Cerebrosterol (BioDeep_00001871869)
Main id: BioDeep_00000009470
代谢物信息卡片
(24S)-Cholest-5-ene-3beta,24-diol
化学式: C27H46O2 (402.34976159999997)
中文名称: 胆固醇-5-烯-3β,24(S)-二醇
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)O
InChI: InChI=1S/C27H46O2/c1-17(2)25(29)11-6-18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20+,21+,22-,23+,24+,25+,26+,27-/m1/s1
描述信息
A 24-hydroxycholesterol that has S configuration at position 24. It is the major metabolic breakdown product of cholesterol in the brain.
24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators[1][2][3].
24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators[1][2][3].
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:34310
- KEGG: C13550
- PubChem: 121948
- ChEMBL: CHEMBL171804
- CAS: 474-73-7
- MetaboLights: MTBLC34310
- PubChem: 7846926
- LipidMAPS: LMST01010019
- NIKKAJI: J637.349F
- medchemexpress: HY-16940
分类词条
相关代谢途径
Reactome(10)
- Metabolism
- Biological oxidations
- Phase I - Functionalization of compounds
- Metabolism of lipids
- Metabolism of steroids
- Cytochrome P450 - arranged by substrate type
- Bile acid and bile salt metabolism
- Synthesis of bile acids and bile salts
- Endogenous sterols
- Synthesis of bile acids and bile salts via 24-hydroxycholesterol
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Meriam Messedi, Fatma Makni-Ayadi. 24S-Hydroxycholesterol in Neuropsychiatric Diseases: Schizophrenia, Autism Spectrum Disorder, and Bipolar Disorder.
Advances in experimental medicine and biology.
2024; 1440(?):293-304. doi:
10.1007/978-3-031-43883-7_15. [PMID: 38036886] - Mahalakshmi Shankaran, Hussein Mohammed, Ellen Tsang, Po-Yin Anne Wong, Joan Protasio, Elizabeth J Murphy, Frederic Bernard, Rui Chang, Tammy Dellovade, Scott Turner, Marc K Hellerstein. 24-hydroxycholesterol replacement rate measured in blood is a non-invasive biomarker of brain demyelination and remyelination in cuprizone-treated mice.
Experimental neurology.
2023 Mar; ?(?):114395. doi:
10.1016/j.expneurol.2023.114395. [PMID: 37003487] - Dejan Jakimovski, Robert Zivadinov, Laura Pelizzari, Cynthia Dunne-Jaffe, Richard W Browne, Niels Bergsland, Michael G Dwyer, Bianca Weinstock-Guttman, Murali Ramanathan. Plasma 24-hydroxycholesterol is associated with narrower common carotid artery and greater flow velocities in relapsing multiple sclerosis.
Multiple sclerosis and related disorders.
2022 Jul; 63(?):103906. doi:
10.1016/j.msard.2022.103906. [PMID: 35671670] - Valérie Brousseau, Patrick Caron, Jocelyn Trottier, Thérèse Di Paolo, Piotr Milkiewicz, Olivier Barbier. Liquid chromatography coupled to tandem mass spectrometry methods for the selective and sensitive determination of 24S-hydroxycholesterol, its sulfate, and/or glucuronide conjugates in plasma.
Journal of mass spectrometry : JMS.
2022 May; 57(5):e4827. doi:
10.1002/jms.4827. [PMID: 35460139] - Dieter Lütjohann, Frans Stellaard, Bediha Bölükbasi, Anja Kerksiek, Klaus G Parhofer, Ulrich Laufs. Anti-PCSK 9 antibodies increase the ratios of the brain-specific oxysterol 24S-hydroxycholesterol to cholesterol and to 27-hydroxycholesterol in the serum.
British journal of clinical pharmacology.
2021 11; 87(11):4252-4261. doi:
10.1111/bcp.14841. [PMID: 33792095] - Wassim Guidara, Meriam Messedi, Manel Maalej, Manel Naifar, Walid Khrouf, Sahar Grayaa, Mohamed Maalej, Dominique Bonnefont-Rousselot, Foudil Lamari, Fatma Ayadi. Plasma oxysterols: Altered level of plasma 24-hydroxycholesterol in patients with bipolar disorder.
The Journal of steroid biochemistry and molecular biology.
2021 07; 211(?):105902. doi:
10.1016/j.jsbmb.2021.105902. [PMID: 33901658] - Aurélie Hanin, Paul Baudin, Sophie Demeret, Delphine Roussel, Sarah Lecas, Elisa Teyssou, Maria Damiano, David Luis, Virginie Lambrecq, Valerio Frazzini, Maxens Decavèle, Isabelle Plu, Dominique Bonnefont-Rousselot, Randa Bittar, Foudil Lamari, Vincent Navarro. Disturbances of brain cholesterol metabolism: A new excitotoxic process associated with status epilepticus.
Neurobiology of disease.
2021 07; 154(?):105346. doi:
10.1016/j.nbd.2021.105346. [PMID: 33774180] - Lucio Boglione, Claudio Caccia, Andrea Civra, Jessica Cusato, Antonio D'Avolio, Fiorella Biasi, David Lembo, Giovanni Di Perri, Giuseppe Poli, Valerio Leoni. Trend of 25-hydroxycholesterol and 27-hydroxycholesterol plasma levels in patients affected by active chronic hepatitis B virus infection and inactive carriers.
The Journal of steroid biochemistry and molecular biology.
2021 06; 210(?):105854. doi:
10.1016/j.jsbmb.2021.105854. [PMID: 33631373] - Cristina R Bosoi, Milène Vandal, Marine Tournissac, Manon Leclerc, Hortense Fanet, Patricia L Mitchell, Mélanie Verreault, Jocelyn Trottier, Jessica Virgili, Cynthia Tremblay, H Robert Lippman, Jasmohan S Bajaj, Olivier Barbier, André Marette, Frédéric Calon. High-Fat Diet Modulates Hepatic Amyloid β and Cerebrosterol Metabolism in the Triple Transgenic Mouse Model of Alzheimer's Disease.
Hepatology communications.
2021 03; 5(3):446-460. doi:
10.1002/hep4.1609. [PMID: 33681678] - Fuxin Lu, Shujuan Fan, Andrea R Romo, Duan Xu, Donna M Ferriero, Xiangning Jiang. Serum 24S-hydroxycholesterol predicts long-term brain structural and functional outcomes after hypoxia-ischemia in neonatal mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2021 02; 41(2):312-323. doi:
10.1177/0271678x20911910. [PMID: 32169014] - Tabea Jahn, Christopher Clark, Anja Kerksiek, Piotr Lewczuk, Dieter Lütjohann, Julius Popp. Cholesterol metabolites and plant sterols in cerebrospinal fluid are associated with Alzheimer's cerebral pathology and clinical disease progression.
The Journal of steroid biochemistry and molecular biology.
2021 01; 205(?):105785. doi:
10.1016/j.jsbmb.2020.105785. [PMID: 33171206] - Oliwia McFarlane, Kornelia Kędziora-Kornatowska. Cholesterol and Dementia: A Long and Complicated Relationship.
Current aging science.
2020; 13(1):42-51. doi:
10.2174/1874609812666190917155400. [PMID: 31530269] - Jocelyne Caboche, Radhia Kacher, Sandrine Betuing. [Regulation of cholesterol metabolism is neuroprotective in Huntington's disease].
Medecine sciences : M/S.
2020 Jan; 36(1):12-15. doi:
10.1051/medsci/2019253. [PMID: 32014090] - Elise Léger-Charnay, Elodie A Y Masson, Tristan Morala, Lucy Martine, Bénédicte Buteau, Laurent Leclere, Lionel Bretillon, Ségolène Gambert. Is 24(S)-hydroxycholesterol a potent modulator of cholesterol metabolism in Müller cells? An in vitro study about neuron to glia communication in the retina.
Experimental eye research.
2019 12; 189(?):107857. doi:
10.1016/j.exer.2019.107857. [PMID: 31654618] - Ulrich Pecks, Verena Bornemann, Anika Klein, Laura Segger, Nicolai Maass, Ibrahim Alkatout, Christel Eckmann-Scholz, Mohamed Elessawy, Dieter Lütjohann. Estimating fetal cholesterol synthesis rates by cord blood analysis in intrauterine growth restriction and normally grown fetuses.
Lipids in health and disease.
2019 Oct; 18(1):185. doi:
10.1186/s12944-019-1117-1. [PMID: 31653257] - Nobuyoshi Tajima, Liu Xiaoyan, Makoto Taniguchi, Nobuo Kato. 24S-hydroxycholesterol alters activity of large-conductance Ca2+-dependent K+ (slo1 BK) channel through intercalation into plasma membrane.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2019 10; 1864(10):1525-1535. doi:
10.1016/j.bbalip.2019.05.010. [PMID: 31136842] - Kelly Fellows Maxwell, Sonia Bhattacharya, Mary Lou Bodziak, Dejan Jakimovski, Jesper Hagemeier, Richard W Browne, Bianca Weinstock-Guttman, Robert Zivadinov, Murali Ramanathan. Oxysterols and apolipoproteins in multiple sclerosis: a 5 year follow-up study.
Journal of lipid research.
2019 07; 60(7):1190-1198. doi:
10.1194/jlr.m089664. [PMID: 31085627] - Raúl Loera-Valencia, Julen Goikolea, Cristina Parrado-Fernandez, Paula Merino-Serrais, Silvia Maioli. Alterations in cholesterol metabolism as a risk factor for developing Alzheimer's disease: Potential novel targets for treatment.
The Journal of steroid biochemistry and molecular biology.
2019 06; 190(?):104-114. doi:
10.1016/j.jsbmb.2019.03.003. [PMID: 30878503] - B Šošić-Jurjević, D Lütjohann, K Renko, B Filipović, N Radulović, V Ajdžanović, S Trifunović, N Nestorović, J Živanović, M Manojlović Stojanoski, J Kӧhrle, V Milošević. The isoflavones genistein and daidzein increase hepatic concentration of thyroid hormones and affect cholesterol metabolism in middle-aged male rats.
The Journal of steroid biochemistry and molecular biology.
2019 06; 190(?):1-10. doi:
10.1016/j.jsbmb.2019.03.009. [PMID: 30885834] - Luisa Cigliano, Maria Stefania Spagnuolo, Gaetana Napolitano, Lucia Iannotta, Gianluca Fasciolo, Daniela Barone, Paola Venditti. 24S-hydroxycholesterol affects redox homeostasis in human glial U-87 MG cells.
Molecular and cellular endocrinology.
2019 04; 486(?):25-33. doi:
10.1016/j.mce.2019.02.013. [PMID: 30802527] - Xuemei Huang, Nicholas W Sterling, Guangwei Du, Dongxiao Sun, Christina Stetter, Lan Kong, Yusheng Zhu, Jeffery Neighbors, Mechelle M Lewis, Honglei Chen, Raymond J Hohl, Richard B Mailman. Brain cholesterol metabolism and Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society.
2019 03; 34(3):386-395. doi:
10.1002/mds.27609. [PMID: 30681742] - Myuri Ruthirakuhan, Nathan Herrmann, Ana C Andreazza, Nicolaas Paul L G Verhoeff, Damien Gallagher, Sandra E Black, Alex Kiss, Krista L Lanctôt. 24S-Hydroxycholesterol Is Associated with Agitation Severity in Patients with Moderate-to-Severe Alzheimer's Disease: Analyses from a Clinical Trial with Nabilone.
Journal of Alzheimer's disease : JAD.
2019; 71(1):21-31. doi:
10.3233/jad-190202. [PMID: 31322567] - Yuki Kimura, Minori Asa, Yasuomi Urano, Yoshiro Saito, Kiyotaka Nishikawa, Noriko Noguchi. Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation.
Biochimie.
2018 Oct; 153(?):203-209. doi:
10.1016/j.biochi.2018.07.004. [PMID: 30244813] - Maryem Bezine, Sonia Maatoug, Rym Ben Khalifa, Meryam Debbabi, Amira Zarrouk, Yuqin Wang, William J Griffiths, Thomas Nury, Mohammad Samadi, Anne Vejux, Jérôme de Sèze, Thibault Moreau, Riadh Kharrat, Mohamed El Ayeb, Gérard Lizard. Modulation of Kv3.1b potassium channel level and intracellular potassium concentration in 158N murine oligodendrocytes and BV-2 murine microglial cells treated with 7-ketocholesterol, 24S-hydroxycholesterol or tetracosanoic acid (C24:0).
Biochimie.
2018 Oct; 153(?):56-69. doi:
10.1016/j.biochi.2018.02.008. [PMID: 29462682] - S Grayaa, C Zerbinati, M Messedi, I HadjKacem, M Chtourou, D Ben Touhemi, M Naifar, H Ayadi, F Ayedi, L Iuliano. Plasma oxysterol profiling in children reveals 24-hydroxycholesterol as a potential marker for Autism Spectrum Disorders.
Biochimie.
2018 Oct; 153(?):80-85. doi:
10.1016/j.biochi.2018.04.026. [PMID: 29730299] - Ling Li, Fan Zeng, Yu-Hui Liu, Hui-Yun Li, Shu-Yang Dong, Ze-Yan Peng, Yan-Jiang Wang, Hua-Dong Zhou. CYP46A1 and the APOEε4 Allele Polymorphisms Correlate with the Risk of Alzheimer's Disease.
Molecular neurobiology.
2018 Oct; 55(10):8179-8187. doi:
10.1007/s12035-018-0952-9. [PMID: 29516283] - Valéria Sutti Nunes, Patrícia Miralda Cazita, Sérgio Catanozi, Edna Regina Nakandakare, Eder Carlos Rocha Quintão. Decreased content, rate of synthesis and export of cholesterol in the brain of apoE knockout mice.
Journal of bioenergetics and biomembranes.
2018 08; 50(4):283-287. doi:
10.1007/s10863-018-9757-9. [PMID: 29675736] - Satoshi Hirayama, Hironori Nagasaka, Akira Honda, Haruki Komatsu, Takahiro Kodama, Ayano Inui, Ichiro Morioka, Shunsaku Kaji, Tsuyoshi Ueno, Kenji Ihara, Mariko Yagi, Zenro Kizaki, Kazuhiko Bessho, Hiroki Kondou, Tohru Yorifuji, Hirokazu Tsukahara, Kazumoto Iijima, Takashi Miida. Cholesterol Metabolism Is Enhanced in the Liver and Brain of Children With Citrin Deficiency.
The Journal of clinical endocrinology and metabolism.
2018 07; 103(7):2488-2497. doi:
10.1210/jc.2017-02664. [PMID: 29659898] - Fuxin Lu, Jun Zhu, Selena Guo, Brandon J Wong, Farid F Chehab, Donna M Ferriero, Xiangning Jiang. Upregulation of cholesterol 24-hydroxylase following hypoxia-ischemia in neonatal mouse brain.
Pediatric research.
2018 06; 83(6):1218-1227. doi:
10.1038/pr.2018.49. [PMID: 29718007] - Concetta Di Natale, Alessandra Monaco, Carlo Pedone, Alessandro Tessitore, Antonio De Mase, Gioacchino Tedeschi, Paolo Antonio Netti, Paolo Abrescia. The level of 24-hydroxycholesteryl esters decreases in plasma of patients with Parkinson's disease.
Neuroscience letters.
2018 04; 672(?):108-112. doi:
10.1016/j.neulet.2018.02.041. [PMID: 29486288] - Kamilla A Mukhutdinova, Marat R Kasimov, Arthur R Giniatullin, Guzel F Zakyrjanova, Alexey M Petrov. 24S-hydroxycholesterol suppresses neuromuscular transmission in SOD1(G93A) mice: A possible role of NO and lipid rafts.
Molecular and cellular neurosciences.
2018 04; 88(?):308-318. doi:
10.1016/j.mcn.2018.03.006. [PMID: 29550246] - Dieter Lütjohann, Adam M Lopez, Jen-Chieh Chuang, Anja Kerksiek, Stephen D Turley. Identification of Correlative Shifts in Indices of Brain Cholesterol Metabolism in the C57BL6/Mecp2tm1.1Bird Mouse, a Model for Rett Syndrome.
Lipids.
2018 04; 53(4):363-373. doi:
10.1002/lipd.12041. [PMID: 29770459] - Daniel S Ory, Elizabeth A Ottinger, Nicole Yanjanin Farhat, Kelly A King, Xuntian Jiang, Lisa Weissfeld, Elizabeth Berry-Kravis, Cristin D Davidson, Simona Bianconi, Lee Ann Keener, Ravichandran Rao, Ariane Soldatos, Rohini Sidhu, Kimberly A Walters, Xin Xu, Audrey Thurm, Beth Solomon, William J Pavan, Bernardus N Machielse, Mark Kao, Steven A Silber, John C McKew, Carmen C Brewer, Charles H Vite, Steven U Walkley, Christopher P Austin, Forbes D Porter. Intrathecal 2-hydroxypropyl-β-cyclodextrin decreases neurological disease progression in Niemann-Pick disease, type C1: a non-randomised, open-label, phase 1-2 trial.
Lancet (London, England).
2017 Oct; 390(10104):1758-1768. doi:
10.1016/s0140-6736(17)31465-4. [PMID: 28803710] - Maryem Bezine, Meryam Debbabi, Thomas Nury, Rym Ben-Khalifa, Mohammad Samadi, Mustapha Cherkaoui-Malki, Anne Vejux, Quentin Raas, Jérôme de Sèze, Thibault Moreau, Mohamed El-Ayeb, Gérard Lizard. Evidence of K+ homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes.
Chemistry and physics of lipids.
2017 10; 207(Pt B):135-150. doi:
10.1016/j.chemphyslip.2017.03.006. [PMID: 28322741] - Ségolène Gambert, Pierre-Henry Gabrielle, Elodie Masson, Elise Leger-Charnay, Arthur Ferrerro, Arthur Vannier, Clément Gendrault, Méline Lachot, Catherine Creuzot-Garcher, Alain Bron, Stéphane Gregoire, Laurent Leclere, Lucy Martine, Géraldine Lucchi, Caroline Truntzer, Delphine Pecqueur, Lionel Bretillon. Cholesterol metabolism and glaucoma: Modulation of Muller cell membrane organization by 24S-hydroxycholesterol.
Chemistry and physics of lipids.
2017 10; 207(Pt B):179-191. doi:
10.1016/j.chemphyslip.2017.05.007. [PMID: 28576383] - Takaya Nakazawa, Yuta Miyanoki, Yasuomi Urano, Madoka Uehara, Yoshiro Saito, Noriko Noguchi. Effect of vitamin E on 24(S)-hydroxycholesterol-induced necroptosis-like cell death and apoptosis.
The Journal of steroid biochemistry and molecular biology.
2017 05; 169(?):69-76. doi:
10.1016/j.jsbmb.2016.03.003. [PMID: 26953980] - M R Kasimov, M R Fatkhrakhmanova, K A Mukhutdinova, A M Petrov. 24S-Hydroxycholesterol enhances synaptic vesicle cycling in the mouse neuromuscular junction: Implication of glutamate NMDA receptors and nitric oxide.
Neuropharmacology.
2017 05; 117(?):61-73. doi:
10.1016/j.neuropharm.2017.01.030. [PMID: 28153530] - Vladimiro Cardenia, Maria Teresa Rodriguez-Estrada, Antonello Lorenzini, Erika Bandini, Cristina Angeloni, Silvana Hrelia, Marco Malaguti. Effect of broccoli extract enriched diet on liver cholesterol oxidation in rats subjected to exhaustive exercise.
The Journal of steroid biochemistry and molecular biology.
2017 05; 169(?):137-144. doi:
10.1016/j.jsbmb.2016.04.005. [PMID: 27084531] - Quanri Liu, Yu An, Huanling Yu, Yanhui Lu, Lingli Feng, Chao Wang, Rong Xiao. Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study.
Lipids in health and disease.
2016 Oct; 15(1):177. doi:
10.1186/s12944-016-0344-y. [PMID: 27724967] - Valeria La Marca, Bernardetta Maresca, Maria Stefania Spagnuolo, Luisa Cigliano, Fabrizio Dal Piaz, Giuseppe Di Iorio, Paolo Abrescia. Lecithin-cholesterol acyltransferase in brain: Does oxidative stress influence the 24-hydroxycholesterol esterification?.
Neuroscience research.
2016 Apr; 105(?):19-27. doi:
10.1016/j.neures.2015.09.008. [PMID: 26454063] - Hua-Long Wang, Yan-Yong Wang, Xin-Gang Liu, Sheng-Han Kuo, Na Liu, Qiao-Yun Song, Ming-Wei Wang. Cholesterol, 24-Hydroxycholesterol, and 27-Hydroxycholesterol as Surrogate Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer's Disease: A Meta-Analysis.
Journal of Alzheimer's disease : JAD.
2016; 51(1):45-55. doi:
10.3233/jad-150734. [PMID: 26836015] - Lenka Novakova, Markus Axelsson, Clas Malmeström, Henrik Zetterberg, Ingemar Björkhem, Virginija Danylaité Karrenbauer, Jan Lycke. Reduced cerebrospinal fluid concentrations of oxysterols in response to natalizumab treatment of relapsing remitting multiple sclerosis.
Journal of the neurological sciences.
2015 Nov; 358(1-2):201-6. doi:
10.1016/j.jns.2015.08.1537. [PMID: 26342940] - Marie-Anne Burlot, Jérôme Braudeau, Kristin Michaelsen-Preusse, Brigitte Potier, Sophie Ayciriex, Jennifer Varin, Benoit Gautier, Fathia Djelti, Mickael Audrain, Luce Dauphinot, Francisco-Jose Fernandez-Gomez, Raphaëlle Caillierez, Olivier Laprévote, Ivan Bièche, Nicolas Auzeil, Marie-Claude Potier, Patrick Dutar, Martin Korte, Luc Buée, David Blum, Nathalie Cartier. Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology.
Human molecular genetics.
2015 Nov; 24(21):5965-76. doi:
10.1093/hmg/ddv268. [PMID: 26358780] - Sourish Ghosh, Sriparna Mukherjee, Anirban Basu. Chandipura virus perturbs cholesterol homeostasis leading to neuronal apoptosis.
Journal of neurochemistry.
2015 Oct; 135(2):368-80. doi:
10.1111/jnc.13208. [PMID: 26118540] - Hiroshi Sugimoto, Masaaki Kakehi, Yoshinori Satomi, Hidenori Kamiguchi, Fumihiro Jinno. Method development for the determination of 24S-hydroxycholesterol in human plasma without derivatization by high-performance liquid chromatography with tandem mass spectrometry in atmospheric pressure chemical ionization mode.
Journal of separation science.
2015 Oct; 38(20):3516-24. doi:
10.1002/jssc.201500719. [PMID: 26249017] - Timothy J Maarup, Agnes H Chen, Forbes D Porter, Nicole Y Farhat, Daniel S Ory, Rohini Sidhu, Xuntian Jiang, Patricia I Dickson. Intrathecal 2-hydroxypropyl-beta-cyclodextrin in a single patient with Niemann-Pick C1.
Molecular genetics and metabolism.
2015 Sep; 116(1-2):75-9. doi:
10.1016/j.ymgme.2015.07.001. [PMID: 26189084] - Valerio Leoni, Claudio Caccia. The impairment of cholesterol metabolism in Huntington disease.
Biochimica et biophysica acta.
2015 Aug; 1851(8):1095-105. doi:
10.1016/j.bbalip.2014.12.018. [PMID: 25596342] - Thomas Nury, Amira Zarrouk, John J Mackrill, Mohammad Samadi, Philippe Durand, Jean-Marc Riedinger, Margaux Doria, Anne Vejux, Emeric Limagne, Dominique Delmas, Michel Prost, Thibault Moreau, Mohamed Hammami, Régis Delage-Mourroux, Nora M O'Brien, Gérard Lizard. Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3).
Steroids.
2015 Jul; 99(Pt B):194-203. doi:
10.1016/j.steroids.2015.02.003. [PMID: 25683890] - Juan Zhang, Qiang Liu. Cholesterol metabolism and homeostasis in the brain.
Protein & cell.
2015 Apr; 6(4):254-64. doi:
10.1007/s13238-014-0131-3. [PMID: 25682154] - A Zarrouk, M Hammami, T Moreau, G Lizard. Accumulation of 24S-hydroxycholesterol in neuronal SK-N-BE cells treated with hexacosanoic acid (C26:0): argument in favor of 24S-hydroxycholesterol as a potential biomarker of neurolipotoxicity.
Revue neurologique.
2015 Feb; 171(2):125-9. doi:
10.1016/j.neurol.2014.10.016. [PMID: 25577946] - V W M Virginio, V S Nunes, F A Moura, F H Menezes, N A Andreollo, F Rogerio, D Z Scherrer, E C R Quintão, E Nakandakare, O Petrucci, W Nadruz-Junior, E C de Faria, A C Sposito. Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activity.
Free radical research.
2015 Feb; 49(2):199-203. doi:
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Journal of Alzheimer's disease : JAD.
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Neuropharmacology.
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Neuroscience letters.
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Biochemical pharmacology.
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Redox biology.
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Free radical biology & medicine.
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Investigative ophthalmology & visual science.
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Bioscience, biotechnology, and biochemistry.
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