isoetarine (BioDeep_00001868269)

Main id: BioDeep_00000002727

 


代谢物信息卡片


isoetharine

化学式: C13H21NO3 (239.1521)
中文名称: 异他林, 异黄嘌呤
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(C(C1=CC(=C(C=C1)O)O)O)NC(C)C
InChI: InChI=1S/C13H21NO3/c1-4-10(14-8(2)3)13(17)9-5-6-11(15)12(16)7-9/h5-8,10,13-17H,4H2,1-3H3

描述信息

R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03C - Adrenergics for systemic use > R03CC - Selective beta-2-adrenoreceptor agonists
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03A - Adrenergics, inhalants > R03AC - Selective beta-2-adrenoreceptor agonists
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents

同义名列表

4 个代谢物同义名

isoetharine; isoetarine; Isoetharine; Isoetharine



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 AXIN2, CFTR, DYRK1A, ITGB1, SULT1A3
Peripheral membrane protein 1 AP1S2
Endosome membrane 3 ADRB2, CFTR, ITGB1
Endoplasmic reticulum membrane 2 CALU, CFTR
Nucleus 4 ADRB2, AXIN2, CFTR, DYRK1A
cytosol 5 AP1S2, AXIN2, CFTR, COMT, SULT1A3
dendrite 2 COMT, DYRK1A
centrosome 1 AXIN2
nucleoplasm 1 DYRK1A
Cell membrane 7 ADRB2, ADRB3, CFTR, COMT, GPRC5A, ITGAM, ITGB1
Cytoplasmic side 1 AP1S2
Cleavage furrow 1 ITGB1
lamellipodium 1 ITGB1
ruffle membrane 1 ITGB1
Early endosome membrane 1 CFTR
Multi-pass membrane protein 4 ADRB2, ADRB3, CFTR, GPRC5A
Synapse 2 COMT, ITGB1
cell junction 1 ITGB1
cell surface 3 CFTR, ITGAM, ITGB1
Golgi apparatus 3 ADRB2, AP1S2, CALU
Golgi membrane 1 AP1S2
lysosomal membrane 2 AP1S2, CFTR
neuromuscular junction 1 ITGB1
sarcolemma 1 ITGB1
Lysosome 1 ADRB2
endosome 1 ADRB2
plasma membrane 10 ADRB2, ADRB3, AXIN2, BCHE, CFTR, COMT, GPRC5A, IGHE, ITGAM, ITGB1
Membrane 6 ADRB2, CALU, CFTR, COMT, ITGAM, ITGB1
apical plasma membrane 2 ADRB2, CFTR
axon 2 COMT, DYRK1A
extracellular exosome 4 COMT, GPRC5A, ITGAM, ITGB1
endoplasmic reticulum 1 CALU
extracellular space 3 BCHE, IGHE, ITGAM
perinuclear region of cytoplasm 1 ITGB1
Schaffer collateral - CA1 synapse 1 ITGB1
intercalated disc 1 ITGB1
protein-containing complex 1 CFTR
intracellular membrane-bounded organelle 3 AP1S2, COMT, GPRC5A
filopodium 1 ITGB1
Single-pass type I membrane protein 3 IGHE, ITGAM, ITGB1
Secreted 2 BCHE, CALU
extracellular region 3 BCHE, CALU, IGHE
Extracellular side 1 COMT
anchoring junction 1 ITGB1
external side of plasma membrane 2 ITGAM, ITGB1
dendritic spine 1 ITGB1
beta-catenin destruction complex 1 AXIN2
nucleolus 1 GPRC5A
Early endosome 3 ADRB2, AP1S2, CFTR
Membrane, clathrin-coated pit 1 AP1S2
clathrin-coated pit 1 AP1S2
recycling endosome 2 CFTR, ITGB1
Single-pass type II membrane protein 1 COMT
vesicle 1 GPRC5A
integrin alpha3-beta1 complex 1 ITGB1
Apical cell membrane 1 CFTR
Cell projection, lamellipodium 1 ITGB1
Cell projection, ruffle membrane 1 ITGB1
Membrane raft 2 ITGAM, ITGB1
Cell junction, focal adhesion 1 ITGB1
focal adhesion 1 ITGB1
nuclear speck 1 DYRK1A
ruffle 1 ITGB1
receptor complex 4 ADRB2, ADRB3, GPRC5A, ITGB1
IgE immunoglobulin complex 1 IGHE
cytoskeleton 1 DYRK1A
blood microparticle 1 BCHE
[Isoform 2]: Cell membrane 1 IGHE
Recycling endosome membrane 1 CFTR
Endomembrane system 1 AP1S2
chloride channel complex 1 CFTR
Cytoplasmic vesicle membrane 2 AP1S2, GPRC5A
specific granule membrane 1 ITGAM
tertiary granule membrane 1 ITGAM
Melanosome 2 CALU, ITGB1
Golgi-associated vesicle membrane 1 CFTR
Nucleus speckle 1 DYRK1A
synaptic membrane 1 ITGB1
trans-Golgi network membrane 1 AP1S2
plasma membrane raft 1 ITGAM
endoplasmic reticulum lumen 2 BCHE, CALU
neuronal dense core vesicle 1 ADRB2
nuclear envelope lumen 1 BCHE
clathrin-coated endocytic vesicle membrane 2 ADRB2, CFTR
Sarcoplasmic reticulum lumen 1 CALU
ribonucleoprotein complex 1 DYRK1A
AP-type membrane coat adaptor complex 1 AP1S2
membrane coat 1 AP1S2
AP-1 adaptor complex 1 AP1S2
cerebellar climbing fiber to Purkinje cell synapse 1 ITGB1
integrin alpha10-beta1 complex 1 ITGB1
integrin complex 2 ITGAM, ITGB1
[Isoform 3]: Cell membrane 1 IGHE
glial cell projection 1 ITGB1
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
integrin alphaM-beta2 complex 1 ITGAM
Cell projection, invadopodium membrane 1 ITGB1
[Isoform 5]: Cell membrane, sarcolemma 1 ITGB1
integrin alpha1-beta1 complex 1 ITGB1
integrin alpha11-beta1 complex 1 ITGB1
integrin alpha2-beta1 complex 1 ITGB1
integrin alpha4-beta1 complex 1 ITGB1
integrin alpha5-beta1 complex 1 ITGB1
integrin alpha6-beta1 complex 1 ITGB1
integrin alpha7-beta1 complex 1 ITGB1
integrin alpha8-beta1 complex 1 ITGB1
integrin alpha9-beta1 complex 1 ITGB1
integrin alphav-beta1 complex 1 ITGB1
myelin sheath abaxonal region 1 ITGB1
[Isoform Soluble]: Cytoplasm 1 COMT
[Isoform Membrane-bound]: Cell membrane 1 COMT


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • D M Gelmont, J R Balmes, A Yee. Hypokalemia induced by inhaled bronchodilators. Chest. 1988 Oct; 94(4):763-6. doi: 10.1378/chest.94.4.763. [PMID: 3168573]
  • G P Zaloga, U R Hierlwimmer, R J Engler. Anaphylaxis following psyllium ingestion. The Journal of allergy and clinical immunology. 1984 Jul; 74(1):79-80. doi: 10.1016/0091-6749(84)90091-5. [PMID: 6736485]
  • G P Berezuk, S W Schondelmeyer, J J Seidenfeld, W N Jones, J L Bootman. Clinical comparison of albuterol, isoetharine, and metaproterenol given by aerosol inhalation. Clinical pharmacy. 1983 Mar; 2(2):129-34. doi: . [PMID: 6349905]
  • G B Park, R F Koss, J Utter, B A Mayes, J Edelson. Determination of isoetharine in plasma by reversed-phase chromatography with amperometric detection. Journal of pharmaceutical sciences. 1982 Aug; 71(8):932-4. doi: 10.1002/jps.2600710824. [PMID: 7120101]
  • A Arnold, J P McAuliff. Relative lipolytic activities of selected catecholamines in the mouse. Pharmacology. 1976; 14(2):158-65. doi: 10.1159/000136591. [PMID: 959317]