SUCCINIMIDE (BioDeep_00001868191)

Main id: BioDeep_00000003420

 

natural product


代谢物信息卡片


SUCCINIMIDE

化学式: C4H5NO2 (99.032)
中文名称: 琥珀酰亚胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC(=O)NC1=O
InChI: InChI=1S/C4H5NO2/c6-3-1-2-4(7)5-3/h1-2H2,(H,5,6,7)

描述信息

G - Genito urinary system and sex hormones > G04 - Urologicals > G04B - Urologicals

同义名列表

3 个代谢物同义名

SUCCINIMIDE; Succinimide; Succinimide



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

13 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 AKR1B1, ALB, ALOX5, PMP2, PTGS1, PTGS2, SNN, TGS1
Peripheral membrane protein 4 ACHE, ALOX5, PTGS1, PTGS2
Endoplasmic reticulum membrane 2 PTGS1, PTGS2
Nucleus 4 ACHE, ALB, PMP2, TGS1
cytosol 5 AKR1B1, ALB, ALOX5, PMP2, TGS1
centrosome 1 ALB
nucleoplasm 4 AKR1B1, ALOX5, SLC3A2, TGS1
Cell membrane 4 ACHE, DPP4, ITGAM, SLC3A2
lamellipodium 1 DPP4
Multi-pass membrane protein 1 CACNA1I
Synapse 2 ACHE, SLC3A2
cell junction 2 DPP4, SLC3A2
cell surface 4 ACHE, DPP4, ITGAM, SLC3A2
Golgi apparatus 3 ACHE, ALB, PTGS1
Golgi membrane 1 INS
lysosomal membrane 3 DPP4, GAA, SLC3A2
neuromuscular junction 1 ACHE
Cytoplasm, cytosol 1 ALOX5
Lysosome 1 GAA
plasma membrane 8 ACHE, BCHE, CACNA1I, DPP4, F2, GAA, ITGAM, SLC3A2
Membrane 7 ACHE, CACNA1I, DPP4, GAA, ITGAM, SLC3A2, SNN
apical plasma membrane 2 DPP4, SLC3A2
basolateral plasma membrane 1 SLC3A2
caveola 1 PTGS2
extracellular exosome 10 AKR1B1, ALB, DPP4, F2, GAA, ITGAM, LYZ, PMP2, PTGS1, SLC3A2
Lysosome membrane 2 GAA, SLC3A2
endoplasmic reticulum 2 ALB, PTGS2
extracellular space 11 ACHE, AKR1B1, ALB, ALOX5, BCHE, CSF3, F2, INS, ITGAM, LYZ, TGS1
lysosomal lumen 2 CSF3, GAA
perinuclear region of cytoplasm 2 ACHE, ALOX5
intercellular canaliculus 1 DPP4
mitochondrion 2 ABAT, AKR1B1
protein-containing complex 2 ALB, PTGS2
intracellular membrane-bounded organelle 2 GAA, PTGS1
Microsome membrane 2 PTGS1, PTGS2
Single-pass type I membrane protein 1 ITGAM
Secreted 8 ACHE, ALB, BCHE, CSF3, DPP4, F2, GAA, INS
extracellular region 10 ACHE, ALB, ALOX5, BCHE, CSF3, DPP4, F2, GAA, INS, LYZ
Mitochondrion outer membrane 1 SNN
Single-pass membrane protein 2 DPP4, SNN
mitochondrial outer membrane 1 SNN
mitochondrial matrix 1 ABAT
Extracellular side 1 ACHE
anchoring junction 3 ALB, DPP4, SLC3A2
photoreceptor outer segment 1 PTGS1
Nucleus membrane 1 ALOX5
nuclear membrane 1 ALOX5
external side of plasma membrane 1 ITGAM
nucleolus 1 TGS1
Single-pass type II membrane protein 2 DPP4, SLC3A2
Apical cell membrane 2 DPP4, SLC3A2
Cytoplasm, perinuclear region 1 ALOX5
Membrane raft 2 DPP4, ITGAM
focal adhesion 1 DPP4
basement membrane 1 ACHE
collagen-containing extracellular matrix 1 F2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 2 PTGS1, PTGS2
ciliary basal body 1 ALB
centriole 1 ALB
Nucleus, nucleolus 1 TGS1
spindle pole 1 ALB
blood microparticle 3 ALB, BCHE, F2
Basolateral cell membrane 1 SLC3A2
Lipid-anchor, GPI-anchor 1 ACHE
nuclear envelope 1 ALOX5
Nucleus envelope 1 ALOX5
Endomembrane system 2 DPP4, PTGS1
endosome lumen 1 INS
specific granule membrane 1 ITGAM
tertiary granule membrane 2 GAA, ITGAM
Melanosome 1 SLC3A2
side of membrane 1 ACHE
myelin sheath 1 PMP2
basal plasma membrane 1 SLC3A2
plasma membrane raft 1 ITGAM
ficolin-1-rich granule lumen 1 ALOX5
secretory granule lumen 2 ALOX5, INS
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 5 ALB, BCHE, F2, INS, PTGS2
nuclear matrix 1 ALOX5
platelet alpha granule lumen 1 ALB
voltage-gated calcium channel complex 1 CACNA1I
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
endocytic vesicle 1 DPP4
transport vesicle 1 INS
azurophil granule membrane 1 GAA
azurophil granule lumen 1 LYZ
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Nucleus matrix 1 ALOX5
nuclear envelope lumen 2 ALOX5, BCHE
Cajal body 1 TGS1
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 GAA
Nucleus, Cajal body 1 TGS1
integrin complex 1 ITGAM
small nuclear ribonucleoprotein complex 1 TGS1
lamellipodium membrane 1 DPP4
endocytic vesicle lumen 1 CSF3
Cell projection, lamellipodium membrane 1 DPP4
integrin alphaM-beta2 complex 1 ITGAM
Cell projection, invadopodium membrane 1 DPP4
amino acid transport complex 1 SLC3A2
apical pole of neuron 1 SLC3A2
Nucleus intermembrane space 1 ALOX5
autolysosome lumen 1 GAA
[Isoform H]: Cell membrane 1 ACHE
[Dipeptidyl peptidase 4 soluble form]: Secreted 1 DPP4
ciliary transition fiber 1 ALB
4-aminobutyrate transaminase complex 1 ABAT


文献列表

  • Jeningsih, Ling Ling Tan, Alizar Ulianas, Lee Yook Heng, Nur-Fadhilah Mazlan, Nur Diyana Jamaluddin, Nurul Yuziana Mohd Yusof, Bahariah Khalid, Goh Choo Ta. Sandwich-Type DNA Micro-Optode Based on Gold-Latex Spheres Label for Reflectance Dengue Virus Detection. Sensors (Basel, Switzerland). 2020 Mar; 20(7):. doi: 10.3390/s20071820. [PMID: 32218202]
  • Mingyan Cao, Weichen Xu, Ben Niu, Ivy Kabundi, Haibin Luo, Meagan Prophet, Weimin Chen, Dengfeng Liu, Sergei V Saveliev, Marjeta Urh, Jihong Wang. An Automated and Qualified Platform Method for Site-Specific Succinimide and Deamidation Quantitation Using Low-pH Peptide Mapping. Journal of pharmaceutical sciences. 2019 11; 108(11):3540-3549. doi: 10.1016/j.xphs.2019.07.019. [PMID: 31374319]
  • Bing Yang, Haifan Wu, Paul D Schnier, Yansheng Liu, Jun Liu, Nanxi Wang, William F DeGrado, Lei Wang. Proximity-enhanced SuFEx chemical cross-linker for specific and multitargeting cross-linking mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America. 2018 10; 115(44):11162-11167. doi: 10.1073/pnas.1813574115. [PMID: 30322930]
  • Melanie Derde, Véronique Vié, Astrid Walrant, Sandrine Sagan, Valérie Lechevalier, Catherine Guérin-Dubiard, Stéphane Pezennec, Marie-Françoise Cochet, Gilles Paboeuf, Maryvonne Pasco, Florence Baron, Michel Gautier, Sophie Jan, Françoise Nau. Antimicrobial activity of lysozyme isoforms: Key molecular features. Biopolymers. 2017 Dec; 107(12):. doi: 10.1002/bip.23040. [PMID: 28944959]
  • Peter Bults, Rainer Bischoff, Hilde Bakker, Jourik A Gietema, Nico C van de Merbel. LC-MS/MS-Based Monitoring of In Vivo Protein Biotransformation: Quantitative Determination of Trastuzumab and Its Deamidation Products in Human Plasma. Analytical chemistry. 2016 Feb; 88(3):1871-7. doi: 10.1021/acs.analchem.5b04276. [PMID: 26713683]
  • John C Lainson, Mariana Ferrer Fuenmayor, Stephen Albert Johnston, Chris W Diehnelt. Conjugation Approach To Produce a Staphylococcus aureus Synbody with Activity in Serum. Bioconjugate chemistry. 2015 Oct; 26(10):2125-32. doi: 10.1021/acs.bioconjchem.5b00420. [PMID: 26365100]
  • D V Krupenya, P A Snegurov, E V Grachova, V V Gurzhiy, S P Tunik, A S Melnikov, P Yu Serdobintsev, E G Vlakh, E S Sinitsyna, T B Tennikova. New supramolecular Au(I)-Cu(I) complex as potential luminescent label for proteins. Inorganic chemistry. 2013 Nov; 52(21):12521-8. doi: 10.1021/ic401569n. [PMID: 24134597]
  • David Ouellette, Chris Chumsae, Anca Clabbers, Czeslaw Radziejewski, Ivan Correia. Comparison of the in vitro and in vivo stability of a succinimide intermediate observed on a therapeutic IgG1 molecule. mAbs. 2013 May; 5(3):432-44. doi: 10.4161/mabs.24458. [PMID: 23608772]
  • Sujeet K Mishra, Devendra Kumar, Ashok M Biradar, Rajesh. Electrochemical impedance spectroscopy characterization of mercaptopropionic acid capped ZnS nanocrystal based bioelectrode for the detection of the cardiac biomarker--myoglobin. Bioelectrochemistry (Amsterdam, Netherlands). 2012 Dec; 88(?):118-26. doi: 10.1016/j.bioelechem.2012.07.006. [PMID: 22922532]
  • Cassie J Fhaner, Sichang Liu, Hong Ji, Richard J Simpson, Gavin E Reid. Comprehensive lipidome profiling of isogenic primary and metastatic colon adenocarcinoma cell lines. Analytical chemistry. 2012 Nov; 84(21):8917-26. doi: 10.1021/ac302154g. [PMID: 23039336]
  • Abhishek Sharma, Naina Sharma, Rakesh Kumar, Upendra K Sharma, Arun K Sinha. Water-promoted cascade synthesis of alpha-arylaldehydes from arylalkenes using N-halosuccinimides: an avenue for asymmetric oxidation using Cinchona organocatalysis. Chemical communications (Cambridge, England). 2009 Sep; ?(35):5299-301. doi: 10.1039/b908717f. [PMID: 19707652]
  • Rong-Min Wang, Teruyuki Komatsu, Akito Nakagawa, Eishun Tsuchida. Human serum albumin bearing covalently attached iron(II) porphyrins as O2-coordination sites. Bioconjugate chemistry. 2005 Jan; 16(1):23-6. doi: 10.1021/bc049859m. [PMID: 15656571]
  • Gary O Rankin. Nephrotoxicity induced by C- and N-arylsuccinimides. Journal of toxicology and environmental health. Part B, Critical reviews. 2004 Sep; 7(5):399-416. doi: 10.1080/10937400490486113. [PMID: 15371242]
  • Ammar Azioune, Amel Ben Slimane, Lobnat Ait Hamou, Anne Pleuvy, Mohamed M Chehimi, Christian Perruchot, Steven P Armes. Synthesis and characterization of active ester-functionalized polypyrrole-silica nanoparticles: application to the covalent attachment of proteins. Langmuir : the ACS journal of surfaces and colloids. 2004 Apr; 20(8):3350-6. doi: 10.1021/la030407s. [PMID: 15875868]
  • E F Bandle, G Wendt, U B Ranalder, K H Trautmann. 2-Pyrrolidinone and succinimide endogenously present in several mammalian species. Life sciences. 1984 Nov; 35(22):2205-12. doi: 10.1016/0024-3205(84)90461-2. [PMID: 6503611]
  • M R Eftink, C A Ghiron. Fluorescence quenching studies with proteins. Analytical biochemistry. 1981 Jul; 114(2):199-227. doi: 10.1016/0003-2697(81)90474-7. [PMID: 7030122]