QUINALPHOS (BioDeep_00001873753)

   


代谢物信息卡片


QUINALPHOS

化学式: C12H15N2O3PS (298.054097)
中文名称: 喹硫磷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOP(=S)(OCC)OC1=NC2=CC=CC=C2N=C1
InChI: InChI=1S/C12H15N2O3PS/c1-3-15-18(19,16-4-2)17-12-9-13-10-7-5-6-8-11(10)14-12/h5-9H,3-4H2,1-2H3

描述信息

C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D010575 - Pesticides > D007306 - Insecticides
D016573 - Agrochemicals

同义名列表

1 个代谢物同义名

QUINALPHOS



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zhenxing Zhang, Min Meng, Qiong Wu, Jeong-Han Kim, Yongzhe Zhu. Biodegradation and metabolic pathway of quinalphos by Cunninghamella elegans ATCC36112. Biotechnology letters. 2023 May; ?(?):. doi: 10.1007/s10529-023-03393-9. [PMID: 37195489]
  • Nachimuthu Krishnan Sujeeth, Ramasamy Aravinth, Murugesan Thandeeswaran, Jayaraman Angayarkanni, Aruliah Rajasekar, R Mythili, Murugesan Gnanadesigan. Toxicity analysis and biomarker response of Quinalphos Organophosphate Insecticide (QOI) on eco-friendly exotic Eudrilus eugeniae earthworm. Environmental monitoring and assessment. 2023 Jan; 195(2):274. doi: 10.1007/s10661-022-10834-x. [PMID: 36607436]
  • Pawan Kumar Verma, Parvinder Singh, Priyanka Sharma, Shilpa Sood, Rajinder Raina. Dose-Dependent Oxidative Damage in Erythrocytes and Hepatic Tissue of Wistar Rats Concurrently Exposed with Arsenic and Quinalphos: a Subacute Study. Biological trace element research. 2022 May; 200(5):2160-2173. doi: 10.1007/s12011-021-02807-x. [PMID: 34189676]
  • Sandhya Kumari, Reyon Dcunha, Sahil Piyush Sanghvi, Guruprasad Nayak, Sneha Guruprasad Kalthur, Sushil Yadaorao Raut, Srinivas Mutalik, Sazada Siddiqui, Sulaiman A Alrumman, Satish Kumar Adiga, Guruprasad Kalthur. Organophosphorus pesticide quinalphos (Ekalux 25 E.C.) reduces sperm functional competence and decreases the fertilisation potential in Swiss albino mice. Andrologia. 2021 Sep; 53(8):e14115. doi: 10.1111/and.14115. [PMID: 34014595]
  • Silju Juby, Divya Choyikutty, A R Nayana, K Jayachandran, E K Radhakrishnan. Quinalphos Tolerant Endophytic Bacillus sp. Fcl1 and its Toxicity-Alleviating Effect in Vigna unguiculata. Current microbiology. 2021 Mar; 78(3):904-910. doi: 10.1007/s00284-020-02317-4. [PMID: 33580334]
  • Parvinder Singh, Pawan Kumar Verma, Rajinder Raina, Shilpa Sood, Priyanka Sharma. Maximum contaminant level of arsenic in drinking water potentiates quinalphos-induced renal damage on co-administration of both arsenic and quinalphos in Wistar rats. Environmental science and pollution research international. 2020 Jun; 27(17):21331-21340. doi: 10.1007/s11356-020-08643-1. [PMID: 32270456]
  • Refaat A Eid. Apoptosis of rat renal cells by organophosphate pesticide, quinalphos: Ultrastructural study. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia. 2017 Jul; 28(4):725-736. doi: . [PMID: 28748873]
  • Islam M Sadiqul, Zannatul Ferdous, Md Tanvir Ahmed Nannu, Golam Mohammod Mostakim, Md Khalilur Rahman. Acute exposure to a quinalphos containing insecticide (convoy) causes genetic damage and nuclear changes in peripheral erythrocytes of silver barb, Barbonymus gonionotus. Environmental pollution (Barking, Essex : 1987). 2016 Dec; 219(?):949-956. doi: 10.1016/j.envpol.2016.09.066. [PMID: 27667680]
  • Limin Yang, Juan Han, Wei Liu, Jiqiang Li, Lei Jiang. Conversion of inhibition biosensing to substrate-like biosensing for quinalphos selective detection. Analytical chemistry. 2015 May; 87(10):5270-7. doi: 10.1021/acs.analchem.5b00376. [PMID: 25921798]
  • Palanivel Kokilavani, Udhayaraj Suriyakalaa, Perumal Elumalai, Bethunaicken Abirami, Rajamanickam Ramachandran, Arunachalam Sankarganesh, Shanmugam Achiraman. Antioxidant mediated ameliorative steroidogenesis by Commelina benghalensis L. and Cissus quadrangularis L. against quinalphos induced male reproductive toxicity. Pesticide biochemistry and physiology. 2014 Feb; 109(?):18-33. doi: 10.1016/j.pestbp.2014.01.002. [PMID: 24581381]
  • Lisa A Konickx, Franz Worek, Shaluka Jayamanne, Horst Thiermann, Nicholas A Buckley, Michael Eddleston. Reactivation of plasma butyrylcholinesterase by pralidoxime chloride in patients poisoned by WHO class II toxicity organophosphorus insecticides. Toxicological sciences : an official journal of the Society of Toxicology. 2013 Dec; 136(2):274-83. doi: 10.1093/toxsci/kft217. [PMID: 24052565]
  • Mythily Subramaneyaan, Smita Jain, Chandrashekhar Yadav, Vinod K Arora, Basu D Banerjee, Rafat S Ahmed. Quinalphos induced oxidative stress and histoarcheitectural alterations in adult male albino rats. Environmental toxicology and pharmacology. 2012 Nov; 34(3):673-8. doi: 10.1016/j.etap.2012.10.003. [PMID: 23146591]
  • Bina Gupta, Manviri Rani, Rajani Salunke, Rahul Kumar. In vitro and in vivo studies on degradation of quinalphos in rats. Journal of hazardous materials. 2012 Apr; 213-214(?):285-91. doi: 10.1016/j.jhazmat.2012.01.089. [PMID: 22356742]
  • Soudamini Mohapatra, M Deepa, G K Jagdish. Residue dynamics of tebuconazole and quinalphos in immature onion bulb with leaves, mature onion bulb and soil. Bulletin of environmental contamination and toxicology. 2011 Dec; 87(6):703-7. doi: 10.1007/s00128-011-0403-z. [PMID: 21922282]
  • Rui Su, Xu Xu, Xinghua Wang, Dan Li, Xueyuan Li, Hanqi Zhang, Aimin Yu. Determination of organophosphorus pesticides in peanut oil by dispersive solid phase extraction gas chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Nov; 879(30):3423-8. doi: 10.1016/j.jchromb.2011.09.016. [PMID: 21963478]
  • Hiroyuki Kojima, Fumihiro Sata, Shinji Takeuchi, Tatsuya Sueyoshi, Tadanori Nagai. Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology. 2011 Feb; 280(3):77-87. doi: 10.1016/j.tox.2010.11.008. [PMID: 21115097]
  • Tarun Balani, Seema Agrawal, A M Thaker. Hematological and biochemical changes due to short-term oral administration of imidacloprid. Toxicology international. 2011 Jan; 18(1):2-4. doi: 10.4103/0971-6580.75843. [PMID: 21430911]
  • George Lekha, Karthik Mohan, Irudhaya Arockia Samy. Effect of Celastrus paniculatus seed oil (Jyothismati oil) on acute and chronic immobilization stress induced in swiss albino mice. Pharmacognosy research. 2010 May; 2(3):169-74. doi: 10.4103/0974-8490.65512. [PMID: 21808561]
  • M Azharul Islam, Vasilios Sakkas, Triantafyllos A Albanis. Application of statistical design of experiment with desirability function for the removal of organophosphorus pesticide from aqueous solution by low-cost material. Journal of hazardous materials. 2009 Oct; 170(1):230-8. doi: 10.1016/j.jhazmat.2009.04.106. [PMID: 19477587]
  • Florian Eyer, Darren M Roberts, Nicholas A Buckley, Michael Eddleston, Horst Thiermann, Franz Worek, Peter Eyer. Extreme variability in the formation of chlorpyrifos oxon (CPO) in patients poisoned by chlorpyrifos (CPF). Biochemical pharmacology. 2009 Sep; 78(5):531-7. doi: 10.1016/j.bcp.2009.05.004. [PMID: 19433070]
  • Michael Eddleston, Peter Eyer, Franz Worek, Edmund Juszczak, Nicola Alder, Fahim Mohamed, Lalith Senarathna, Ariyasena Hittarage, Shifa Azher, K Jeganathan, Shaluka Jayamanne, Ludwig von Meyer, Andrew H Dawson, Mohamed Hussain Rezvi Sheriff, Nick A Buckley. Pralidoxime in acute organophosphorus insecticide poisoning--a randomised controlled trial. PLoS medicine. 2009 Jun; 6(6):e1000104. doi: 10.1371/journal.pmed.1000104. [PMID: 19564902]
  • Guifang Jia, Chunguang Lv, Wentao Zhu, Jing Qiu, Xinquan Wang, Zhiqiang Zhou. Applicability of cloud point extraction coupled with microwave-assisted back-extraction to the determination of organophosphorous pesticides in human urine by gas chromatography with flame photometry detection. Journal of hazardous materials. 2008 Nov; 159(2-3):300-5. doi: 10.1016/j.jhazmat.2008.02.081. [PMID: 18468789]
  • Sandra Yucra, Manuel Gasco, Julio Rubio, Gustavo F Gonzales. Semen quality in Peruvian pesticide applicators: association between urinary organophosphate metabolites and semen parameters. Environmental health : a global access science source. 2008 Nov; 7(?):59. doi: 10.1186/1476-069x-7-59. [PMID: 19014632]
  • Sonja Riediger, Andreas Behrends, Björn Croll, Ignacio Vega-Naredo, Nils Hänig, Burkhard Poeggeler, Jutta Böker, Sascha Grube, Juliane Gipp, Ana Coto-Montes, Chandana Haldar, Rüdiger Hardeland. Toxicity of the quinalphos metabolite 2-hydroxyquinoxaline: growth inhibition, induction of oxidative stress, and genotoxicity in test organisms. Environmental toxicology. 2007 Feb; 22(1):33-43. doi: 10.1002/tox.20231. [PMID: 17295279]
  • E Gallardo, M Barroso, C Margalho, A Cruz, D N Vieira, M López-Rivadulla. Determination of quinalphos in blood and urine by direct solid-phase microextraction combined with gas chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Feb; 832(1):162-8. doi: 10.1016/j.jchromb.2005.12.029. [PMID: 16414313]
  • Kuladip Jana, Subarna Jana, Prabhat Kumar Samanta. Effects of chronic exposure to sodium arsenite on hypothalamo-pituitary-testicular activities in adult rats: possible an estrogenic mode of action. Reproductive biology and endocrinology : RB&E. 2006 Feb; 4(?):9. doi: 10.1186/1477-7827-4-9. [PMID: 16483355]
  • J Castillo-Cadena, L E Tenorio-Vieyra, A I Quintana-Carabia, M M García-Fabila, E Ramírez-San Juan, E Madrigal-Bujaidar. Determination of DNA damage in floriculturists exposed to mixtures of pesticides. Journal of biomedicine & biotechnology. 2006; 2006(2):97896. doi: 10.1155/jbb/2006/97896. [PMID: 16883059]
  • Rogelio Recio, Guadalupe Ocampo-Gómez, Javier Morán-Martínez, Victor Borja-Aburto, Malaquías López-Cervante, Marisela Uribe, Luisa Torres-Sánchez, Mariano E Cebrián. Pesticide exposure alters follicle-stimulating hormone levels in Mexican agricultural workers. Environmental health perspectives. 2005 Sep; 113(9):1160-3. doi: 10.1289/ehp.7374. [PMID: 16140621]
  • Pramila Menon, Madhuban Gopal, Rajender Prasad. Influence of two insecticides, chlorpyrifos and quinalphos, on arginine ammonification and mineralizable nitrogen in two tropical soil types. Journal of agricultural and food chemistry. 2004 Dec; 52(24):7370-6. doi: 10.1021/jf049502c. [PMID: 15563221]
  • Brenda Eskenazi, Kim Harley, Asa Bradman, Erin Weltzien, Nicholas P Jewell, Dana B Barr, Clement E Furlong, Nina T Holland. Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population. Environmental health perspectives. 2004 Jul; 112(10):1116-24. doi: 10.1289/ehp.6789. [PMID: 15238287]
  • A Gupta, N S Parihar, A Bhatnagar. Lindane, chlorpyriphos, and quinalphos residues in mustard seed and oil. Bulletin of environmental contamination and toxicology. 2001 Jul; 67(1):122-5. doi: 10.1007/s001280099. [PMID: 11381321]
  • D Debnath, T K Mandal. Study of quinalphos (an environmental oestrogenic insecticide) formulation (Ekalux 25 E.C.)-induced damage of the testicular tissues and antioxidant defence systems in Sprague-Dawley albino rats. Journal of applied toxicology : JAT. 2000 May; 20(3):197-204. doi: 10.1002/(sici)1099-1263(200005/06)20:3<197::aid-jat634>3.0.co;2-7. [PMID: 10797472]
  • B K Das, S C Mukherjee. Chronic toxic effects of quinalphos on some biochemical parameters in Labeo rohita (Ham.). Toxicology letters. 2000 Apr; 114(1-3):11-8. doi: 10.1016/s0378-4274(99)00185-x. [PMID: 10713464]
  • R Sarkar, K P Mohanakumar, M Chowdhury. Effects of an organophosphate pesticide, quinalphos, on the hypothalamo-pituitary-gonadal axis in adult male rats. Journal of reproduction and fertility. 2000 Jan; 118(1):29-38. doi: . [PMID: 10793623]
  • M K Srivastava, R B Raizada. Assessment of the no-observed-effect level (NOEL) of quinalphos in pregnant rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1999 Jun; 37(6):649-53. doi: 10.1016/s0278-6915(99)00036-8. [PMID: 10478833]
  • P D Dwivedi, M Das, S K Khanna. Role of cytochrome P-450 in quinalphos toxicity: effect on hepatic and brain antioxidant enzymes in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1998 May; 36(5):437-44. doi: 10.1016/s0278-6915(97)00165-8. [PMID: 9662419]
  • A Gupta, A Gupta, G S Shukla. Effects of neonatal quinalphos exposure and subsequent withdrawal on free radical generation and antioxidative defenses in developing rat brain. Journal of applied toxicology : JAT. 1998 Jan; 18(1):71-7. doi: 10.1002/(sici)1099-1263(199801/02)18:1<71::aid-jat482>3.0.co;2-b. [PMID: 9526837]
  • M Jokanović. Studies on the delayed neuropathic and anticholinesterase potential of quinalphos (diethyl 2-quinoxalyl phosphorothionate) in hens. Journal of applied toxicology : JAT. 1993 Sep; 13(5):337-9. doi: 10.1002/jat.2550130507. [PMID: 8258630]
  • Z Vasilić, V Drevenkar, V Rumenjak, B Stengl, Z Fröbe. Urinary excretion of diethylphosphorus metabolites in persons poisoned by quinalphos or chlorpyrifos. Archives of environmental contamination and toxicology. 1992 May; 22(4):351-7. doi: 10.1007/bf00212552. [PMID: 1375016]
  • M K Srivastava, R B Raizada, T S Dikshith. Fetotoxic response of technical quinalphos in rats. Veterinary and human toxicology. 1992 Apr; 34(2):131-3. doi: . [PMID: 1509672]
  • A Ray, S Chatterjee, S Ghosh, K Bhattacharya, A Pakrashi, C Deb. Quinalphos-induced suppression of spermatogenesis, plasma gonadotrophins, testicular testosterone production, and secretion in adult rats. Environmental research. 1992 Apr; 57(2):181-9. doi: 10.1016/s0013-9351(05)80078-7. [PMID: 1568439]
  • A Ray, S Chatterjee, S Ghosh, S N Kabir, A Pakrashi, C Deb. Suppressive effect of quinalphos on the activity of accessory sex glands and plasma concentrations of gonadotrophins and testosterone in rats. Archives of environmental contamination and toxicology. 1991 Sep; 21(3):383-7. doi: 10.1007/bf01060360. [PMID: 1659331]
  • A Ray, S Chatterjee, P Bagchi, T K Das, C Deb. Effect of quinalphos on testicular steroidogenesis in rats. Andrologia. 1988 Mar; 20(2):163-8. doi: . [PMID: 3164589]
  • D Bokonjić, D Jovanović, M Jokanović, M Maksimović. Protective effects of oximes HI-6 and PAM-2 applied by osmotic minipumps in quinalphos-poisoned rats. Archives internationales de pharmacodynamie et de therapie. 1987 Aug; 288(2):309-18. doi: . [PMID: 3675088]
  • A K Srivastava, B S Paul, J K Malik. Effect of repeated oral administration of quinalphos on blood esterases in Bubalus bubalis. Toxicology letters. 1983 Oct; 19(1-2):165-9. doi: 10.1016/0378-4274(83)90278-3. [PMID: 6658822]
  • V Drevenkar, B Stengl, B Tkalcević, Z Vasilić. Occupational exposure control by simultaneous determination of N-methylcarbamates and organophosphorus pesticide residues in human urine. International journal of environmental analytical chemistry. 1983; 14(3):215-30. doi: 10.1080/03067318308071621. [PMID: 6853013]
  • T S Dikshith, K K Datta, R B Raizada. Response of carbon tetrachloride treated male rats to benzene hexachloride & Quinalphos. Indian journal of experimental biology. 1980 Nov; 18(11):1267-72. doi: NULL. [PMID: 6163700]