THYMIDINE-5-triphosphATE (BioDeep_00001868470)

Main id: BioDeep_00000001601

 

PANOMIX_OTCML-2023


代谢物信息卡片


THYMIDINE-5-triphosphATE

化学式: C10H17N2O14P3 (481.9893)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O
InChI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/t6-,7+,8+/m0/s1

描述信息

A thymidine phosphate having a triphosphate group at the 5-position.

同义名列表

2 个代谢物同义名

THYMIDINE-5-triphosphATE; dTTP



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 APRT, CMPK2, DCK, DCTD, DHFR, DTYMK, PNP, POLB, RAD51, TK2, TP53, TYMS
Nucleus 11 DCK, DTYMK, DUT, POLB, POLH, RAD51, SAMHD1, TK1, TP53, TYMS, UNG
cytosol 13 APRT, CDA, DCK, DCTD, DHFR, DTYMK, PNP, POLH, RAD51, TK1, TP53, TYMP, TYMS
centrosome 2 RAD51, TP53
nucleoplasm 11 APRT, ATP2B1, CMPK2, DCK, DUT, POLB, POLH, RAD51, SAMHD1, TP53, UNG
Cell membrane 1 ATP2B1
Multi-pass membrane protein 1 ATP2B1
Synapse 1 ATP2B1
glutamatergic synapse 1 ATP2B1
Golgi apparatus 1 POLH
mitochondrial inner membrane 1 TYMS
presynaptic membrane 1 ATP2B1
plasma membrane 2 ATP2B1, SAMHD1
synaptic vesicle membrane 1 ATP2B1
Membrane 2 ATP2B1, TP53
basolateral plasma membrane 1 ATP2B1
extracellular exosome 4 APRT, ATP2B1, DUT, PNP
endoplasmic reticulum 1 TP53
extracellular space 1 PNP
perinuclear region of cytoplasm 1 RAD51
mitochondrion 10 CMPK2, DCK, DHFR, DTYMK, DUT, RAD51, TK2, TP53, TYMS, UNG
protein-containing complex 3 POLB, RAD51, TP53
intracellular membrane-bounded organelle 1 ATP2B1
Secreted 1 PNP
extracellular region 3 APRT, CDA, PNP
Mitochondrion matrix 3 RAD51, TP53, TYMS
mitochondrial matrix 5 DTYMK, RAD51, TK2, TP53, TYMS
transcription regulator complex 1 TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 RAD51, TP53
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
nucleolus 2 RAD51, TP53
Mitochondrion inner membrane 1 TYMS
Cytoplasm, cytoskeleton 1 TP53
microtubule 1 POLB
mitochondrial nucleoid 1 POLH
Nucleus, PML body 1 TP53
PML body 2 RAD51, TP53
lateral plasma membrane 1 ATP2B1
chromatin 2 RAD51, TP53
cell projection 1 ATP2B1
Chromosome 3 POLH, RAD51, SAMHD1
chromosome, telomeric region 1 RAD51
nuclear chromosome 1 RAD51
Basolateral cell membrane 1 ATP2B1
site of double-strand break 4 POLH, RAD51, SAMHD1, TP53
lateral element 1 RAD51
Presynaptic cell membrane 1 ATP2B1
germ cell nucleus 1 TP53
replication fork 2 POLH, TP53
ficolin-1-rich granule lumen 2 CDA, PNP
secretory granule lumen 3 APRT, CDA, PNP
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
male germ cell nucleus 1 RAD51
tertiary granule lumen 1 CDA
immunological synapse 1 ATP2B1
tetraspanin-enriched microdomain 1 SAMHD1
condensed nuclear chromosome 1 RAD51
[Isoform 2]: Nucleus 1 DUT
[Isoform 1]: Nucleus 1 TP53
spindle microtubule 1 POLB
condensed chromosome 1 RAD51
[Isoform 3]: Mitochondrion 1 DUT
site of DNA damage 1 POLH
presynaptic intermediate filament cytoskeleton 1 RAD51
photoreceptor ribbon synapse 1 ATP2B1
nuclear ubiquitin ligase complex 1 RAD51


文献列表

  • Apurba Sarkar, Shreya Ghosh, Rahul Shaw, Madhu Manti Patra, Fatema Calcuttawala, Noyonika Mukherjee, Sujoy K Das Gupta. Mycobacterium tuberculosis thymidylate synthase (ThyX) is a target for plumbagin, a natural product with antimycobacterial activity. PloS one. 2020; 15(2):e0228657. doi: 10.1371/journal.pone.0228657. [PMID: 32017790]
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  • Ming-Hsiang Lee, Liya Wang, Zee-Fen Chang. The contribution of mitochondrial thymidylate synthesis in preventing the nuclear genome stress. Nucleic acids research. 2014 Apr; 42(8):4972-84. doi: 10.1093/nar/gku152. [PMID: 24561807]
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  • Yuanzheng Zhang, Frank Maley, Gladys F Maley, Garry Duncan, David D Dunigan, James L Van Etten. Chloroviruses encode a bifunctional dCMP-dCTP deaminase that produces two key intermediates in dTTP formation. Journal of virology. 2007 Jul; 81(14):7662-71. doi: 10.1128/jvi.00186-07. [PMID: 17475641]
  • Sarah Garton, Heather Knight, Gareth J Warren, Marc R Knight, Glenn J Thorlby. crinkled leaves 8--a mutation in the large subunit of ribonucleotide reductase--leads to defects in leaf development and chloroplast division in Arabidopsis thaliana. The Plant journal : for cell and molecular biology. 2007 Apr; 50(1):118-27. doi: 10.1111/j.1365-313x.2007.03035.x. [PMID: 17346262]
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