GW 3965 (BioDeep_00001871577)
Main id: BioDeep_00000010801
代谢物信息卡片
3-(3-(N-(2-Chloro-3-trifluoromethylbenzyl)(2,2-diphenylethyl)amino)propoxy)phenylacetic acid
化学式: C33H31ClF3NO3 (581.1944441999999)
中文名称: 3-[3-[[[2-氯-3-(三氟甲基)苯基]甲基](2,2-联苯基乙基)氨基]丙氧基]苯乙酸盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)C(CN(CCCOC2=CC=CC(=C2)CC(=O)O)CC3=C(C(=CC=C3)C(F)(F)F)Cl)C4=CC=CC=C4
InChI: InChI=1S/C33H31ClF3NO3/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40)
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:79995
- KEGG: C15631
- PubChem: 447905
- DrugBank: DB03791
- ChEMBL: CHEMBL59030
- CAS: 475207-20-6
- CAS: 405911-09-3
- PubChem: 17396621
- PDB-CCD: 965
- NIKKAJI: J2.039.239H
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- YuChen Jiang, LiShuang Hou, JiaYi Dou, MeiYan Xuan, ZhenYu Cui, LiHua Lian, JiXing Nan, YanLing Wu. Sesamol as a potential candidate for the treatment of hepatic fibrosis, based on its regulation of FXR/LXR axis-mediated inhibition of autophagy through crosstalk between hepatic cells and macrophage.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jan; 123(?):155145. doi:
10.1016/j.phymed.2023.155145. [PMID: 37976698] - Fenfang Yu, Lin Gao, Ke Xu, Xiaobing Yang, Junran Zhang, Yu Tang, Zhifei Ma, Wei Gu, Bining Wu, Ying Shi. Protective effect of liver X receptor on cigarette smoke and lipopolysaccharide induced airway inflammation and emphysema in mice.
Experimental lung research.
2024; 50(1):53-64. doi:
10.1080/01902148.2024.2329436. [PMID: 38509754] - Sheetal Uppal, Olga Postnikova, Rafael Villasmil, Igor B Rogozin, Alexander V Bocharov, Thomas L Eggerman, Eugenia Poliakov, T Michael Redmond. Low-Density Lipoprotein Receptor (LDLR) Is Involved in Internalization of Lentiviral Particles Pseudotyped with SARS-CoV-2 Spike Protein in Ocular Cells.
International journal of molecular sciences.
2023 Jul; 24(14):. doi:
10.3390/ijms241411860. [PMID: 37511618] - Ruiyi Zhang, Yifei Dong, Yang Liu, Dorsa Moezzi, Samira Ghorbani, Reza Mirzaei, Brian M Lozinski, Jeff F Dunn, V Wee Yong, Mengzhou Xue. Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage: roles of microglia/macrophages.
Stroke and vascular neurology.
2023 May; ?(?):. doi:
10.1136/svn-2023-002331. [PMID: 37137522] - Lara Bideyan, Wenxin Fan, Karolina Elżbieta Kaczor-Urbanowicz, Christina Priest, David Casero, Peter Tontonoz. Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver.
Proceedings of the National Academy of Sciences of the United States of America.
2022 02; 119(7):. doi:
10.1073/pnas.2122683119. [PMID: 35145035] - Kirsty E Waddington, George A Robinson, Beatriz Rubio-Cuesta, Eden Chrifi-Alaoui, Sara Andreone, Kok-Siong Poon, Iveta Ivanova, Lucia Martin-Gutierrez, Dylan M Owen, Elizabeth C Jury, Inés Pineda-Torra. LXR directly regulates glycosphingolipid synthesis and affects human CD4+ T cell function.
Proceedings of the National Academy of Sciences of the United States of America.
2021 05; 118(21):. doi:
10.1073/pnas.2017394118. [PMID: 34006637] - Peng Wang, Xingjiang Mu, Hongyan Zhao, Yutian Li, Lu Wang, Vivian Wolfe, Shu-Nan Cui, Xiaohong Wang, Tianqing Peng, Basilia Zingarelli, Chunting Wang, Guo-Chang Fan. Administration of GDF3 Into Septic Mice Improves Survival via Enhancing LXRα-Mediated Macrophage Phagocytosis.
Frontiers in immunology.
2021; 12(?):647070. doi:
10.3389/fimmu.2021.647070. [PMID: 33679812] - Tao Zhang, Zhikun Zhan, Yulian Chen, Jianwu Chen, Weichao Han, Zhi Liang, Qiuyue Liu, Shuwen Liu, Lan Tang. Regulation of cytochrome P450 4F11 expression by liver X receptor alpha.
International immunopharmacology.
2021 Jan; 90(?):107240. doi:
10.1016/j.intimp.2020.107240. [PMID: 33310663] - Shivangi Srivastava, Scott Widmann, Charles Ho, Donovan Nguyen, Alexis Nguyen, Asitha Premaratne, Jan-Åke Gustafsson, Chin-Yo Lin. Novel Liver X Receptor Ligand GAC0001E5 Disrupts Glutamine Metabolism and Induces Oxidative Stress in Pancreatic Cancer Cells.
International journal of molecular sciences.
2020 Dec; 21(24):. doi:
10.3390/ijms21249622. [PMID: 33348693] - Yongchao Mou, Yi Dong, Zhenyu Chen, Kyle R Denton, Michael O Duff, Craig Blackstone, Su-Chun Zhang, Xue-Jun Li. Impaired lipid metabolism in astrocytes underlies degeneration of cortical projection neurons in hereditary spastic paraplegia.
Acta neuropathologica communications.
2020 12; 8(1):214. doi:
10.1186/s40478-020-01088-0. [PMID: 33287888] - Yong Huang, Ke Ning, Wen-Wen Li, Ge Lin, Cui-Lan Hou, Ming-Jie Wang, Yi-Chun Zhu. Hydrogen sulfide accumulates LDL receptor precursor via downregulating PCSK9 in HepG2 cells.
American journal of physiology. Cell physiology.
2020 12; 319(6):C1082-C1096. doi:
10.1152/ajpcell.00244.2019. [PMID: 32938225] - Jing Zeng, Daitze Wu, Hui Hu, John A T Young, Zhipeng Yan, Lu Gao. Activation of the Liver X Receptor Pathway Inhibits HBV Replication in Primary Human Hepatocytes.
Hepatology (Baltimore, Md.).
2020 12; 72(6):1935-1948. doi:
10.1002/hep.31217. [PMID: 32145089] - Mirko E Minniti, Matteo Pedrelli, Lise-Lotte Vedin, Anne-Sophie Delbès, Raphaël G P Denis, Katariina Öörni, Claudia Sala, Chiara Pirazzini, Divya Thiagarajan, Harri J Nurmi, Markus Grompe, Kevin Mills, Paolo Garagnani, Ewa C S Ellis, Stephen C Strom, Serge H Luquet, Elizabeth M Wilson, John Bial, Knut R Steffensen, Paolo Parini. Insights From Liver-Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR-Agonist Pharmacodynamics in Humans.
Hepatology (Baltimore, Md.).
2020 08; 72(2):656-670. doi:
10.1002/hep.31052. [PMID: 31785104] - Naomi Benne, Renata Martins Cardoso, Aimee L Boyle, Alexander Kros, Wim Jiskoot, Johan Kuiper, Joke Bouwstra, Miranda Van Eck, Bram Slütter. Complement Receptor Targeted Liposomes Encapsulating the Liver X Receptor Agonist GW3965 Accumulate in and Stabilize Atherosclerotic Plaques.
Advanced healthcare materials.
2020 05; 9(10):e2000043. doi:
10.1002/adhm.202000043. [PMID: 32329226] - Deolinda Santinha, Anna Klopot, Igor Marques, Ewa Ellis, Carl Jorns, Helene Johansson, Tânia Melo, Per Antonson, Tomas Jakobsson, Vítor Félix, Jan-Åke Gustafsson, Maria Rosário Domingues, Agneta Mode, Luisa A Helguero. Lipidomic analysis of human primary hepatocytes following LXR activation with GW3965 identifies AGXT2L1 as a main target associated to changes in phosphatidylethanolamine.
The Journal of steroid biochemistry and molecular biology.
2020 04; 198(?):105558. doi:
10.1016/j.jsbmb.2019.105558. [PMID: 31783151] - Dorothy Moseti, Alemu Regassa, Chongxiao Chen, Karmin O, Woo Kyun Kim. 25-Hydroxycholesterol Inhibits Adipogenic Differentiation of C3H10T1/2 Pluripotent Stromal Cells.
International journal of molecular sciences.
2020 Jan; 21(2):. doi:
10.3390/ijms21020412. [PMID: 31936485] - Tomofumi Fujino, Kouta Sugizaki, Rei Kato, Masaki Beppu, Satoshi Murakami, Hyunjung Lee, Toshiyuki Oshima, Makio Hayakawa. Farnesoid X receptor and liver X receptors regulate Oct3/4 expression by multiple feedback regulating system in normal renal-derived cells and renal adenocarcinoma cells.
The Journal of toxicological sciences.
2020; 45(1):25-35. doi:
10.2131/jts.45.25. [PMID: 31932555] - Matteo Curtarello, Martina Tognon, Carolina Venturoli, Micol Silic-Benussi, Angela Grassi, Martina Verza, Sonia Minuzzo, Marica Pinazza, Valentina Brillo, Giovanni Tosi, Ruggero Ferrazza, Graziano Guella, Egidio Iorio, Adrien Godfroid, Nor Eddine Sounni, Alberto Amadori, Stefano Indraccolo. Rewiring of Lipid Metabolism and Storage in Ovarian Cancer Cells after Anti-VEGF Therapy.
Cells.
2019 12; 8(12):. doi:
10.3390/cells8121601. [PMID: 31835444] - Tyler K T Smith, Zaina Kahiel, Nicholas D LeBlond, Peyman Ghorbani, Eliya Farah, Refel Al-Awosi, Marceline Cote, Suresh Gadde, Morgan D Fullerton. Characterization of Redox-Responsive LXR-Activating Nanoparticle Formulations in Primary Mouse Macrophages.
Molecules (Basel, Switzerland).
2019 Oct; 24(20):. doi:
10.3390/molecules24203751. [PMID: 31635211] - Priscila Calle, Selene Torrico, Angeles Muñoz, Georgina Hotter. CPT1a downregulation protects against cholesterol-induced fibrosis in tubular epithelial cells by downregulating TGFβ-1 and inflammasome.
Biochemical and biophysical research communications.
2019 10; 517(4):715-721. doi:
10.1016/j.bbrc.2019.07.121. [PMID: 31405564] - Xin Han, Zhen-Yu Cui, Jian Song, Hui-Qing Piao, Li-Hua Lian, Li-Shuang Hou, Ge Wang, Shuang Zheng, Xiu-Xiu Dong, Ji-Xing Nan, Yan-Ling Wu. Acanthoic acid modulates lipogenesis in nonalcoholic fatty liver disease via FXR/LXRs-dependent manner.
Chemico-biological interactions.
2019 Sep; 311(?):108794. doi:
10.1016/j.cbi.2019.108794. [PMID: 31421115] - Zizhen Zhang, Hao Chen, Ziyang Chen, Peng Ding, Yingchen Ju, Qiong Gu, Jun Xu, Huihao Zhou. Identify liver X receptor β modulator building blocks by developing a fluorescence polarization-based competition assay.
European journal of medicinal chemistry.
2019 Sep; 178(?):458-467. doi:
10.1016/j.ejmech.2019.06.011. [PMID: 31202993] - Nur Banu Bal, Sevtap Han, Suzan Emel Usanmaz, Saba Kiremitci, Gökhan Sadi, Orhan Uludag, Emine Demirel-Yilmaz. Activation of Liver X Receptors by GW3965 Attenuated Deoxycorticosterone Acetate-Salt Hypertension-Induced Cardiac Functional and Structural Changes.
Journal of cardiovascular pharmacology.
2019 08; 74(2):105-117. doi:
10.1097/fjc.0000000000000693. [PMID: 31397742] - Tibor Sághy, Krisztina Köröskényi, Krisztina Hegedűs, Miklós Antal, Csaba Bankó, Zsolt Bacsó, Attila Papp, Rinke Stienstra, Zsuzsa Szondy. Loss of transglutaminase 2 sensitizes for diet-induced obesity-related inflammation and insulin resistance due to enhanced macrophage c-Src signaling.
Cell death & disease.
2019 06; 10(6):439. doi:
10.1038/s41419-019-1677-z. [PMID: 31165747] - Diego Y Grinman, Valeria P Careaga, Elizabeth A Wellberg, María V Dansey, Edith C Kordon, Steven M Anderson, Marta S Maier, Gerardo Burton, Paul S MacLean, Michael C Rudolph, Adali Pecci. Liver X receptor-α activation enhances cholesterol secretion in lactating mammary epithelium.
American journal of physiology. Endocrinology and metabolism.
2019 06; 316(6):E1136-E1145. doi:
10.1152/ajpendo.00548.2018. [PMID: 30964702] - Ming-Xiang Cheng, Ping Huang, Qiang He, Yong Chen, Jin-Zheng Li. Liver X Receptors Activation Attenuates Ischemia Reperfusion Injury of Liver Graft in Rats.
Journal of investigative surgery : the official journal of the Academy of Surgical Research.
2019 Jun; 32(4):298-303. doi:
10.1080/08941939.2017.1412543. [PMID: 29286833] - Chuanwei Li, Zhangxue Hu, Wen Zhang, Junyi Yu, Yang Yang, Zaicheng Xu, Hao Luo, Xiaoli Liu, Yukai Liu, Caiyu Chen, Yue Cai, Xuewei Xia, Xiaoqun Zhang, Da-Zhi Wang, Gengze Wu, Chunyu Zeng. Regulation of Cholesterol Homeostasis by a Novel Long Non-coding RNA LASER.
Scientific reports.
2019 05; 9(1):7693. doi:
10.1038/s41598-019-44195-2. [PMID: 31118464] - Bin Dong, Amar B Singh, Grace L Guo, Mark Young, Jingwen Liu. Activation of FXR by obeticholic acid induces hepatic gene expression of SR-BI through a novel mechanism of transcriptional synergy with the nuclear receptor LXR.
International journal of molecular medicine.
2019 May; 43(5):1927-1938. doi:
10.3892/ijmm.2019.4136. [PMID: 30896855] - Tianpeng Zhang, Jiangyan Duan, Lei Zhang, Zhuoyu Li, Clifford J Steer, Guiqin Yan, Guisheng Song. LXRα Promotes Hepatosteatosis in Part Through Activation of MicroRNA-378 Transcription and Inhibition of Ppargc1β Expression.
Hepatology (Baltimore, Md.).
2019 04; 69(4):1488-1503. doi:
10.1002/hep.30301. [PMID: 30281809] - Celio Ferreira, Ramona Meyer, Henriette E Meyer Zu Schwabedissen. The nuclear receptors PXR and LXR are regulators of the scaffold protein PDZK1.
Biochimica et biophysica acta. Gene regulatory mechanisms.
2019 04; 1862(4):447-456. doi:
10.1016/j.bbagrm.2019.02.007. [PMID: 30831268] - Leonore Wigger, Cristina Casals-Casas, Michaël Baruchet, Khanh B Trang, Sylvain Pradervand, Aurélien Naldi, Béatrice Desvergne. System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells.
PloS one.
2019; 14(8):e0220894. doi:
10.1371/journal.pone.0220894. [PMID: 31437187] - Sevtap Han, Nur Banu Bal, Gökhan Sadi, Suzan Emel Usanmaz, Mecit Orhan Uludag, Emine Demirel-Yilmaz. The effects of LXR agonist GW3965 on vascular reactivity and inflammation in hypertensive rat aorta.
Life sciences.
2018 Nov; 213(?):287-293. doi:
10.1016/j.lfs.2018.10.042. [PMID: 30366037] - Guohui Zhang, Jin Zhou, Wen Huang, Luting Yu, Yuanzhen Zhang, Hui Wang. Placental mechanism of prenatal nicotine exposure-reduced blood cholesterol levels in female fetal rats.
Toxicology letters.
2018 Oct; 296(?):31-38. doi:
10.1016/j.toxlet.2018.07.022. [PMID: 30036686] - Chaitanya K Gavini, Angie L Bookout, Raiza Bonomo, Laurent Gautron, Syann Lee, Virginie Mansuy-Aubert. Liver X Receptors Protect Dorsal Root Ganglia from Obesity-Induced Endoplasmic Reticulum Stress and Mechanical Allodynia.
Cell reports.
2018 10; 25(2):271-277.e4. doi:
10.1016/j.celrep.2018.09.046. [PMID: 30304667] - Ju-Hee Lee, Su Youn Baek, Eun Jeong Jang, Sae Kwang Ku, Kyu Min Kim, Sung Hwan Ki, Chang-Eop Kim, Kwang Il Park, Sang Chan Kim, Young Woo Kim. Oxyresveratrol ameliorates nonalcoholic fatty liver disease by regulating hepatic lipogenesis and fatty acid oxidation through liver kinase B1 and AMP-activated protein kinase.
Chemico-biological interactions.
2018 Jun; 289(?):68-74. doi:
10.1016/j.cbi.2018.04.023. [PMID: 29702089] - Pattira Chonlaket, Teerasak Wongwan, Sunhapas Soodvilai. Liver X receptor activation inhibits SGLT2-mediated glucose transport in human renal proximal tubular cells.
Experimental physiology.
2018 02; 103(2):250-260. doi:
10.1113/ep086478. [PMID: 29127736] - Teerasak Wongwan, Suticha Kittayaruksakul, Nithi Asavapanumas, Varanuj Chatsudthipong, Sunhapas Soodvilai. Activation of liver X receptor inhibits OCT2-mediated organic cation transport in renal proximal tubular cells.
Pflugers Archiv : European journal of physiology.
2017 11; 469(11):1471-1481. doi:
10.1007/s00424-017-2033-8. [PMID: 28741179] - Mikyung Yu, Jaume Amengual, Arjun Menon, Nazila Kamaly, Felix Zhou, Xiaoding Xu, Phei Er Saw, Seung-Joo Lee, Kevin Si, Carleena Angelica Ortega, Won Il Choi, In-Hyun Lee, Yazan Bdour, Jinjun Shi, Morteza Mahmoudi, Sangyong Jon, Edward A Fisher, Omid C Farokhzad. Targeted Nanotherapeutics Encapsulating Liver X Receptor Agonist GW3965 Enhance Antiatherogenic Effects without Adverse Effects on Hepatic Lipid Metabolism in Ldlr-/- Mice.
Advanced healthcare materials.
2017 Oct; 6(20):. doi:
10.1002/adhm.201700313. [PMID: 28730752] - Alistair C Leitch, Philip M E Probert, James A Shayman, Stephanie K Meyer, George E N Kass, Matthew C Wright. B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals.
Toxicology.
2017 07; 386(?):120-132. doi:
10.1016/j.tox.2017.05.014. [PMID: 28552552] - Xu Cui, Michael Chopp, Zhenggang Zhang, Rongwen Li, Alex Zacharek, Julie Landschoot-Ward, Poornima Venkat, Jieli Chen. ABCA1/ApoE/HDL Pathway Mediates GW3965-Induced Neurorestoration After Stroke.
Stroke.
2017 02; 48(2):459-467. doi:
10.1161/strokeaha.116.015592. [PMID: 28028143] - Jing-Zhong Wang, Yan Fang, Wei-Dong Ji, Hui Xu. LXR agonists promote the proliferation of neural progenitor cells through MEK-ERK pathway.
Biochemical and biophysical research communications.
2017 01; 483(1):216-222. doi:
10.1016/j.bbrc.2016.12.163. [PMID: 28034754] - Zhengyang Wang, Xiaoming Yang, Liang Chen, Xiuling Zhi, Hanyu Lu, Yanxia Ning, Joe Yeong, Sifeng Chen, Lianhua Yin, Xinhong Wang, Xiaobo Li. Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced LXR activation in a mouse model of liver injury.
Archives of toxicology.
2017 Jan; 91(1):271-287. doi:
10.1007/s00204-016-1693-z. [PMID: 27052460] - Cristian R Rodriguez, Lautaro D Alvarez, M Virginia Dansey, Luciano S Paolo, Adriana S Veleiro, Adali Pecci, Gerardo Burton. Fluorinated oxysterol analogues: Synthesis, molecular modelling and LXRβ activity.
The Journal of steroid biochemistry and molecular biology.
2017 01; 165(Pt B):268-276. doi:
10.1016/j.jsbmb.2016.07.001. [PMID: 27452335] - Adrián G Sandoval-Hernández, Alejandro Restrepo, Gloria P Cardona-Gómez, Gonzalo Arboleda. LXR activation protects hippocampal microvasculature in very old triple transgenic mouse model of Alzheimer's disease.
Neuroscience letters.
2016 05; 621(?):15-21. doi:
10.1016/j.neulet.2016.04.007. [PMID: 27057732] - Olivier Briand, Véronique Touche, Sophie Colin, Gemma Brufau, Alberto Davalos, Marleen Schonewille, Fabiola Bovenga, Véronique Carrière, Jan Freark de Boer, Camille Dugardin, Béatrice Riveau, Véronique Clavey, Anne Tailleux, Antonio Moschetta, Miguel A Lasunción, Albert K Groen, Bart Staels, Sophie Lestavel. Liver X Receptor Regulates Triglyceride Absorption Through Intestinal Down-regulation of Scavenger Receptor Class B, Type 1.
Gastroenterology.
2016 Mar; 150(3):650-8. doi:
10.1053/j.gastro.2015.11.015. [PMID: 26602218] - Aihui Fan, Qian Wang, Yongjun Yuan, Jilun Cheng, Lixian Chen, Xiaohua Guo, Qiang Li, Bo Chen, Xuliang Huang, Qiaobing Huang. Liver X receptor-α and miR-130a-3p regulate expression of sphingosine 1-phosphate receptor 2 in human umbilical vein endothelial cells.
American journal of physiology. Cell physiology.
2016 Feb; 310(3):C216-26. doi:
10.1152/ajpcell.00102.2015. [PMID: 26669941] - Caroline Lucia Pinto, Sharanya Maanasi Kalasekar, Catherine W McCollum, Anne Riu, Philip Jonsson, Justin Lopez, Eric C Swindell, Abdel Bouhlatouf, Patrick Balaguer, Maria Bondesson, Jan-Åke Gustafsson. Lxr regulates lipid metabolic and visual perception pathways during zebrafish development.
Molecular and cellular endocrinology.
2016 Jan; 419(?):29-43. doi:
10.1016/j.mce.2015.09.030. [PMID: 26427652] - Hai Thi Do, Céline Bruelle, Dan Duc Pham, Matti Jauhiainen, Ove Eriksson, Laura T Korhonen, Dan Lindholm. Nerve growth factor (NGF) and pro-NGF increase low-density lipoprotein (LDL) receptors in neuronal cells partly by different mechanisms: role of LDL in neurite outgrowth.
Journal of neurochemistry.
2016 Jan; 136(2):306-15. doi:
10.1111/jnc.13397. [PMID: 26484803] - Jianjia Fan, Shahab Zareyan, Wenchen Zhao, Yoko Shimizu, Tom A Pfeifer, Jun-Hyung Tak, Murray B Isman, Bernard Van den Hoven, Mark E Duggan, Michael W Wood, Cheryl L Wellington, Iva Kulic. Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes.
PloS one.
2016; 11(9):e0162384. doi:
10.1371/journal.pone.0162384. [PMID: 27598782] - Yan Huang, Xiaohong Fu, Xilin Lyu, Zhizhen Xu, Zhicheng He, Yan Zhang, Yijun Zeng, Fengtian He, Gang Huang. Activation of LXR attenuates collagen-induced arthritis via suppressing BLyS production.
Clinical immunology (Orlando, Fla.).
2015 Dec; 161(2):339-47. doi:
10.1016/j.clim.2015.09.015. [PMID: 26431776] - Rebecca Skerrett, Mateus P Pellegrino, Brad T Casali, Laura Taraboanta, Gary E Landreth. Combined Liver X Receptor/Peroxisome Proliferator-activated Receptor γ Agonist Treatment Reduces Amyloid β Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 Mice.
The Journal of biological chemistry.
2015 Aug; 290(35):21591-602. doi:
10.1074/jbc.m115.652008. [PMID: 26163517] - Minoru Koura, Takayuki Matsuda, Ayumu Okuda, Yuichiro Watanabe, Yuki Yamaguchi, Sayaka Kurobuchi, Yuuki Matsumoto, Kimiyuki Shibuya. Design, synthesis and pharmacology of 1,1-bistrifluoromethylcarbinol derivatives as liver X receptor β-selective agonists.
Bioorganic & medicinal chemistry letters.
2015 Jul; 25(13):2668-74. doi:
10.1016/j.bmcl.2015.04.080. [PMID: 25998501] - Takayuki Matsuda, Ayumu Okuda, Yuichiro Watanabe, Tohru Miura, Hidefumi Ozawa, Ayako Tosaka, Koichi Yamazaki, Yuki Yamaguchi, Sayaka Kurobuchi, Minoru Koura, Kimiyuki Shibuya. Design and discovery of 2-oxochromene derivatives as liver X receptor β-selective agonists.
Bioorganic & medicinal chemistry letters.
2015 Mar; 25(6):1274-8. doi:
10.1016/j.bmcl.2015.01.047. [PMID: 25677664] - Julie R Secor McVoy, Hanadi Ajam Oughli, Unsong Oh. Liver X receptor-dependent inhibition of microglial nitric oxide synthase 2.
Journal of neuroinflammation.
2015 Feb; 12(?):27. doi:
10.1186/s12974-015-0247-2. [PMID: 25889344] - Xue-Qing Zhang, Orli Even-Or, Xiaoyang Xu, Mariska van Rosmalen, Lucas Lim, Suresh Gadde, Omid C Farokhzad, Edward A Fisher. Nanoparticles containing a liver X receptor agonist inhibit inflammation and atherosclerosis.
Advanced healthcare materials.
2015 Jan; 4(2):228-36. doi:
10.1002/adhm.201400337. [PMID: 25156796] - C Hu, D Liu, Y Zhang, G Lou, G Huang, B Chen, X Shen, M Gao, W Gong, P Zhou, S Dai, Y Zeng, F He. LXRα-mediated downregulation of FOXM1 suppresses the proliferation of hepatocellular carcinoma cells.
Oncogene.
2014 May; 33(22):2888-97. doi:
10.1038/onc.2013.250. [PMID: 23812424] - Amena Archer, Jurga Laurencikiene, Osman Ahmed, Knut R Steffensen, Paolo Parini, Jan-Åke Gustafsson, Marion Korach-André. Skeletal muscle as a target of LXR agonist after long-term treatment: focus on lipid homeostasis.
American journal of physiology. Endocrinology and metabolism.
2014 Mar; 306(5):E494-502. doi:
10.1152/ajpendo.00410.2013. [PMID: 24368671] - Simone Bocchetta, Patrick Maillard, Mami Yamamoto, Claire Gondeau, Florian Douam, Stéphanie Lebreton, Sylvie Lagaye, Stanislas Pol, François Helle, Wanee Plengpanich, Maryse Guérin, Maryline Bourgine, Marie Louise Michel, Dimitri Lavillette, Philippe Roingeard, Wilfried le Goff, Agata Budkowska. Up-regulation of the ATP-binding cassette transporter A1 inhibits hepatitis C virus infection.
PloS one.
2014; 9(3):e92140. doi:
10.1371/journal.pone.0092140. [PMID: 24646941] - J Svärd, F Blanco, D Nevin, D Fayne, F Mulcahy, M Hennessy, J P Spiers. Differential interactions of antiretroviral agents with LXR, ER and GR nuclear receptors: potential contributing factors to adverse events.
British journal of pharmacology.
2014 Jan; 171(2):480-97. doi:
10.1111/bph.12480. [PMID: 24372550] - Kristina Kannisto, Mats Gåfvels, Zhao-Yan Jiang, Katharina Slätis, Xiaoli Hu, Carl Jorns, Knut R Steffensen, Gösta Eggertsen. LXR driven induction of HDL-cholesterol is independent of intestinal cholesterol absorption and ABCA1 protein expression.
Lipids.
2014 Jan; 49(1):71-83. doi:
10.1007/s11745-013-3853-8. [PMID: 24163219] - Nicholes R Candelaria, Sridevi Addanki, Jine Zheng, Trang Nguyen-Vu, Husna Karaboga, Prasenjit Dey, Chiara Gabbi, Lise-Lotte Vedin, Ka Liu, Wanfu Wu, Philip K Jonsson, Jean Z Lin, Fei Su, Lakshmi Reddy Bollu, Sally E Hodges, Amy L McElhany, Mehdi A Issazadeh, William E Fisher, Michael M Ittmann, Knut R Steffensen, Jan-Åke Gustafsson, Chin-Yo Lin. Antiproliferative effects and mechanisms of liver X receptor ligands in pancreatic ductal adenocarcinoma cells.
PloS one.
2014; 9(9):e106289. doi:
10.1371/journal.pone.0106289. [PMID: 25184494] - Jonas Sieber, Astrid Weins, Kapil Kampe, Stefan Gruber, Maja T Lindenmeyer, Clemens D Cohen, Jana M Orellana, Peter Mundel, Andreas W Jehle. Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2.
The American journal of pathology.
2013 Sep; 183(3):735-44. doi:
10.1016/j.ajpath.2013.05.023. [PMID: 23867797] - A M L Pettersson, B M Stenson, S Lorente-Cebrián, D P Andersson, N Mejhert, J Krätzel, G Aström, I Dahlman, A V Chibalin, P Arner, J Laurencikiene. LXR is a negative regulator of glucose uptake in human adipocytes.
Diabetologia.
2013 Sep; 56(9):2044-54. doi:
10.1007/s00125-013-2954-5. [PMID: 23765184] - Yun Hu, Yaqi Yang, Yanjun Yu, Gesi Wen, Nana Shang, Wei Zhuang, Dihan Lu, Binhua Zhou, Baoxia Liang, Xin Yue, Feng Li, Jun Du, Xianzhang Bu. Synthesis and identification of new flavonoids targeting liver X receptor β involved pathway as potential facilitators of Aβ clearance with reduced lipid accumulation.
Journal of medicinal chemistry.
2013 Aug; 56(15):6033-53. doi:
10.1021/jm301913k. [PMID: 23844653] - Minako Ishibashi, Rodolphe Filomenko, Cédric Rébé, Angélique Chevriaux, Alexis Varin, Valentin Derangère, Ginette Bessède, Philippe Gambert, Laurent Lagrost, David Masson. Knock-down of the oxysterol receptor LXRα impairs cholesterol efflux in human primary macrophages: lack of compensation by LXRβ activation.
Biochemical pharmacology.
2013 Jul; 86(1):122-9. doi:
10.1016/j.bcp.2012.12.024. [PMID: 23313547] - Hyun-Ju Kim, Kyung-Ae Yoon, Hye-Jin Yoon, Jung Min Hong, Min-Jung Lee, In-Kyu Lee, Shin-Yoon Kim. Liver X receptor activation inhibits osteoclastogenesis by suppressing NF-κB activity and c-Fos induction and prevents inflammatory bone loss in mice.
Journal of leukocyte biology.
2013 Jul; 94(1):99-107. doi:
10.1189/jlb.1112601. [PMID: 23657115] - Amena Archer, Emilie Stolarczyk, Maria Luisa Doria, Luisa Helguero, Rosário Domingues, Jane K Howard, Agneta Mode, Marion Korach-André, Jan-Åke Gustafsson. LXR activation by GW3965 alters fat tissue distribution and adipose tissue inflammation in ob/ob female mice.
Journal of lipid research.
2013 May; 54(5):1300-11. doi:
10.1194/jlr.m033977. [PMID: 23446231] - Eva Kiss, Bettina Kränzlin, Katja Wagenblaβ, Mahnaz Bonrouhi, Joachim Thiery, Elisabeth Gröne, Viola Nordström, Daniel Teupser, Norbert Gretz, Ernst Malle, Hermann-Josef Gröne. Lipid droplet accumulation is associated with an increase in hyperglycemia-induced renal damage: prevention by liver X receptors.
The American journal of pathology.
2013 Mar; 182(3):727-41. doi:
10.1016/j.ajpath.2012.11.033. [PMID: 23318573] - Dhananjay R Namjoshi, Georgina Martin, James Donkin, Anna Wilkinson, Sophie Stukas, Jianjia Fan, Michael Carr, Sepideh Tabarestani, Kelli Wuerth, Robert E W Hancock, Cheryl L Wellington. The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E.
PloS one.
2013; 8(1):e53529. doi:
10.1371/journal.pone.0053529. [PMID: 23349715] - Peng Lei, Anton Baysa, Hilde Irene Nebb, Guro Valen, Tor Skomedal, Jan Bjørn Osnes, Zaiqing Yang, Fred Haugen. Activation of Liver X receptors in the heart leads to accumulation of intracellular lipids and attenuation of ischemia-reperfusion injury.
Basic research in cardiology.
2013 Jan; 108(1):323. doi:
10.1007/s00395-012-0323-z. [PMID: 23266787] - Sunhapas Soodvilai, Zhanjun Jia, Somsak Fongsupa, Varanuj Chatsudthipong, Tianxin Yang. Liver X receptor agonists decrease ENaC-mediated sodium transport in collecting duct cells.
American journal of physiology. Renal physiology.
2012 Dec; 303(12):F1610-6. doi:
10.1152/ajprenal.00283.2012. [PMID: 23077096] - Amena Archer, Nicolas Venteclef, Agneta Mode, Matteo Pedrelli, Chiara Gabbi, Karine Clément, Paolo Parini, Jan-Åke Gustafsson, Marion Korach-André. Fasting-induced FGF21 is repressed by LXR activation via recruitment of an HDAC3 corepressor complex in mice.
Molecular endocrinology (Baltimore, Md.).
2012 Dec; 26(12):1980-90. doi:
10.1210/me.2012-1151. [PMID: 23073827] - Min Gao, Yijun Zeng, Yaqun Guan, Zhangxue Hu, Dan Zhong, Xiaodong Shen, Li Zhang, Zhizhen Xu, Wei Gong, Yan Zhang, Minfang Zhang, Yingru Zheng, Fengtian He. Activation of liver X receptor attenuates endothelin-1 expression in vascular endothelial cells.
The international journal of biochemistry & cell biology.
2012 Dec; 44(12):2299-307. doi:
10.1016/j.biocel.2012.09.010. [PMID: 23018104] - X Hu, K R Steffensen, Z-Y Jiang, P Parini, J-Å Gustafsson, M Gåfvels, G Eggertsen. LXRβ activation increases intestinal cholesterol absorption, leading to an atherogenic lipoprotein profile.
Journal of internal medicine.
2012 Nov; 272(5):452-64. doi:
10.1111/j.1365-2796.2012.02529.x. [PMID: 22329358] - Magnus Bentinger, Michael Tekle, Gustav Dallner, Kerstin Brismar, Jan-Åke Gustafsson, Knut R Steffensen, Sergiu-Bogdan Catrina. Influence of liver-X-receptor on tissue cholesterol, coenzyme Q and dolichol content.
Molecular membrane biology.
2012 Nov; 29(7):299-308. doi:
10.3109/09687688.2012.694484. [PMID: 22694168] - Paul B Noto, Yuri Bukhtiyarov, Meng Shi, Brian M McKeever, Gerard M McGeehan, Deepak S Lala. Regulation of sphingomyelin phosphodiesterase acid-like 3A gene (SMPDL3A) by liver X receptors.
Molecular pharmacology.
2012 Oct; 82(4):719-27. doi:
10.1124/mol.112.078865. [PMID: 22810003] - Alessio Noghero, Alessia Perino, Giorgio Seano, Elisa Saglio, Giuseppe Lo Sasso, Franco Veglio, Luca Primo, Emilio Hirsch, Federico Bussolino, Fulvio Morello. Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2.
Arteriosclerosis, thrombosis, and vascular biology.
2012 Sep; 32(9):2280-8. doi:
10.1161/atvbaha.112.250621. [PMID: 22723445] - Dongmei Di, Zongchun Wang, Yang Liu, Guanghua Luo, Yuanping Shi, Maria Berggren-Söderlund, Peter Nilsson-Ehle, Xiaoying Zhang, Ning Xu. ABCA1 upregulating apolipoproein M expression mediates via the RXR/LXR pathway in HepG2 cells.
Biochemical and biophysical research communications.
2012 Apr; 421(1):152-6. doi:
10.1016/j.bbrc.2012.04.022. [PMID: 22516753] - Sophie Stukas, Sharon May, Anna Wilkinson, Jeniffer Chan, James Donkin, Cheryl L Wellington. The LXR agonist GW3965 increases apoA-I protein levels in the central nervous system independent of ABCA1.
Biochimica et biophysica acta.
2012 Mar; 1821(3):536-46. doi:
10.1016/j.bbalip.2011.08.014. [PMID: 21889608] - Suticha Kittayaruksakul, Sunhapas Soodvilai, Nithi Asavapanumas, Chatchai Muanprasat, Varanuj Chatsudthipong. Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule.
American journal of physiology. Renal physiology.
2012 Mar; 302(5):F552-60. doi:
10.1152/ajprenal.00341.2011. [PMID: 22169006] - Chiara Gabbi, Xiaomu Kong, Hitoshi Suzuki, Hyun-Jin Kim, Min Gao, Xiao Jia, Hideo Ohnishi, Yoichi Ueta, Margaret Warner, Youfei Guan, Jan-Åke Gustafsson. Central diabetes insipidus associated with impaired renal aquaporin-1 expression in mice lacking liver X receptor β.
Proceedings of the National Academy of Sciences of the United States of America.
2012 Feb; 109(8):3030-4. doi:
10.1073/pnas.1200588109. [PMID: 22323586] - Nancy Nader, Sinnie Sin Man Ng, Yonghong Wang, Brent S Abel, George P Chrousos, Tomoshige Kino. Liver x receptors regulate the transcriptional activity of the glucocorticoid receptor: implications for the carbohydrate metabolism.
PloS one.
2012; 7(3):e26751. doi:
10.1371/journal.pone.0026751. [PMID: 22457708] - Elizabeth J Tarling, Peter A Edwards. ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter.
Proceedings of the National Academy of Sciences of the United States of America.
2011 Dec; 108(49):19719-24. doi:
10.1073/pnas.1113021108. [PMID: 22095132] - Eva Kiss, Zoran Popovic, Jens Bedke, Shijun Wang, Mahnaz Bonrouhi, Norbert Gretz, Paula Stettner, Daniel Teupser, Joachim Thiery, Stefan Porubsky, Judith Adams, Hermann-Josef Gröne. Suppression of chronic damage in renal allografts by Liver X receptor (LXR) activation relevant contribution of macrophage LXRα.
The American journal of pathology.
2011 Jul; 179(1):92-103. doi:
10.1016/j.ajpath.2011.03.019. [PMID: 21703396] - Jwa van der Hoorn, D Lindén, U Lindahl, Mea Bekkers, M Voskuilen, R Nilsson, J Oscarsson, El Lindstedt, Hmg Princen. Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels.
British journal of pharmacology.
2011 Apr; 162(7):1553-63. doi:
10.1111/j.1476-5381.2010.01168.x. [PMID: 21175581] - Sung-E Choi, Ik-Rak Jung, Youn-Jung Lee, Soo-Jin Lee, Ji-Hyun Lee, Youngsoo Kim, Hee-Sook Jun, Kwan-Woo Lee, Chan Bae Park, Yup Kang. Stimulation of lipogenesis as well as fatty acid oxidation protects against palmitate-induced INS-1 beta-cell death.
Endocrinology.
2011 Mar; 152(3):816-27. doi:
10.1210/en.2010-0924. [PMID: 21209018] - Marion Korach-André, Amena Archer, Rodrigo P Barros, Paolo Parini, Jan-Åke Gustafsson. Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity.
Proceedings of the National Academy of Sciences of the United States of America.
2011 Jan; 108(1):403-8. doi:
10.1073/pnas.1017884108. [PMID: 21173252] - Kang Ho Kim, Gha Young Lee, Jong In Kim, Mira Ham, Joo Won Lee, Jae Bum Kim. Inhibitory effect of LXR activation on cell proliferation and cell cycle progression through lipogenic activity.
Journal of lipid research.
2010 Dec; 51(12):3425-33. doi:
10.1194/jlr.m007989. [PMID: 20847297] - Cynthia Hong, Sarah Duit, Pilvi Jalonen, Ruud Out, Lilith Scheer, Vincenzo Sorrentino, Rima Boyadjian, Kees W Rodenburg, Edan Foley, Laura Korhonen, Dan Lindholm, Johannes Nimpf, Theo J C van Berkel, Peter Tontonoz, Noam Zelcer. The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.
The Journal of biological chemistry.
2010 Jun; 285(26):19720-6. doi:
10.1074/jbc.m110.123729. [PMID: 20427281] - Min-Chan Park, Yong-Jin Kwon, Soo-Jin Chung, Yong-Beom Park, Soo-Kon Lee. Liver X receptor agonist prevents the evolution of collagen-induced arthritis in mice.
Rheumatology (Oxford, England).
2010 May; 49(5):882-90. doi:
10.1093/rheumatology/keq007. [PMID: 20159908] - Baihua Hu, Rayomand J Unwalla, Igor Goljer, James W Jetter, Elaine M Quinet, Thomas J Berrodin, Michael D Basso, Irene B Feingold, Annika Goos Nilsson, Anna Wilhelmsson, Mark J Evans, Jay E Wrobel. Identification of phenylsulfone-substituted quinoxaline (WYE-672) as a tissue selective liver X-receptor (LXR) agonist.
Journal of medicinal chemistry.
2010 Apr; 53(8):3296-304. doi:
10.1021/jm100034x. [PMID: 20350005] - Rosalinda Sorrentino, Silvana Morello, Shuang Chen, Eduardo Bonavita, Aldo Pinto. The activation of liver X receptors inhibits toll-like receptor-9-induced foam cell formation.
Journal of cellular physiology.
2010 Apr; 223(1):158-67. doi:
10.1002/jcp.22022. [PMID: 20049870] - François Briand, Morgan Tréguier, Agnès André, Didier Grillot, Marc Issandou, Khadija Ouguerram, Thierry Sulpice. Liver X receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster model.
Journal of lipid research.
2010 Apr; 51(4):763-70. doi:
10.1194/jlr.m001552. [PMID: 19965597] - Tomoyuki Yasuda, Didier Grillot, Jeffery T Billheimer, François Briand, Philippe Delerive, Stephane Huet, Daniel J Rader. Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo.
Arteriosclerosis, thrombosis, and vascular biology.
2010 Apr; 30(4):781-6. doi:
10.1161/atvbaha.109.195693. [PMID: 20110577] - Pia Kotokorpi, Nicolas Venteclef, Ewa Ellis, Jan-Ake Gustafsson, Agneta Mode. The human ADFP gene is a direct liver-X-receptor (LXR) target gene and differentially regulated by synthetic LXR ligands.
Molecular pharmacology.
2010 Jan; 77(1):79-86. doi:
10.1124/mol.109.059063. [PMID: 19843633] - Yun Yong Wang, Maria K Dahle, Knut R Steffensen, Finn P Reinholt, Jon L Collins, Christoph Thiemermann, Ansgar O Aasen, Jan-Ake Gustafsson, Jacob E Wang. Liver X receptor agonist GW3965 dose-dependently regulates lps-mediated liver injury and modulates posttranscriptional TNF-alpha production and p38 mitogen-activated protein kinase activation in liver macrophages.
Shock (Augusta, Ga.).
2009 Nov; 32(5):548-53. doi:
10.1097/shk.0b013e3181a47f85. [PMID: 19295476] - Joseph P Marino, Lara S Kallander, Chun Ma, Hye-Ja Oh, Dennis Lee, Dimitri E Gaitanopoulos, John A Krawiec, Derek J Parks, Christine L Webb, Kelly Ziegler, Michael Jaye, Scott K Thompson. The discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages.
Bioorganic & medicinal chemistry letters.
2009 Oct; 19(19):5617-21. doi:
10.1016/j.bmcl.2009.08.036. [PMID: 19717304] - Britta M Stenson, Mikael Rydén, Knut R Steffensen, Kerstin Wåhlén, Amanda T Pettersson, Johan W Jocken, Peter Arner, Jurga Laurencikiene. Activation of liver X receptor regulates substrate oxidation in white adipocytes.
Endocrinology.
2009 Sep; 150(9):4104-13. doi:
10.1210/en.2009-0676. [PMID: 19556420] - H Scholz, T Lund, M K Dahle, J L Collins, O Korsgren, J E Wang, A Foss. The synthetic liver X receptor agonist GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro.
Diabetologia.
2009 Jul; 52(7):1352-62. doi:
10.1007/s00125-009-1366-z. [PMID: 19415233]