ribostamycin (BioDeep_00001868412)

Main id: BioDeep_00000003419

 

natural product


代谢物信息卡片


ribostamycin

化学式: C17H34N4O10 (454.2275)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)O)O)O)N
InChI: InChI=1S/C17H34N4O10/c18-2-6-10(24)12(26)8(21)16(28-6)30-14-5(20)1-4(19)9(23)15(14)31-17-13(27)11(25)7(3-22)29-17/h4-17,22-27H,1-3,18-21H2/t4-,5+,6-,7-,8-,9+,10-,11-,12-,13-,14-,15-,16-,17+/m1/s1

描述信息

An amino cyclitol glycoside that is 4,6-diaminocyclohexane-1,2,3-triol having a 2,6-diamino-2,6-dideoxy-alpha-D-glucosyl residue attached at position 1 and a beta-D-ribosyl residue attached at position 2. It is an antibiotic produced by Streptomyces ribosidificus (formerly S. thermoflavus).
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01G - Aminoglycoside antibacterials
C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic

同义名列表

2 个代谢物同义名

ribostamycin; Ribostamycin



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

21 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 AHR, BTRC, MYC
Peripheral membrane protein 1 CYP1B1
Endosome membrane 1 TF
Endoplasmic reticulum membrane 1 CYP1B1
Nucleus 3 AHR, BTRC, MYC
cytosol 3 AHR, B2M, BTRC
nucleoplasm 3 AHR, BTRC, MYC
Cell membrane 1 B2M
Early endosome membrane 1 B2M
cell surface 3 AMELX, B2M, TF
Golgi apparatus 2 ATRN, B2M
Golgi membrane 1 B2M
lysosomal membrane 1 B2M
plasma membrane 3 ATRN, B2M, TF
Membrane 3 B2M, CYP1B1, MYC
apical plasma membrane 1 TF
extracellular exosome 4 ATRN, B2M, SPINK1, TF
endoplasmic reticulum 1 B2M
extracellular space 6 ATRN, B2M, GH1, IL6, PTH, TF
perinuclear region of cytoplasm 1 TF
mitochondrion 1 CYP1B1
protein-containing complex 2 AHR, MYC
intracellular membrane-bounded organelle 1 CYP1B1
Microsome membrane 1 CYP1B1
Single-pass type I membrane protein 1 ATRN
Secreted 5 B2M, GH1, IL6, SPINK1, TF
extracellular region 6 AMELX, B2M, GH1, IL6, PTH, TF
basal part of cell 1 TF
[Isoform 2]: Secreted 1 ATRN
transcription regulator complex 1 AHR
external side of plasma membrane 1 B2M
Secreted, extracellular space, extracellular matrix 1 AMELX
cytoplasmic vesicle 1 TF
nucleolus 1 MYC
Early endosome 1 TF
clathrin-coated pit 1 TF
recycling endosome 1 TF
vesicle 1 TF
focal adhesion 1 B2M
collagen-containing extracellular matrix 1 AMELX
Late endosome 1 TF
chromatin 2 AHR, MYC
Late endosome membrane 1 B2M
phagocytic vesicle membrane 1 B2M
Nucleus, nucleolus 1 MYC
mismatch repair complex 1 PMS2P3
blood microparticle 1 TF
[Isoform 3]: Secreted 1 ATRN
nuclear envelope 1 MYC
Recycling endosome membrane 1 B2M
endosome lumen 1 GH1
aryl hydrocarbon receptor complex 1 AHR
Nucleus, nucleoplasm 1 MYC
basal plasma membrane 1 TF
secretory granule lumen 1 TF
HFE-transferrin receptor complex 2 B2M, TF
endoplasmic reticulum lumen 4 AMELX, B2M, IL6, TF
specific granule lumen 1 B2M
tertiary granule lumen 1 B2M
endocytic vesicle 2 AMELX, TF
RNA polymerase II transcription repressor complex 1 MYC
ER to Golgi transport vesicle membrane 1 B2M
clathrin-coated endocytic vesicle membrane 1 TF
MHC class I peptide loading complex 1 B2M
[Isoform 1]: Cell membrane 1 ATRN
Rough endoplasmic reticulum 1 MYC
vesicle coat 1 TF
Myc-Max complex 1 MYC
growth hormone receptor complex 1 GH1
MHC class I protein complex 1 B2M
MHC class II protein complex 1 B2M
interleukin-6 receptor complex 1 IL6
SCF ubiquitin ligase complex 1 BTRC
nuclear aryl hydrocarbon receptor complex 1 AHR
cytosolic aryl hydrocarbon receptor complex 1 AHR
early endosome lumen 1 B2M
dense body 1 TF
nucleoplasmic reticulum 1 MYC


文献列表

  • Laurence Dallet, Marion Decossas, Jean-Christophe Taveau, Sophie Lecomte, Sylvie Poussard, Olivier Lambert, Bruno Pitard. Single lipoaminoglycoside promotes efficient intracellular antibody delivery: A comprehensive insight into the mechanism of action. Nanomedicine : nanotechnology, biology, and medicine. 2018 01; 14(1):141-151. doi: 10.1016/j.nano.2017.09.005. [PMID: 28939489]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • H B Lee, Y Kim, J C Kim, G J Choi, S-H Park, C-J Kim, H S Jung. Activity of some aminoglycoside antibiotics against true fungi, Phytophthora and Pythium species. Journal of applied microbiology. 2005; 99(4):836-43. doi: 10.1111/j.1365-2672.2005.02684.x. [PMID: 16162234]
  • S L Zhou, G Shen, H F Zhong. Pharmacokinetics of ribostamycin in paediatric patients. Clinical pharmacokinetics. 1992 Feb; 22(2):144-51. doi: 10.2165/00003088-199222020-00005. [PMID: 1551291]
  • Z F Zhu, T X Ma. [Influence of carbenicillin on pharmacokinetics of ribostamycin in 7 volunteers when they were used combinedly]. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1991 May; 12(3):229-31. doi: NULL. [PMID: 1781284]
  • M Yoshida, T Koeda. Effect of aminoglycoside antibiotics on the electrical stimulation-induced contractile response of the guinea-pig ureter. Nihon Heikatsukin Gakkai zasshi. 1989 Jun; 25(3):75-87. doi: 10.1540/jsmr1965.25.75. [PMID: 2607711]
  • S Inouye, T Niizato, T Shomura, I Kitasato. Nephrotoxicity of dactimicin, a novel pseudo-disaccharide aminoglycoside possessing the N-formimidoyl group, compared with that of astromicin, amikacin and other aminoglycoside antibiotics in animals. Drugs under experimental and clinical research. 1989; 15(5):189-209. doi: . [PMID: 2791871]
  • I Kitasato, T Niizato, S Inouye. Comparative nephrotoxicity of ribostamycin and gentamicin in rats evaluated by urinalysis. Drugs under experimental and clinical research. 1989; 15(6-7):273-89. doi: . [PMID: 2591299]
  • S Inouye, T Watanabe, I Kitasato. Comparative antimicrobial activities of ribostamycin, gentamicin, ampicillin and lincomycin in vitro and in vivo. Drugs under experimental and clinical research. 1989; 15(10):465-76. doi: . [PMID: 2632215]
  • M Casal, J Gutierrez Aroca. In vitro activity of ribostamycin against Prototheca sp. Mycopathologia. 1983; 83(1):21-3. doi: 10.1007/bf00437408. [PMID: 6633631]
  • A Lechi, P Rizzotti, C Mengoli, E Arosio, P Pancera. Lactic dehydrogenase isoenzymes in urinary tract infections and aminoglycoside nephrotoxicity. Infection. 1983 Jan; 11(1):52-3. doi: 10.1007/bf01651359. [PMID: 6840866]
  • E S Harpur, I Gonda. Analysis of the phamacokinetics of ribostamycin in serum and perilymph of guinea pigs after single and multiple doses. British journal of audiology. 1982 May; 16(2):95-9. doi: 10.3109/03005368209081453. [PMID: 7093568]
  • F Di Nola. [Update on antibiotic therapy. 4) Ribostamycin]. Minerva medica. 1982 Apr; 73(14):813-6. doi: NULL. [PMID: 7070690]
  • A Pagano, S Russolo, P Montorsi, S B Doldi, R Germiniani. [Plasma and urinary levels of ribostamycin in man]. Il Farmaco; edizione pratica. 1981 Oct; 36(10):462-8. doi: NULL. [PMID: 7308419]
  • R Marre, C Ost, K Sack. [Animal studies on ribostamycin (author's transl)]. Immunitat und Infektion. 1981 Apr; 9(2):66-71. doi: . [PMID: 7228116]
  • F Yamasaku, Y Suzuki, K Umemura. Pharmacokinetics of ribostamycin in healthy volunteers and patients with impaired renal function. The Japanese journal of antibiotics. 1980 Dec; 33(12):1318-31. doi: . [PMID: 7241802]