 INSR
microtubule cytoskeleton 1 AKT1
midbody 1 PIK3C3
cell-cell junction 1 AKT1
vesicle 1 AKT1
Mitochondrion inner membrane 1 MPC2
Cytoplasm, cytoskeleton, spindle 1 NR3C1
spindle 2 AKT1, NR3C1
GABA-ergic synapse 1 PIK3C3
Peroxisome 1 PIK3C3
collagen trimer 1 ADIPOQ
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ADIPOQ
axoneme 1 PIK3C3
nuclear speck 1 NR3C1
Late endosome 2 INSR, PIK3C3
receptor complex 2 INSR, PPARG
ciliary basal body 1 AKT1
chromatin 2 NR3C1, PPARG
phagocytic vesicle membrane 1 PIK3C3
Chromosome 1 NR3C1
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
endosome lumen 1 INS
Lipid droplet 1 ADIG
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
Nucleus, nucleoplasm 1 NR3C1
[Isoform 1]: Cytoplasm 1 TSC22D3
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
presynaptic endosome 1 PIK3C3
dendrite membrane 1 INSR
Cytoplasmic vesicle, phagosome 1 MTOR
[Isoform Alpha]: Cytoplasm 1 NR3C1
postsynaptic endosome 1 PIK3C3
inner mitochondrial membrane protein complex 1 MPC2
Autolysosome 1 PIK3C3
[Isoform Beta]: Nucleus 1 NR3C1
[Isoform Alpha-B]: Nucleus 1 NR3C1
insulin receptor complex 2 INSR, IRS1


文献列表

  • A'Lexxus F Davis, Allen A Thomas, Kimberly S Shorter, Stephan L Brown, Bradley L Baumgarner. Cellular fatty acid level regulates the effect of tolylfluanid on mitochondrial dysfunction and insulin sensitivity in C2C12 skeletal myotubes. Biochemical and biophysical research communications. 2018 10; 505(2):392-398. doi: 10.1016/j.bbrc.2018.09.131. [PMID: 30262144]
  • Jessica K Hartman, Tyler Beames, Bethany Parks, Daniel Doheny, Gina Song, Alina Efremenko, Miyoung Yoon, Briana Foley, Chad Deisenroth, Patrick D McMullen, Rebecca A Clewell. An in vitro approach for prioritization and evaluation of chemical effects on glucocorticoid receptor mediated adipogenesis. Toxicology and applied pharmacology. 2018 09; 355(?):112-126. doi: 10.1016/j.taap.2018.05.016. [PMID: 29782964]
  • Shane M Regnier, Andrew G Kirkley, Honggang Ye, Essam El-Hashani, Xiaojie Zhang, Brian A Neel, Wakanene Kamau, Celeste C Thomas, Ayanna K Williams, Emily T Hayes, Nicole L Massad, Daniel N Johnson, Lei Huang, Chunling Zhang, Robert M Sargis. Dietary exposure to the endocrine disruptor tolylfluanid promotes global metabolic dysfunction in male mice. Endocrinology. 2015 Mar; 156(3):896-910. doi: 10.1210/en.2014-1668. [PMID: 25535829]
  • S Gielen, L Vogels, B Seels, R Aerts. Phytotoxicity of tolylfluanid in tomatoes. Communications in agricultural and applied biological sciences. 2006; 71(2 Pt A):79-82. doi: . [PMID: 17390776]