(R)-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE (BioDeep_00001874807)
BioNovoGene_Lab2019
代谢物信息卡片
1-methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol
化学式: C10H13NO2 (179.09462380000002)
中文名称: 1,2,3,4-四氢-1-甲基-6,7-异喹啉二醇
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C2=CC(=C(C=C2CCN1)O)O
InChI: InChI=1S/C10H13NO2/c1-6-8-5-10(13)9(12)4-7(8)2-3-11-6/h4-6,11-13H,2-3H2,1H3
描述信息
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:194221
- ChEBI: CHEBI:88801
- PubChem: 54456
- ChEMBL: CHEMBL416732
- CAS: 525-72-4
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-506
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Bruk Getachew, Antonei B Csoka, Robert L Copeland, Kebreten F Manaye, Yousef Tizabi. Dihydromyricetin Protects Against Salsolinol-Induced Toxicity in Dopaminergic Cell Line: Implication for Parkinson's Disease.
Neurotoxicity research.
2022 Dec; ?(?):. doi:
10.1007/s12640-022-00631-2. [PMID: 36585544] - Qianqian Xiong, Xiaotong Zheng, Jianan Wang, Zixuan Chen, Yulin Deng, Rugang Zhong, Juan Wang, Xuechai Chen. Sal synthase induced cytotoxicity of PC12 cells through production of the dopamine metabolites salsolinol and N-methyl-salsolinol.
Journal of integrative neuroscience.
2022 Mar; 21(2):71. doi:
10.31083/j.jin2102071. [PMID: 35364659] - Gabriel Gonzalez, Jiří Grúz, Cosimo Walter D'Acunto, Petr Kaňovský, Miroslav Strnad. Cytokinin Plant Hormones Have Neuroprotective Activity in In Vitro Models of Parkinson's Disease.
Molecules (Basel, Switzerland).
2021 Jan; 26(2):. doi:
10.3390/molecules26020361. [PMID: 33445611] - Yuxia Yang, Ping Hu, Xianjian Zhou, Ping Wu, Xinxin Si, Bo Lu, Yanxi Zhu, Yanli Xia. Transcriptome analysis of Aconitum carmichaelii and exploration of the salsolinol biosynthetic pathway.
Fitoterapia.
2020 Jan; 140(?):104412. doi:
10.1016/j.fitote.2019.104412. [PMID: 31698060] - Er-Lan Yang, Bin Sun, Zi-Yi Huang, Jian-Guang Lin, Bo Jiao, Lan Xiang. Synthesis, Purification, and Selective β2-AR Agonist and Bronchodilatory Effects of Catecholic Tetrahydroisoquinolines from Portulaca oleracea.
Journal of natural products.
2019 11; 82(11):2986-2993. doi:
10.1021/acs.jnatprod.9b00418. [PMID: 31625751] - Tomasz Misztal, Małgorzata Hasiec, Michał Szlis, Dorota Tomaszewska-Zaremba, Elżbieta Marciniak. Stimulatory effect of dopamine derivative, salsolinol, on pulsatile luteinizing hormone secretion in seasonally anestrous sheep: Focus on dopamine, kisspeptin and gonadotropin-releasing hormone.
Animal reproduction science.
2019 Sep; 208(?):106102. doi:
10.1016/j.anireprosci.2019.06.014. [PMID: 31405485] - Magdalena Kurnik-Łucka, Pertti Panula, Andrzej Bugajski, Krzysztof Gil. Salsolinol: an Unintelligible and Double-Faced Molecule-Lessons Learned from In Vivo and In Vitro Experiments.
Neurotoxicity research.
2018 02; 33(2):485-514. doi:
10.1007/s12640-017-9818-6. [PMID: 29063289] - K Górski, T Misztal, E Marciniak, M K Zielińska-Górska, F Fülöp, K Romanowicz. Involvement of salsolinol in the suckling-induced oxytocin surge in sheep.
Domestic animal endocrinology.
2017 04; 59(?):75-80. doi:
10.1016/j.domaniend.2016.11.001. [PMID: 28013044] - E Marciniak, M Hasiec, F Fülöp, T Misztal. Salsolinol-a potential inhibitor of the gonadotropic axis in sheep during lactation.
Domestic animal endocrinology.
2017 01; 58(?):97-103. doi:
10.1016/j.domaniend.2016.09.003. [PMID: 27792889] - Magdalena Kurnik-Lucka, Krzysztof Gil, Andrzej Bugajski, Agata Furgała, Piotr Thor. Nutritional parameters and carbohydrate and fat metabolism after prolonged salsolinol administration in rats fed normal or high-fat diets.
Neuro endocrinology letters.
2016 Dec; 37(7):501-510. doi:
. [PMID: 28326744] - Yuki Inaba, Yuki Kato, Azumi Itou, Aoi Chiba, Ken Sawai, Ferenc Fülöp, György Miklos Nagy, Tsutomu Hashizume. Effects of extracerebral dopamine on salsolinol- or thyrotropin-releasing hormone-induced prolactin (PRL) secretion in goats.
Animal science journal = Nihon chikusan Gakkaiho.
2016 Dec; 87(12):1522-1527. doi:
10.1111/asj.12586. [PMID: 26997651] - Elżbieta Marciniak, Konrad Górski, Małgorzata Hasiec, Tomasz Misztal. Hypothalamic-pituitary GnRH/LH axis activity is affected by salsolinol in sheep during lactation: Effects of intracerebroventricular infusions of salsolinol and its antagonizing analogue.
Theriogenology.
2016 Nov; 86(8):1931-8. doi:
10.1016/j.theriogenology.2016.06.005. [PMID: 27393219] - K Górski, E Marciniak, M Zielińska-Górska, T Misztal. Salsolinol Up-Regulates Oxytocin Expression and Release During Lactation in Sheep.
Journal of neuroendocrinology.
2016 Mar; 28(3):12362. doi:
10.1111/jne.12362. [PMID: 26749292] - M Hasiec, A P Herman, T Misztal. Salsolinol: a potential modulator of the activity of the hypothalamic-pituitary-adrenal axis in nursing and postweaning sheep.
Domestic animal endocrinology.
2015 Oct; 53(?):26-34. doi:
10.1016/j.domaniend.2015.04.004. [PMID: 26057577] - M Hasiec, D Tomaszewska-Zaremba, T Misztal. Suckling and salsolinol attenuate responsiveness of the hypothalamic-pituitary-adrenal axis to stress: focus on catecholamines, corticotrophin-releasing hormone, adrenocorticotrophic hormone, cortisol and prolactin secretion in lactating sheep.
Journal of neuroendocrinology.
2014 Dec; 26(12):844-52. doi:
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Acta biochimica et biophysica Sinica.
2014 Nov; 46(11):950-6. doi:
10.1093/abbs/gmu094. [PMID: 25274329] - Jin Jin, Sayaka Hara, Ken Sawai, Ferenc Fülöp, György Miklos Nagy, Tsutomu Hashizume. Effects of hypothalamic dopamine (DA) on salsolinol (SAL)-induced prolactin (PRL) secretion in male goats.
Animal science journal = Nihon chikusan Gakkaiho.
2014 Apr; 85(4):461-7. doi:
10.1111/asj.12157. [PMID: 24329779] - Zakiya Qualls, Dwayne Brown, Carlana Ramlochansingh, Laura L Hurley, Yousef Tizabi. Protective effects of curcumin against rotenone and salsolinol-induced toxicity: implications for Parkinson's disease.
Neurotoxicity research.
2014 Jan; 25(1):81-9. doi:
10.1007/s12640-013-9433-0. [PMID: 24122264] - Gabrielle D Briggs, Gyorgy M Nagy, Phillip W Dickson. Mechanism of action of salsolinol on tyrosine hydroxylase.
Neurochemistry international.
2013 Dec; 63(8):726-31. doi:
10.1016/j.neuint.2013.09.016. [PMID: 24083987] - Mariko Murata, Kaoru Midorikawa, Shosuke Kawanishi. Oxidative DNA damage and mammary cell proliferation by alcohol-derived salsolinol.
Chemical research in toxicology.
2013 Oct; 26(10):1455-63. doi:
10.1021/tx400182n. [PMID: 24020587] - Tsutomu Hashizume, Tomoyoshi Yaegashi, Jin Jin, Ken Sawai, Ferenc Fülöp, György Miklos Nagy. Effects of melatonin on salsolinol-induced prolactin secretion in goats.
Animal science journal = Nihon chikusan Gakkaiho.
2013 Apr; 84(4):334-40. doi:
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Journal of ethnopharmacology.
2012 Mar; 140(1):166-78. doi:
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Folia medica Cracoviensia.
2012; 52(3-4):5-20. doi:
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Acta neurobiologiae experimentalis.
2011; 71(3):305-12. doi:
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Neuroscience.
2010 Nov; 170(4):1165-71. doi:
10.1016/j.neuroscience.2010.08.011. [PMID: 20708656] - K Górski, K Romanowicz, A Herman, E Molik, A Gajewska, D Tomaszewska-Zaremba, T Misztal. The possible involvement of salsolinol and hypothalamic prolactin in the central regulatory processes in ewes during lactation.
Reproduction in domestic animals = Zuchthygiene.
2010 Oct; 45(5):e54-60. doi:
10.1111/j.1439-0531.2009.01521.x. [PMID: 19747187] - Jeongrim Lee, Vijay A Ramchandani, Kei Hamazaki, Eric A Engleman, William J McBride, Ting-Kai Li, Hee-Yong Kim. A critical evaluation of influence of ethanol and diet on salsolinol enantiomers in humans and rats.
Alcoholism, clinical and experimental research.
2010 Feb; 34(2):242-50. doi:
10.1111/j.1530-0277.2009.01087.x. [PMID: 19951298] - Konrad Górski, Katarzyna Romanowicz, Edyta Molik, Ferenc Fulop, Tomasz Misztal. Effects of salsolinol and its antagonistic analogue, 1-MeDIQ, on growth hormone release in nursing sheep.
Acta neurobiologiae experimentalis.
2010; 70(1):20-7. doi:
. [PMID: 20407483] - T Hashizume, Y Onodera, R Shida, E Isobe, S Suzuki, K Sawai, E Kasuya, G M Nagy. Characteristics of prolactin-releasing response to salsolinol (SAL) and thyrotropin-releasing hormone (TRH) in ruminants.
Domestic animal endocrinology.
2009 Feb; 36(2):99-104. doi:
10.1016/j.domaniend.2008.11.001. [PMID: 19070987] - Tomasz Misztal, Konrad Górski, Dorota Tomaszewska-Zaremba, Edyta Molik, Katarzyna Romanowicz. Identification of salsolinol in the mediobasal hypothalamus of lactating ewes and its relation to suckling-induced prolactin and GH release.
The Journal of endocrinology.
2008 Jul; 198(1):83-9. doi:
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Bioorganic & medicinal chemistry letters.
2008 Apr; 18(7):2475-8. doi:
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Domestic animal endocrinology.
2008 Feb; 34(2):146-52. doi:
10.1016/j.domaniend.2006.12.003. [PMID: 17267162] - Jeongrim Lee, Bill X Huang, Zhixin Yuan, Hee-Yong Kim. Simultaneous determination of salsolinol enantiomers and dopamine in human plasma and cerebrospinal fluid by chemical derivatization coupled to chiral liquid chromatography/electrospray ionization-tandem mass spectrometry.
Analytical chemistry.
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Neurochemistry international.
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Brain research.
2006 Jul; 1099(1):141-9. doi:
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Brain research bulletin.
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10.1016/j.brainresbull.2004.11.007. [PMID: 15763175] - Boris Mravec, Ibolya Bodnar, Marton I K Fekete, Gyorgy M Nagy, Richard Kvetnansky. Salsolinol, an antagonist of prolactoliberine, induces an increase in plasma catecholamine levels in the rat.
Autonomic neuroscience : basic & clinical.
2004 Sep; 115(1-2):35-40. doi:
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Annals of the New York Academy of Sciences.
2004 Jun; 1018(?):124-30. doi:
10.1196/annals.1296.014. [PMID: 15240360] - J Scholz, I Klingemann, A Moser. Increased systemic levels of norsalsolinol derivatives are induced by levodopa treatment and do not represent biological markers of Parkinson's disease.
Journal of neurology, neurosurgery, and psychiatry.
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Bioorganicheskaia khimiia.
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Addiction biology.
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Alcohol (Fayetteville, N.Y.).
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Alcohol (Fayetteville, N.Y.).
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Alcohol (Fayetteville, N.Y.).
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Alcohol (Fayetteville, N.Y.).
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Alcoholism, clinical and experimental research.
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Journal of neural transmission. General section.
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1988 Dec; 459(?):245-9. doi:
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Alcohol and drug research.
1987; 7(5-6):493-501. doi:
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Alcohol (Fayetteville, N.Y.).
1986 Nov; 3(6):371-5. doi:
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Alcohol (Fayetteville, N.Y.).
1986 May; 3(3):215-20. doi:
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1986 Apr; 377(?):145-54. doi:
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1985 Dec; 16(3):241-9. doi:
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1985 Sep; 343(1):1-8. doi:
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Social biology.
1985 Sep; 32(3-4):255-71. doi:
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Pharmacology, biochemistry, and behavior.
1985 Jun; 22(6):993-1000. doi:
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The Journal of clinical endocrinology and metabolism.
1985 Apr; 60(4):673-7. doi:
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Biomedical mass spectrometry.
1985 Mar; 12(3):106-14. doi:
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Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence.
1985 Mar; 20(1):50-9. doi:
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Alcohol and drug research.
1985 198; 6(4):281-8. doi:
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Progress in clinical and biological research.
1985; 183(?):85-100. doi:
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Progress in clinical and biological research.
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