Classification Term: 452

Carbonylimidazoles (ontology term: CHEMONTID:0002529)

Substituted imidazoles in which the imidazole ring bears a carbonyl group." []

found 11 associated metabolites at family metabolite taxonomy ontology rank level.

Ancestor: Substituted imidazoles

Child Taxonomies: There is no child term of current ontology term.

Etomidate

(R)-(+)-1-(alpha-Methylbenzyl)imidazole-5-carboxylic acid ethyl ester

C14H16N2O2 (244.1211716)


Etomidate is only found in individuals that have used or taken this drug. It is an midazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic. [PubChem]Etomidate binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent

   

Carbimazole

ethyl 3-methyl-2-sulfanylidene-2,3-dihydro-1H-imidazole-1-carboxylate

C7H10N2O2S (186.046296)


Carbimazole is only found in individuals that have used or taken this drug. It is an imidazole antithyroid agent. Carbimazole is metabolized to methimazole, which is responsible for the antithyroid activity. [PubChem]Carbimazole is an aitithyroid agent that decreases the uptake and concentration of inorganic iodine by thyroid, it also reduces the formation of di-iodotyrosine and thyroxine. Once converted to its active form of methimazole, it prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4. H - Systemic hormonal preparations, excl. sex hormones and insulins > H03 - Thyroid therapy > H03B - Antithyroid preparations > H03BB - Sulfur-containing imidazole derivatives D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D013956 - Antithyroid Agents C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist > C885 - Antithyroid Agent

   

N-Acetylimidazole

1-(1H-imidazol-1-yl)ethan-1-one

C5H6N2O (110.0480106)


   

1,1'-Oxalyldiimidazole

bis(1H-imidazol-1-yl)ethane-1,2-dione

C8H6N4O2 (190.0490736)


   

1,1'-Carbonyldiimidazole

1-(1H-imidazole-1-carbonyl)-1H-imidazole

C7H6N4O (162.0541586)


   

Metomidate

Methyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid

C13H14N2O2 (230.1055224)


   

n-Heptafluorobutyrylimidazole

2,2,3,3,4,4,4-heptafluoro-1-(1H-imidazol-1-yl)butan-1-one

C7H3F7N2O (264.0133592)


   

Propoxate

Propyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid

C15H18N2O2 (258.1368208)


   

Propranolol glucuronide

3,4,5-trihydroxy-6-{[1-(naphthalen-1-yloxy)-3-[(propan-2-yl)amino]propan-2-yl]oxy}oxane-2-carboxylic acid

C22H29NO8 (435.1893074)


   

4-[(2R)-2-Aminopropyl]imidazole-1-carboxylic acid

4-[(2R)-2-Aminopropyl]imidazole-1-carboxylic acid

C7H11N3O2 (169.0851226)


   

Cyclopropyl-methoxycarbonyl metomidate

1-(Methoxycarbonyl)cyclopropyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid

C17H18N2O4 (314.1266508)


D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018755 - GABA Agonists