Quinapril (BioDeep_00001868209)

Main id: BioDeep_00000002769

 


代谢物信息卡片


Quinapril

化学式: C25H30N2O5 (438.215461)
中文名称: 喹那普利
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3=CC=CC=C3CC2C(=O)O
InChI: InChI=1S/C25H30N2O5/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30)/t17-,21-,22-/m0/s1

描述信息

C - Cardiovascular system > C09 - Agents acting on the renin-angiotensin system > C09A - Ace inhibitors, plain > C09AA - Ace inhibitors, plain
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents

同义名列表

1 个代谢物同义名

Quinapril



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Majid Jaberi-Douraki, Emma Meyer, Jim Riviere, Nuwan Indika Millagaha Gedara, Jessica Kawakami, Gerald J Wyckoff, Xuan Xu. Pulmonary adverse drug event data in hypertension with implications on COVID-19 morbidity. Scientific reports. 2021 06; 11(1):13349. doi: 10.1038/s41598-021-92734-7. [PMID: 34172790]
  • A Gromotowicz-Poplawska, A Stankiewicz, J Mikita, M Aleksiejczuk, N Marcinczyk, J Szemraj, E Chabielska. Beneficial effect of combined spironolactone and quinapril treatment on thrombosis and hemostasis in 2K1C hypertensive rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2018 Apr; 69(2):. doi: 10.26402/jpp.2018.2.10. [PMID: 29980144]
  • Shuangjiao Sun, Yanfen Wei, Hao Wang, Yupin Cao, Biyang Deng. A novel electrochemiluminescence sensor coupled with capillary electrophoresis for simultaneous determination of quinapril hydrochloride and its metabolite quinaprilat hydrochloride in human plasma. Talanta. 2018 Mar; 179(?):213-220. doi: 10.1016/j.talanta.2017.10.050. [PMID: 29310224]
  • Jie-Hua Shi, Dong-Qi Pan, Min Jiang, Ting-Ting Liu, Qi Wang. In vitro study on binding interaction of quinapril with bovine serum albumin (BSA) using multi-spectroscopic and molecular docking methods. Journal of biomolecular structure & dynamics. 2017 Aug; 35(10):2211-2223. doi: 10.1080/07391102.2016.1213663. [PMID: 27418394]
  • Gábor Kökény, Lilla Fang, Csaba Révész, Miklós M Mózes, Péter Vörös, Gábor Szénási, László Rosivall. The Effect of Combined Treatment with the (Pro)Renin Receptor Blocker HRP and Quinapril in Type 1 Diabetic Rats. Kidney & blood pressure research. 2017; 42(1):109-122. doi: 10.1159/000471915. [PMID: 28359068]
  • Marzena Wojewodzka-Zelezniakowicz, Wioleta Kisiel, Karol Kramkowski, Anna Gromotowicz-Poplawska, Agnieszka Zakrzeska, Adrian Stankiewicz, Patrycjusz Kolodziejczyk, Janusz Szemraj, Jerzy Robert Ladny, Ewa Chabielska. Quinapril decreases antifibrinolytic and prooxidative potential of propofol in arterial thrombosis in hypertensive rats. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2016 Apr; 17(2):1470320316647239. doi: 10.1177/1470320316647239. [PMID: 27169890]
  • E Katriina Tarkiainen, Aleksi Tornio, Mikko T Holmberg, Terhi Launiainen, Pertti J Neuvonen, Janne T Backman, Mikko Niemi. Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril. British journal of clinical pharmacology. 2015 Nov; 80(5):1131-8. doi: 10.1111/bcp.12667. [PMID: 25919042]
  • A A Nagornaya, S Magomedov, N A Gorchakova, I F Belenichev, I S Ghekman, T A Kuzub. [INFLUENCE OF QUINAPRIL IN COMBINATION WITH ANGIOLINE ON THE CONNECTIVE TISSUE COMPONENTS IN THE RATS SERUM WITH EXPERIMENTAL HYPERTENSION]. Likars'ka sprava. 2015 Jul; ?(5-6):116-20. doi: . [PMID: 27089728]
  • Su Chi Lim, Jian-Jun Liu, Tavintharan Subramaniam, Chee Fang Sum. Elevated circulating alpha-klotho by angiotensin II receptor blocker losartan is associated with reduction of albuminuria in type 2 diabetic patients. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2014 Dec; 15(4):487-90. doi: 10.1177/1470320313475905. [PMID: 23380567]
  • J L Davis, K Kruger, D H LaFevers, B M Barlow, J M Schirmer, B A Breuhaus. Effects of quinapril on angiotensin converting enzyme and plasma renin activity as well as pharmacokinetic parameters of quinapril and its active metabolite, quinaprilat, after intravenous and oral administration to mature horses. Equine veterinary journal. 2014 Nov; 46(6):729-33. doi: 10.1111/evj.12206. [PMID: 24175935]
  • Anna M D Watson, Jiaze Li, Dian Samijono, Angelika Bierhaus, Merlin C Thomas, Karin A M Jandeleit-Dahm, Mark E Cooper. Quinapril treatment abolishes diabetes-associated atherosclerosis in RAGE/apolipoprotein E double knockout mice. Atherosclerosis. 2014 Aug; 235(2):444-8. doi: 10.1016/j.atherosclerosis.2014.05.945. [PMID: 24945577]
  • Charalambos Koumaras, Konstantinos Tziomalos, Eirini Stavrinou, Niki Katsiki, Vasilios G Athyros, Dimitri P Mikhailidis, Asterios Karagiannis. Effects of renin-angiotensin-aldosterone system inhibitors and beta-blockers on markers of arterial stiffness. Journal of the American Society of Hypertension : JASH. 2014 Feb; 8(2):74-82. doi: 10.1016/j.jash.2013.09.001. [PMID: 24139833]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Anna M D Watson, Stephen P Gray, Li Jiaze, Aino Soro-Paavonen, Benedict Wong, Mark E Cooper, Angelika Bierhaus, Raelene Pickering, Christos Tikellis, Despina Tsorotes, Merlin C Thomas, Karin A M Jandeleit-Dahm. Alagebrium reduces glomerular fibrogenesis and inflammation beyond preventing RAGE activation in diabetic apolipoprotein E knockout mice. Diabetes. 2012 Aug; 61(8):2105-13. doi: 10.2337/db11-1546. [PMID: 22698914]
  • Marek Rajzer, Wiktoria Wojciechowska, Kalina Kawecka-Jaszcz, Anetta Undas. Plasma fibrin clot properties in arterial hypertension and their modification by antihypertensive medication. Thrombosis research. 2012 Jul; 130(1):99-103. doi: 10.1016/j.thromres.2011.08.022. [PMID: 21917299]
  • Tomoe Fujita, Kazuhiko Ishihara, Shuichi Yasuda, Tomomi Nakamura, Mika Maeda, Mami Kobayashi, Kunihiko Sahashi, Yasuhiko Ikeda, Yuji Kumagai, Masataka Majima. In vivo kinetics of indoxyl sulfate in humans and its renal interaction with angiotensin-converting enzyme inhibitor quinapril in rats. The Journal of pharmacology and experimental therapeutics. 2012 Jun; 341(3):626-33. doi: 10.1124/jpet.111.187732. [PMID: 22389425]
  • Stephen T Turner, Gary L Schwartz, Arlene B Chapman, Amber L Beitelshees, John G Gums, Rhonda M Cooper-Dehoff, Eric Boerwinkle, Julie A Johnson, Kent R Bailey. Power to identify a genetic predictor of antihypertensive drug response using different methods to measure blood pressure response. Journal of translational medicine. 2012 Mar; 10(?):47. doi: 10.1186/1479-5876-10-47. [PMID: 22413836]
  • Yaman Kaakeh, Sanna Kanjee, Kevin Boone, James Sutton. Liraglutide-induced acute kidney injury. Pharmacotherapy. 2012 Jan; 32(1):e7-11. doi: 10.1002/phar.1014. [PMID: 22392833]
  • Vassilios G Athyros, Emmanouel Ganotakis, Genovefa D Kolovou, Vassilios Nicolaou, Apostolos Achimastos, Eleni Bilianou, Theodore Alexandrides, Asterios Karagiannis, Konstantinos Paletas, Evangelos N Liberopoulos, Konstantinos Tziomalos, Dimitrios Petridis, Anna Kakafika, Moses S Elisaf, Dimitri P Mikhailidis. Assessing the treatment effect in metabolic syndrome without perceptible diabetes (ATTEMPT): a prospective-randomized study in middle aged men and women. Current vascular pharmacology. 2011 Nov; 9(6):647-57. doi: 10.2174/157016111797484080. [PMID: 21476961]
  • Vassilios G Athyros, Olga Giouleme, Emmanouel S Ganotakis, Moses Elisaf, Konstantinos Tziomalos, Themistoklis Vassiliadis, Evangelos N Liberopoulos, Eleni Theocharidou, Asterios Karagiannis, Dimitri P Mikhailidis. Safety and impact on cardiovascular events of long-term multifactorial treatment in patients with metabolic syndrome and abnormal liver function tests: a post hoc analysis of the randomised ATTEMPT study. Archives of medical science : AMS. 2011 Oct; 7(5):796-805. doi: 10.5114/aoms.2011.25554. [PMID: 22291824]
  • Chi-Yu Lu, Fei-Tsui Liu, Chia-Hsien Feng. Quantitation of quinapril in human plasma by matrix-assisted laser desorption ionization time-of-flight mass spectrometry with quinolone matrix additives. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Sep; 879(26):2688-94. doi: 10.1016/j.jchromb.2011.07.026. [PMID: 21868293]
  • Xueying Tan, Jianping Li, Xinyue Wang, Nan Chen, Benzhi Cai, Gang Wang, Hongli Shan, Deli Dong, Yanju Liu, Xingda Li, Fan Yang, Xin Li, Peng Zhang, Xueqi Li, Baofeng Yang, Yanjie Lu. Tanshinone IIA protects against cardiac hypertrophy via inhibiting calcineurin/NFATc3 pathway. International journal of biological sciences. 2011 Apr; 7(3):383-9. doi: 10.7150/ijbs.7.383. [PMID: 21494433]
  • Cia-Hin Lau, Sekaran Muniandy. Novel adiponectin-resistin (AR) and insulin resistance (IRAR) indexes are useful integrated diagnostic biomarkers for insulin resistance, type 2 diabetes and metabolic syndrome: a case control study. Cardiovascular diabetology. 2011 Jan; 10(?):8. doi: 10.1186/1475-2840-10-8. [PMID: 21251282]
  • S G Kanorskiĭ, V G Tregubov, V M Pokrovskiĭ. [Alternative therapy with ivabradine in patients with functional class III chronic heart failure]. Kardiologiia. 2011; 51(8):39-44. doi: . [PMID: 21942957]
  • Jose Marcos Girardi, Rogerio Estevan Farias, Ana Paula Ferreira, Nadia Rezende Barbosa Raposo. Rosuvastatin prevents proteinuria and renal inflammation in nitric oxide-deficient rats. Clinics (Sao Paulo, Brazil). 2011; 66(8):1457-62. doi: 10.1590/s1807-59322011000800025. [PMID: 21915500]
  • Robert A Ettlin, Junji Kuroda, Stephanie Plassmann, Makoto Hayashi, David E Prentice. Successful drug development despite adverse preclinical findings part 2: examples. Journal of toxicologic pathology. 2010 Dec; 23(4):213-34. doi: 10.1293/tox.23.213. [PMID: 22272032]
  • Ping Xie, Yun-Shan Cao, Peng Su, Yu-Hong Li, Zhi-Ling Gao, Mathias M Borst. Expression of toll-like receptor 4, tumor necrosis factor- alpha, matrix metalloproteinase-9 and effects of benazepril in patients with acute coronary syndromes. Clinical Medicine Insights. Cardiology. 2010 Oct; 4(?):89-93. doi: 10.4137/cmc.s5659. [PMID: 20981132]
  • Dulcenombre Gómez-Garre, Ma Luisa González-Rubio, Paloma Muñoz-Pacheco, Alicia Caro-Vadillo, Paloma Aragoncillo, Arturo Fernández-Cruz. Rosuvastatin added to standard heart failure therapy improves cardiac remodelling in heart failure rats with preserved ejection fraction. European journal of heart failure. 2010 Sep; 12(9):903-12. doi: 10.1093/eurjhf/hfq101. [PMID: 20601374]
  • José L Miguel-Carrasco, Sonia Zambrano, Antonio J Blanca, Alfonso Mate, Carmen M Vázquez. Captopril reduces cardiac inflammatory markers in spontaneously hypertensive rats by inactivation of NF-kB. Journal of inflammation (London, England). 2010 May; 7(?):21. doi: 10.1186/1476-9255-7-21. [PMID: 20462420]
  • Marc E Gomes, Jacques W M Lenders, Louise Bellersen, Freek W A Verheugt, Paul Smits, Cees J Tack. Sympathoinhibitory effect of statins in chronic heart failure. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 2010 Apr; 20(2):73-8. doi: 10.1007/s10286-009-0041-2. [PMID: 19960360]
  • Dinko Susic, Jasmina Varagic, Edward D Frohlich. Cardiovascular effects of inhibition of renin-angiotensin-aldosterone system components in hypertensive rats given salt excess. American journal of physiology. Heart and circulatory physiology. 2010 Apr; 298(4):H1177-81. doi: 10.1152/ajpheart.00866.2009. [PMID: 20118410]
  • Spyridon Deftereos, Georgios Giannopoulos, Charalampos Kossyvakis, Andreas Kaoukis, Konstantin Raisakis, Metaxia Driva, Vasiliki Panagopoulou, Spyridon Lappos, Ilias Rentoukas, Vlasios Pyrgakis, Martin A Alpert. Effect of quinapril on in-stent restenosis and relation to plasma apoptosis signaling molecules. The American journal of cardiology. 2010 Jan; 105(1):54-8. doi: 10.1016/j.amjcard.2009.08.648. [PMID: 20102890]
  • A M D Watson, J Li, C Schumacher, M de Gasparo, B Feng, M C Thomas, T J Allen, M E Cooper, K A M Jandeleit-Dahm. The endothelin receptor antagonist avosentan ameliorates nephropathy and atherosclerosis in diabetic apolipoprotein E knockout mice. Diabetologia. 2010 Jan; 53(1):192-203. doi: 10.1007/s00125-009-1540-3. [PMID: 19862499]
  • . Adolescent type 1 Diabetes Cardio-renal Intervention Trial (AdDIT). BMC pediatrics. 2009 Dec; 9(?):79. doi: 10.1186/1471-2431-9-79. [PMID: 20017932]
  • Zalan Nemeth, Gabor Kokeny, Maria Godo, Miklós Mózes, László Rosivall, Marie-Luise Gross, Eberhard Ritz, Péter Hamar. Increased renoprotection with ACE inhibitor plus aldosterone antagonist as compared to monotherapies--the effect on podocytes. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2009 Dec; 24(12):3640-51. doi: 10.1093/ndt/gfp371. [PMID: 19666910]
  • Arne Georg Kieback, Stephan B Felix, Thorsten Reffelmann. Quinaprilat: a review of its pharmacokinetics, pharmacodynamics, toxicological data and clinical application. Expert opinion on drug metabolism & toxicology. 2009 Oct; 5(10):1337-47. doi: 10.1517/17425250903282773. [PMID: 19761414]
  • Haodan Yuan, Bo Feng, Ying Yu, Jonathan Chupka, Jenny Y Zheng, Timothy G Heath, Brian R Bond. Renal organic anion transporter-mediated drug-drug interaction between gemcabene and quinapril. The Journal of pharmacology and experimental therapeutics. 2009 Jul; 330(1):191-7. doi: 10.1124/jpet.108.149476. [PMID: 19349522]
  • Georgios Kitsios, Elias Zintzaras. ACE (I/D) polymorphism and response to treatment in coronary artery disease: a comprehensive database and meta-analysis involving study quality evaluation. BMC medical genetics. 2009 Jun; 10(?):50. doi: 10.1186/1471-2350-10-50. [PMID: 19497121]
  • Felicio Savioli Neto, Hélio M Magalhães, Michel Batlouni, Leopoldo S Piegas. ACE inhibitors and plasma B-type natriuretic peptide levels in elderly patients with heart failure. Arquivos brasileiros de cardiologia. 2009 May; 92(5):320-6, 336. doi: 10.1590/s0066-782x2009000500003. [PMID: 19629285]
  • Bhavesh Dasandi, Sanjay Shah. Determination of quinapril and quinaprilat in human plasma by ultraperformance liquid chromatography-electrospray ionization mass spectrometry. Biomedical chromatography : BMC. 2009 May; 23(5):492-8. doi: 10.1002/bmc.1143. [PMID: 19016233]
  • B Seruga, H K Gan, J J Knox. Managing toxicities and optimal dosing of targeted drugs in advanced kidney cancer. Current oncology (Toronto, Ont.). 2009 May; 16 Suppl 1(?):S52-9. doi: 10.3747/co.v16i0.402. [PMID: 19478903]
  • Iulia Sora, Elena Cristea, Florin Albu, Stefan Udrescu, Victor David, Andrei Medvedovici. LC-MS/MS assay of quinapril and its metabolite quinaprilat for drug bioequivalence evaluation: prospective, concurrential and retrospective method validation. Bioanalysis. 2009 Apr; 1(1):71-86. doi: 10.4155/bio.09.5. [PMID: 21083190]
  • Tokihiko Sawada, Yasuo Ishii, Ichiro Nakajima, Shohei Fuchinoue, Keiichi Kubota, Satoshi Teraoka. An experimental model of encapsulating peritoneal sclerosis. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. 2009 Feb; 29 Suppl 2(?):S49-50. doi: 10.1177/089686080902902s09. [PMID: 19270231]
  • Hanrui Zhang, Yoonjung Park, Junxi Wu, Xiu ping Chen, Sewon Lee, Jiyeon Yang, Kevin C Dellsperger, Cuihua Zhang. Role of TNF-alpha in vascular dysfunction. Clinical science (London, England : 1979). 2009 Feb; 116(3):219-30. doi: 10.1042/cs20080196. [PMID: 19118493]
  • Bart Westendorp, Inge Hamming, Mariusz K Szymanski, Gerjan Navis, Harry van Goor, Hendrik Buikema, Wiek H van Gilst, Regien G Schoemaker. Adverse renal effects of hydrochlorothiazide in rats with myocardial infarction treated with an ACE inhibitor. European journal of pharmacology. 2009 Jan; 602(2-3):373-9. doi: 10.1016/j.ejphar.2008.11.055. [PMID: 19084001]
  • Iu I Nesterov, O V Poltavtseva, I N Bondareva, A T Tepliakov. [Combined antihypertensive therapy in patients with arterial hypertension and type 2 diabetes]. Klinicheskaia meditsina. 2009; 87(8):29-32. doi: ". [PMID: 19827527]
  • Iu I Nesterov, I N Bondareva, A T Tepliakov, O V Poltavtseva. [Combined antihypertensive treatment of patients with hypertension and type 2 diabetes mellitus]. Terapevticheskii arkhiv. 2009; 81(2):75-9. doi: ". [PMID: 19334497]
  • Ilka Knütter, Claudia Wollesky, Gabor Kottra, Martin G Hahn, Wiebke Fischer, Katja Zebisch, Reinhard H H Neubert, Hannelore Daniel, Matthias Brandsch. Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. The Journal of pharmacology and experimental therapeutics. 2008 Nov; 327(2):432-41. doi: 10.1124/jpet.108.143339. [PMID: 18713951]
  • Sagar A Parekh, Ashutosh Pudage, Santosh S Joshi, Vikas V Vaidya, Noel A Gomes, Sudhir S Kamat. Simultaneous determination of hydrochlorothiazide, quinapril and quinaprilat in human plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Sep; 873(1):59-69. doi: 10.1016/j.jchromb.2008.07.046. [PMID: 18723407]
  • Matthew E Bourcier, Aaron I Vinik. A 41-year-old man with polyarthritis and severe autonomic neuropathy. Therapeutics and clinical risk management. 2008 Aug; 4(4):837-42. doi: 10.2147/tcrm.s2712. [PMID: 19209266]
  • Noppamas Rojanasthien, Nayada Nasangiam, Boonyium Kumsorn, Sukit Roongapinun, Apiwat Jengjareon. Pharmacokinetics and bioequivalence study of the two 20-mg quinapril hydrochloride tablet formulations in healthy Thai male volunteers. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. 2008 May; 91(5):739-46. doi: NULL. [PMID: 18672641]
  • Jie Ren, Han Li, Barry M Prior, H T Yang. Angiotensin converting enzyme inhibition enhances collateral artery remodeling in rats with femoral artery occlusion. The American journal of the medical sciences. 2008 Mar; 335(3):177-87. doi: 10.1097/maj.0b013e318142b978. [PMID: 18344690]
  • Mohammad Reza Vaez Mahdavi, Mehrdad Roghani, Tourandokht Baluchnejadmojarad. Mechanisms responsible for the vascular effect of aqueous Trigonella foenum-graecum leaf extract in diabetic rats. Indian journal of pharmacology. 2008 Mar; 40(2):59-63. doi: 10.4103/0253-7613.41039. [PMID: 21279167]
  • Katalin Farkas, Emília Fábián, Lajos Nagy. Quinapril improves endothelial function in postmenopausal hypertensive patients. Kidney & blood pressure research. 2008; 31(4):226-33. doi: 10.1159/000141927. [PMID: 18587241]
  • Saniye Sen, Sen Saniye, Mehmet Kanter, Kanter Mehmet, Sedat Ustundag, Ustundag Sedat, Cevat Aktas, Aktas Cevat, Haluk Dogutan, Omer Yalcin, Yalcin Omer. Effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on streptozotocin-induced diabetic nephropathy. Renal failure. 2008; 30(10):1023-33. doi: 10.1080/08860220802495248. [PMID: 19016156]
  • Ahmet Yildiz, M Akif Cakar, Murat Baskurt, Baris Okcun, Deniz Guzelsoy, Ugur Coskun. The effects of atorvastatin therapy on endothelial function in patients with coronary artery disease. Cardiovascular ultrasound. 2007 Dec; 5(?):51. doi: 10.1186/1476-7120-5-51. [PMID: 18163915]
  • Lucy H Clerk, Michelle A Vincent, Eugene J Barrett, Miles F Lankford, Jonathan R Lindner. Skeletal muscle capillary responses to insulin are abnormal in late-stage diabetes and are restored by angiotensin-converting enzyme inhibition. American journal of physiology. Endocrinology and metabolism. 2007 Dec; 293(6):E1804-9. doi: 10.1152/ajpendo.00498.2007. [PMID: 17911341]
  • C Ceconi, G Francolini, D Bastianon, G L Gitti, L Comini, R Ferrari. Differences in the effect of angiotensin-converting enzyme inhibitors on the rate of endothelial cell apoptosis: in vitro and in vivo studies. Cardiovascular drugs and therapy. 2007 Dec; 21(6):423-9. doi: 10.1007/s10557-007-6068-5. [PMID: 18004652]
  • Marvin Sinsakul, Mohammed Sika, Roger Rodby, John Middleton, Yu Shyr, Heidi Chen, Ernest Han, Ruediger Lehrich, Stephen Clyne, Gerald Schulman, Raymond Harris, Julia Lewis. A randomized trial of a 6-week course of celecoxib on proteinuria in diabetic kidney disease. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2007 Dec; 50(6):946-51. doi: 10.1053/j.ajkd.2007.09.005. [PMID: 18037095]
  • A E Gliddon, C J Doré, C M Black, N McHugh, R Moots, C P Denton, A Herrick, T Barnes, J Camilleri, K Chakravarty, P Emery, B Griffiths, N D Hopkinson, P Hickling, P Lanyon, C Laversuch, T Lawson, R Mallya, M Nisar, C Rhys-Dillon, T Sheeran, P J Maddison. Prevention of vascular damage in scleroderma and autoimmune Raynaud's phenomenon: a multicenter, randomized, double-blind, placebo-controlled trial of the angiotensin-converting enzyme inhibitor quinapril. Arthritis and rheumatism. 2007 Nov; 56(11):3837-46. doi: 10.1002/art.22965. [PMID: 17968938]
  • Marcel Ruzicka, Elizabeth Coletta, Frans H H Leenen. Does blockade of the renin angiotensin system affect sympathetic and blood pressure responses to amlodipine in young hypertensive patients?. American journal of hypertension. 2007 Nov; 20(11):1202-8. doi: 10.1016/j.amjhyper.2007.05.014. [PMID: 17954368]
  • Samira Ubaid-Girioli, Sílvia Elaine Ferreira-Melo, Leoní Adriana Souza, Eduardo Arantes Nogueira, Juan Carlos Yugar-Toledo, Antonio Coca, Heitor Moreno. Aldosterone escape with diuretic or angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker combination therapy in patients with mild to moderate hypertension. Journal of clinical hypertension (Greenwich, Conn.). 2007 Oct; 9(10):770-4. doi: 10.1111/j.1751-7176.2007.tb00091.x. [PMID: 17917504]
  • S-C Lim, A F Y Koh, S K Goh, C-L Chua, B-L Heng, T Subramaniam, C-F Sum. Angiotensin receptor antagonist vs. angiotensin-converting enzyme inhibitor in Asian subjects with type 2 diabetes and albuminuria - a randomized crossover study. Diabetes, obesity & metabolism. 2007 Jul; 9(4):477-82. doi: 10.1111/j.1463-1326.2006.00623.x. [PMID: 17587389]
  • Dariusz Andrzejczak, Dorota Górska, Elzbieta Czarnecka. Influence of enalapril, quinapril and losartan on lipopolysaccharide (LPS)-induced serum concentrations of TNF-alpha, IL-1 beta, IL-6 in spontaneously hypertensive rats (SHR). Pharmacological reports : PR. 2007 Jul; 59(4):437-46. doi: . [PMID: 17901573]
  • Jesus Egido, Marta Ruiz-Ortega. Anti-inflammatory actions of quinapril. Cardiovascular drugs and therapy. 2007 Jun; 21(3):211-20. doi: 10.1007/s10557-007-6019-1. [PMID: 17404826]
  • Xiao-Yan Chu, Kelly Bleasby, Jocelyn Yabut, Xiaoxin Cai, Grace Hoyee Chan, Michael J Hafey, Shiyao Xu, Arthur J Bergman, Matthew P Braun, Dennis C Dean, Raymond Evers. Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein. The Journal of pharmacology and experimental therapeutics. 2007 May; 321(2):673-83. doi: 10.1124/jpet.106.116517. [PMID: 17314201]
  • Magdalena Gibas, Jolanta Miszczak-Smiałek, Edyta Madry, Jerzy Głuszek, Henryk Witmanowski, Janusz Piotrowski. Influence of preventive therapy with quinapril on IL-6 level in patients with chronic stable angina. Pharmacological reports : PR. 2007 May; 59(3):330-8. doi: . [PMID: 17652834]
  • Ulrich Kintscher, Peter Bramlage, W Dieter Paar, Martin Thoenes, Thomas Unger. Irbesartan for the treatment of hypertension in patients with the metabolic syndrome: a sub analysis of the Treat to Target post authorization survey. Prospective observational, two armed study in 14,200 patients. Cardiovascular diabetology. 2007 Apr; 6(?):12. doi: 10.1186/1475-2840-6-12. [PMID: 17407587]
  • Ramón C Hermida, Diana E Ayala, Carlos Calvo. Optimal timing for antihypertensive dosing: focus on valsartan. Therapeutics and clinical risk management. 2007 Mar; 3(1):119-31. doi: 10.2147/tcrm.2007.3.1.119. [PMID: 18360620]
  • John M Flack, Karl Duncan, Suzanne E Ohmit, Ruth Quah, Xuefeng Liu, Preeti Ramappa, Sandra Norris, Lowell Hedquist, Amanda Dudley, Samar A Nasser. Influence of albuminuria and glomerular filtration rate on blood pressure response to antihypertensive drug therapy. Vascular health and risk management. 2007; 3(6):1029-37. doi: NULL. [PMID: 18200821]
  • José Tuñón, José Luis Martín-Ventura, Luis Miguel Blanco-Colio, Nieves Tarín, Jesús Egido. Common pathways of hypercholesterolemia and hypertension leading to atherothrombosis: the need for a global approach in the management of cardiovascular risk factors. Vascular health and risk management. 2007; 3(4):521-6. doi: ". [PMID: 17969382]
  • Ramadan A Hammoud, Christopher S Vaccari, Sameer H Nagamia, Bobby V Khan. Regulation of the renin-angiotensin system in coronary atherosclerosis: a review of the literature. Vascular health and risk management. 2007; 3(6):937-45. doi: ". [PMID: 18200812]
  • Sameer Nagamia, Anbu Pandian, Faiz Cheema, Rama Natarajan, Qamar A Khan, Amar D Patel, Nadya Merchant, Srikanth Sola, Bobby V Khan. The role of quinapril in the presence of a weight loss regimen: endothelial function and markers of obesity in patients with the metabolic syndrome. Preventive cardiology. 2007; 10(4):204-9. doi: 10.1111/j.1520-037x.2007.06556.x. [PMID: 17917517]
  • Yilmaz Ozbay, Mehmet Akbulut, Mehmet Balin, Hidayet Kayancicek, Adil Baydas, Hasan Korkmaz. The level of hs-CRP in coronary artery ectasia and its response to statin and angiotensin-converting enzyme inhibitor treatment. Mediators of inflammation. 2007; 2007(?):89649. doi: 10.1155/2007/89649. [PMID: 17497040]
  • Toshihiko Ishimitsu, Takeaki Honda, Satoshi Ohta, Akira Akashiba, Toshiaki Takahashi, Tomoko Kameda, Masayoshi Yoshii, Junichi Minami, Masaki Takahashi, Hidehiko Ono, Hiroaki Matsuoka. Cardiorenal protective effects of year-long antihypertensive therapy with an angiotensin-converting enzyme inhibitor or a calcium channel blocker in spontaneously hypertensive rats. American journal of hypertension. 2006 Dec; 19(12):1233-40. doi: 10.1016/j.amjhyper.2006.05.019. [PMID: 17161768]
  • Vanesa Esteban, Julio Gallego-Delgado, Alberto Lazaro, Julio Osende, Sergio Mezzano, Jesus Egido, Marta Ruiz-Ortega. Long-term treatment with an ACE inhibitor or an AT1 antagonist avoids hypertension-induced inflammation in the kidney. Journal of nephrology. 2006 Nov; 19(6):725-31. doi: NULL. [PMID: 17173244]
  • Julio Gallego-Delgado, Alberto Lazaro, Dulcenombre Gomez-Garre, Julio I Osende, Maria L Gonzalez-Rubio, Marta Herraiz, Félix Manzarbeitia, José Fortes, Arturo Fernandez-Cruz, Jesús Egido. Long-term organ protection by doxazosin and/or quinapril as antihypertensive therapy. Journal of nephrology. 2006 Sep; 19(5):588-98. doi: . [PMID: 17136686]
  • Imre Kovacs, Janos Toth, Jeno Tarjan, Akos Koller. Correlation of flow mediated dilation with inflammatory markers in patients with impaired cardiac function. Beneficial effects of inhibition of ACE. European journal of heart failure. 2006 Aug; 8(5):451-9. doi: 10.1016/j.ejheart.2005.10.011. [PMID: 16325470]
  • Jørgen Vesti Nielsen, Per Westerlund, Per Bygren. A low-carbohydrate diet may prevent end-stage renal failure in type 2 diabetes. A case report. Nutrition & metabolism. 2006 Jun; 3(?):23. doi: 10.1186/1743-7075-3-23. [PMID: 16774676]
  • M Wojewódzka-Zelezniakowicz, E Chabielska, A Mogielnicki, K Kramkowski, A Karp, A Opadczuk, T Domaniewski, M Malinowska-Zaprzałka, W Buczko. Antithrombotic effect of tissue and plasma type angiotensin converting enzyme inhibitors in experimental thrombosis in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2006 Jun; 57(2):231-45. doi: . [PMID: 16845228]
  • A Undas, M Celinska-Löwenhoff, T Löwenhoff, A Szczeklik. Statins, fenofibrate, and quinapril increase clot permeability and enhance fibrinolysis in patients with coronary artery disease. Journal of thrombosis and haemostasis : JTH. 2006 May; 4(5):1029-36. doi: 10.1111/j.1538-7836.2006.01882.x. [PMID: 16689755]
  • Polichronis Alivanis, Ioannis Giannikouris, Christos Paliuras, Antonios Arvanitis, Maria Volanaki, Agelos Zervos. Metformin-associated lactic acidosis treated with continuous renal replacement therapy. Clinical therapeutics. 2006 Mar; 28(3):396-400. doi: 10.1016/j.clinthera.2006.03.004. [PMID: 16750454]
  • H Deniz, B Oğütmen, F Cakalağaoğlu, S Tuğlular, C Ozener, E Akoğlu. Inhibition of the renin angiotensin system decreases fibrogenic cytokine expression in tacrolimus nephrotoxicity in rats. Transplantation proceedings. 2006 Mar; 38(2):483-6. doi: 10.1016/j.transproceed.2005.12.056. [PMID: 16549154]
  • Bart Westendorp, Regien G Schoemaker, Hendrik Buikema, Frans Boomsma, Dirk J van Veldhuisen, Wiek H van Gilst. Progressive left ventricular hypertrophy after withdrawal of long-term ACE inhibition following experimental myocardial infarction. European journal of heart failure. 2006 Mar; 8(2):122-30. doi: 10.1016/j.ejheart.2005.04.014. [PMID: 16084760]
  • A C Pessina, L Ciccariello, F Perrone, V Stoico, G Gussoni, A Scotti, M Muggeo. Clinical efficacy and tolerability of alpha-blocker doxazosin as add-on therapy in patients with hypertension and impaired glucose metabolism. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2006 Mar; 16(2):137-47. doi: 10.1016/j.numecd.2005.04.005. [PMID: 16487914]
  • Karol Kramkowski, Andrzej Mogielnicki, Ewa Chabielska, Dorota Cylwik, Włodzimierz Buczko. The effect of 'tissue' and 'plasma' angiotensin converting enzyme inhibitors on overall haemostatic potentials in rats. Thrombosis research. 2006; 117(5):557-61. doi: 10.1016/j.thromres.2005.05.014. [PMID: 15985287]
  • A A Skvortsov, V Iu Mareev, S N Nasonova, A V Sychev, G N Arbolishvili, N A Baklanova, V P Masenko, Iu N Belenkov. [Is triple combination of different neurohormonal modulators recommended for treatment of mild-to-moderate congestive heart failure patients? (Results of Sadko-CHF study)]. Terapevticheskii arkhiv. 2006; 78(8):14-20. doi: NULL. [PMID: 17078211]
  • A A Skvortsov, V Iu Mareev, S N Nasonova, A V Sychev, G N Arbolishvili, N A Baklanova, V P Masenko, Iu N Belenkov. [Is triple combination of different neurohormonal modulators recommended for treatment of mild-to-moderate congestive heart failure patients? (Results of SADKO-CHF study). Part 2]. Terapevticheskii arkhiv. 2006; 78(9):61-71. doi: . [PMID: 17076227]
  • Bart Westendorp, Regien G Schoemaker, Hendrik Buikema, Dick de Zeeuw, Frans Boomsma, Wiek H van Gilst, Dirk J van Veldhuisen. Beneficial effects of add-on hydrochlorothiazide in rats with myocardial infarction optimally treated with quinapril. European journal of heart failure. 2005 Dec; 7(7):1085-94. doi: 10.1016/j.ejheart.2004.12.002. [PMID: 16326361]
  • Karin Jandeleit-Dahm, Markus Lassila, Belinda J Davis, Riccardo Candido, Colin I Johnston, Terri J Allen, Louise M Burrell, Mark E Cooper. Anti-atherosclerotic and renoprotective effects of combined angiotensin-converting enzyme and neutral endopeptidase inhibition in diabetic apolipoprotein E-knockout mice. Journal of hypertension. 2005 Nov; 23(11):2071-82. doi: 10.1097/01.hjh.0000184747.41565.a1. [PMID: 16208151]
  • Canan Tikiz, Ozan Utuk, Timur Pirildar, Ozgur Bayturan, Petek Bayindir, Fatma Taneli, Hakan Tikiz, Cigdem Tuzun. Effects of Angiotensin-converting enzyme inhibition and statin treatment on inflammatory markers and endothelial functions in patients with longterm rheumatoid arthritis. The Journal of rheumatology. 2005 Nov; 32(11):2095-101. doi: . [PMID: 16265685]
  • Alberto Lazaro, Julio Gallego-Delgado, Pilar Justo, Vanesa Esteban, Julio Osende, Sergio Mezzano, Alberto Ortiz, Jesus Egido. Long-term blood pressure control prevents oxidative renal injury. Antioxidants & redox signaling. 2005 Sep; 7(9-10):1285-93. doi: 10.1089/ars.2005.7.1285. [PMID: 16115034]
  • Markus Ferrari, Gerald S Werner, Barbara M Richartz, Albrecht Oehme, Eberhard Straube, Hans R Figulla. Lack of association between Chlamydia Pneumoniae serology and endothelial dysfunction of coronary arteries. Cardiovascular ultrasound. 2005 Apr; 3(?):12. doi: 10.1186/1476-7120-3-12. [PMID: 15857519]
  • Arantxa Ortega, David Rámila, Adriana Izquierdo, Laura González, Antonio Barat, Rosa Gazapo, Ricardo J Bosch, Pedro Esbrit. Role of the renin-angiotensin system on the parathyroid hormone-related protein overexpression induced by nephrotoxic acute renal failure in the rat. Journal of the American Society of Nephrology : JASN. 2005 Apr; 16(4):939-49. doi: 10.1681/asn.2004040328. [PMID: 15728788]
  • Sandra Blanco, Manuel Vaquero, Carmen Gómez-Guerrero, Dolores López, Jesús Egido, Ramón Romero. Potential role of angiotensin-converting enzyme inhibitors and statins on early podocyte damage in a model of type 2 diabetes mellitus, obesity, and mild hypertension. American journal of hypertension. 2005 Apr; 18(4 Pt 1):557-65. doi: 10.1016/j.amjhyper.2004.10.034. [PMID: 15831368]
  • Daniel R Pomaro, Silvia S M Ihara, Leonor E S A Pinto, Ivete Ueda, Dulce E Casarini, Fabiana Ebihara, Andreza O Santos, Maria C O Izar, Francisco A H Fonseca. High glucose levels abolish antiatherosclerotic benefits of ACE inhibition in alloxan-induced diabetes in rabbits. Journal of cardiovascular pharmacology. 2005 Apr; 45(4):295-300. doi: 10.1097/01.fjc.0000155384.64350.45. [PMID: 15772516]
  • Yoko Uchiyama-Tanaka, Yasukiyo Mori, Noriko Kishimoto, Masayoshi Fukui, Atsuko Nose, Yasuaki Kijima, Hideki Yamahara, Takamasa Hasegawa, Atsushi Kosaki, Hiroaki Matsubara, Toshiji Iwasaka. Comparison of the effects of quinapril and losartan on carotid artery intima-media thickness in patients with mild-to-moderate arterial hypertension. Kidney & blood pressure research. 2005; 28(2):111-6. doi: 10.1159/000084254. [PMID: 15741734]
  • Mark S MacGregor, Christopher J Deighan, R Stuart C Rodger, J Michael Boulton-Jones. A prospective open-label randomised trial of quinapril and/or amlodipine in progressive non-diabetic renal failure. Nephron. Clinical practice. 2005; 101(3):c139-49. doi: 10.1159/000086714. [PMID: 16015004]
  • Hadi A R Hadi, Cornelia S Carr, Jassim Al Suwaidi. Endothelial dysfunction: cardiovascular risk factors, therapy, and outcome. Vascular health and risk management. 2005; 1(3):183-98. doi: NULL. [PMID: 17319104]