Carbimazole (BioDeep_00000001923)

 

Secondary id: BioDeep_00000399169

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


ethyl 3-methyl-2-sulfanylidene-2,3-dihydro-1H-imidazole-1-carboxylate

化学式: C7H10N2O2S (186.0463)
中文名称: 卡比吗唑, 卡比马唑
谱图信息: 最多检出来源 Homo sapiens(plant) 8.57%

分子结构信息

SMILES: CCOC(=O)N1C=CN(C)C1=S
InChI: InChI=1S/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H,3H2,1-2H3

描述信息

Carbimazole is only found in individuals that have used or taken this drug. It is an imidazole antithyroid agent. Carbimazole is metabolized to methimazole, which is responsible for the antithyroid activity. [PubChem]Carbimazole is an aitithyroid agent that decreases the uptake and concentration of inorganic iodine by thyroid, it also reduces the formation of di-iodotyrosine and thyroxine. Once converted to its active form of methimazole, it prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4.
H - Systemic hormonal preparations, excl. sex hormones and insulins > H03 - Thyroid therapy > H03B - Antithyroid preparations > H03BB - Sulfur-containing imidazole derivatives
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D013956 - Antithyroid Agents
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist > C885 - Antithyroid Agent

同义名列表

23 个代谢物同义名

ethyl 3-methyl-2-sulfanylidene-2,3-dihydro-1H-imidazole-1-carboxylate; Ethyl 3-methyl-2-thioimidazoline-1-carboxylic acid; Ethyl 3-methyl-2-thioimidazoline-1-carboxylate; Sanofi synthelabo brand OF carbimazole; Henning berlin brand OF carbimazole; Herbrand brand OF carbimazole; Tarbis brand OF carbimazole; Roche brand OF carbimazole; Carbethoxymethimazole; Carbimazole henning; Carbimazol henning; Neo-thyreostat; Neo-mercazole; Neomercazole; Carbimazolum; Athyromazole; Carbinazole; Neo tomizol; Carbimazole; Carbimazol; Thyrostat; Carbimazole; Carbimazole



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ALB, BCL2, CAT, POMC, TSHB
Peripheral membrane protein 1 PRTN3
Endosome membrane 1 HLA-B
Endoplasmic reticulum membrane 2 BCL2, HLA-B
Nucleus 4 ALB, BCL2, MPO, PCNA
cytosol 5 ALB, BCL2, CAT, GPT, PRTN3
nuclear body 1 PCNA
centrosome 2 ALB, PCNA
nucleoplasm 2 MPO, PCNA
Cell membrane 3 HLA-B, PRTN3, TSHR
Cytoplasmic granule 1 PRTN3
Early endosome membrane 1 HLA-B
Multi-pass membrane protein 1 TSHR
cell surface 3 HLA-B, TPO, TSHR
Golgi apparatus 2 ALB, HLA-B
Golgi membrane 2 HLA-B, INS
lysosomal membrane 2 CP, HLA-B
Lysosome 1 MPO
plasma membrane 6 CP, CSF2, HLA-B, PRTN3, TPO, TSHR
Membrane 5 BCL2, CAT, HLA-B, TPO, TSHR
basolateral plasma membrane 1 TSHR
extracellular exosome 9 ALB, CAT, CP, GPT, HLA-B, MPO, PCNA, PRTN3, SHBG
Lysosome membrane 1 HLA-B
endoplasmic reticulum 3 ALB, BCL2, HLA-B
extracellular space 13 ALB, CP, CSF2, CSF3, HLA-B, IL2, INS, MPO, POMC, PRTN3, TG, TPO, TSHB
lysosomal lumen 1 CSF3
mitochondrion 2 BCL2, CAT
protein-containing complex 3 ALB, BCL2, CAT
intracellular membrane-bounded organelle 4 CAT, CSF2, MPO, PRTN3
Single-pass type I membrane protein 2 HLA-B, TPO
Secreted 12 ALB, CP, CSF2, CSF3, IL2, INS, POMC, PRTN3, SHBG, TG, TRH, TSHB
extracellular region 14 ALB, CAT, CP, CSF2, CSF3, IL2, INS, MPO, POMC, PRTN3, SHBG, TG, TRH, TSHB
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, HLA-B
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 CAT
Extracellular side 1 PRTN3
anchoring junction 1 ALB
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 HLA-B
Membrane raft 1 PRTN3
pore complex 1 BCL2
focal adhesion 1 CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
secretory granule 3 MPO, POMC, TRH
lateral plasma membrane 1 TSHR
receptor complex 1 TSHR
ciliary basal body 1 ALB
chromatin 1 PCNA
phagocytic vesicle membrane 1 HLA-B
centriole 1 ALB
spindle pole 1 ALB
nuclear replication fork 1 PCNA
chromosome, telomeric region 1 PCNA
blood microparticle 2 ALB, CP
Basolateral cell membrane 1 TSHR
Recycling endosome membrane 1 HLA-B
endosome lumen 1 INS
replication fork 1 PCNA
myelin sheath 1 BCL2
azurophil granule 1 MPO
plasma membrane raft 1 PRTN3
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 3 CAT, INS, POMC
secretory granule membrane 1 HLA-B
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, CP, INS
male germ cell nucleus 1 PCNA
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
azurophil granule lumen 2 MPO, PRTN3
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
ER to Golgi transport vesicle membrane 1 HLA-B
nuclear lamina 1 PCNA
phagocytic vesicle lumen 1 MPO
lumenal side of endoplasmic reticulum membrane 1 HLA-B
granulocyte macrophage colony-stimulating factor receptor complex 1 CSF2
cyclin-dependent protein kinase holoenzyme complex 1 PCNA
endocytic vesicle lumen 1 CSF3
MHC class I protein complex 1 HLA-B
MHC class II protein complex 1 HLA-B
catalase complex 1 CAT
BAD-BCL-2 complex 1 BCL2
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
ciliary transition fiber 1 ALB


文献列表

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