Thymidine 5'-triphosphate (BioDeep_00000001601)

 

Secondary id: BioDeep_00000405435, BioDeep_00001868470

natural product human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


{[hydroxy({[hydroxy({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy})phosphoryl]oxy})phosphoryl]oxy}phosphonic acid

化学式: C10H17N2O14P3 (481.9892652)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 0.83%

分子结构信息

SMILES: CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O
InChI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/t6-,7+,8+/m0/s1

描述信息

Thymidine-5-triphosphate, also known as ttp or deoxythymidine 5-triphosphoric acid, is a member of the class of compounds known as pyrimidine 2-deoxyribonucleoside triphosphates. Pyrimidine 2-deoxyribonucleoside triphosphates are pyrimidine nucleotides with a triphosphate group linked to the ribose moiety lacking a hydroxyl group at position 2. Thymidine-5-triphosphate is slightly soluble (in water) and an extremely strong acidic compound (based on its pKa). Thymidine-5-triphosphate can be found in a number of food items such as kohlrabi, garden tomato (variety), cardoon, and star anise, which makes thymidine-5-triphosphate a potential biomarker for the consumption of these food products. Thymidine-5-triphosphate exists in all living species, ranging from bacteria to humans. In humans, thymidine-5-triphosphate is involved in the pyrimidine metabolism. Thymidine-5-triphosphate is also involved in few metabolic disorders, which include beta ureidopropionase deficiency, dihydropyrimidinase deficiency, MNGIE (mitochondrial neurogastrointestinal encephalopathy), and UMP synthase deficiency (orotic aciduria).
Deoxythymidine triphosphate (dTTP) is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA. Unlike the other deoxyribonucleoside triphosphates, thymidine triphosphate does not always contain the "deoxy" prefix in its name. The corresponding ribonucleoside triphosphate is called uridine triphosphate. Thymidine 5-triphosphate, also known as TTP or DTHD5ppp, belongs to the class of organic compounds known as pyrimidine 2-deoxyribonucleoside triphosphates. These are pyrimidine nucleotides with a triphosphate group linked to the ribose moiety lacking a hydroxyl group at position 2. Thymidine 5-triphosphate exists in all living species, ranging from bacteria to humans. Outside of the human body, Thymidine 5-triphosphate has been detected, but not quantified in several different foods, such as elliotts blueberries, mamey sapotes, sesames, alliums, and sweet oranges.

同义名列表

31 个代谢物同义名

{[hydroxy({[hydroxy({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy})phosphoryl]oxy})phosphoryl]oxy}phosphonic acid; Thymidine mono(tetrahydrogen triphosphate); Thymidine 5-triphosphate, p-(32)p-labeled; Thymidine 5-triphosphate, trisodium salt; Thymidine 5-triphosphate, magnesium salt; Thymidine-5-triphosphate sodium salt; 2-Deoxythymidine triphosphoric acid; Deoxythymidine 5-triphosphoric acid; Deoxythymidine triphosphoric acid; 2’-Deoxythymidine 5’-triphosphate; 2-Deoxythymidine-5-triphosphate; 2-Deoxythymidine 5-triphosphate; Thymidine 5-triphosphoric acid; Deoxythymidine 5’-triphosphate; THYMIDINE-5-triphosphoric acid; 2’-Deoxythymidine triphosphate; 2-Deoxythymidine triphosphate; Deoxythymidine 5-triphosphate; Deoxythymidine triphosphate; Thymidine 5’-triphosphate; Thymidine 5-triphosphate; THYMIDINE-5-triphosphATE; Thymidine triphosphate; 5-Methyl-dUTP; Deoxy-TTP; DTHD5ppp; 5’-TTP; PPPDT; 5-TTP; dTTP; TTP



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

85 个相关的代谢反应过程信息。

Reactome(52)

  • DNA Replication: ATP + pre-replicative complex ⟶ ADP + Homologues of p-S,T-ORC1 + pre-replicative complex (Orc1-minus)
  • Synthesis of DNA: ATP + pre-replicative complex ⟶ ADP + Homologues of p-S,T-ORC1 + pre-replicative complex (Orc1-minus)
  • DNA replication initiation: RNA primer:origin duplex:DNA polymerase alpha:primase complex + TTP + dATP + dCTP + dGTP ⟶ RNA primer-DNA primer:origin duplex
  • Cell Cycle: 2OG + Oxygen + PHF8:Nucleosome with H3K4me2/3:H4K20me1 ⟶ CH2O + PHF8:Nucleosome with H3K4me2/3 + SUCCA + carbon dioxide
  • Cell Cycle, Mitotic: 2OG + Oxygen + PHF8:Nucleosome with H3K4me2/3:H4K20me1 ⟶ CH2O + PHF8:Nucleosome with H3K4me2/3 + SUCCA + carbon dioxide
  • S Phase: ATP + pre-replicative complex ⟶ ADP + Homologues of p-S,T-ORC1 + pre-replicative complex (Orc1-minus)
  • Chromosome Maintenance: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Telomere Maintenance: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Extension of Telomeres: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Telomere Extension By Telomerase: TTP + Telomerase RNP Bound and base-paired to the Telomeric Chromosome End + dATP + dCTP + dGTP ⟶ Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat
  • Telomere C-strand (Lagging Strand) Synthesis: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Telomere C-strand synthesis initiation: RNA primer:G-strand extended telomere end:DNA polymerase alpha:primase complex + TTP + dATP + dCTP + dGTP ⟶ RNA primer-DNA primer:G-strand extended telomere
  • Processive synthesis on the C-strand of the telomere: Processive complex loaded on telomere + TTP + dATP + dCTP + dGTP ⟶ Processive complex loaded on telomere:Okazaki fragment complex
  • Telomere C-strand synthesis initiation: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • Telomere C-strand (Lagging Strand) Synthesis: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • Telomere C-strand synthesis initiation: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • Telomere C-strand synthesis initiation: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • DNA Replication: ATP + Q5N897 ⟶ ADP + phospho-p-CDC6
  • Synthesis of DNA: ATP + Q5N897 ⟶ ADP + phospho-p-CDC6
  • DNA replication initiation: RNA primer:origin duplex:DNA polymerase alpha:primase complex + TTP + dATP + dCTP + dGTP ⟶ RNA primer-DNA primer:origin duplex
  • Cell Cycle: ATP + Q5N897 ⟶ ADP + phospho-p-CDC6
  • Cell Cycle, Mitotic: ATP + Q5N897 ⟶ ADP + phospho-p-CDC6
  • S Phase: ATP + Q5N897 ⟶ ADP + phospho-p-CDC6
  • Chromosome Maintenance: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Telomere Maintenance: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Extension of Telomeres: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Telomere C-strand (Lagging Strand) Synthesis: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Telomere C-strand synthesis initiation: RNA primer:G-strand extended telomere end:DNA polymerase alpha:primase complex + TTP + dATP + dCTP + dGTP ⟶ RNA primer-DNA primer:G-strand extended telomere
  • Processive synthesis on the C-strand of the telomere: Processive complex loaded on telomere + TTP + dATP + dCTP + dGTP ⟶ Processive complex loaded on telomere:Okazaki fragment complex
  • Chromosome Maintenance: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • Telomere Maintenance: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • Extension of Telomeres: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • Telomere C-strand (Lagging Strand) Synthesis: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • Telomere C-strand synthesis initiation: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • Telomere C-strand (Lagging Strand) Synthesis: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • Telomere C-strand synthesis initiation: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • Telomere C-strand synthesis initiation: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • Cell Cycle: ATP + p21,p27 ⟶ ADP + p-T-CDKN1A/B
  • Cell Cycle, Mitotic: ATP + p21,p27 ⟶ ADP + p-T-CDKN1A/B
  • S Phase: ATP + p21,p27 ⟶ ADP + p-T-CDKN1A/B
  • Synthesis of DNA: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:origin duplex ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer
  • DNA replication initiation: RNA primer:origin duplex:DNA polymerase alpha:primase complex + TTP + dATP + dCTP + dGTP ⟶ RNA primer-DNA primer:origin duplex
  • Chromosome Maintenance: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Telomere Maintenance: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Extension of Telomeres: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Telomere Extension By Telomerase: TTP + Telomerase RNP Bound and base-paired to the Telomeric Chromosome End + dATP + dCTP + dGTP ⟶ Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat
  • Telomere C-strand (Lagging Strand) Synthesis: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Telomere C-strand synthesis initiation: RNA primer:G-strand extended telomere end:DNA polymerase alpha:primase complex + TTP + dATP + dCTP + dGTP ⟶ RNA primer-DNA primer:G-strand extended telomere
  • DNA Replication: ATP + MCM2-7 ⟶ ADP + p-MCM2-7
  • Processive synthesis on the C-strand of the telomere: Processive complex loaded on telomere + TTP + dATP + dCTP + dGTP ⟶ Processive complex loaded on telomere:Okazaki fragment complex
  • Processive synthesis on the C-strand of the telomere: Processive complex loaded on telomere + TTP + dATP + dCTP + dGTP ⟶ Processive complex loaded on telomere:Okazaki fragment complex
  • Telomere Extension By Telomerase: TTP + Telomerase RNP Bound and base-paired to the Telomeric Chromosome End + dATP + dCTP + dGTP ⟶ Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(2)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(29)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

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  • Yuanzheng Zhang, Frank Maley, Gladys F Maley, Garry Duncan, David D Dunigan, James L Van Etten. Chloroviruses encode a bifunctional dCMP-dCTP deaminase that produces two key intermediates in dTTP formation. Journal of virology. 2007 Jul; 81(14):7662-71. doi: 10.1128/jvi.00186-07. [PMID: 17475641]
  • Sarah Garton, Heather Knight, Gareth J Warren, Marc R Knight, Glenn J Thorlby. crinkled leaves 8--a mutation in the large subunit of ribonucleotide reductase--leads to defects in leaf development and chloroplast division in Arabidopsis thaliana. The Plant journal : for cell and molecular biology. 2007 Apr; 50(1):118-27. doi: 10.1111/j.1365-313x.2007.03035.x. [PMID: 17346262]
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  • Deliang Cao, Janine J Leffert, James McCabe, Bradford Kim, Giuseppe Pizzorno. Abnormalities in uridine homeostatic regulation and pyrimidine nucleotide metabolism as a consequence of the deletion of the uridine phosphorylase gene. The Journal of biological chemistry. 2005 Jun; 280(22):21169-75. doi: 10.1074/jbc.m412343200. [PMID: 15772079]
  • Nicholas A Boyle, Vivek K Rajwanshi, Marija Prhavc, Guangyi Wang, Patrick Fagan, Fu Chen, Gregory J Ewing, Jennifer L Brooks, Tiffany Hurd, Janet M Leeds, Thomas W Bruice, P Dan Cook. Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase. Journal of medicinal chemistry. 2005 Apr; 48(7):2695-700. doi: 10.1021/jm040101y. [PMID: 15801860]
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  • Chun Hung Ma, Joannie Hui, Janet Tsui Ying Tang, Danny Tze Ming Leung, Yiu Loon Chui, Tai Fai Fok, Pak-Leong Lim. Antibodies to guanosine triphosphate misidentified as anti-double-stranded DNA antibodies in a patient with antinuclear antibody-negative lupus, due to buckling of insolubilized assay DNA. Arthritis and rheumatism. 2004 May; 50(5):1533-8. doi: 10.1002/art.20188. [PMID: 15146423]
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  • Chikako Murakami, Masaharu Takemura, Yuichi Sugiyama, Shinji Kamisuki, Hitomi Asahara, Miho Kawasaki, Tomomi Ishidoh, Stuart Linn, Shonen Yoshida, Fumio Sugawara, Hiromi Yoshida, Kengo Sakaguchi, Yoshiyuki Mizushina. Vitamin A-related compounds, all-trans retinal and retinoic acids, selectively inhibit activities of mammalian replicative DNA polymerases. Biochimica et biophysica acta. 2002 Feb; 1574(1):85-92. doi: 10.1016/s0167-4781(01)00348-7. [PMID: 11955616]
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