Paromomycin (BioDeep_00001868233)

Main id: BioDeep_00000003480

 

Chemicals and Drugs


代谢物信息卡片


D-Streptamine,O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(1®3)-O-b-D-ribofuranosyl-(1®5)-O-[2-amino-2-deoxy-a-D-glucopyranosyl-(1®4)]-2-deoxy-

化学式: C23H45N5O14 (615.296287)
中文名称: 巴龙霉素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N
InChI: InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1

描述信息

An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.
A - Alimentary tract and metabolism > A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents > A07A - Intestinal antiinfectives > A07AA - Antibiotics
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic

同义名列表

2 个代谢物同义名

D-Streptamine,O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(1®3)-O-b-D-ribofuranosyl-(1®5)-O-[2-amino-2-deoxy-a-D-glucopyranosyl-(1®4)]-2-deoxy-; Paromomycin



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mingxiao Liu, Di Zhang, Dongqiang Wang, Xiaodong Wu, Ying Zhang, Jigang Yin, Guan Zhu. Cost-effective In vivo and In vitro Mouse Models for Evaluating Anti-Cryptosporidial Drug Efficacy: Assessing Vorinostat, Docetaxel and Baicalein. The Journal of infectious diseases. 2023 Jul; ?(?):. doi: 10.1093/infdis/jiad243. [PMID: 37418629]
  • Yiğit Kaçar, Ahmet Tarık Baykal, Levent Aydin, Hasan Batmaz. Evaluation of the efficacy of cow colostrum in the treatment and its effect on serum proteomes in calves with cryptosporidiosis. Veterinary immunology and immunopathology. 2022 Jun; 248(?):110429. doi: 10.1016/j.vetimm.2022.110429. [PMID: 35500421]
  • Shipra Gupta, Layne Smith, Adriana Diakiw. Amebiasis and Amebic Liver Abscess in Children. Pediatric clinics of North America. 2022 02; 69(1):79-97. doi: 10.1016/j.pcl.2021.08.003. [PMID: 34794678]
  • Luka Verrest, Monique Wasunna, Gilbert Kokwaro, Rashid Aman, Ahmed M Musa, Eltahir A G Khalil, Mahmoud Mudawi, Brima M Younis, Asrat Hailu, Zewdu Hurissa, Workagegnehu Hailu, Samson Tesfaye, Eyasu Makonnen, Yalemtsehay Mekonnen, Alwin D R Huitema, Jos H Beijnen, Smita A Kshirsagar, Jaya Chakravarty, Madhukar Rai, Shyam Sundar, Fabiana Alves, Thomas P C Dorlo. Geographical Variability in Paromomycin Pharmacokinetics Does Not Explain Efficacy Differences between Eastern African and Indian Visceral Leishmaniasis Patients. Clinical pharmacokinetics. 2021 11; 60(11):1463-1473. doi: 10.1007/s40262-021-01036-8. [PMID: 34105063]
  • Aschalew Tamiru, Rezika Mohammed, Saba Atnafu, Girmay Medhin, Asrat Hailu. Efficacy and safety of a combined treatment of sodium stibogluconate at 20mg/kg/day with upper maximum daily dose limit of 850mg and Paromomycin 15mg/kg/day in HIV negative visceral leishmaniasis patients. A retrospective study, northwest Ethiopia. PLoS neglected tropical diseases. 2021 08; 15(8):e0009713. doi: 10.1371/journal.pntd.0009713. [PMID: 34464401]
  • Sapna Jain Chowdhary, Amit Chowdhary, Govind Prasad Agrawal, Ashish Jain. A Formulation of Paromomycin Sulphate as a Promising Fucose-Conjugated Nanostructured Lipid Carrier for Antileishmanial Drug Delivery. ACS biomaterials science & engineering. 2021 01; 7(1):157-165. doi: 10.1021/acsbiomaterials.0c01165. [PMID: 33350804]
  • Tiget Ayelgn Mengstie, Hiwot Tezera Endale, Tadele Mulaw, Aman Mossa Abdella, Rezika Mohammed, Tabarak Malik, Gashaw Dessie. Assessment of serum amylase, lipase and associated factors among patients with visceral leishmaniasis treated with sodium stibogluconate/paromomycin at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia. PloS one. 2021; 16(10):e0257229. doi: 10.1371/journal.pone.0257229. [PMID: 34597312]
  • Kerem Teralı, Buket Baddal, Hayrettin Ozan Gülcan. Prioritizing potential ACE2 inhibitors in the COVID-19 pandemic: Insights from a molecular mechanics-assisted structure-based virtual screening experiment. Journal of molecular graphics & modelling. 2020 11; 100(?):107697. doi: 10.1016/j.jmgm.2020.107697. [PMID: 32739642]
  • Shabi Parvez, Ganesh Yadagiri, Aakriti Singh, Archana Karole, Om Prakash Singh, Shyam Sundar, Shyam Lal Mudavath. Improvising anti-leishmanial activity of amphotericin B and paromomycin using co-delivery in d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) tailored nano-lipid carrier system. Chemistry and physics of lipids. 2020 09; 231(?):104946. doi: 10.1016/j.chemphyslip.2020.104946. [PMID: 32621810]
  • Asma Tariq, Rana Muhammad Mateen, Muhammad Sohail Afzal, Mahjabeen Saleem. Paromomycin: A potential dual targeted drug effectively inhibits both spike (S1) and main protease of COVID-19. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2020 Sep; 98(?):166-175. doi: 10.1016/j.ijid.2020.06.063. [PMID: 32579907]
  • Shabi Parvez, Ganesh Yadagiri, Mallikarjuna Rao Gedda, Aakriti Singh, Om Prakash Singh, Anurag Verma, Shyam Sundar, Shyam Lal Mudavath. Modified solid lipid nanoparticles encapsulated with Amphotericin B and Paromomycin: an effective oral combination against experimental murine visceral leishmaniasis. Scientific reports. 2020 07; 10(1):12243. doi: 10.1038/s41598-020-69276-5. [PMID: 32699361]
  • Moriah Jospe-Kaufman, Liza Siomin, Micha Fridman. The relationship between the structure and toxicity of aminoglycoside antibiotics. Bioorganic & medicinal chemistry letters. 2020 07; 30(13):127218. doi: 10.1016/j.bmcl.2020.127218. [PMID: 32360102]
  • D Kasabalis, M K Chatzis, K Apostolidis, T Petanides, L V Athanasiou, P G Xenoulis, A Mataragka, J Ikonomopoulos, L S Leontides, M N Saridomichelakis. A randomized, blinded, controlled clinical trial comparing the efficacy of aminosidine (paromomycin)-allopurinol combination with the efficacy of meglumine antimoniate-allopurinol combination for the treatment of canine leishmaniosis due to Leishmania infantum. Experimental parasitology. 2020 Jul; 214(?):107903. doi: 10.1016/j.exppara.2020.107903. [PMID: 32360142]
  • Ignace C Roseboom, Bas Thijssen, Hilde Rosing, Jane Mbui, Jos H Beijnen, Thomas P C Dorlo. Highly sensitive UPLC-MS/MS method for the quantification of paromomycin in human plasma. Journal of pharmaceutical and biomedical analysis. 2020 Jun; 185(?):113245. doi: 10.1016/j.jpba.2020.113245. [PMID: 32199328]
  • Md Shahiduzzaman, Refaat Ras, Giovanni Widmer. Effect of Ginsenoside-Rh2 and Curcurbitacin-B on Cryptosporidium parvum in vitro. Experimental parasitology. 2020 May; 212(?):107873. doi: 10.1016/j.exppara.2020.107873. [PMID: 32165146]
  • Albert Bernet Sánchez, Alba Bellés Bellés, Jesus Aramburu Arnuelos, Alfredo Jover Sanz, Eva Sesé Abizanda, Montserrat Vallverdú Vidal, Mercè García González. Entamoeba histolytica liver abscess case: could stool PCR avoid it?. Diagnosis (Berlin, Germany). 2020 01; 7(1):69-73. doi: 10.1515/dx-2019-0006. [PMID: 31256063]
  • Shabi Parvez, Ganesh Yadagiri, Archana Karole, Om Prakash Singh, Anurag Verma, Shyam Sundar, Shyam Lal Mudavath. Recuperating Biopharmaceutical Aspects of Amphotericin B and Paromomycin Using a Chitosan Functionalized Nanocarrier via Oral Route for Enhanced Anti-leishmanial Activity. Frontiers in cellular and infection microbiology. 2020; 10(?):570573. doi: 10.3389/fcimb.2020.570573. [PMID: 33178626]
  • Mojdeh Khosravi, Hanieh Mohammad Rahimi, Delaram Doroud, Elnaz Sadat Mirsamadi, Hamed Mirjalali, Mohammad Reza Zali. In vitro Evaluation of Mannosylated Paromomycin-Loaded Solid Lipid Nanoparticles on Acute Toxoplasmosis. Frontiers in cellular and infection microbiology. 2020; 10(?):33. doi: 10.3389/fcimb.2020.00033. [PMID: 32117807]
  • Arijit Bhattacharya, Philippe Leprohon, Sophia Bigot, Prasad Kottayil Padmanabhan, Angana Mukherjee, Gaétan Roy, Hélène Gingras, Anais Mestdagh, Barbara Papadopoulou, Marc Ouellette. Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania. Nature communications. 2019 12; 10(1):5627. doi: 10.1038/s41467-019-13344-6. [PMID: 31819054]
  • Dipti Debnath, Md Akil Hossain, Munny Das, Asma Kabir, Md Ibrahim, Mohammad Nurul Amin, Amrita Chowdhury, Rokeya Pervin. Characterization of Transplasma Membrane Electron Transport Chain in Wild and Drug-Resistant Leishmania donovani Promastigote and Amastigote. Acta parasitologica. 2019 Dec; 64(4):710-719. doi: 10.2478/s11686-019-00050-y. [PMID: 30941668]
  • Ander Burgaña, Rosa Abellana, Stanislav Zlatanov Yordanov, Rabee Kazan, A Mauricio Pérez Ortiz, Cristina Castillo Ramos, Christian Garavito Hernández, Miriam Molina Rivero, Alessandra Queiroga Gonçalves, Emma Padilla, Josefa Pérez, Roger García-Puig, Tomas M Perez-Porcuna. Paromomycin is superior to metronidazole in Dientamoeba fragilis treatment. International journal for parasitology. Drugs and drug resistance. 2019 12; 11(?):95-100. doi: 10.1016/j.ijpddr.2019.10.005. [PMID: 31759244]
  • D Kasabalis, M K Chatzis, K Apostolidis, P G Xenoulis, A Buono, T Petanides, L S Leontides, Z S Polizopoulou, J M Steiner, J S Suchodolski, M N Saridomichelakis. Evaluation of nephrotoxicity and ototoxicity of aminosidine (paromomycin)-allopurinol combination in dogs with leishmaniosis due to Leishmania infantum: A randomized, blinded, controlled study. Experimental parasitology. 2019 Nov; 206(?):107768. doi: 10.1016/j.exppara.2019.107768. [PMID: 31539540]
  • José Ignacio Manzano, Jelena Konstantinović, Diletta Scaccabarozzi, Ana Perea, Aleksandar Pavić, Loredana Cavicchini, Nicoletta Basilico, Francisco Gamarro, Bogdan A Šolaja. 4-Aminoquinoline-based compounds as antileishmanial agents that inhibit the energy metabolism of Leishmania. European journal of medicinal chemistry. 2019 Oct; 180(?):28-40. doi: 10.1016/j.ejmech.2019.07.010. [PMID: 31299585]
  • Shinichiro Nakamura, Iori Itagaki, Takahiro Nakagawa, Ikuo Kawamoto, Takahiro Asano, Daichi Arakawa, Hideaki Tsuchiya. Paromomycin sulfate is an effective treatment for balantidiasis in captive cynomolgus monkeys. Experimental animals. 2019 Aug; 68(3):285-292. doi: 10.1538/expanim.18-0133. [PMID: 30814394]
  • Clare F Collett, Carl Kitson, Nicola Baker, Heather B Steele-Stallard, Marie-Victoire Santrot, Sebastian Hutchinson, David Horn, Sam Alsford. Chemogenomic Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei. Antimicrobial agents and chemotherapy. 2019 08; 63(8):. doi: 10.1128/aac.00795-19. [PMID: 31160283]
  • Anne E Rivas, Donal M Boyer, Kevin Torregrosa, William J Orrico, Jean A Paré. TREATMENT OF CRYPTOSPORIDIUM SERPENTIS INFECTION IN A KING COBRA ( OPHIOPHAGUS HANNAH) WITH PAROMOMYCIN. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2018 12; 49(4):1061-1063. doi: 10.1638/2018-0080.1. [PMID: 30592920]
  • Mohammad Asadpour, Fatemeh Namazi, Seyed Mostafa Razavi, Saeed Nazifi. Curcumin: A promising treatment for Cryptosporidium parvum infection in immunosuppressed BALB/c mice. Experimental parasitology. 2018 Dec; 195(?):59-65. doi: 10.1016/j.exppara.2018.10.008. [PMID: 30385266]
  • Huawen Lin, Paul F Cliften, Susan K Dutcher. MAPINS, a Highly Efficient Detection Method That Identifies Insertional Mutations and Complex DNA Rearrangements. Plant physiology. 2018 12; 178(4):1436-1447. doi: 10.1104/pp.18.00474. [PMID: 30206105]
  • Md Sakhawat Hossain, Amresh Kumar, A F M Akhtar Hossain, Md Mahshin, Abhijit Sharma, Md Akter Hossain, Varun Sharma, Rashidul Haque, A K M Shamsuzzaman, Shomik Maruf, Prakash Ghosh, Vivek Ahuja, Dinesh Mondal. Using focused pharmacovigilance for ensuring patient safety against antileishmanial drugs in Bangladesh's National Kala-azar Elimination Programme. Infectious diseases of poverty. 2018 Aug; 7(1):80. doi: 10.1186/s40249-018-0461-0. [PMID: 30099967]
  • Mohammad Asadpour, Fatemeh Namazi, Seyed Mostafa Razavi, Saeed Nazifi. Comparative efficacy of curcumin and paromomycin against Cryptosporidium parvum infection in a BALB/c model. Veterinary parasitology. 2018 Jan; 250(?):7-14. doi: 10.1016/j.vetpar.2017.12.008. [PMID: 29329627]
  • Christina Petridou, Adnan Al-Badri, Anjana Dua, Matthew Dryden, Kordo Saeed. Learning points from a case of severe amoebic colitis. Le infezioni in medicina. 2017 Sep; 25(3):281-284. doi: NULL. [PMID: 28956549]
  • Muslim Raza, Yang Jiang, Yun Wei, Aftab Ahmad, Ajmal Khan, Yuan Qipeng. Insights from spectroscopic and in-silico techniques for the exploitation of biomolecular interactions between Human serum albumin and Paromomycin. Colloids and surfaces. B, Biointerfaces. 2017 Sep; 157(?):242-253. doi: 10.1016/j.colsurfb.2017.05.076. [PMID: 28601753]
  • Laura Escolà-Vergé, Maider Arando, Martí Vall, Roger Rovira, Mateu Espasa, Elena Sulleiro, Pere Armengol, Francesc Zarzuela, María-Jesús Barberá. Outbreak of intestinal amoebiasis among men who have sex with men, Barcelona (Spain), October 2016 and January 2017. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. 2017 Jul; 22(30):. doi: 10.2807/1560-7917.es.2017.22.30.30581. [PMID: 28797327]
  • Gilles Darcis, Gert Van der Auwera, Jean-Baptiste Giot, Marie-Pierre Hayette, Françoise Tassin, Jorge Arrese Estrada, Lieselotte Cnops, Michel Moutschen, Laurence de Leval, Philippe Leonard. Recurrence of visceral and muco-cutaneous leishmaniasis in a patient under immunosuppressive therapy. BMC infectious diseases. 2017 07; 17(1):478. doi: 10.1186/s12879-017-2571-x. [PMID: 28687071]
  • M Jakir S K Pinjari, Rahul Somani, Ritu M Gilhotra. Investigation of in vitro absorption, distribution, metabolism, and excretion and in vivo pharmacokinetics of paromomycin: Influence on oral bioavailability. Indian journal of pharmacology. 2017 Jul; 49(4):297-303. doi: 10.4103/ijp.ijp_651_16. [PMID: 29326490]
  • M Heidari-Kharaji, T Taheri, D Doroud, S Habibzadeh, A Badirzadeh, S Rafati. Enhanced paromomycin efficacy by solid lipid nanoparticle formulation against Leishmania in mice model. Parasite immunology. 2016 Oct; 38(10):599-608. doi: 10.1111/pim.12340. [PMID: 27213964]
  • Maryam Heidari Kharaji, Delaram Doroud, Tahereh Taheri, Sima Rafati. Drug Targeting to Macrophages With Solid Lipid Nanoparticles Harboring Paromomycin: an In Vitro Evaluation Against L. major and L. tropica. AAPS PharmSciTech. 2016 Oct; 17(5):1110-9. doi: 10.1208/s12249-015-0439-1. [PMID: 26552399]
  • Kotnala Balaraju, Chang-Jin Kim, Dong-Jin Park, Ki-Woong Nam, Kecheng Zhang, Mee Kyung Sang, Kyungseok Park. Paromomycin Derived from Streptomyces sp. AG-P 1441 Induces Resistance against Two Major Pathogens of Chili Pepper. Journal of microbiology and biotechnology. 2016 Sep; 26(9):1542-50. doi: 10.4014/jmb.1603.03019. [PMID: 27291677]
  • Maryam Heidari-Kharaji, Tahereh Taheri, Delaram Doroud, Sima Habibzadeh, Sima Rafati. Solid lipid nanoparticle loaded with paromomycin: in vivo efficacy against Leishmania tropica infection in BALB/c mice model. Applied microbiology and biotechnology. 2016 Aug; 100(16):7051-60. doi: 10.1007/s00253-016-7422-y. [PMID: 26960322]
  • Maria Manuela Gaspar, Susana Calado, Joana Pereira, Helena Ferronha, Ivone Correia, Helena Castro, Ana M Tomás, Maria Eugénia Meirinhos Cruz. Targeted delivery of paromomycin in murine infectious diseases through association to nano lipid systems. Nanomedicine : nanotechnology, biology, and medicine. 2015 Oct; 11(7):1851-60. doi: 10.1016/j.nano.2015.06.008. [PMID: 26169150]
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