Paromomycin (BioDeep_00000003480)

 

Secondary id: BioDeep_00001868233

human metabolite blood metabolite Chemicals and Drugs Antibiotics natural product


代谢物信息卡片


(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(2R,3S,4R,5S)-5-{[(1R,2R,3S,5R,6S)-3,5-diamino-2-{[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-hydroxycyclohexyl]oxy}-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}oxane-3,4-diol

化学式: C23H45N5O14 (615.2963)
中文名称: 巴龙霉素
谱图信息: 最多检出来源 Homo sapiens(blood) 43.64%

分子结构信息

SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N
InChI: InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1

描述信息

Paromomycin is only found in individuals that have used or taken this drug. It is an oligosaccharide antibiotic produced by various streptomyces. [PubChem]Paromomycin inhibits protein synthesis by binding to 16S ribosomal RNA. Bacterial proteins are synthesized by ribosomal RNA complexes which are composed of 2 subunits, a large subunit (50s) and small (30s) subunit, which forms a 70s ribosomal subunit. tRNA binds to the top of this ribosomal structure. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced. Continuous production of defective proteins eventually leads to bacterial death.
A - Alimentary tract and metabolism > A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents > A07A - Intestinal antiinfectives > A07AA - Antibiotics
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
KEIO_ID P126

同义名列表

44 个代谢物同义名

(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(2R,3S,4R,5S)-5-{[(1R,2R,3S,5R,6S)-3,5-diamino-2-{[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-hydroxycyclohexyl]oxy}-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}oxane-3,4-diol; (1R,2R,3S,4R,6S)-4,6-Diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside; (1R,2R,3S,4R,6S)-4,6-Diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-β-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-α-D-glucopyranoside; (1R,2R,3S,4R,6S)-4,6-Diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-b-L-idopyranosyl)-b-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-a-D-glucopyranoside; D-Streptamine,O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(1®3)-O-b-D-ribofuranosyl-(1®5)-O-[2-amino-2-deoxy-a-D-glucopyranosyl-(1®4)]-2-deoxy-; Paromomycin, beta D glucopyranosyl isomer; Paromomycin, beta-D-glucopyranosyl-isomer; beta-D-Glucopyranosyl-isomer paromomycin; Parke davis brand OF paromomycin sulfate; Cheminova brand OF paromomycin sulfate; Monarch brand OF paromomycin sulfate; Pfizer brand OF paromomycin sulfate; Paromomycin sulfate (1:1); Paromomycin sulfate (2:5); Phosphate, paromomycin; Paromomycin phosphate; Paramomycin sulphate; Sulfate, paromomycin; Paromomycin sulfate; Paramomycin sulfate; Paromomycin I; Paromomycinum; Paromomycine; Hydroxymycin; Zygomycin a1; Gabbromicina; Paucimycinum; Paromomicina; Gabbromycin; Paromomycin; Monomycin a; Paramomycin; Aminosidine; Crestomycin; Neomycin e; Aminosidin; Paucimycin; Catenulin; Estomycin; Humatin; R-400; R 400; PRM; Paromomycin



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

16 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ABCB1, ALB, LMLN, MYD88, ODC1, PRKX, RBMS3, RPS12
Endosome membrane 1 MYD88
Nucleus 4 ALB, MYD88, PRKX, RBMS3
cytosol 9 ALB, GOLPH3, LMLN, MTO1, MYD88, ODC1, PKD2L1, RBMS3, RPS12
trans-Golgi network 1 GOLPH3
centrosome 1 ALB
nucleoplasm 2 PRKX, RPS12
Cell membrane 4 ABCB1, GOLPH3, PKD2L1, TNF
Multi-pass membrane protein 2 ABCB1, PKD2L1
cell surface 5 ABCB1, MYD88, PKD2L1, TNF, TNR
glutamatergic synapse 1 TNR
Golgi apparatus 4 ALB, GOLPH3, RPS12, SERPINA1
Golgi membrane 1 GOLPH3
neuronal cell body 1 TNF
endosome 1 GOLPH3
plasma membrane 6 ABCB1, GOLPH3, IFNLR1, MYD88, PKD2L1, TNF
Membrane 6 ABCB1, GOLPH3, IFNLR1, LMLN, PKD2L1, RPS12
apical plasma membrane 1 ABCB1
extracellular exosome 4 ABCB1, ALB, SERPINA1, SPINK1
endoplasmic reticulum 3 ALB, PKD2L1, SERPINA1
extracellular space 8 ALB, IFNG, IL10, IL4, IL6, SERPINA1, TNF, TNR
Schaffer collateral - CA1 synapse 1 TNR
mitochondrion 2 GOLPH3, MTO1
protein-containing complex 2 ALB, MYD88
intracellular membrane-bounded organelle 4 GOLPH3, PKD2L1, RPS12, SERPINA1
Single-pass type I membrane protein 1 IFNLR1
Secreted 6 ALB, IFNG, IL10, IL4, IL6, SPINK1
extracellular region 8 ALB, IFNG, IL10, IL4, IL6, SERPINA1, TNF, TNR
anchoring junction 1 ALB
ciliary membrane 1 PKD2L1
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 TNR
actin cytoskeleton 1 PKD2L1
cytoplasmic vesicle 1 PKD2L1
nucleolus 1 RPS12
COPII-coated ER to Golgi transport vesicle 1 SERPINA1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 ABCB1
Membrane raft 2 TNF, TNR
focal adhesion 1 LMLN
mitochondrial intermembrane space 1 GOLPH3
collagen-containing extracellular matrix 2 SERPINA1, TNR
receptor complex 1 PKD2L1
ciliary basal body 1 ALB
phagocytic cup 1 TNF
centriole 1 ALB
Nucleus, nucleolus 1 RPS12
spindle pole 1 ALB
blood microparticle 1 ALB
non-motile cilium 1 PKD2L1
Lipid droplet 1 LMLN
Golgi cisterna membrane 1 GOLPH3
ficolin-1-rich granule lumen 1 SERPINA1
endoplasmic reticulum lumen 3 ALB, IL6, SERPINA1
platelet alpha granule lumen 2 ALB, SERPINA1
small-subunit processome 1 RPS12
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 SERPINA1
perineuronal net 1 TNR
Golgi cisterna 1 GOLPH3
calcium channel complex 1 PKD2L1
ribonucleoprotein complex 1 RBMS3
extrinsic component of cytoplasmic side of plasma membrane 1 MYD88
external side of apical plasma membrane 1 ABCB1
cytosolic ribosome 1 RPS12
extrinsic component of plasma membrane 1 MYD88
Cell projection, cilium membrane 1 PKD2L1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
cytosolic small ribosomal subunit 1 RPS12
tenascin complex 1 TNR
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Mingxiao Liu, Di Zhang, Dongqiang Wang, Xiaodong Wu, Ying Zhang, Jigang Yin, Guan Zhu. Cost-effective In vivo and In vitro Mouse Models for Evaluating Anti-Cryptosporidial Drug Efficacy: Assessing Vorinostat, Docetaxel and Baicalein. The Journal of infectious diseases. 2023 Jul; ?(?):. doi: 10.1093/infdis/jiad243. [PMID: 37418629]
  • Yiğit Kaçar, Ahmet Tarık Baykal, Levent Aydin, Hasan Batmaz. Evaluation of the efficacy of cow colostrum in the treatment and its effect on serum proteomes in calves with cryptosporidiosis. Veterinary immunology and immunopathology. 2022 Jun; 248(?):110429. doi: 10.1016/j.vetimm.2022.110429. [PMID: 35500421]
  • Shipra Gupta, Layne Smith, Adriana Diakiw. Amebiasis and Amebic Liver Abscess in Children. Pediatric clinics of North America. 2022 02; 69(1):79-97. doi: 10.1016/j.pcl.2021.08.003. [PMID: 34794678]
  • Luka Verrest, Monique Wasunna, Gilbert Kokwaro, Rashid Aman, Ahmed M Musa, Eltahir A G Khalil, Mahmoud Mudawi, Brima M Younis, Asrat Hailu, Zewdu Hurissa, Workagegnehu Hailu, Samson Tesfaye, Eyasu Makonnen, Yalemtsehay Mekonnen, Alwin D R Huitema, Jos H Beijnen, Smita A Kshirsagar, Jaya Chakravarty, Madhukar Rai, Shyam Sundar, Fabiana Alves, Thomas P C Dorlo. Geographical Variability in Paromomycin Pharmacokinetics Does Not Explain Efficacy Differences between Eastern African and Indian Visceral Leishmaniasis Patients. Clinical pharmacokinetics. 2021 11; 60(11):1463-1473. doi: 10.1007/s40262-021-01036-8. [PMID: 34105063]
  • Aschalew Tamiru, Rezika Mohammed, Saba Atnafu, Girmay Medhin, Asrat Hailu. Efficacy and safety of a combined treatment of sodium stibogluconate at 20mg/kg/day with upper maximum daily dose limit of 850mg and Paromomycin 15mg/kg/day in HIV negative visceral leishmaniasis patients. A retrospective study, northwest Ethiopia. PLoS neglected tropical diseases. 2021 08; 15(8):e0009713. doi: 10.1371/journal.pntd.0009713. [PMID: 34464401]
  • Sapna Jain Chowdhary, Amit Chowdhary, Govind Prasad Agrawal, Ashish Jain. A Formulation of Paromomycin Sulphate as a Promising Fucose-Conjugated Nanostructured Lipid Carrier for Antileishmanial Drug Delivery. ACS biomaterials science & engineering. 2021 01; 7(1):157-165. doi: 10.1021/acsbiomaterials.0c01165. [PMID: 33350804]
  • Tiget Ayelgn Mengstie, Hiwot Tezera Endale, Tadele Mulaw, Aman Mossa Abdella, Rezika Mohammed, Tabarak Malik, Gashaw Dessie. Assessment of serum amylase, lipase and associated factors among patients with visceral leishmaniasis treated with sodium stibogluconate/paromomycin at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia. PloS one. 2021; 16(10):e0257229. doi: 10.1371/journal.pone.0257229. [PMID: 34597312]
  • Kerem Teralı, Buket Baddal, Hayrettin Ozan Gülcan. Prioritizing potential ACE2 inhibitors in the COVID-19 pandemic: Insights from a molecular mechanics-assisted structure-based virtual screening experiment. Journal of molecular graphics & modelling. 2020 11; 100(?):107697. doi: 10.1016/j.jmgm.2020.107697. [PMID: 32739642]
  • Shabi Parvez, Ganesh Yadagiri, Aakriti Singh, Archana Karole, Om Prakash Singh, Shyam Sundar, Shyam Lal Mudavath. Improvising anti-leishmanial activity of amphotericin B and paromomycin using co-delivery in d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) tailored nano-lipid carrier system. Chemistry and physics of lipids. 2020 09; 231(?):104946. doi: 10.1016/j.chemphyslip.2020.104946. [PMID: 32621810]
  • Asma Tariq, Rana Muhammad Mateen, Muhammad Sohail Afzal, Mahjabeen Saleem. Paromomycin: A potential dual targeted drug effectively inhibits both spike (S1) and main protease of COVID-19. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2020 Sep; 98(?):166-175. doi: 10.1016/j.ijid.2020.06.063. [PMID: 32579907]
  • Shabi Parvez, Ganesh Yadagiri, Mallikarjuna Rao Gedda, Aakriti Singh, Om Prakash Singh, Anurag Verma, Shyam Sundar, Shyam Lal Mudavath. Modified solid lipid nanoparticles encapsulated with Amphotericin B and Paromomycin: an effective oral combination against experimental murine visceral leishmaniasis. Scientific reports. 2020 07; 10(1):12243. doi: 10.1038/s41598-020-69276-5. [PMID: 32699361]
  • Moriah Jospe-Kaufman, Liza Siomin, Micha Fridman. The relationship between the structure and toxicity of aminoglycoside antibiotics. Bioorganic & medicinal chemistry letters. 2020 07; 30(13):127218. doi: 10.1016/j.bmcl.2020.127218. [PMID: 32360102]
  • D Kasabalis, M K Chatzis, K Apostolidis, T Petanides, L V Athanasiou, P G Xenoulis, A Mataragka, J Ikonomopoulos, L S Leontides, M N Saridomichelakis. A randomized, blinded, controlled clinical trial comparing the efficacy of aminosidine (paromomycin)-allopurinol combination with the efficacy of meglumine antimoniate-allopurinol combination for the treatment of canine leishmaniosis due to Leishmania infantum. Experimental parasitology. 2020 Jul; 214(?):107903. doi: 10.1016/j.exppara.2020.107903. [PMID: 32360142]
  • Ignace C Roseboom, Bas Thijssen, Hilde Rosing, Jane Mbui, Jos H Beijnen, Thomas P C Dorlo. Highly sensitive UPLC-MS/MS method for the quantification of paromomycin in human plasma. Journal of pharmaceutical and biomedical analysis. 2020 Jun; 185(?):113245. doi: 10.1016/j.jpba.2020.113245. [PMID: 32199328]
  • Md Shahiduzzaman, Refaat Ras, Giovanni Widmer. Effect of Ginsenoside-Rh2 and Curcurbitacin-B on Cryptosporidium parvum in vitro. Experimental parasitology. 2020 May; 212(?):107873. doi: 10.1016/j.exppara.2020.107873. [PMID: 32165146]
  • Albert Bernet Sánchez, Alba Bellés Bellés, Jesus Aramburu Arnuelos, Alfredo Jover Sanz, Eva Sesé Abizanda, Montserrat Vallverdú Vidal, Mercè García González. Entamoeba histolytica liver abscess case: could stool PCR avoid it?. Diagnosis (Berlin, Germany). 2020 01; 7(1):69-73. doi: 10.1515/dx-2019-0006. [PMID: 31256063]
  • Shabi Parvez, Ganesh Yadagiri, Archana Karole, Om Prakash Singh, Anurag Verma, Shyam Sundar, Shyam Lal Mudavath. Recuperating Biopharmaceutical Aspects of Amphotericin B and Paromomycin Using a Chitosan Functionalized Nanocarrier via Oral Route for Enhanced Anti-leishmanial Activity. Frontiers in cellular and infection microbiology. 2020; 10(?):570573. doi: 10.3389/fcimb.2020.570573. [PMID: 33178626]
  • Mojdeh Khosravi, Hanieh Mohammad Rahimi, Delaram Doroud, Elnaz Sadat Mirsamadi, Hamed Mirjalali, Mohammad Reza Zali. In vitro Evaluation of Mannosylated Paromomycin-Loaded Solid Lipid Nanoparticles on Acute Toxoplasmosis. Frontiers in cellular and infection microbiology. 2020; 10(?):33. doi: 10.3389/fcimb.2020.00033. [PMID: 32117807]
  • Arijit Bhattacharya, Philippe Leprohon, Sophia Bigot, Prasad Kottayil Padmanabhan, Angana Mukherjee, Gaétan Roy, Hélène Gingras, Anais Mestdagh, Barbara Papadopoulou, Marc Ouellette. Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania. Nature communications. 2019 12; 10(1):5627. doi: 10.1038/s41467-019-13344-6. [PMID: 31819054]
  • Dipti Debnath, Md Akil Hossain, Munny Das, Asma Kabir, Md Ibrahim, Mohammad Nurul Amin, Amrita Chowdhury, Rokeya Pervin. Characterization of Transplasma Membrane Electron Transport Chain in Wild and Drug-Resistant Leishmania donovani Promastigote and Amastigote. Acta parasitologica. 2019 Dec; 64(4):710-719. doi: 10.2478/s11686-019-00050-y. [PMID: 30941668]
  • Ander Burgaña, Rosa Abellana, Stanislav Zlatanov Yordanov, Rabee Kazan, A Mauricio Pérez Ortiz, Cristina Castillo Ramos, Christian Garavito Hernández, Miriam Molina Rivero, Alessandra Queiroga Gonçalves, Emma Padilla, Josefa Pérez, Roger García-Puig, Tomas M Perez-Porcuna. Paromomycin is superior to metronidazole in Dientamoeba fragilis treatment. International journal for parasitology. Drugs and drug resistance. 2019 12; 11(?):95-100. doi: 10.1016/j.ijpddr.2019.10.005. [PMID: 31759244]
  • D Kasabalis, M K Chatzis, K Apostolidis, P G Xenoulis, A Buono, T Petanides, L S Leontides, Z S Polizopoulou, J M Steiner, J S Suchodolski, M N Saridomichelakis. Evaluation of nephrotoxicity and ototoxicity of aminosidine (paromomycin)-allopurinol combination in dogs with leishmaniosis due to Leishmania infantum: A randomized, blinded, controlled study. Experimental parasitology. 2019 Nov; 206(?):107768. doi: 10.1016/j.exppara.2019.107768. [PMID: 31539540]
  • José Ignacio Manzano, Jelena Konstantinović, Diletta Scaccabarozzi, Ana Perea, Aleksandar Pavić, Loredana Cavicchini, Nicoletta Basilico, Francisco Gamarro, Bogdan A Šolaja. 4-Aminoquinoline-based compounds as antileishmanial agents that inhibit the energy metabolism of Leishmania. European journal of medicinal chemistry. 2019 Oct; 180(?):28-40. doi: 10.1016/j.ejmech.2019.07.010. [PMID: 31299585]
  • Shinichiro Nakamura, Iori Itagaki, Takahiro Nakagawa, Ikuo Kawamoto, Takahiro Asano, Daichi Arakawa, Hideaki Tsuchiya. Paromomycin sulfate is an effective treatment for balantidiasis in captive cynomolgus monkeys. Experimental animals. 2019 Aug; 68(3):285-292. doi: 10.1538/expanim.18-0133. [PMID: 30814394]
  • Clare F Collett, Carl Kitson, Nicola Baker, Heather B Steele-Stallard, Marie-Victoire Santrot, Sebastian Hutchinson, David Horn, Sam Alsford. Chemogenomic Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei. Antimicrobial agents and chemotherapy. 2019 08; 63(8):. doi: 10.1128/aac.00795-19. [PMID: 31160283]
  • Anne E Rivas, Donal M Boyer, Kevin Torregrosa, William J Orrico, Jean A Paré. TREATMENT OF CRYPTOSPORIDIUM SERPENTIS INFECTION IN A KING COBRA ( OPHIOPHAGUS HANNAH) WITH PAROMOMYCIN. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2018 12; 49(4):1061-1063. doi: 10.1638/2018-0080.1. [PMID: 30592920]
  • Mohammad Asadpour, Fatemeh Namazi, Seyed Mostafa Razavi, Saeed Nazifi. Curcumin: A promising treatment for Cryptosporidium parvum infection in immunosuppressed BALB/c mice. Experimental parasitology. 2018 Dec; 195(?):59-65. doi: 10.1016/j.exppara.2018.10.008. [PMID: 30385266]
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  • Md Sakhawat Hossain, Amresh Kumar, A F M Akhtar Hossain, Md Mahshin, Abhijit Sharma, Md Akter Hossain, Varun Sharma, Rashidul Haque, A K M Shamsuzzaman, Shomik Maruf, Prakash Ghosh, Vivek Ahuja, Dinesh Mondal. Using focused pharmacovigilance for ensuring patient safety against antileishmanial drugs in Bangladesh's National Kala-azar Elimination Programme. Infectious diseases of poverty. 2018 Aug; 7(1):80. doi: 10.1186/s40249-018-0461-0. [PMID: 30099967]
  • Mohammad Asadpour, Fatemeh Namazi, Seyed Mostafa Razavi, Saeed Nazifi. Comparative efficacy of curcumin and paromomycin against Cryptosporidium parvum infection in a BALB/c model. Veterinary parasitology. 2018 Jan; 250(?):7-14. doi: 10.1016/j.vetpar.2017.12.008. [PMID: 29329627]
  • Christina Petridou, Adnan Al-Badri, Anjana Dua, Matthew Dryden, Kordo Saeed. Learning points from a case of severe amoebic colitis. Le infezioni in medicina. 2017 Sep; 25(3):281-284. doi: NULL. [PMID: 28956549]
  • Muslim Raza, Yang Jiang, Yun Wei, Aftab Ahmad, Ajmal Khan, Yuan Qipeng. Insights from spectroscopic and in-silico techniques for the exploitation of biomolecular interactions between Human serum albumin and Paromomycin. Colloids and surfaces. B, Biointerfaces. 2017 Sep; 157(?):242-253. doi: 10.1016/j.colsurfb.2017.05.076. [PMID: 28601753]
  • Laura Escolà-Vergé, Maider Arando, Martí Vall, Roger Rovira, Mateu Espasa, Elena Sulleiro, Pere Armengol, Francesc Zarzuela, María-Jesús Barberá. Outbreak of intestinal amoebiasis among men who have sex with men, Barcelona (Spain), October 2016 and January 2017. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. 2017 Jul; 22(30):. doi: 10.2807/1560-7917.es.2017.22.30.30581. [PMID: 28797327]
  • Gilles Darcis, Gert Van der Auwera, Jean-Baptiste Giot, Marie-Pierre Hayette, Françoise Tassin, Jorge Arrese Estrada, Lieselotte Cnops, Michel Moutschen, Laurence de Leval, Philippe Leonard. Recurrence of visceral and muco-cutaneous leishmaniasis in a patient under immunosuppressive therapy. BMC infectious diseases. 2017 07; 17(1):478. doi: 10.1186/s12879-017-2571-x. [PMID: 28687071]
  • M Jakir S K Pinjari, Rahul Somani, Ritu M Gilhotra. Investigation of in vitro absorption, distribution, metabolism, and excretion and in vivo pharmacokinetics of paromomycin: Influence on oral bioavailability. Indian journal of pharmacology. 2017 Jul; 49(4):297-303. doi: 10.4103/ijp.ijp_651_16. [PMID: 29326490]
  • M Heidari-Kharaji, T Taheri, D Doroud, S Habibzadeh, A Badirzadeh, S Rafati. Enhanced paromomycin efficacy by solid lipid nanoparticle formulation against Leishmania in mice model. Parasite immunology. 2016 Oct; 38(10):599-608. doi: 10.1111/pim.12340. [PMID: 27213964]
  • Maryam Heidari Kharaji, Delaram Doroud, Tahereh Taheri, Sima Rafati. Drug Targeting to Macrophages With Solid Lipid Nanoparticles Harboring Paromomycin: an In Vitro Evaluation Against L. major and L. tropica. AAPS PharmSciTech. 2016 Oct; 17(5):1110-9. doi: 10.1208/s12249-015-0439-1. [PMID: 26552399]
  • Kotnala Balaraju, Chang-Jin Kim, Dong-Jin Park, Ki-Woong Nam, Kecheng Zhang, Mee Kyung Sang, Kyungseok Park. Paromomycin Derived from Streptomyces sp. AG-P 1441 Induces Resistance against Two Major Pathogens of Chili Pepper. Journal of microbiology and biotechnology. 2016 Sep; 26(9):1542-50. doi: 10.4014/jmb.1603.03019. [PMID: 27291677]
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