Phenylsulfate (BioDeep_00001868794)

Main id: BioDeep_00000004497

 

natural product


代谢物信息卡片


Phenyl hydrogen sulfate

化学式: C6H6O4S (173.9987)
中文名称: 硫酸苯酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)OS(=O)(=O)O
InChI: InChI=1S/C6H6O4S/c7-11(8,9)10-6-4-2-1-3-5-6/h1-5H,(H,7,8,9)

描述信息

An aryl sulfate that is phenol bearing an O-sulfo substituent.

同义名列表

3 个代谢物同义名

Phenyl hydrogen sulfate; Phenylsulfate; Phenylsulfate



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ALB, ARSA, ATF4, CLTRN, CYP1A1, HMGB1, HPGDS, PMP2
Peripheral membrane protein 4 AMBP, CYP1A1, HMGB1, HSD17B6
Endoplasmic reticulum membrane 3 ARSA, CYP1A1, STS
Nucleus 4 ALB, ATF4, HMGB1, PMP2
cytosol 5 ALB, AMBP, ATF4, HPGDS, PMP2
centrosome 2 ALB, ATF4
nucleoplasm 4 ARSA, ATF4, HMGB1, HPGDS
RNA polymerase II transcription regulator complex 1 ATF4
Cell membrane 5 AMBP, ATF4, CLTRN, HMGB1, SLC5A2
Early endosome membrane 2 GPNMB, HSD17B6
Multi-pass membrane protein 3 SLC5A1, SLC5A2, SLCO4C1
cell surface 3 AMBP, ARSB, HMGB1
Golgi apparatus 2 ALB, STS
Golgi membrane 1 INS
mitochondrial inner membrane 2 AMBP, CYP1A1
Cytoplasm, cytosol 1 AMBP
Lysosome 4 ARSA, ARSB, SGSH, STS
acrosomal vesicle 1 ARSA
endosome 3 ARSA, HMGB1, STS
plasma membrane 8 AMBP, CLTRN, GPNMB, HMGB1, SLC5A1, SLC5A2, SLCO4C1, STS
Membrane 4 CD276, GPNMB, SLC5A2, STS
apical plasma membrane 2 SLC5A1, SLC5A2
axon 1 CCK
basolateral plasma membrane 1 SLCO4C1
extracellular exosome 10 ALB, AMBP, ARSA, ARSB, CLTRN, PMP2, SGSH, SLC5A1, SLC5A2, SLCO4C1
Lumenal side 1 HSD17B6
endoplasmic reticulum 6 ALB, AMBP, ARSA, HMGB1, HSD17B6, STS
extracellular space 6 ALB, AMBP, ARSA, CCK, HMGB1, INS
lysosomal lumen 3 ARSA, ARSB, SGSH
perinuclear region of cytoplasm 1 SLC5A1
mitochondrion 1 CYP1A1
protein-containing complex 2 ALB, ATF4
intracellular membrane-bounded organelle 4 CYP1A1, HPGDS, HSD17B6, STS
Microsome membrane 2 CYP1A1, HSD17B6
Single-pass type I membrane protein 3 CD276, CLTRN, GPNMB
Secreted 4 ALB, CCK, HMGB1, INS
extracellular region 7 ALB, AMBP, ARSA, ARSB, CCK, HMGB1, INS
Single-pass membrane protein 1 CD276
Extracellular side 1 HMGB1
anchoring junction 1 ALB
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 ATF4
Nucleus membrane 1 AMBP
nuclear membrane 1 AMBP
external side of plasma membrane 1 CD276
Secreted, extracellular space, extracellular matrix 1 AMBP
nucleolus 1 ARSA
Melanosome membrane 1 GPNMB
Early endosome 1 SLC5A1
Apical cell membrane 2 SLC5A1, SLC5A2
Mitochondrion inner membrane 2 AMBP, CYP1A1
intracellular vesicle 1 SLC5A1
collagen-containing extracellular matrix 1 AMBP
nuclear speck 1 ATF4
neuron projection 1 ATF4
ciliary basal body 1 ALB
chromatin 1 ATF4
Chromosome 1 HMGB1
centriole 1 ALB
brush border membrane 2 CLTRN, SLC5A1
Nucleus, nucleolus 1 ARSA
spindle pole 1 ALB
blood microparticle 2 ALB, AMBP
Basolateral cell membrane 1 SLCO4C1
endosome lumen 1 INS
specific granule membrane 1 SLCO4C1
Nucleus speckle 1 ATF4
myelin sheath 1 PMP2
ficolin-1-rich granule lumen 2 ARSB, HMGB1
secretory granule lumen 2 HMGB1, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 5 ALB, ARSA, ARSB, INS, STS
transcription repressor complex 1 HMGB1
GET complex 1 ARSA
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
azurophil granule membrane 1 SLCO4C1
azurophil granule lumen 2 ARSA, ARSB
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
endoplasmic reticulum-Golgi intermediate compartment 1 HMGB1
dendrite membrane 1 ATF4
condensed chromosome 1 HMGB1
extrinsic component of external side of plasma membrane 1 ARSA
nuclear periphery 1 ATF4
[Alpha-1-microglobulin]: Secreted 1 AMBP
[Inter-alpha-trypsin inhibitor light chain]: Secreted 1 AMBP
alphav-beta3 integrin-HMGB1 complex 1 HMGB1
Cytoplasmic vesicle, secretory vesicle, microneme membrane 1 STS
microneme membrane 1 STS
intracellular organelle 1 SLC5A1
ATF4-CREB1 transcription factor complex 1 ATF4
ATF1-ATF4 transcription factor complex 1 ATF4
CHOP-ATF4 complex 1 ATF4
Lewy body core 1 ATF4
ciliary transition fiber 1 ALB


文献列表

  • Suguru Yamamoto, Kenichi Sasahara, Mio Domon, Keiichi Yamaguchi, Toru Ito, Shin Goto, Yuji Goto, Ichiei Narita. pH-Dependent Protein Binding Properties of Uremic Toxins In Vitro. Toxins. 2021 02; 13(2):. doi: 10.3390/toxins13020116. [PMID: 33557434]
  • Koichi Kikuchi, Daisuke Saigusa, Yoshitomi Kanemitsu, Yotaro Matsumoto, Paxton Thanai, Naoto Suzuki, Koki Mise, Hiroaki Yamaguchi, Tomohiro Nakamura, Kei Asaji, Chikahisa Mukawa, Hiroki Tsukamoto, Toshihiro Sato, Yoshitsugu Oikawa, Tomoyuki Iwasaki, Yuji Oe, Tomoya Tsukimi, Noriko N Fukuda, Hsin-Jung Ho, Fumika Nanto-Hara, Jiro Ogura, Ritsumi Saito, Shizuko Nagao, Yusuke Ohsaki, Satoshi Shimada, Takehiro Suzuki, Takafumi Toyohara, Eikan Mishima, Hisato Shima, Yasutoshi Akiyama, Yukako Akiyama, Mariko Ichijo, Tetsuro Matsuhashi, Akihiro Matsuo, Yoshiaki Ogata, Ching-Chin Yang, Chitose Suzuki, Matthew C Breeggemann, Jurgen Heymann, Miho Shimizu, Susumu Ogawa, Nobuyuki Takahashi, Takashi Suzuki, Yuji Owada, Shigeo Kure, Nariyasu Mano, Tomoyoshi Soga, Takashi Wada, Jeffrey B Kopp, Shinji Fukuda, Atsushi Hozawa, Masayuki Yamamoto, Sadayoshi Ito, Jun Wada, Yoshihisa Tomioka, Takaaki Abe. Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease. Nature communications. 2019 04; 10(1):1835. doi: 10.1038/s41467-019-09735-4. [PMID: 31015435]
  • Takeo Edamatsu, Ayako Fujieda, Yoshiharu Itoh. Phenyl sulfate, indoxyl sulfate and p-cresyl sulfate decrease glutathione level to render cells vulnerable to oxidative stress in renal tubular cells. PloS one. 2018; 13(2):e0193342. doi: 10.1371/journal.pone.0193342. [PMID: 29474405]
  • Yoshitomi Kanemitsu, Hiroki Tsukamoto, Yotaro Matsumoto, Kanako Nozawa-Kumada, Yoshinori Kondo, Takaaki Abe, Yoshihisa Tomioka. Generation and Characterization of Anti-phenyl Sulfate Monoclonal Antibodies and a Potential Use for Phenyl Sulfate Analysis in Human Blood. Biological & pharmaceutical bulletin. 2018; 41(8):1170-1177. doi: 10.1248/bpb.b17-00925. [PMID: 30068866]
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