Cytidine monophosphate N-acetylneuraminic acid (BioDeep_00001868999)
Main id: BioDeep_00000004384
PANOMIX_OTCML-2023 Volatile Flavor Compounds
代谢物信息卡片
Cytidine monophosphate N-acetylneuraminic acid
化学式: C20H31N4O16P (614.1472616)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)NC1C(CC(OC1C(C(CO)O)O)(C(=O)O)OP(=O)(O)OCC2C(C(C(O2)N3C=CC(=NC3=O)N)O)O)O
InChI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1
描述信息
COVID info from WikiPathways
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:16556
- KEGG: C00128
- PubChem: 448209
- DrugBank: DB02485
- ChEMBL: CHEMBL1234647
- MeSH: Cytidine Monophosphate N-Acetylneuraminic Acid
- CAS: 3063-71-6
- CAS: 22-12-8
- PubChem: 3428
- PDB-CCD: NCC
- 3DMET: B01167
- NIKKAJI: J472.301E
- KNApSAcK: 16556
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Emmanuel Nji, Ashutosh Gulati, Abdul Aziz Qureshi, Mathieu Coincon, David Drew. Structural basis for the delivery of activated sialic acid into Golgi for sialyation.
Nature structural & molecular biology.
2019 06; 26(6):415-423. doi:
10.1038/s41594-019-0225-y. [PMID: 31133698] - J Alfredo Blakeley-Ruiz, Alison R Erickson, Brandi L Cantarel, Weili Xiong, Rachel Adams, Janet K Jansson, Claire M Fraser, Robert L Hettich. Metaproteomics reveals persistent and phylum-redundant metabolic functional stability in adult human gut microbiomes of Crohn's remission patients despite temporal variations in microbial taxa, genomes, and proteomes.
Microbiome.
2019 02; 7(1):18. doi:
10.1186/s40168-019-0631-8. [PMID: 30744677] - Sunita Gulati, Ian C Schoenhofen, Dennis M Whitfield, Andrew D Cox, Jianjun Li, Frank St Michael, Evgeny V Vinogradov, Jacek Stupak, Bo Zheng, Makoto Ohnishi, Magnus Unemo, Lisa A Lewis, Rachel E Taylor, Corinna S Landig, Sandra Diaz, George W Reed, Ajit Varki, Peter A Rice, Sanjay Ram. Utilizing CMP-Sialic Acid Analogs to Unravel Neisseria gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics.
PLoS pathogens.
2015 Dec; 11(12):e1005290. doi:
10.1371/journal.ppat.1005290. [PMID: 26630657] - Paola Rota, Federica Cirillo, Marco Piccoli, Antonio Gregorio, Guido Tettamanti, Pietro Allevi, Luigi Anastasia. Synthesis and biological evaluation of several dephosphonated analogues of CMP-Neu5Ac as inhibitors of GM3-synthase.
Chemistry (Weinheim an der Bergstrasse, Germany).
2015 Oct; 21(41):14614-29. doi:
10.1002/chem.201501770. [PMID: 26397189] - Christopher Burlak, Marshall Bern, Alejandro E Brito, Dragan Isailovic, Zheng-Yu Wang, Jose L Estrada, Ping Li, A Joseph Tector. N-linked glycan profiling of GGTA1/CMAH knockout pigs identifies new potential carbohydrate xenoantigens.
Xenotransplantation.
2013 Sep; 20(5):277-91. doi:
10.1111/xen.12047. [PMID: 24033743] - Thomas J Inzana, Rajiv Balyan, Michael D Howard. Decoration of Histophilus somni lipooligosaccharide with N-acetyl-5-neuraminic acid enhances bacterial binding of complement factor H and resistance to killing by serum and polymorphonuclear leukocytes.
Veterinary microbiology.
2012 Dec; 161(1-2):113-21. doi:
10.1016/j.vetmic.2012.07.008. [PMID: 22868182] - Birgit Weinhold, Melanie Sellmeier, Wiebke Schaper, Linda Blume, Brigitte Philippens, Elina Kats, Ulrike Bernard, Sebastian P Galuska, Hildegard Geyer, Rudolf Geyer, Kirstin Worthmann, Mario Schiffer, Stephanie Groos, Rita Gerardy-Schahn, Anja K Münster-Kühnel. Deficits in sialylation impair podocyte maturation.
Journal of the American Society of Nephrology : JASN.
2012 Aug; 23(8):1319-28. doi:
10.1681/asn.2011090947. [PMID: 22745475] - Leo Y-C Lin, Bojana Rakic, Cecilia P C Chiu, Emilie Lameignere, Warren W Wakarchuk, Stephen G Withers, Natalie C J Strynadka. Structure and mechanism of the lipooligosaccharide sialyltransferase from Neisseria meningitidis.
The Journal of biological chemistry.
2011 Oct; 286(43):37237-48. doi:
10.1074/jbc.m111.249920. [PMID: 21880735] - M Eugenia Giorgi, Rosa M de Lederkremer. Trans-sialidase and mucins of Trypanosoma cruzi: an important interplay for the parasite.
Carbohydrate research.
2011 Sep; 346(12):1389-93. doi:
10.1016/j.carres.2011.04.006. [PMID: 21645882] - Amin A Momin, Hyejung Park, Brent J Portz, Christopher A Haynes, Rebecca L Shaner, Samuel L Kelly, I King Jordan, Jr Alfred H Merrill. A method for visualization of 'omic' datasets for sphingolipid metabolism to predict potentially interesting differences.
Journal of lipid research.
2011 Jun; 52(6):1073-1083. doi:
10.1194/jlr.m010454. [PMID: 21415121] - Alexandra Castilho, Pia Gattinger, Josephine Grass, Jakub Jez, Martin Pabst, Friedrich Altmann, Markus Gorfer, Richard Strasser, Herta Steinkellner. N-glycosylation engineering of plants for the biosynthesis of glycoproteins with bisected and branched complex N-glycans.
Glycobiology.
2011 Jun; 21(6):813-23. doi:
10.1093/glycob/cwr009. [PMID: 21317243] - Hiroyuki Kajiura, Ryo Misaki, Kazuhito Fujiyama, Tatsuji Seki. Stable coexpression of two human sialylation enzymes in plant suspension-cultured tobacco cells.
Journal of bioscience and bioengineering.
2011 Apr; 111(4):471-7. doi:
10.1016/j.jbiosc.2010.11.018. [PMID: 21220208] - Martin Pabst, Josephine Grass, Richard Fischl, Renaud Léonard, Chunsheng Jin, Georg Hinterkörner, Nicole Borth, Friedrich Altmann. Nucleotide and nucleotide sugar analysis by liquid chromatography-electrospray ionization-mass spectrometry on surface-conditioned porous graphitic carbon.
Analytical chemistry.
2010 Dec; 82(23):9782-8. doi:
10.1021/ac101975k. [PMID: 21043458] - Yohei Hayashi, Techuan Chan, Masaki Warashina, Masakazu Fukuda, Takashi Ariizumi, Koji Okabayashi, Naoya Takayama, Makoto Otsu, Koji Eto, Miho Kusuda Furue, Tatsuo Michiue, Kiyoshi Ohnuma, Hiromitsu Nakauchi, Makoto Asashima. Reduction of N-glycolylneuraminic acid in human induced pluripotent stem cells generated or cultured under feeder- and serum-free defined conditions.
PloS one.
2010 Nov; 5(11):e14099. doi:
10.1371/journal.pone.0014099. [PMID: 21124894] - Nabin B Basnet, Kentaro Ide, Hiroyuki Tahara, Yuka Tanaka, Hideki Ohdan. Deficiency of N-glycolylneuraminic acid and Galα1-3Galβ1-4GlcNAc epitopes in xenogeneic cells attenuates cytotoxicity of human natural antibodies.
Xenotransplantation.
2010 Nov; 17(6):440-8. doi:
10.1111/j.1399-3089.2010.00610.x. [PMID: 21158945] - Karin Ilg, Elif Yavuz, Carola Maffioli, Bernard Priem, Markus Aebi. Glycomimicry: display of the GM3 sugar epitope on Escherichia coli and Salmonella enterica sv Typhimurium.
Glycobiology.
2010 Oct; 20(10):1289-97. doi:
10.1093/glycob/cwq091. [PMID: 20574043] - Pilar M Crespo, Vanina Torres Demichelis, José L Daniotti. Neobiosynthesis of glycosphingolipids by plasma membrane-associated glycosyltransferases.
The Journal of biological chemistry.
2010 Sep; 285(38):29179-90. doi:
10.1074/jbc.m110.123422. [PMID: 20639193] - Yu-Xin Xu, Li Liu, Carolina E Caffaro, Carlos B Hirschberg. Inhibition of Golgi apparatus glycosylation causes endoplasmic reticulum stress and decreased protein synthesis.
The Journal of biological chemistry.
2010 Aug; 285(32):24600-8. doi:
10.1074/jbc.m110.134544. [PMID: 20529871] - Alexandra Castilho, Richard Strasser, Johannes Stadlmann, Josephine Grass, Jakub Jez, Pia Gattinger, Renate Kunert, Heribert Quendler, Martin Pabst, Renaud Leonard, Friedrich Altmann, Herta Steinkellner. In planta protein sialylation through overexpression of the respective mammalian pathway.
The Journal of biological chemistry.
2010 May; 285(21):15923-30. doi:
10.1074/jbc.m109.088401. [PMID: 20305285] - Chawaree Chaipan, Imke Steffen, Theodros Solomon Tsegaye, Stephanie Bertram, Ilona Glowacka, Yukinari Kato, Jan Schmökel, Jan Münch, Graham Simmons, Rita Gerardy-Schahn, Stefan Pöhlmann. Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2.
Retrovirology.
2010 May; 7(?):47. doi:
10.1186/1742-4690-7-47. [PMID: 20482880] - Wanderley de Souza, Tecia Maria Ulisses de Carvalho, Emile Santos Barrias. Review on Trypanosoma cruzi: Host Cell Interaction.
International journal of cell biology.
2010; 2010(?):. doi:
10.1155/2010/295394. [PMID: 20811486] - Mariano R Gabri, Laura L Otero, Daniel E Gomez, Daniel F Alonso. Exogenous incorporation of neugc-rich mucin augments n-glycolyl sialic acid content and promotes malignant phenotype in mouse tumor cell lines.
Journal of experimental & clinical cancer research : CR.
2009 Dec; 28(?):146. doi:
10.1186/1756-9966-28-146. [PMID: 19951433] - Shou Takashima, Junichi Seino, Takeshi Nakano, Kazuhito Fujiyama, Masafumi Tsujimoto, Nobuhiro Ishida, Yasuhiro Hashimoto. Analysis of CMP-sialic acid transporter-like proteins in plants.
Phytochemistry.
2009 Dec; 70(17-18):1973-81. doi:
10.1016/j.phytochem.2009.09.017. [PMID: 19822337] - Thierry Hennet. From glycosylation disorders back to glycosylation: what have we learned?.
Biochimica et biophysica acta.
2009 Sep; 1792(9):921-4. doi:
10.1016/j.bbadis.2008.10.006. [PMID: 19007883] - Hans Bakker, Françoise Routier, Angel Ashikov, Detlef Neumann, Dirk Bosch, Rita Gerardy-Schahn. A CMP-sialic acid transporter cloned from Arabidopsis thaliana.
Carbohydrate research.
2008 Aug; 343(12):2148-52. doi:
10.1016/j.carres.2008.01.010. [PMID: 18258224] - Alexandra Castilho, Martin Pabst, Renaud Leonard, Christiane Veit, Friedrich Altmann, Lukas Mach, Josef Glössl, Richard Strasser, Herta Steinkellner. Construction of a functional CMP-sialic acid biosynthesis pathway in Arabidopsis.
Plant physiology.
2008 May; 147(1):331-9. doi:
10.1104/pp.108.117572. [PMID: 18326787] - Daniel R Hill, Jared J Aumiller, Xianzong Shi, Donald L Jarvis. Isolation and analysis of a baculovirus vector that supports recombinant glycoprotein sialylation by SfSWT-1 cells cultured in serum-free medium.
Biotechnology and bioengineering.
2006 Sep; 95(1):37-47. doi:
10.1002/bit.20945. [PMID: 16607656] - Ryo Misaki, Kazuhito Fujiyama, Tatsuji Seki. Expression of human CMP-N-acetylneuraminic acid synthetase and CMP-sialic acid transporter in tobacco suspension-cultured cell.
Biochemical and biophysical research communications.
2006 Jan; 339(4):1184-9. doi:
10.1016/j.bbrc.2005.11.130. [PMID: 16343442] - Mariusz Olczak, Eduardo Guillen. Characterization of a mutation and an alternative splicing of UDP-galactose transporter in MDCK-RCAr cell line.
Biochimica et biophysica acta.
2006 Jan; 1763(1):82-92. doi:
10.1016/j.bbamcr.2005.12.006. [PMID: 16434112] - Christopher T Campbell, Kevin J Yarema. Large-scale approaches for glycobiology.
Genome biology.
2005; 6(11):236. doi:
10.1186/gb-2005-6-11-236. [PMID: 16277754] - Laura Huopaniemi, Meelis Kolmer, Jaana Niittymäki, Markku Pelto-Huikko, Risto Renkonen. Inflammation-induced transcriptional regulation of Golgi transporters required for the synthesis of sulfo sLex glycan epitopes.
Glycobiology.
2004 Dec; 14(12):1285-94. doi:
10.1093/glycob/cwh131. [PMID: 15269183] - Jared J Aumiller, Jason R Hollister, Donald L Jarvis. A transgenic insect cell line engineered to produce CMP-sialic acid and sialylated glycoproteins.
Glycobiology.
2003 Jun; 13(6):497-507. doi:
10.1093/glycob/cwg051. [PMID: 12626399] - Jason Hollister, Harald Conradt, Donald L Jarvis. Evidence for a sialic acid salvaging pathway in lepidopteran insect cells.
Glycobiology.
2003 Jun; 13(6):487-95. doi:
10.1093/glycob/cwg053. [PMID: 12626401] - Lorena Norambuena, Lorena Marchant, Patricia Berninsone, Carlos B Hirschberg, Herman Silva, Ariel Orellana. Transport of UDP-galactose in plants. Identification and functional characterization of AtUTr1, an Arabidopsis thaliana UDP-galactos/UDP-glucose transporter.
The Journal of biological chemistry.
2002 Sep; 277(36):32923-9. doi:
10.1074/jbc.m204081200. [PMID: 12042319] - Timo Wittenberger, Susanne Hellebrand, Antonia Munck, Hans-Jürgen Kreienkamp, H Chica Schaller, Wolfgang Hampe. GPR99, a new G protein-coupled receptor with homology to a new subgroup of nucleotide receptors.
BMC genomics.
2002 Jul; 3(?):17. doi:
10.1186/1471-2164-3-17. [PMID: 12098360] - Sunita Gulati, Kedarnath Sastry, Jens C Jensenius, Peter A Rice, Sanjay Ram. Regulation of the mannan-binding lectin pathway of complement on Neisseria gonorrhoeae by C1-inhibitor and alpha 2-macroglobulin.
Journal of immunology (Baltimore, Md. : 1950).
2002 Apr; 168(8):4078-86. doi:
10.4049/jimmunol.168.8.4078. [PMID: 11937567] - Chao-Ming Tsai, George Kao, Peixuan Zhu. Influence of the length of the lipooligosaccharide alpha chain on its sialylation in Neisseria meningitidis.
Infection and immunity.
2002 Jan; 70(1):407-11. doi:
10.1128/iai.70.1.407-411.2002. [PMID: 11748209] - A E Hills, A Patel, P Boyd, D C James. Metabolic control of recombinant monoclonal antibody N-glycosylation in GS-NS0 cells.
Biotechnology and bioengineering.
2001 Oct; 75(2):239-51. doi:
10.1002/bit.10022. [PMID: 11536148] - D L Jack, G A Jarvis, C L Booth, M W Turner, N J Klein. Mannose-binding lectin accelerates complement activation and increases serum killing of Neisseria meningitidis serogroup C.
The Journal of infectious diseases.
2001 Oct; 184(7):836-45. doi:
10.1086/323204. [PMID: 11509995] - M M McGowen, J Vionnet, W F Vann. Elongation of alternating alpha 2,8/2,9 polysialic acid by the Escherichia coli K92 polysialyltransferase.
Glycobiology.
2001 Aug; 11(8):613-20. doi:
10.1093/glycob/11.8.613. [PMID: 11479272] - T S Raju, J B Briggs, S M Chamow, M E Winkler, A J Jones. Glycoengineering of therapeutic glycoproteins: in vitro galactosylation and sialylation of glycoproteins with terminal N-acetylglucosamine and galactose residues.
Biochemistry.
2001 Jul; 40(30):8868-76. doi:
10.1021/bi010475i. [PMID: 11467948] - K Aoki, N Ishida, M Kawakita. Substrate recognition by UDP-galactose and CMP-sialic acid transporters. Different sets of transmembrane helices are utilized for the specific recognition of UDP-galactose and CMP-sialic acid.
The Journal of biological chemistry.
2001 Jun; 276(24):21555-61. doi:
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American journal of human genetics.
2001 Jun; 68(6):1419-27. doi:
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Glycoconjugate journal.
2001 Mar; 18(3):205-13. doi:
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Molecular genetics and metabolism.
1999 Jun; 67(2):131-7. doi:
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Journal of biochemistry.
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Molecular biology of the cell.
1996 Nov; 7(11):1691-707. doi:
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Infection and immunity.
1996 Nov; 64(11):4630-7. doi:
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Microbial pathogenesis.
1996 Sep; 21(3):193-204. doi:
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Infection and immunity.
1996 Aug; 64(8):3374-8. doi:
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The Journal of infectious diseases.
1996 Jun; 173(6):1422-7. doi:
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Pathologie-biologie.
1996 Apr; 44(4):249-53. doi:
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Journal of chromatography. A.
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Microbial pathogenesis.
1996 Feb; 20(2):87-100. doi:
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Infection and immunity.
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Microbial pathogenesis.
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Antonie van Leeuwenhoek.
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Annals of the New York Academy of Sciences.
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Microbial pathogenesis.
1994 Jun; 16(6):413-21. doi:
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Microbial pathogenesis.
1993 Jul; 15(1):51-63. doi:
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The Journal of biological chemistry.
1993 May; 268(14):10185-96. doi:
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The Journal of biological chemistry.
1993 May; 268(14):10197-206. doi:
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Infection and immunity.
1993 May; 61(5):1657-66. doi:
10.1128/iai.61.5.1657-1666.1993. [PMID: 8478054] - N J Parsons, P R Ashton, C Constantinidou, J A Cole, H Smith. Identification by mass spectrometry of CMP-NANA in diffusible material released from high M(r) blood cell fractions that confers serum resistance on gonococci.
Microbial pathogenesis.
1993 Apr; 14(4):329-35. doi:
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Microbial pathogenesis.
1992 Jun; 12(6):421-32. doi:
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Infection and immunity.
1992 Mar; 60(3):989-97. doi:
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FEMS microbiology letters.
1992 Jan; 69(3):295-9. doi:
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Infection and immunity.
1992 Jan; 60(1):39-43. doi:
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Proceedings. Biological sciences.
1991 Nov; 246(1316):97-105. doi:
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Microbial pathogenesis.
1991 Sep; 11(3):199-210. doi:
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Microbial pathogenesis.
1991 Apr; 10(4):323-32. doi:
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Proceedings. Biological sciences.
1990 Jul; 241(1300):3-5. doi:
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Histochemistry.
1990; 94(5):509-16. doi:
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FEMS microbiology letters.
1990 Jan; 54(1-3):75-80. doi:
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Cancer research.
1989 Nov; 49(22):6258-64. doi:
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The Journal of biological chemistry.
1989 Oct; 264(29):16992-9. doi:
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Microbial pathogenesis.
1989 Oct; 7(4):317-8. doi:
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Journal of lipid research.
1989 Aug; 30(8):1259-66. doi:
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Microbial pathogenesis.
1989 Jul; 7(1):63-72. doi:
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Microbial pathogenesis.
1989 Jul; 7(1):73-7. doi:
10.1016/0882-4010(89)90113-7. [PMID: 2509854] - C A Nairn, J A Cole, P V Patel, N J Parsons, J E Fox, H Smith. Cytidine 5'-monophospho-N-acetylneuraminic acid or a related compound is the low Mr factor from human red blood cells which induces gonococcal resistance to killing by human serum.
Journal of general microbiology.
1988 Dec; 134(12):3295-306. doi:
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The Journal of biological chemistry.
1988 Nov; 263(31):16283-90. doi:
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Microbial pathogenesis.
1988 Oct; 5(4):303-9. doi:
10.1016/0882-4010(88)90103-9. [PMID: 3148816] - H Kadowaki, L A Symanski, R S Koff. Nonspecific lipid transfer protein in the assay of a membrane-bound enzyme CMP-N-acetyl-neuraminate:lactosylceramide sialyltransferase.
Journal of lipid research.
1988 Jan; 29(1):52-62. doi:
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Journal of neuroscience research.
1987; 18(3):456-65. doi:
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Journal of neurochemistry.
1986 Dec; 47(6):1720-7. doi:
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FEBS letters.
1986 Nov; 208(2):407-12. doi:
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The Biochemical journal.
1984 Nov; 224(1):277-84. doi:
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Biochimica et biophysica acta.
1984 Apr; 793(2):133-40. doi:
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Analytical biochemistry.
1983 Apr; 130(2):369-75. doi:
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Biochimica et biophysica acta.
1982 Aug; 706(1):36-41. doi:
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Journal of neurochemistry.
1981 Apr; 36(4):1492-9. doi:
10.1111/j.1471-4159.1981.tb00591.x. [PMID: 7264646] - I M Evans, R Hilf, M Murphy, H B Bosmann. Correlation of serum, tumor, and liver serum glycoprotein: N-acetylneuraminic acid transferase activity with growth of the R3230AC mammary tumor in rats and relationship of the serum activity to tumor burden.
Cancer research.
1980 Sep; 40(9):3103-11. doi:
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Laboratory investigation; a journal of technical methods and pathology.
1980 Sep; 43(3):217-24. doi:
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Biochemistry.
1980 Apr; 19(9):1893-900. doi:
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Biochemistry.
1979 May; 18(10):2086-92. doi:
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Biochimica et biophysica acta.
1979 Apr; 584(1):129-42. doi:
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Biochimica et biophysica acta.
1979 Mar; 583(3):403-8. doi:
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